Compile Data Set for Download or QSAR
Report error Found 35 Enz. Inhib. hit(s) with all data for entry = 50022401
TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Cairo University

Curated by ChEMBL
LigandPNGBDBM374727(US10246466, Example 93 | (7S,13R)-11-fluoro-7,13-d...)
Affinity DataIC50: 0.0700nMAssay Description:Inhibition of human ROS1 by discoverX kinome scan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetNT-3 growth factor receptor(Human)
Cairo University

Curated by ChEMBL
LigandPNGBDBM50579500(CHEMBL4864729)
Affinity DataIC50: 0.210nMAssay Description:Inhibition of TRKC (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Cairo University

Curated by ChEMBL
LigandPNGBDBM374727(US10246466, Example 93 | (7S,13R)-11-fluoro-7,13-d...)
Affinity DataIC50: 0.830nMAssay Description:Inhibition of wild type N-terminal 6His-tagged human recombinant TRKA (502 to 796 residues) expressed in Bac-to-Bac baculovirus expression system inc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase JAK2(Human)
Cairo University

Curated by ChEMBL
LigandPNGBDBM374727(US10246466, Example 93 | (7S,13R)-11-fluoro-7,13-d...)
Affinity DataIC50: 1nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetALK tyrosine kinase receptor(Human)
Cairo University

Curated by ChEMBL
LigandPNGBDBM374727(US10246466, Example 93 | (7S,13R)-11-fluoro-7,13-d...)
Affinity DataIC50: 1nMAssay Description:Inhibition of ALK (unknown origin) by kinome scan-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetNT-3 growth factor receptor(Human)
Cairo University

Curated by ChEMBL
LigandPNGBDBM158154(US9029356, 11 | US9255087, 11 | US10081622, Compou...)
Affinity DataIC50: 1nMAssay Description:Inhibition of TRKC (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetBDNF/NT-3 growth factors receptor(Human)
Cairo University

Curated by ChEMBL
LigandPNGBDBM50579500(CHEMBL4864729)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of TRKB (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Cairo University

Curated by ChEMBL
LigandPNGBDBM50651836(CHEMBL5639271)
Affinity DataIC50: 2nMAssay Description:Inhibition of TRKA (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetBDNF/NT-3 growth factors receptor(Human)
Cairo University

Curated by ChEMBL
LigandPNGBDBM50651836(CHEMBL5639271)
Affinity DataIC50: 2nMAssay Description:Inhibition of TRKB (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetNT-3 growth factor receptor(Human)
Cairo University

Curated by ChEMBL
LigandPNGBDBM50651836(CHEMBL5639271)
Affinity DataIC50: 2nMAssay Description:Inhibition of TRKC (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Cairo University

Curated by ChEMBL
LigandPNGBDBM50507492(Loxo-195 | Selitrectinib | US10966985, Compound 33...)
Affinity DataIC50: 2nMAssay Description:Inhibition of wild type N-terminal 6His-tagged TRKA G595R mutant (486 to 786 residues) (unknown origin) expressed in Escherichia coli measured after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Cairo University

Curated by ChEMBL
LigandPNGBDBM50579500(CHEMBL4864729)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of TRKA (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetNT-3 growth factor receptor(Human)
Cairo University

Curated by ChEMBL
LigandPNGBDBM50507492(Loxo-195 | Selitrectinib | US10966985, Compound 33...)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of wild type N-terminal 6His-tagged TRKC G623R mutant (506 to 829 residues) (unknown origin) expressed in Escherichia coli measured after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Cairo University

Curated by ChEMBL
LigandPNGBDBM50651831(CHEMBL5639362)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of human TRKAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Cairo University

Curated by ChEMBL
LigandPNGBDBM136597(US8865698, 14 | US10047097, 14 | US9676783, 14 | U...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human TRKAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Cairo University

Curated by ChEMBL
LigandPNGBDBM50651833(CHEMBL5647538)
Affinity DataIC50: 5nMAssay Description:Inhibition of TRKA (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetAurora kinase A(Human)
Cairo University

Curated by ChEMBL
LigandPNGBDBM50579500(CHEMBL4864729)
Affinity DataIC50: 6nMAssay Description:Inhibition of AurA (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Cairo University

Curated by ChEMBL
LigandPNGBDBM50651832(CHEMBL5639481)
Affinity DataIC50: 6.5nMAssay Description:Inhibition of TRKA (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Cairo University

Curated by ChEMBL
LigandPNGBDBM158154(US9029356, 11 | US9255087, 11 | US10081622, Compou...)
Affinity DataIC50: 7nMAssay Description:Inhibition of ROS1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Cairo University

Curated by ChEMBL
LigandPNGBDBM50651834(CHEMBL5639790)
Affinity DataIC50: 7nMAssay Description:Inhibition of TRKA (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Cairo University

Curated by ChEMBL
LigandPNGBDBM50507492(Loxo-195 | Selitrectinib | US10966985, Compound 33...)
Affinity DataIC50: 9.80nMAssay Description:Inhibition of wild type N-terminal 6His-tagged TRKA G667C mutant (486 to 786 residues) (unknown origin) expressed in Escherichia coli measured after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetBDNF/NT-3 growth factors receptor(Human)
Cairo University

Curated by ChEMBL
LigandPNGBDBM50577791(CHEMBL4849505)
Affinity DataIC50: 11nMAssay Description:Inhibition of human intracellular domain of TRKB expressed in Sf9 cells incubated for 1 hr by HTRF methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetALK tyrosine kinase receptor(Human)
Cairo University

Curated by ChEMBL
LigandPNGBDBM158154(US9029356, 11 | US9255087, 11 | US10081622, Compou...)
Affinity DataIC50: 12nMAssay Description:Inhibition of ALK (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetAurora kinase B(Human)
Cairo University

Curated by ChEMBL
LigandPNGBDBM50579500(CHEMBL4864729)
Affinity DataIC50: 13nMAssay Description:Inhibition of AurB (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetNT-3 growth factor receptor(Human)
Cairo University

Curated by ChEMBL
LigandPNGBDBM50651836(CHEMBL5639271)
Affinity DataIC50: 15nMAssay Description:Inhibition of His-tagged human recombinant TRKC G623R mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase PAK 4(Human)
Cairo University

Curated by ChEMBL
LigandPNGBDBM50615896(CHEMBL5282566)
Affinity DataIC50: 26nMAssay Description:Inhibition of PAK4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Cairo University

Curated by ChEMBL
LigandPNGBDBM50577791(CHEMBL4849505)
Affinity DataIC50: 28nMAssay Description:Inhibition of human intracellular domain of TRKA expressed in Sf9 cells incubated for 1 hr by HTRF methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase PLK4(Human)
Cairo University

Curated by ChEMBL
LigandPNGBDBM50615896(CHEMBL5282566)
Affinity DataIC50: 56nMAssay Description:Inhibition of PLK4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetFocal adhesion kinase 1(Human)
Cairo University

Curated by ChEMBL
LigandPNGBDBM50615896(CHEMBL5282566)
Affinity DataIC50: 57nMAssay Description:Inhibition of FAK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Cairo University

Curated by ChEMBL
LigandPNGBDBM50507490(CHEMBL4468886)
Affinity DataIC50: 99nMAssay Description:Inhibition of wild type N-terminal 6His-tagged human recombinant TRKA (502 to 796 residues) expressed in Bac-to-Bac baculovirus expression system inc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Cairo University

Curated by ChEMBL
LigandPNGBDBM50615899(CHEMBL5266273)
Affinity DataIC50: 293nMAssay Description:Inhibition of TRKA (unknown origin) by HTRF methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Cairo University

Curated by ChEMBL
LigandPNGBDBM50651835(CHEMBL5647177)
Affinity DataIC50: 810nMAssay Description:Inhibition of TRKA (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Cairo University

Curated by ChEMBL
LigandPNGBDBM50577757(CHEMBL4874296)
Affinity DataIC50: 1.24E+3nMAssay Description:Inhibition of human intracellular domain of TRKA expressed in Sf9 cells incubated for 1 hr by HTRF methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetBDNF/NT-3 growth factors receptor(Human)
Cairo University

Curated by ChEMBL
LigandPNGBDBM50651831(CHEMBL5639362)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of TRKB (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetNT-3 growth factor receptor(Human)
Cairo University

Curated by ChEMBL
LigandPNGBDBM50651831(CHEMBL5639362)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of TRKC (unknown origin) by TR-FRET analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed