Compile Data Set for Download or QSAR
Report error Found 21 Enz. Inhib. hit(s) with all data for entry = 50020486
TargetTyrosine-protein kinase ABL1(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50322535(3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-meth...)
Affinity DataIC50: 0.370nMAssay Description:Inhibition of Abl (unknown origin) in presence of ATP by ADP Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM5446(Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...)
Affinity DataIC50: 2nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetVascular endothelial growth factor receptor 2(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50363397(CHEMBL1946170 | REGORAFENIB | US10183928, Regorafe...)
Affinity DataIC50: 4.20nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50537138(CHEMBL4531690)
Affinity DataIC50: 5.30nMAssay Description:Inhibition of recombinant RIPK2 (unknown origin) expressed in insect cells using RBER-CHKtide as substrate assessed as inhibition of tyrosine autopho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)
Affinity DataIC50: 6nMAssay Description:Inhibition of RAF-1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50322535(3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-meth...)
Affinity DataIC50: 7nMAssay Description:Inhibition of human RIPK2 (8 to 317 residues) expressed in Sf9 cells in presence of ATP by ADP Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50630337(CHEMBL5394595)
Affinity DataIC50: 10nMAssay Description:Inhibition of human RIPK2 assessed as inhibition of autophosphorylation incubated for 45 to 60 mins in presence of 32P-gamma-ATP by immunoprecipitati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50630336(CHEMBL5402906)
Affinity DataIC50: 14nMAssay Description:Inhibition of recombinant RIPK2 (unknown origin) expressed in insect cells using RBER-CHKtide as substrate assessed as inhibition of tyrosine autopho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM5447(ZD1839 | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[...)
Affinity DataIC50: 33nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50363397(CHEMBL1946170 | REGORAFENIB | US10183928, Regorafe...)
Affinity DataIC50: 41nMAssay Description:Inhibition of human RIPK2 (8 to 317 residues) expressed in Sf9 cells in presence of ATP by ADP Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
University of Lille

Curated by ChEMBL
LigandPNGBDBM15239(SB4 | 4-[4-(4-fluorophenyl)-1-(piperidin-4-yl)-1H-...)
Affinity DataIC50: 60nMAssay Description:Inhibition of p38-MAPK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50230001(4-(4-fluorophenyl)-2-(4-nitrophenyl)-5-(4-pyridyl)...)
Affinity DataIC50: 70nMAssay Description:Inhibition of amino terminal HA-tagged human RIPK2 transfected in mouse AML12 cells assessed as inhibition of autophosphorylation incubated for 24 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)
Affinity DataIC50: 75nMAssay Description:Inhibition of human RIPK2 (8 to 317 residues) expressed in Sf9 cells in presence of ATP by ADP Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50230001(4-(4-fluorophenyl)-2-(4-nitrophenyl)-5-(4-pyridyl)...)
Affinity DataIC50: 89nMAssay Description:Inhibition of p38-MAPK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50597347(CHEMBL5206121)
Affinity DataIC50: 134nMAssay Description:Inhibition of recombinant RIPK2 (unknown origin) using CRRKSLVGTPYWMAPE peptide as substrate assessed as inhibition of autophosphorylation incubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50045333(CHEBI:90705 | SB-203580)
Affinity DataIC50: 390nMAssay Description:Inhibition of amino terminal HA-tagged human RIPK2 transfected in mouse AML12 cells assessed as inhibition of autophosphorylation incubated for 24 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50045333(CHEBI:90705 | SB-203580)
Affinity DataIC50: 600nMAssay Description:Inhibition of p38-MAPK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM15239(SB4 | 4-[4-(4-fluorophenyl)-1-(piperidin-4-yl)-1H-...)
Affinity DataIC50: 700nMAssay Description:Inhibition of amino terminal HA-tagged human RIPK2 transfected in mouse AML12 cells assessed as inhibition of autophosphorylation incubated for 24 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50630338(CHEMBL1186759)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of RIPK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50597347(CHEMBL5206121)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of EGFR (unknown origin) by KINOMEscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50597347(CHEMBL5206121)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of p38 (unknown origin) by KINOMEscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed