Compile Data Set for Download or QSAR
Report error Found 58 Enz. Inhib. hit(s) with all data for entry = 50018179
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM414751(US10435405, Example 168 | US10934288, Example 168)
Affinity DataIC50: 91nMAssay Description:Inhibition of human HPK1 in human Jurkat cells assessed as reduction in SLP76 phosphorylation incubated for 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM414772(US10435405, Example 189 | US10435405, Example 190 ...)
Affinity DataIC50: 94nMAssay Description:Inhibition of human HPK1 in human Jurkat cells assessed as reduction in SLP76 phosphorylation incubated for 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM414705(US10435405, Example 122 | US10934288, Example 122)
Affinity DataIC50: 117nMAssay Description:Inhibition of human HPK1 in human Jurkat cells assessed as reduction in SLP76 phosphorylation incubated for 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM414714(US10435405, Example 131 | US10934288, Example 131)
Affinity DataIC50: 128nMAssay Description:Inhibition of human HPK1 in human Jurkat cells assessed as reduction in SLP76 phosphorylation incubated for 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM414759(US10435405, Example 176 | US10934288, Example 176)
Affinity DataIC50: 137nMAssay Description:Inhibition of human HPK1 in human Jurkat cells assessed as reduction in SLP76 phosphorylation incubated for 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM414757(US10435405, Example 174 | US10435405, Example 175 ...)
Affinity DataIC50: 138nMAssay Description:Inhibition of human HPK1 in human Jurkat cells assessed as reduction in SLP76 phosphorylation incubated for 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM414626(US10435405, Example 43 | US10934288, Example 43)
Affinity DataIC50: 144nMAssay Description:Inhibition of human HPK1 in human Jurkat cells assessed as reduction in SLP76 phosphorylation incubated for 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM414765(US10435405, Example 182 | 5-(4-(Azetidin-1-ylmethy...)
Affinity DataIC50: 146nMAssay Description:Inhibition of human HPK1 in human Jurkat cells assessed as reduction in SLP76 phosphorylation incubated for 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM50405796(CHEMBL5277555)
Affinity DataIC50: 148nMAssay Description:Inhibition of human HPK1 in human Jurkat cells assessed as reduction in SLP76 phosphorylation incubated for 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM50405792(CHEMBL5281791)
Affinity DataIC50: 219nMAssay Description:Inhibition of human HPK1 in human Jurkat cells assessed as reduction in SLP76 phosphorylation incubated for 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM498971(US11014929, Example 11 | US11542265, Example 11)
Affinity DataIC50: 258nMAssay Description:Inhibition of human HPK1 in human Jurkat cells assessed as reduction in SLP76 phosphorylation incubated for 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM50405792(CHEMBL5281791)
Affinity DataIC50: 260nMAssay Description:Inhibition of FLT3 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM414765(US10435405, Example 182 | 5-(4-(Azetidin-1-ylmethy...)
Affinity DataIC50: 302nMAssay Description:Inhibition of human HPK1 in human whole blood assessed as reduction in SLP76 phosphorylation incubated for 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM50405792(CHEMBL5281791)
Affinity DataIC50: 330nMAssay Description:Inhibition of TrkA (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM414705(US10435405, Example 122 | US10934288, Example 122)
Affinity DataIC50: 366nMAssay Description:Inhibition of FLT3 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM536101(US11242343, Example 8 | US11891388, Example 8)
Affinity DataIC50: 395nMAssay Description:Inhibition of human HPK1 in human Jurkat cells assessed as reduction in SLP76 phosphorylation incubated for 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM498974(US11014929, Example 14 | US11542265, Example 14)
Affinity DataIC50: 640nMAssay Description:Inhibition of human HPK1 in human Jurkat cells assessed as reduction in SLP76 phosphorylation incubated for 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM50405792(CHEMBL5281791)
Affinity DataIC50: 857nMAssay Description:Inhibition of KIT (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM414714(US10435405, Example 131 | US10934288, Example 131)
Affinity DataIC50: 959nMAssay Description:Inhibition of TrkA (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM414705(US10435405, Example 122 | US10934288, Example 122)
Affinity DataIC50: 1.08E+3nMAssay Description:Inhibition of KIT (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM414751(US10435405, Example 168 | US10934288, Example 168)
Affinity DataIC50: 1.51E+3nMAssay Description:Inhibition of FLT3 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM414751(US10435405, Example 168 | US10934288, Example 168)
Affinity DataIC50: 1.62E+3nMAssay Description:Inhibition of TrkA (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM414714(US10435405, Example 131 | US10934288, Example 131)
Affinity DataIC50: 1.98E+3nMAssay Description:Inhibition of KIT (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM414714(US10435405, Example 131 | US10934288, Example 131)
Affinity DataIC50: 2.23E+3nMAssay Description:Inhibition of FLT3 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM414705(US10435405, Example 122 | US10934288, Example 122)
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of TrkA (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM536097(US11242343, Example 4 | US11891388, Example 4)
Affinity DataIC50: 2.74E+3nMAssay Description:Inhibition of human HPK1 in human Jurkat cells assessed as reduction in SLP76 phosphorylation incubated for 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM414751(US10435405, Example 168 | US10934288, Example 168)
Affinity DataIC50: 7.47E+3nMAssay Description:Inhibition of KIT (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetCytochrome P450 1A2(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM414765(US10435405, Example 182 | 5-(4-(Azetidin-1-ylmethy...)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using 7- ethoxyresorufin as substrate by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetCytochrome P450 2B6(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM414765(US10435405, Example 182 | 5-(4-(Azetidin-1-ylmethy...)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of CYP2B6 in human liver microsomes using bupropion as substrate by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetCytochrome P450 2C8(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM414765(US10435405, Example 182 | 5-(4-(Azetidin-1-ylmethy...)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of CYP2C8 in human liver microsomes using amodiaquine as substrate by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetCytochrome P450 2C9(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM414765(US10435405, Example 182 | 5-(4-(Azetidin-1-ylmethy...)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetCytochrome P450 2D6(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM414765(US10435405, Example 182 | 5-(4-(Azetidin-1-ylmethy...)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using bufuralol as substrate by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM414765(US10435405, Example 182 | 5-(4-(Azetidin-1-ylmethy...)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using testosterone as substrate by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetCytochrome P450 2C19(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM414765(US10435405, Example 182 | 5-(4-(Azetidin-1-ylmethy...)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using S mephenytoin as substrate by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM414705(US10435405, Example 122 | US10934288, Example 122)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM414714(US10435405, Example 131 | US10934288, Example 131)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM414751(US10435405, Example 168 | US10934288, Example 168)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using testosterone as substrate by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM414714(US10435405, Example 131 | US10934288, Example 131)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using testosterone as substrate by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM414705(US10435405, Example 122 | US10934288, Example 122)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using testosterone as substrate by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM414751(US10435405, Example 168 | US10934288, Example 168)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM414626(US10435405, Example 43 | US10934288, Example 43)
Affinity DataKi: <1nMAssay Description:Binding affinity to recombinant human HPK1 (1 to 346 residues) expressed sf9 cells incubated for 1 hr by LanthaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM50405796(CHEMBL5277555)
Affinity DataKi:  2nMAssay Description:Binding affinity to recombinant human HPK1 (1 to 346 residues) expressed sf9 cells incubated for 1 hr by LanthaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM498971(US11014929, Example 11 | US11542265, Example 11)
Affinity DataKi:  2.5nMAssay Description:Binding affinity to recombinant human HPK1 (1 to 346 residues) expressed sf9 cells incubated for 1 hr by LanthaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM414751(US10435405, Example 168 | US10934288, Example 168)
Affinity DataKi:  2.70nMAssay Description:Binding affinity to recombinant human HPK1 (1 to 346 residues) expressed sf9 cells incubated for 1 hr by LanthaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM536101(US11242343, Example 8 | US11891388, Example 8)
Affinity DataKi:  3nMAssay Description:Binding affinity to recombinant human HPK1 (1 to 346 residues) expressed sf9 cells incubated for 1 hr by LanthaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM50405792(CHEMBL5281791)
Affinity DataKi:  3nMAssay Description:Binding affinity to recombinant human HPK1 (1 to 346 residues) expressed sf9 cells incubated for 1 hr by LanthaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM414714(US10435405, Example 131 | US10934288, Example 131)
Affinity DataKi:  3.5nMAssay Description:Binding affinity to recombinant human HPK1 (1 to 346 residues) expressed sf9 cells incubated for 1 hr by LanthaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM414772(US10435405, Example 189 | US10435405, Example 190 ...)
Affinity DataKi:  4nMAssay Description:Binding affinity to recombinant human HPK1 (1 to 346 residues) expressed sf9 cells incubated for 1 hr by LanthaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM414765(US10435405, Example 182 | 5-(4-(Azetidin-1-ylmethy...)
Affinity DataKi:  4.10nMAssay Description:Binding affinity to recombinant human HPK1 (1 to 346 residues) expressed sf9 cells incubated for 1 hr by LanthaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM414757(US10435405, Example 174 | US10435405, Example 175 ...)
Affinity DataKi:  4.60nMAssay Description:Binding affinity to recombinant human HPK1 (1 to 346 residues) expressed sf9 cells incubated for 1 hr by LanthaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
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