Compile Data Set for Download or QSAR
Report error Found 17 Enz. Inhib. hit(s) with all data for entry = 50019342
TargetMitogen-activated protein kinase 8(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50618274(CHEMBL5432138)
Affinity DataKd:  1.00E+3nMAssay Description:Binding affinity to JNK1 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50618275(CHEMBL5424788)
Affinity DataKd:  15nMAssay Description:Binding affinity to TNKS1 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetBifunctional epoxide hydrolase 2(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50532278(CHEMBL4452411)
Affinity DataIC50: 2nMAssay Description:Inhibition of human recombinant sEHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetKynurenine 3-monooxygenase(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50618282(CHEMBL5439164)
Affinity DataIC50: 14nMAssay Description:Inhibition of GST-tagged full length human KMOMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetKynurenine 3-monooxygenase(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50618281(CHEMBL5414238)
Affinity DataIC50: 14nMAssay Description:Inhibition of GST-tagged full length human KMOMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCarbonic anhydrase 9(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50618284(CHEMBL5418792)
Affinity DataIC50: 20nMAssay Description:Inhibition of human recombinant carbonic anhydrase IXMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetProteinase-activated receptor 2(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50618279(CHEMBL5431335)
Affinity DataIC50: 23nMAssay Description:Antagonist activity at PAR2 (unknown origin) expressed in human 1321N1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetDiscoidin domain-containing receptor 2(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM438155(US10618897, Example 23)
Affinity DataIC50: 29nMAssay Description:Inhibition of DDR2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetEpithelial discoidin domain-containing receptor 1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM371924(2-[8-(1H-Indazole-5-carbonyl)-4-oxo-1-phenyl-1,3,8...)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of DDR1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetAutotaxin(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50618286(CHEMBL5426380)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of ATX (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetProtein-arginine deiminase type-4(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50618277(CHEMBL5438778)
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of PAD4 (unknown origin) in presence of 2 mM CaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetProtein-arginine deiminase type-4(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50618276(CHEMBL5400067)
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of PAD4 (unknown origin) in presence of 2 mM CaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCREB-binding protein(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50618283(CHEMBL5393792)
Affinity DataIC50: 1.70E+4nMAssay Description:Inhibition of N-terminal His-tagged CREBBP (unknown origin) expressed in Escherichia coli BL21 (DE3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetProthrombin(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50618285(CHEMBL5427224)
Affinity DataKi:  1nMAssay Description:Binding affinity to thrombin (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase 10(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50618278(CHEMBL4633869)
Affinity DataKi:  1.20nMAssay Description:Binding affinity to JNK3 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
Target2',5'-phosphodiesterase 12(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50618273(CHEMBL5415518)
Affinity DataKi:  18nMAssay Description:Binding affinity to PDE12 (unknown origin) (17 to 609 residues) assessed as inhibition constant by AMP-glo reagent based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetAlbumin(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50618280(CHEMBL5436933)
Affinity DataKi:  50nMAssay Description:Binding affinity to human serum albumin by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed