Compile Data Set for Download or QSAR
Report error Found 9 Enz. Inhib. hit(s) with all data for entry = 50020409
TargetElongin-C(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50446138(CHEMBL3108881)
Affinity DataKd:  5.40E+3nMAssay Description:Binding affinity to N-terminal 6xHis-tagged VHL (54 to 213 residues)/Elongin B (1 to 120 residues)/Elogin C (17 to 112 residues) (unknown origin) exp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50629711(CHEMBL5427338)
Affinity DataEC50: <50nMAssay Description:Induction of HiBit-tagged BRD4 degradation in human A549 cells incubated for 4 to 24 hrs by luminescence based Nano-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetLethal(3)malignant brain tumor-like protein 3(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50440614(CHEMBL2426364)
Affinity DataKd:  120nMAssay Description:Binding affinity to His-tagged wild type L3MBTL3 (unknown origin) assessed as dissociation constant by ITC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetE3 ubiquitin-protein ligase RNF114(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50611351(CHEMBL5274261)
Affinity DataIC50: 470nMAssay Description:Inhibition of IA-rhodamine-labeled recombinant human RNF114 preincubated for 30 mins followed by IA-rhodamine addition for 30 mins by competitive gel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetE3 ubiquitin-protein ligase RNF4(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50404382(CHEMBL5274757)
Affinity DataIC50: 540nMAssay Description:Inhibition of IA-rhodamine-labeled human RNF4 preincubated for 30 mins followed by IA-rhodamine addition for 1 hr by gel-based ABPP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetE3 ubiquitin-protein ligase RNF4(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50404381(CHEMBL5274740)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of IA-rhodamine-labeled human RNF4 preincubated for 30 mins followed by IA-rhodamine addition for 1 hr by gel-based ABPP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetFolliculin-interacting protein 1(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50611352(CHEMBL5289726)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of recombinant MBP-tagged FEM1B/TAMRA-labeled FNIP (562 to 591 residues) interaction (unknown origin) preincubated for 1 hr followed by FN...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetElongin-C(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50446138(CHEMBL3108881)
Affinity DataIC50: 4.10E+3nMAssay Description:Inhibition of 6xHis-tagged VHL (1 to 213 residues)/Elongin B/Elongin C (unknown origin) expressed in Escherichia coli BL21 cells using FAM-DEALAHyp-Y...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50014097(CHEMBL3260851)
Affinity DataKi:  670nMAssay Description:Binding affinity to VHL (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed