Compile Data Set for Download or QSAR
Report error Found 46 Enz. Inhib. hit(s) with all data for entry = 50018601
TargetTyrosine-protein kinase BTK(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50610140(CHEMBL5266817)
Affinity DataIC50: 1nMAssay Description:Inhibition of unphosphorylated BTK (unknown origin) in the presence of ATP by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50610140(CHEMBL5266817)
Affinity DataIC50: 1nMAssay Description:Inhibition of unphosphorylated BTK (unknown origin) in the presence of ATP by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50610139(CHEMBL5287698)
Affinity DataIC50: 2nMAssay Description:Inhibition of unphosphorylated BTK (unknown origin) in the presence of ATP by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50610137(CHEMBL5269111)
Affinity DataIC50: 2nMAssay Description:Inhibition of unphosphorylated BTK (unknown origin) in the presence of ATP by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50610136(CHEMBL5274179)
Affinity DataIC50: 2nMAssay Description:Inhibition of unphosphorylated BTK (unknown origin) in the presence of ATP by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50610128(CHEMBL5284310)
Affinity DataIC50: 2nMAssay Description:Inhibition of unphosphorylated BTK (unknown origin) in the presence of ATP by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50610138(CHEMBL5268773)
Affinity DataIC50: 3nMAssay Description:Inhibition of unphosphorylated BTK (unknown origin) in the presence of ATP by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50610134(CHEMBL5280787)
Affinity DataIC50: 5nMAssay Description:Inhibition of unphosphorylated BTK (unknown origin) in the presence of ATP by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50610129(CHEMBL5276931)
Affinity DataIC50: 5nMAssay Description:Inhibition of unphosphorylated BTK (unknown origin) in the presence of ATP by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase BTK(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50610127(CHEMBL5269279)
Affinity DataIC50: 7nMAssay Description:Inhibition of unphosphorylated BTK (unknown origin) in the presence of ATP by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50610126(CHEMBL5266943)
Affinity DataIC50: 9nMAssay Description:Inhibition of unphosphorylated BTK (unknown origin) in the presence of ATP by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50588008(CHEMBL5196798)
Affinity DataIC50: 13nMAssay Description:Inhibition of unphosphorylated BTK (unknown origin) in the presence of ATP by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50610141(CHEMBL5274934)
Affinity DataIC50: 15nMAssay Description:Inhibition of unphosphorylated BTK (unknown origin) in the presence of ATP by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50610119(CHEMBL5285015)
Affinity DataIC50: 20nMAssay Description:Inhibition of unphosphorylated BTK (unknown origin) in the presence of ATP by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50610125(CHEMBL5276135)
Affinity DataIC50: 22nMAssay Description:Inhibition of unphosphorylated BTK (unknown origin) in the presence of ATP by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50610124(CHEMBL5274214)
Affinity DataIC50: 43nMAssay Description:Inhibition of unphosphorylated BTK (unknown origin) in the presence of ATP by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50610131(CHEMBL5289054)
Affinity DataIC50: 45nMAssay Description:Inhibition of unphosphorylated BTK (unknown origin) in the presence of ATP by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50610132(CHEMBL5290011)
Affinity DataIC50: 45nMAssay Description:Inhibition of unphosphorylated BTK (unknown origin) in the presence of ATP by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50610142(CHEMBL5286967)
Affinity DataIC50: 49nMAssay Description:Inhibition of unphosphorylated BTK (unknown origin) in the presence of ATP by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50610123(CHEMBL5276339)
Affinity DataIC50: 53nMAssay Description:Inhibition of unphosphorylated BTK (unknown origin) in the presence of ATP by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50610135(CHEMBL5267533)
Affinity DataIC50: 58nMAssay Description:Inhibition of unphosphorylated BTK (unknown origin) in the presence of ATP by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50610117(CHEMBL5269357)
Affinity DataIC50: 80nMAssay Description:Inhibition of unphosphorylated BTK (unknown origin) in the presence of ATP by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50610120(CHEMBL5286154)
Affinity DataIC50: 110nMAssay Description:Inhibition of unphosphorylated BTK (unknown origin) in the presence of ATP by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50610130(CHEMBL5276857)
Affinity DataIC50: 180nMAssay Description:Inhibition of unphosphorylated BTK (unknown origin) in the presence of ATP by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50610121(CHEMBL5274555)
Affinity DataIC50: 220nMAssay Description:Inhibition of unphosphorylated BTK (unknown origin) in the presence of ATP by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50610122(CHEMBL5289459)
Affinity DataIC50: 270nMAssay Description:Inhibition of unphosphorylated BTK (unknown origin) in the presence of ATP by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50610118(CHEMBL5273873)
Affinity DataIC50: 380nMAssay Description:Inhibition of unphosphorylated BTK (unknown origin) in the presence of ATP by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50610115(CHEMBL5275020)
Affinity DataIC50: 650nMAssay Description:Inhibition of unphosphorylated BTK (unknown origin) in the presence of ATP by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50610116(CHEMBL5270872)
Affinity DataIC50: 890nMAssay Description:Inhibition of unphosphorylated BTK (unknown origin) in the presence of ATP by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50610112(CHEMBL5266996)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of unphosphorylated BTK (unknown origin) in the presence of ATP by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50610136(CHEMBL5274179)
Affinity DataIC50: 1.59E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using testosterone as substrate measured after 15 mins in the presence of NADPH by LC/MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50610114(CHEMBL5266164)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of unphosphorylated BTK (unknown origin) in the presence of ATP by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50610113(CHEMBL5289611)
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of unphosphorylated BTK (unknown origin) in the presence of ATP by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50610133(CHEMBL5290736)
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of unphosphorylated BTK (unknown origin) in the presence of ATP by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50610111(CHEMBL5279801)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of unphosphorylated BTK (unknown origin) in the presence of ATP by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50610140(CHEMBL5266817)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using testosterone as substrate measured after 15 mins in the presence of NADPH by LC/MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50610136(CHEMBL5274179)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate measured after 15 mins in the presence of NADPH by LC/MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50610140(CHEMBL5266817)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate measured after 15 mins in the presence of NADPH by LC/MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetCytochrome P450 2C9(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50610136(CHEMBL5274179)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using tolbutamide as substrate measured after 15 mins in the presence of NADPH by LC/MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetCytochrome P450 2C9(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50610140(CHEMBL5266817)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using tolbutamide as substrate measured after 15 mins in the presence of NADPH by LC/MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetCytochrome P450 2D6(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50610136(CHEMBL5274179)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate measured after 15 mins in the presence of NADPH by LC/MS/MS analys...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetCytochrome P450 2D6(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50610140(CHEMBL5266817)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate measured after 15 mins in the presence of NADPH by LC/MS/MS analys...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetCytochrome P450 1A2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50610136(CHEMBL5274179)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate measured after 15 mins in the presence of NADPH by LC/MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetCytochrome P450 1A2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50610140(CHEMBL5266817)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate measured after 15 mins in the presence of NADPH by LC/MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetCytochrome P450 2C19(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50610136(CHEMBL5274179)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using S-mephenytoin as substrate measured after 30 mins in the presence of NADPH by LC/MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetCytochrome P450 2C19(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50610140(CHEMBL5266817)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using S-mephenytoin as substrate measured after 30 mins in the presence of NADPH by LC/MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed