Compile Data Set for Download or QSAR
Report error Found 122 Enz. Inhib. hit(s) with all data for entry = 50018195
TargetHigh affinity nerve growth factor receptor(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM50405896(CHEMBL5281003)
Affinity DataIC50: 4.80nMAssay Description:Inhibition of TRKA (unknown origin) incubated for 90 mins in presence of ATP by microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM50405897(CHEMBL5277241)
Affinity DataIC50: 6.90nMAssay Description:Inhibition of TRKA (unknown origin) incubated for 90 mins in presence of ATP by microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM50405895(CHEMBL5279971)
Affinity DataIC50: 13nMAssay Description:Inhibition of TRKA (unknown origin) incubated for 90 mins in presence of ATP by microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM50405893(CHEMBL5271378)
Affinity DataIC50: 18nMAssay Description:Inhibition of TRKA (unknown origin) incubated for 90 mins in presence of ATP by microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM50405898(CHEMBL5283973)
Affinity DataIC50: 18nMAssay Description:Inhibition of TRKA (unknown origin) incubated for 90 mins in presence of ATP by microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 2(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM466705(US10800761, Example 24)
Affinity DataIC50: 40nMAssay Description:Inhibition of MAP4K2 (unknown origin) incubated for 90 mins in presence of ATP by microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM50405897(CHEMBL5277241)
Affinity DataIC50: 53nMAssay Description:Inhibition of FLT3 (unknown origin) incubated for 90 mins in presence of ATP by microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM50405896(CHEMBL5281003)
Affinity DataIC50: 58nMAssay Description:Inhibition of FLT3 (unknown origin) incubated for 90 mins in presence of ATP by microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM466723(US10800761, Example 96 | US10800761, Example 55 | ...)
Affinity DataIC50: 59nMAssay Description:Inhibition of human HPK1 in human whole blood assessed as reduction in SLP76 phosphorylation incubated for 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM459444(US10752635, Example 4, Peak 2 | US11492354, Exampl...)
Affinity DataIC50: 73nMAssay Description:Inhibition of TRKA (unknown origin) incubated for 90 mins in presence of ATP by microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM50405894(CHEMBL5269770)
Affinity DataIC50: 78nMAssay Description:Inhibition of TRKA (unknown origin) incubated for 90 mins in presence of ATP by microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetTyrosine-protein kinase Lck(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM50405896(CHEMBL5281003)
Affinity DataIC50: 83nMAssay Description:Inhibition of Lck (unknown origin) incubated for 90 mins in presence of ATP by microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM50405899(CHEMBL5288420)
Affinity DataIC50: 90nMAssay Description:Inhibition of TRKA (unknown origin) incubated for 90 mins in presence of ATP by microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase 4(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM466682(US10800761, Example 1 | US11731958, Example 1)
Affinity DataIC50: 94nMAssay Description:Inhibition of STK4 (unknown origin) incubated for 90 mins in presence of ATP by microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 2(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM466682(US10800761, Example 1 | US11731958, Example 1)
Affinity DataIC50: 104nMAssay Description:Inhibition of MAP4K2 (unknown origin) incubated for 90 mins in presence of ATP by microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM459443(US10752635, Example 4, Peak 1 | US11492354, Exampl...)
Affinity DataIC50: 110nMAssay Description:Inhibition of TRKA (unknown origin) incubated for 90 mins in presence of ATP by microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetCytochrome P450 2D6(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM459484(US10752635, Example 35 | US11492354, Example 35)
Affinity DataIC50: 110nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase 4(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM466724(US10800761, Example 43 | US11731958, Example 43)
Affinity DataIC50: 112nMAssay Description:Inhibition of STK4 (unknown origin) incubated for 90 mins in presence of ATP by microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase 4(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM466705(US10800761, Example 24)
Affinity DataIC50: 122nMAssay Description:Inhibition of STK4 (unknown origin) incubated for 90 mins in presence of ATP by microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM50406013(CHEMBL5267188)
Affinity DataIC50: 127nMAssay Description:Inhibition of human HPK1 in human whole blood assessed as reduction in SLP76 phosphorylation incubated for 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM50405896(CHEMBL5281003)
Affinity DataIC50: 147nMAssay Description:Inhibition of PDGFRB (unknown origin) incubated for 90 mins in presence of ATP by microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase 4(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM466687(US10800761, Example 6 | US11731958, Example 6 | US...)
Affinity DataIC50: 150nMAssay Description:Inhibition of STK4 (unknown origin) incubated for 90 mins in presence of ATP by microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM50405947(CHEMBL5274764)
Affinity DataIC50: 174nMAssay Description:Inhibition of TRKA (unknown origin) incubated for 90 mins in presence of ATP by microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM50406012(CHEMBL5273201)
Affinity DataIC50: 174nMAssay Description:Inhibition of TRKA (unknown origin) incubated for 90 mins in presence of ATP by microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM459445(US10752635, Example 5, Peak 1 | US11492354, Exampl...)
Affinity DataIC50: 182nMAssay Description:Inhibition of TRKA (unknown origin) incubated for 90 mins in presence of ATP by microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase 4(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM466723(US10800761, Example 96 | US10800761, Example 55 | ...)
Affinity DataIC50: 192nMAssay Description:Inhibition of STK4 (unknown origin) incubated for 90 mins in presence of ATP by microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetTyrosine-protein kinase Lck(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM50405897(CHEMBL5277241)
Affinity DataIC50: 198nMAssay Description:Inhibition of Lck (unknown origin) incubated for 90 mins in presence of ATP by microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase 4(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM459441(US10752635, Example 3, Peak 1 | US11492354, Exampl...)
Affinity DataIC50: 201nMAssay Description:Inhibition of STK4 (unknown origin) incubated for 90 mins in presence of ATP by microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
Target5'-AMP-activated protein kinase catalytic subunit alpha-1(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM50405896(CHEMBL5281003)
Affinity DataIC50: 202nMAssay Description:Inhibition of PRKAA1 (unknown origin) incubated for 90 mins in presence of ATP by microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 2(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM466723(US10800761, Example 96 | US10800761, Example 55 | ...)
Affinity DataIC50: 242nMAssay Description:Inhibition of MAP4K2 (unknown origin) incubated for 90 mins in presence of ATP by microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM466728(US10800761, Example 47 | US11731958, Example 47)
Affinity DataIC50: 251nMAssay Description:Inhibition of human HPK1 in human whole blood assessed as reduction in SLP76 phosphorylation incubated for 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM50405897(CHEMBL5277241)
Affinity DataIC50: 268nMAssay Description:Inhibition of PDGFRB (unknown origin) incubated for 90 mins in presence of ATP by microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase 4(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM50406013(CHEMBL5267188)
Affinity DataIC50: 318nMAssay Description:Inhibition of STK4 (unknown origin) incubated for 90 mins in presence of ATP by microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 2(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM50406013(CHEMBL5267188)
Affinity DataIC50: 356nMAssay Description:Inhibition of MAP4K2 (unknown origin) incubated for 90 mins in presence of ATP by microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM466724(US10800761, Example 43 | US11731958, Example 43)
Affinity DataIC50: 364nMAssay Description:Inhibition of human HPK1 in human whole blood assessed as reduction in SLP76 phosphorylation incubated for 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM466727(US10800761, Example 46 | US11731958, Example 46)
Affinity DataIC50: 373nMAssay Description:Inhibition of human HPK1 in human whole blood assessed as reduction in SLP76 phosphorylation incubated for 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM459441(US10752635, Example 3, Peak 1 | US11492354, Exampl...)
Affinity DataIC50: 400nMAssay Description:Inhibition of human HPK1 in human whole blood assessed as reduction in SLP76 phosphorylation incubated for 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
Target5'-AMP-activated protein kinase catalytic subunit alpha-1(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM50405897(CHEMBL5277241)
Affinity DataIC50: 409nMAssay Description:Inhibition of PRKAA1 (unknown origin) incubated for 90 mins in presence of ATP by microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
Target5'-AMP-activated protein kinase catalytic subunit alpha-1(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM50405895(CHEMBL5279971)
Affinity DataIC50: 446nMAssay Description:Inhibition of PRKAA1 (unknown origin) incubated for 90 mins in presence of ATP by microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 2(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM466727(US10800761, Example 46 | US11731958, Example 46)
Affinity DataIC50: 464nMAssay Description:Inhibition of MAP4K2 (unknown origin) incubated for 90 mins in presence of ATP by microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM50405895(CHEMBL5279971)
Affinity DataIC50: 465nMAssay Description:Inhibition of FLT3 (unknown origin) incubated for 90 mins in presence of ATP by microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 2(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM459441(US10752635, Example 3, Peak 1 | US11492354, Exampl...)
Affinity DataIC50: 530nMAssay Description:Inhibition of MAP4K2 (unknown origin) incubated for 90 mins in presence of ATP by microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 2(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM466687(US10800761, Example 6 | US11731958, Example 6 | US...)
Affinity DataIC50: 570nMAssay Description:Inhibition of MAP4K2 (unknown origin) incubated for 90 mins in presence of ATP by microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM466705(US10800761, Example 24)
Affinity DataIC50: 605nMAssay Description:Inhibition of human HPK1 in human whole blood assessed as reduction in SLP76 phosphorylation incubated for 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
Target5'-AMP-activated protein kinase catalytic subunit alpha-1(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM459444(US10752635, Example 4, Peak 2 | US11492354, Exampl...)
Affinity DataIC50: 643nMAssay Description:Inhibition of PRKAA1 (unknown origin) incubated for 90 mins in presence of ATP by microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 2(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM466724(US10800761, Example 43 | US11731958, Example 43)
Affinity DataIC50: 819nMAssay Description:Inhibition of MAP4K2 (unknown origin) incubated for 90 mins in presence of ATP by microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetTyrosine-protein kinase Lck(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM459443(US10752635, Example 4, Peak 1 | US11492354, Exampl...)
Affinity DataIC50: 846nMAssay Description:Inhibition of Lck (unknown origin) incubated for 90 mins in presence of ATP by microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM50405900(CHEMBL5268277)
Affinity DataIC50: 907nMAssay Description:Inhibition of TRKA (unknown origin) incubated for 90 mins in presence of ATP by microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 2(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM466728(US10800761, Example 47 | US11731958, Example 47)
Affinity DataIC50: 1.05E+3nMAssay Description:Inhibition of MAP4K2 (unknown origin) incubated for 90 mins in presence of ATP by microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM50406010(CHEMBL5277513)
Affinity DataIC50: 1.11E+3nMAssay Description:Inhibition of TRKA (unknown origin) incubated for 90 mins in presence of ATP by microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
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