Compile Data Set for Download or QSAR
Report error Found 25 Enz. Inhib. hit(s) with all data for entry = 50019411
TargetGlycogen synthase kinase-3 beta(Human)
L. M. College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50619017(CHEMBL1232189)
Affinity DataKd:  0.0500nMAssay Description:Binding affinity to GSK-3beta (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
L. M. College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50313013(CT-98024 | N2-(2-(4-(2,4-dichlorophenyl)-5-(1H-imi...)
Affinity DataIC50: 0.0600nMAssay Description:Inhibition of GSK-3beta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
L. M. College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50325983(6-(2-(4-(2,4-dichlorophenyl)-5-(4-methyl-1H-imidaz...)
Affinity DataIC50: 3nMAssay Description:Inhibition of human wildtype full length GSK-3betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetGlycogen synthase kinase-3 beta(Human)
L. M. College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50325983(6-(2-(4-(2,4-dichlorophenyl)-5-(4-methyl-1H-imidaz...)
Affinity DataIC50: 3nMAssay Description:Inhibition of N-terminal His6-tagged GSK-3 beta (unknown origin) expressed in Rosetta 2DE3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetGlycogen synthase kinase-3 beta(Human)
L. M. College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM7262(NSC 705701 | BDBM84528 | alsterpaullone | 9-Nitrop...)
Affinity DataIC50: 4nMAssay Description:Inhibition of GSK-3beta (unknown origin) expressed in Sf21 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
L. M. College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM188515((S)-3-cyclopropyl-4,7,7-trimethyl-4-phenyl-2,4,6,7...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human recombinant GSK-3betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetGlycogen synthase kinase-3 beta(Human)
L. M. College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50619014(CHEMBL5410800)
Affinity DataIC50: 5nMAssay Description:Inhibition of GSK-3beta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetGlycogen synthase kinase-3 beta(Human)
L. M. College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50325983(6-(2-(4-(2,4-dichlorophenyl)-5-(4-methyl-1H-imidaz...)
Affinity DataIC50: 5nMAssay Description:Inhibition of GSK-3beta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetGlycogen synthase kinase-3 beta(Human)
L. M. College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50619016(CHEMBL1242830)
Affinity DataIC50: 8nMAssay Description:Inhibition of GSK-3beta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
L. M. College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50619022(CHEMBL5438428)
Affinity DataIC50: 9nMAssay Description:Inhibition of GSK-3beta (unknown origin) incubated for 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
L. M. College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50601414(CHEMBL5173945)
Affinity DataIC50: 9nMAssay Description:Inhibition of his-tagged human recombinant GSK-3beta expressed in baculovirus infected Sf9 insect cells using peptide as substrate preincubated for 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
L. M. College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM25036(CHEMBL393525 | N'-[(1E)-{6-bromoimidazo[1,2-a]pyri...)
Affinity DataIC50: 10nMAssay Description:Inhibition of GSK-3beta (unknown origin) expressed in Sf9 cells by spectrometry based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetGlycogen synthase kinase-3 beta(Human)
L. M. College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50619020(CHEMBL5422310)
Affinity DataIC50: 10nMAssay Description:Inhibition of full length GST-tagged human recombinant GSK-3beta (1 to 420 residues) expressed in Escherichia coliMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
L. M. College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50397755(CHEMBL2177175)
Affinity DataKi:  12nMAssay Description:Binding affinity to full length GST-tagged human recombinant GSK-3beta (1 to 420 residues) expressed in Escherichia coli assessed as inhibition const...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
L. M. College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 15nMAssay Description:Inhibition of GSK-3beta (unknown origin) expressed in Sf21 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
L. M. College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50049730(Epalrestat | 2-(5-(2-methyl-3-phenylallylidene)-4-...)
Affinity DataIC50: 21nMAssay Description:Inhibition of human GSK-3betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
L. M. College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50166289(CHEBI:43645 | CHEMBL216543)
Affinity DataIC50: 22nMAssay Description:Inhibition of GSK-3beta (unknown origin) expressed in Sf21 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetGlycogen synthase kinase-3 beta(Human)
L. M. College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50619015(CHEMBL5434004)
Affinity DataIC50: 36nMAssay Description:Inhibition of GSK-3beta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
L. M. College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50229962(N-(4-METHOXYBENZYL)-N'-(5-NITRO-1,3-THIAZOL-2-YL)U...)
Affinity DataKi:  38nMAssay Description:Binding affinity to human full length GSK-3 beta transfected in Sf21 cells assessed as inhibition constant measured after 6 hrs by scintillation meth...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetGlycogen synthase kinase-3 beta(Human)
L. M. College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM8269(2-chloro-5-{[4-(3-chlorophenyl)-2,5-dioxo-2,5-dihy...)
Affinity DataKd:  40nMAssay Description:Binding affinity to GSK-3beta (unknown origin) expressed in Sf21 cells assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetGlycogen synthase kinase-3 beta(Human)
L. M. College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50619018(CHEMBL5419370)
Affinity DataIC50: 54nMAssay Description:Inhibition of human wildtype full length GSK-3betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
L. M. College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50619021(CHEMBL5397508)
Affinity DataIC50: 72nMAssay Description:Inhibition of GSK-3beta (unknown origin) incubated for 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
L. M. College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098 | US12...)
Affinity DataIC50: 89nMAssay Description:Inhibition of GSK-3beta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
L. M. College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50619019(CHEMBL5416998)
Affinity DataKi:  90nMAssay Description:Binding affinity to full length GST-tagged human recombinant GSK-3beta (1 to 420 residues) expressed in Escherichia coli assessed as inhibition const...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
L. M. College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50267521(3-(5-Fluoro-6-iodo-1-methyl-1H-indol-3-yl)-4-(7-me...)
Affinity DataIC50: 247nMAssay Description:Inhibition of GSK-3beta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMedPDB3D3D Structure (crystal)