Compile Data Set for Download or QSAR
Report error Found 24 Enz. Inhib. hit(s) with all data for entry = 50017503
TargetHistone deacetylase 6(Human)
Leipzig University

Curated by ChEMBL
LigandPNGBDBM50602361(CHEMBL5206304)
Affinity DataIC50: 4.90nMAssay Description:Inhibition of recombinant full length N-terminal GST-tagged human HDAC6 (1 to 1215 residues) using Z-Lys(Ac)-AMC as substrate preincubated for 90 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
Leipzig University

Curated by ChEMBL
LigandPNGBDBM50602356(CHEMBL5198411)
Affinity DataIC50: 12nMAssay Description:Inhibition of recombinant full length N-terminal GST-tagged human HDAC6 (1 to 1215 residues) using Z-Lys(Ac)-AMC as substrate preincubated for 90 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
Leipzig University

Curated by ChEMBL
LigandPNGBDBM50602360(CHEMBL5194900)
Affinity DataIC50: 15nMAssay Description:Inhibition of recombinant full length N-terminal GST-tagged human HDAC6 (1 to 1215 residues) using Z-Lys(Ac)-AMC as substrate preincubated for 90 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
Leipzig University

Curated by ChEMBL
LigandPNGBDBM50602358(CHEMBL5173745)
Affinity DataIC50: 17nMAssay Description:Inhibition of recombinant full length N-terminal GST-tagged human HDAC6 (1 to 1215 residues) using Z-Lys(Ac)-AMC as substrate preincubated for 90 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
Leipzig University

Curated by ChEMBL
LigandPNGBDBM50602359(CHEMBL5180701)
Affinity DataIC50: 21nMAssay Description:Inhibition of recombinant full length N-terminal GST-tagged human HDAC6 (1 to 1215 residues) using Z-Lys(Ac)-AMC as substrate preincubated for 90 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
Leipzig University

Curated by ChEMBL
LigandPNGBDBM50602357(CHEMBL5169821)
Affinity DataIC50: 27nMAssay Description:Inhibition of recombinant full length N-terminal GST-tagged human HDAC6 (1 to 1215 residues) using Z-Lys(Ac)-AMC as substrate preincubated for 90 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
Leipzig University

Curated by ChEMBL
LigandPNGBDBM19149(Zolinza | suberoylanilide hydroxamic acid | CHEMBL...)
Affinity DataIC50: 88nMAssay Description:Inhibition of recombinant full length N-terminal GST-tagged human HDAC6 (1 to 1215 residues) using Z-Lys(Ac)-AMC as substrate preincubated for 90 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
Leipzig University

Curated by ChEMBL
LigandPNGBDBM19149(Zolinza | suberoylanilide hydroxamic acid | CHEMBL...)
Affinity DataIC50: 88nMAssay Description:Inhibition of recombinant full length C-terminal His/Flag-tagged human HDAC1 (1 to 482 residues) using Z-Lys(Ac)-AMC as substrate preincubated for 90...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetHistone deacetylase 1(Human)
Leipzig University

Curated by ChEMBL
LigandPNGBDBM50602361(CHEMBL5206304)
Affinity DataIC50: 100nMAssay Description:Inhibition of recombinant full length C-terminal His/Flag-tagged human HDAC1 (1 to 482 residues) using Z-Lys(Ac)-AMC as substrate preincubated for 90...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
Leipzig University

Curated by ChEMBL
LigandPNGBDBM50602356(CHEMBL5198411)
Affinity DataIC50: 156nMAssay Description:Inhibition of recombinant full length C-terminal His/Flag-tagged human HDAC1 (1 to 482 residues) using Z-Lys(Ac)-AMC as substrate preincubated for 90...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
Leipzig University

Curated by ChEMBL
LigandPNGBDBM50602358(CHEMBL5173745)
Affinity DataIC50: 161nMAssay Description:Inhibition of recombinant full length C-terminal His/Flag-tagged human HDAC1 (1 to 482 residues) using Z-Lys(Ac)-AMC as substrate preincubated for 90...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
Leipzig University

Curated by ChEMBL
LigandPNGBDBM50602357(CHEMBL5169821)
Affinity DataIC50: 174nMAssay Description:Inhibition of recombinant full length C-terminal His/Flag-tagged human HDAC1 (1 to 482 residues) using Z-Lys(Ac)-AMC as substrate preincubated for 90...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
Leipzig University

Curated by ChEMBL
LigandPNGBDBM50602360(CHEMBL5194900)
Affinity DataIC50: 186nMAssay Description:Inhibition of recombinant full length C-terminal His/Flag-tagged human HDAC1 (1 to 482 residues) using Z-Lys(Ac)-AMC as substrate preincubated for 90...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
Leipzig University

Curated by ChEMBL
LigandPNGBDBM50602359(CHEMBL5180701)
Affinity DataIC50: 208nMAssay Description:Inhibition of recombinant full length C-terminal His/Flag-tagged human HDAC1 (1 to 482 residues) using Z-Lys(Ac)-AMC as substrate preincubated for 90...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
Leipzig University

Curated by ChEMBL
LigandPNGBDBM50602361(CHEMBL5206304)
Affinity DataEC50:  460nMAssay Description:Induction of HDAC6 degradation in human HL-60 cells assessed as hyperacetylation of alpha-tubulin after 6 hrs by Western immunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
Leipzig University

Curated by ChEMBL
LigandPNGBDBM50602365(CHEMBL5185463)
Affinity DataIC50: 647nMAssay Description:Inhibition of recombinant full length N-terminal GST-tagged human HDAC6 (1 to 1215 residues) using Z-Lys(Ac)-AMC as substrate preincubated for 90 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
Leipzig University

Curated by ChEMBL
LigandPNGBDBM50602365(CHEMBL5185463)
Affinity DataIC50: 647nMAssay Description:Inhibition of recombinant full length C-terminal His/Flag-tagged human HDAC1 (1 to 482 residues) using Z-Lys(Ac)-AMC as substrate preincubated for 90...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
Leipzig University

Curated by ChEMBL
LigandPNGBDBM50602362(CHEMBL5208683)
Affinity DataIC50: 1.31E+3nMAssay Description:Inhibition of recombinant full length N-terminal GST-tagged human HDAC6 (1 to 1215 residues) using Z-Lys(Ac)-AMC as substrate preincubated for 90 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
Leipzig University

Curated by ChEMBL
LigandPNGBDBM50602362(CHEMBL5208683)
Affinity DataIC50: 1.31E+3nMAssay Description:Inhibition of recombinant full length C-terminal His/Flag-tagged human HDAC1 (1 to 482 residues) using Z-Lys(Ac)-AMC as substrate preincubated for 90...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
Leipzig University

Curated by ChEMBL
LigandPNGBDBM50602364(CHEMBL5204018)
Affinity DataIC50: 1.42E+3nMAssay Description:Inhibition of recombinant full length N-terminal GST-tagged human HDAC6 (1 to 1215 residues) using Z-Lys(Ac)-AMC as substrate preincubated for 90 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
Leipzig University

Curated by ChEMBL
LigandPNGBDBM50602364(CHEMBL5204018)
Affinity DataIC50: 1.42E+3nMAssay Description:Inhibition of recombinant full length C-terminal His/Flag-tagged human HDAC1 (1 to 482 residues) using Z-Lys(Ac)-AMC as substrate preincubated for 90...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
Leipzig University

Curated by ChEMBL
LigandPNGBDBM50602363(CHEMBL5183247)
Affinity DataIC50: 1.49E+3nMAssay Description:Inhibition of recombinant full length N-terminal GST-tagged human HDAC6 (1 to 1215 residues) using Z-Lys(Ac)-AMC as substrate preincubated for 90 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
Leipzig University

Curated by ChEMBL
LigandPNGBDBM50602363(CHEMBL5183247)
Affinity DataIC50: 1.49E+3nMAssay Description:Inhibition of recombinant full length C-terminal His/Flag-tagged human HDAC1 (1 to 482 residues) using Z-Lys(Ac)-AMC as substrate preincubated for 90...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
Leipzig University

Curated by ChEMBL
LigandPNGBDBM50602365(CHEMBL5185463)
Affinity DataEC50:  5.45E+3nMAssay Description:Induction of HDAC6 degradation in human HL-60 cells assessed as hyperacetylation of alpha-tubulin after 6 hrs by Western immunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed