Compile Data Set for Download or QSAR
Report error Found 31 Enz. Inhib. hit(s) with all data for entry = 50018208
TargetSon of sevenless homolog 1(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50406167(CHEMBL5275216)
Affinity DataIC50: 67nMAssay Description:Inhibition of 6His-tagged SOS1 (unknown origin) mediated GST-tagged KRAS G12D activation preincubated for 15 mins followed by KRAS G12D addition and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50406154(CHEMBL5280533)
Affinity DataIC50: 71nMAssay Description:Inhibition of 6His-tagged SOS1 (unknown origin) mediated GST-tagged KRAS G12D activation preincubated for 15 mins followed by KRAS G12D addition and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50581659(CHEMBL4519023 | US20230339952, Comparative Compoun...)
Affinity DataIC50: 72nMAssay Description:Inhibition of 6His-tagged SOS1 (unknown origin) mediated GST-tagged KRAS G12D activation preincubated for 15 mins followed by KRAS G12D addition and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSon of sevenless homolog 1(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50406153(CHEMBL5290547)
Affinity DataIC50: 72nMAssay Description:Inhibition of 6His-tagged SOS1 (unknown origin) mediated GST-tagged KRAS G12D activation preincubated for 15 mins followed by KRAS G12D addition and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50406161(CHEMBL5286601)
Affinity DataIC50: 73nMAssay Description:Inhibition of 6His-tagged SOS1 (unknown origin) mediated GST-tagged KRAS G12D activation preincubated for 15 mins followed by KRAS G12D addition and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50406169(CHEMBL5269963)
Affinity DataIC50: 78nMAssay Description:Inhibition of 6His-tagged SOS1 (unknown origin) mediated GST-tagged KRAS G12D activation preincubated for 15 mins followed by KRAS G12D addition and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50406155(CHEMBL5284292)
Affinity DataIC50: 86nMAssay Description:Inhibition of 6His-tagged SOS1 (unknown origin) mediated GST-tagged KRAS G12D activation preincubated for 15 mins followed by KRAS G12D addition and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50406151(CHEMBL5266985)
Affinity DataIC50: 88nMAssay Description:Inhibition of 6His-tagged SOS1 (unknown origin) mediated GST-tagged KRAS G12D activation preincubated for 15 mins followed by KRAS G12D addition and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50406168(CHEMBL5267612)
Affinity DataIC50: 91nMAssay Description:Inhibition of 6His-tagged SOS1 (unknown origin) mediated GST-tagged KRAS G12D activation preincubated for 15 mins followed by KRAS G12D addition and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50406162(CHEMBL5275839)
Affinity DataIC50: 93nMAssay Description:Inhibition of 6His-tagged SOS1 (unknown origin) mediated GST-tagged KRAS G12D activation preincubated for 15 mins followed by KRAS G12D addition and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50406150(CHEMBL5280431)
Affinity DataIC50: 94nMAssay Description:Inhibition of 6His-tagged SOS1 (unknown origin) mediated GST-tagged KRAS G12D activation preincubated for 15 mins followed by KRAS G12D addition and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50406166(CHEMBL5274267)
Affinity DataIC50: 95nMAssay Description:Inhibition of 6His-tagged SOS1 (unknown origin) mediated GST-tagged KRAS G12D activation preincubated for 15 mins followed by KRAS G12D addition and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50406159(CHEMBL5279147)
Affinity DataIC50: 134nMAssay Description:Inhibition of 6His-tagged SOS1 (unknown origin) mediated GST-tagged KRAS G12D activation preincubated for 15 mins followed by KRAS G12D addition and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50406163(CHEMBL5266146)
Affinity DataIC50: 138nMAssay Description:Inhibition of 6His-tagged SOS1 (unknown origin) mediated GST-tagged KRAS G12D activation preincubated for 15 mins followed by KRAS G12D addition and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50406152(CHEMBL5282775)
Affinity DataIC50: 171nMAssay Description:Inhibition of 6His-tagged SOS1 (unknown origin) mediated GST-tagged KRAS G12D activation preincubated for 15 mins followed by KRAS G12D addition and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50406164(CHEMBL5279160)
Affinity DataIC50: 226nMAssay Description:Inhibition of 6His-tagged SOS1 (unknown origin) mediated GST-tagged KRAS G12D activation preincubated for 15 mins followed by KRAS G12D addition and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50406148(CHEMBL5287813)
Affinity DataIC50: 463nMAssay Description:Inhibition of 6His-tagged SOS1 (unknown origin) mediated GST-tagged KRAS G12D activation preincubated for 15 mins followed by KRAS G12D addition and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50406157(CHEMBL5281607)
Affinity DataIC50: 690nMAssay Description:Inhibition of 6His-tagged SOS1 (unknown origin) mediated GST-tagged KRAS G12D activation preincubated for 15 mins followed by KRAS G12D addition and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50406158(CHEMBL5271901)
Affinity DataIC50: 801nMAssay Description:Inhibition of 6His-tagged SOS1 (unknown origin) mediated GST-tagged KRAS G12D activation preincubated for 15 mins followed by KRAS G12D addition and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50406160(CHEMBL5275170)
Affinity DataIC50: 869nMAssay Description:Inhibition of 6His-tagged SOS1 (unknown origin) mediated GST-tagged KRAS G12D activation preincubated for 15 mins followed by KRAS G12D addition and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50406147(CHEMBL5270088)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of 6His-tagged SOS1 (unknown origin) mediated GST-tagged KRAS G12D activation preincubated for 15 mins followed by KRAS G12D addition and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50406165(CHEMBL5288876)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of 6His-tagged SOS1 (unknown origin) mediated GST-tagged KRAS G12D activation preincubated for 15 mins followed by KRAS G12D addition and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50406156(CHEMBL5288585)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of 6His-tagged SOS1 (unknown origin) mediated GST-tagged KRAS G12D activation preincubated for 15 mins followed by KRAS G12D addition and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50406149(CHEMBL5290546)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of 6His-tagged SOS1 (unknown origin) mediated GST-tagged KRAS G12D activation preincubated for 15 mins followed by KRAS G12D addition and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50406146(CHEMBL5270449)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of 6His-tagged SOS1 (unknown origin) mediated GST-tagged KRAS G12D activation preincubated for 15 mins followed by KRAS G12D addition and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetFibroblast growth factor receptor 1(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50406166(CHEMBL5274267)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of FGFR1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50406166(CHEMBL5274267)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50406166(CHEMBL5274267)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of HER2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50406166(CHEMBL5274267)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDGFRalpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetCyclin-dependent kinase 2(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50406166(CHEMBL5274267)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetCyclin-dependent kinase 4(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50406166(CHEMBL5274267)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CDK4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed