Compile Data Set for Download or QSAR
Report error Found 26 Enz. Inhib. hit(s) with all data for entry = 50019310
TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50592604(CHEMBL5201264)
Affinity DataIC50: 33nMAssay Description:Inhibition of N-terminal His6-tagged recombinant full length SARS-CoV-2 3CLpro expressed in Escherichia coli BL21(DE3) using MCA-AVLQSGFR-Lys(Dnp)-Ly...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50617985(CHEMBL5406478)
Affinity DataIC50: 322nMAssay Description:Inhibition of N-terminal His6-tagged recombinant full length SARS-CoV-2 3CLpro expressed in Escherichia coli BL21(DE3) using MCA-AVLQSGFR-Lys(Dnp)-Ly...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50617980(CHEMBL5428557)
Affinity DataIC50: 478nMAssay Description:Inhibition of N-terminal His6-tagged recombinant full length SARS-CoV-2 3CLpro expressed in Escherichia coli BL21(DE3) using MCA-AVLQSGFR-Lys(Dnp)-Ly...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50617987(CHEMBL5409259)
Affinity DataIC50: 524nMAssay Description:Inhibition of N-terminal His6-tagged recombinant full length SARS-CoV-2 3CLpro expressed in Escherichia coli BL21(DE3) using MCA-AVLQSGFR-Lys(Dnp)-Ly...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50617983(CHEMBL5426704)
Affinity DataIC50: 1.06E+3nMAssay Description:Inhibition of N-terminal His6-tagged recombinant full length SARS-CoV-2 3CLpro expressed in Escherichia coli BL21(DE3) using MCA-AVLQSGFR-Lys(Dnp)-Ly...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50617979(CHEMBL5398303)
Affinity DataIC50: 1.85E+3nMAssay Description:Inhibition of N-terminal His6-tagged recombinant full length SARS-CoV-2 3CLpro expressed in Escherichia coli BL21(DE3) using MCA-AVLQSGFR-Lys(Dnp)-Ly...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50617978(CHEMBL1488059)
Affinity DataIC50: 2.21E+3nMAssay Description:Inhibition of N-terminal His6-tagged recombinant full length SARS-CoV-2 3CLpro expressed in Escherichia coli BL21(DE3) using MCA-AVLQSGFR-Lys(Dnp)-Ly...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50617986(CHEMBL5406269)
Affinity DataIC50: 2.64E+3nMAssay Description:Inhibition of N-terminal His6-tagged recombinant full length SARS-CoV-2 3CLpro expressed in Escherichia coli BL21(DE3) using MCA-AVLQSGFR-Lys(Dnp)-Ly...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50617982(CHEMBL5405232)
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of N-terminal His6-tagged recombinant full length SARS-CoV-2 3CLpro expressed in Escherichia coli BL21(DE3) using MCA-AVLQSGFR-Lys(Dnp)-Ly...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50617984(CHEMBL5398507)
Affinity DataIC50: 3.33E+3nMAssay Description:Inhibition of N-terminal His6-tagged recombinant full length SARS-CoV-2 3CLpro expressed in Escherichia coli BL21(DE3) using MCA-AVLQSGFR-Lys(Dnp)-Ly...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50617988(CHEMBL5439420)
Affinity DataIC50: 3.96E+3nMAssay Description:Inhibition of N-terminal His6-tagged recombinant full length SARS-CoV-2 3CLpro expressed in Escherichia coli BL21(DE3) using MCA-AVLQSGFR-Lys(Dnp)-Ly...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50617981(CHEMBL5402852)
Affinity DataIC50: 4.60E+3nMAssay Description:Inhibition of N-terminal His6-tagged recombinant full length SARS-CoV-2 3CLpro expressed in Escherichia coli BL21(DE3) using MCA-AVLQSGFR-Lys(Dnp)-Ly...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCaspase-6(Human)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50617985(CHEMBL5406478)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of Caspase-6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCaspase-6(Human)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50617978(CHEMBL1488059)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of Caspase-6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCathepsin G(Human)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50617985(CHEMBL5406478)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of Cathepsin G (unknown origin) measured for 1 to 2 hrs by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCathepsin B(Human)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50617978(CHEMBL1488059)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of Cathepsin B (unknown origin) using Z-RR-AMC as fluorogenic substrate preincubated for 10 mins followed by substrate addition and measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCathepsin B(Human)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50617985(CHEMBL5406478)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of Cathepsin B (unknown origin) using Z-RR-AMC as fluorogenic substrate preincubated for 10 mins followed by substrate addition and measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCathepsin G(Human)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50617978(CHEMBL1488059)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of Cathepsin G (unknown origin) measured for 1 to 2 hrs by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50617985(CHEMBL5406478)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of SARS-CoV-2 PLpro using RLRGG-AMC as fluorogenic substrate preincubated with compound for 30 mins followed by substrate addition by fluo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetProcathepsin L(Human)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50617985(CHEMBL5406478)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of Cathepsin L (unknown origin) using Z-VVR-AMC as fluorogenic substrate preincubated for 10 mins followed by substrate addition and measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetChymotrypsinogen B2(Human)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50617985(CHEMBL5406478)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of Chymotrypsin (unknown origin) using N-succinyl-AAPF-AMC as fluorogenic substrate preincubated for 10 mins followed by substrate additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetChymotrypsinogen B2(Human)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50617978(CHEMBL1488059)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of Chymotrypsin (unknown origin) using N-succinyl-AAPF-AMC as fluorogenic substrate preincubated for 10 mins followed by substrate additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50617978(CHEMBL1488059)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of SARS-CoV-2 PLpro using RLRGG-AMC as fluorogenic substrate preincubated with compound for 30 mins followed by substrate addition by fluo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50617985(CHEMBL5406478)
Affinity DataKi:  1.81E+4nMAssay Description:Inhibition of N-terminal His6-tagged recombinant full length SARS-CoV-2 3CLpro expressed in Escherichia coli BL21(DE3) assessed as inhibition constan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50617980(CHEMBL5428557)
Affinity DataKi:  2.49E+4nMAssay Description:Inhibition of N-terminal His6-tagged recombinant full length SARS-CoV-2 3CLpro expressed in Escherichia coli BL21(DE3) assessed as inhibition constan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50617978(CHEMBL1488059)
Affinity DataKi:  4.36E+4nMAssay Description:Inhibition of N-terminal His6-tagged recombinant full length SARS-CoV-2 3CLpro expressed in Escherichia coli BL21(DE3) assessed as inhibition constan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed