Compile Data Set for Download or QSAR
Report error Found 19 Enz. Inhib. hit(s) with all data for entry = 50019870
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50462572(CHEMBL4249337)
Affinity DataKd: <0.630nMAssay Description:Binding affinity to Full-length human PRMT5/human MEP50 assessed as equilibrium dissociation constant by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50623921(CHEMBL5434784)
Affinity DataEC50:  6.90nMAssay Description:Inhibition of PRMT5 in human MCF7 cells assessed as suppression of arginine sDMA incubated for 3 days by target engagement assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50623921(CHEMBL5434784)
Affinity DataEC50:  0.900nMAssay Description:Inhibition of full-length recombinant PRMT5/full-length recombinant MEP50 (unknown origin) expressed in baculovirus infected Sf21 cells using biotiny...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50462572(CHEMBL4249337)
Affinity DataKd: <4nMAssay Description:Binding affinity to Full-length human PRMT5/human MEP50 assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50523657(CHEMBL4563402)
Affinity DataKd:  11nMAssay Description:Binding affinity to N-terminal 6xHis-tagged full length human PRMT5/MEP50 expressed in sf21 cells using S-Adenosyl-L-methionine as substrate assessed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM415557(US10428104, Example 88)
Affinity DataKd:  241nMAssay Description:Binding affinity to N-terminal 6xHis-tagged full length human PRMT5/MEP50 expressed in sf21 cells using S-Adenosyl-L-methionine as substrate assessed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50623919(CHEMBL5422317)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of PRMT5 in human Z138 cells assessed as decrease in sDMA modification incubated for 2 days by fluorescence based assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50523657(CHEMBL4563402)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of PRMT5 in human A427 cells assessed as reduction in sDMA level incubated for 72 hrs by liquid scintillation analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetProtein arginine N-methyltransferase 5(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM453006((2R,3R,4S,5S)-2-(4-amino-7H- pyrrolo[2,3-d]pyrimid...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of PRMT5 in human U-87 MG cells incubated for 4 mins by western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50623920(CHEMBL5423656)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of PRMT5 in human Z138 cells assessed as suppression of sDMA levelMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50623919(CHEMBL5422317)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of PRMT5/MEP50 (unknown origin) using histone H4 peptide as substrate preincubated for 30 mins followed by substrate addition and measured...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM452962((2R,3R,4S,5S)-2-(4-amino- 7H-pyrrolo[2,3-d]pyrimid...)
Affinity DataIC50: 3.80nMAssay Description:Inhibition of PRMT5 in human U-87 MG cells incubated for 3 days by western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50623920(CHEMBL5423656)
Affinity DataIC50: 4.20nMAssay Description:Inhibition of PRMT5 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM453000((2S,3S,4R,5R)-2-((R)-6- chloroisochroman-1-yl)-5-(...)
Affinity DataIC50: 4.80nMAssay Description:Inhibition of PRMT5 in human U-87 MG cells incubated for 4 mins by western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM452962((2R,3R,4S,5S)-2-(4-amino- 7H-pyrrolo[2,3-d]pyrimid...)
Affinity DataIC50: 27nMAssay Description:Inhibition of PRMT5 in human Granta-519 cells assessed as suppression of sDMA level incubated for 3 days by western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM665696(US20240116918, Example 1)
Affinity DataIC50: 33nMAssay Description:Inhibition of PRMT5 (unknown origin) using H4(1-21)S1ac as substrate preincubated for 15 mins followed by substrate addition and measured for 60 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50623918(CHEMBL5398215)
Affinity DataIC50: 50nMAssay Description:Inhibition of PRMT5 (unknown origin) using H4(1-21)S1ac as substrate preincubated for 15 mins followed by substrate addition and measured for 60 mins...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM452962((2R,3R,4S,5S)-2-(4-amino- 7H-pyrrolo[2,3-d]pyrimid...)
Affinity DataIC50: 120nMAssay Description:Inhibition of PRMT5 in human U-87 MG cells assessed as suppression of sDMA level incubated for 3 days by western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50623922(CHEMBL5426836)
Affinity DataKi:  0.0500nMAssay Description:Binding affinity to PRMT5/MEP50 (unknown origin) using histone H4 peptide assessed as inhibition constant preincubated for 24 hrs followed by substra...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed