Compile Data Set for Download or QSAR
Report error Found 24 Enz. Inhib. hit(s) with all data for entry = 50019665
Targetvon Hippel-Lindau disease tumor suppressor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50463158(CHEMBL4244103)
Affinity DataKd:  5.00E+6nMAssay Description:Binding affinity to VHL (unknown origin) assessed as dissociation constant by isothermal titration calorimetry assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50446138(CHEMBL3108881)
Affinity DataKd:  5.00E+3nMAssay Description:Binding affinity to VHL (unknown origin) assessed as dissociation constant by isothermal calorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetE3 ubiquitin-protein ligase RNF31(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50621582(CHEMBL5404305)
Affinity DataKd: >4.00E+5nMAssay Description:Binding affinity to HOIP (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetE3 ubiquitin-protein ligase UHRF1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50608078(CHEMBL1876546)
Affinity DataEC50:  5.67E+4nMAssay Description:Inhibition of UHRF1 (unknown origin) by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetE3 ubiquitin-protein ligase UHRF1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50608078(CHEMBL1876546)
Affinity DataEC50:  4.51E+4nMAssay Description:Inhibition of UHRF1 (unknown origin) by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50463159(CHEMBL4241500)
Affinity DataKd:  6.70E+6nMAssay Description:Binding affinity to VHL (unknown origin) assessed as dissociation constant by isothermal titration calorimetry assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetE3 ubiquitin-protein ligase UHRF1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50608079(CHEMBL5286019)
Affinity DataEC50:  2.92E+4nMAssay Description:Inhibition of UHRF1 (unknown origin) by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetE3 ubiquitin-protein ligase UHRF1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50608079(CHEMBL5286019)
Affinity DataEC50:  1.00E+4nMAssay Description:Inhibition of UHRF1 (unknown origin) by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetBaculoviral IAP repeat-containing protein 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50450046(CHEMBL4173974)
Affinity DataIC50: 0.220nMAssay Description:Inhibition of cIAP1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetE3 ubiquitin-protein ligase XIAP(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50450046(CHEMBL4173974)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of XIAP (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetBaculoviral IAP repeat-containing protein 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM156012(US9018214, 63)
Affinity DataIC50: 10nMAssay Description:Inhibition of cIAP1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetE3 ubiquitin-protein ligase XIAP(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM156012(US9018214, 63)
Affinity DataIC50: 160nMAssay Description:Inhibition of XIAP (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetE3 ubiquitin-protein ligase RNF4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50404382(CHEMBL5274757)
Affinity DataIC50: 540nMAssay Description:Inhibition of human recombinant RNF4 incubated for 30 mins by SDS-PAGE based densitometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetE3 ubiquitin-protein ligase RNF4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50404381(CHEMBL5274740)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of human recombinant RNF4 incubated for 30 mins by SDS-PAGE based densitometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetE3 ubiquitin-protein ligase RNF4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50621583(CHEMBL2164311)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant RNF4 incubated for 30 mins by SDS-PAGE based densitometryMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetProtein cereblon(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM7814(pyrrolidine-2,5-dione | Maleimide-Related Compound...)
Affinity DataKi:  4.30E+3nMAssay Description:Binding affinity to CRBN (unknown origin) assessed as inhibition constant by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetProtein cereblon(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50070114(CHEMBL468 | 2-(2,6-dioxopiperidin-3-yl)isoindoline...)
Affinity DataKi:  4.40E+3nMAssay Description:Binding affinity to CRBN (unknown origin) assessed as inhibition constant by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetProtein cereblon(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50146597(CHEMBL3763941)
Affinity DataKi:  2.80E+4nMAssay Description:Binding affinity to CRBN (unknown origin) assessed as inhibition constant by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetProtein cereblon(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50549809(SQ-8493 | Fluorouracil specified compound c | SQ-7...)
Affinity DataKi:  3.50E+4nMAssay Description:Binding affinity to CRBN (unknown origin) assessed as inhibition constant by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetProtein cereblon(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50549804(CHEBI:27612 | Hydantoin | Imidazolidine-2,4-Dione)
Affinity DataKi:  4.30E+4nMAssay Description:Binding affinity to CRBN (unknown origin) assessed as inhibition constant by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetProtein cereblon(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50621580(CHEMBL344042 | CHEBI:327119 | beta-propiolactam)
Affinity DataKi:  7.70E+4nMAssay Description:Binding affinity to CRBN (unknown origin) assessed as inhibition constant by FRET assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetProtein cereblon(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50621579(CHEMBL1232394 | CHEBI:15901)
Affinity DataKi:  8.80E+4nMAssay Description:Binding affinity to CRBN (unknown origin) assessed as inhibition constant by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPDBSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetProtein cereblon(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM10(CHEMBL12193 | piperidin-2-one | delta-valerolactam)
Affinity DataKi:  1.46E+5nMAssay Description:Binding affinity to CRBN (unknown origin) assessed as inhibition constant by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetProtein cereblon(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50621581(CHEMBL5399028)
Affinity DataKi:  5.22E+5nMAssay Description:Binding affinity to CRBN (unknown origin) assessed as inhibition constant by FRET assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed