Compile Data Set for Download or QSAR
Report error Found 58 Enz. Inhib. hit(s) with all data for entry = 50020999
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Lanzhou University Second Hospital

Curated by ChEMBL
LigandPNGBDBM50635882(CHEMBL5565328)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of human RIPK1 using myelin basic protein as substrate measured after 120 mins in presence of [gamma33P]ATP by scintillation counting meth...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetEukaryotic translation initiation factor 2-alpha kinase 3(Human)
Lanzhou University Second Hospital

Curated by ChEMBL
LigandPNGBDBM50442165(CHEMBL2441341)
Affinity DataIC50: 3.80nMAssay Description:Inhibition of GST-tagged human recombinant PERK by ADP-glo reagent based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Lanzhou University Second Hospital

Curated by ChEMBL
LigandPNGBDBM50513014(CHEMBL4442060)
Affinity DataIC50: 4nMAssay Description:Inhibition of RIPK1 (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Lanzhou University Second Hospital

Curated by ChEMBL
LigandPNGBDBM50635875(CHEMBL5518057)
Affinity DataIC50: 5.80nMAssay Description:Inhibition of RIPK1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Lanzhou University Second Hospital

Curated by ChEMBL
LigandPNGBDBM185674(Rebastinib | 4-[4-[(5-tert-butyl-2-quinolin-6-ylpy...)
Affinity DataIC50: 6.5nMAssay Description:Inhibition of recombinant RIPK1 (unknown origin) by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Lanzhou University Second Hospital

Curated by ChEMBL
LigandPNGBDBM50355496(CHEMBL1908397)
Affinity DataIC50: 6.60nMAssay Description:Inhibition of FLT3 (unknown origin) by enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Lanzhou University Second Hospital

Curated by ChEMBL
LigandPNGBDBM50635879(CHEMBL5517778)
Affinity DataKd:  8.70nMAssay Description:Binding affinity to RIPK1 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetEukaryotic translation initiation factor 2-alpha kinase 3(Human)
Lanzhou University Second Hospital

Curated by ChEMBL
LigandPNGBDBM50442167(CHEMBL2441339)
Affinity DataIC50: 9.70nMAssay Description:Inhibition of GST-tagged human recombinant PERK by ADP-glo reagent based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Lanzhou University Second Hospital

Curated by ChEMBL
LigandPNGBDBM50263058(CHEMBL4090723)
Affinity DataIC50: 10nMAssay Description:Inhibition of N-terminal His-tagged human RIPK1 (1 to 294 residues) expressed in baculovirus infected Sf9 cells incubated for 48 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Lanzhou University Second Hospital

Curated by ChEMBL
LigandPNGBDBM50065454(CHEMBL3348846 | CHEBI:63453)
Affinity DataIC50: 12nMAssay Description:Inhibition of human recombinant RIPK1 (1 to 327 residues) using myelin basic protein as substrate incubated for 4 hrs by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Lanzhou University Second Hospital

Curated by ChEMBL
LigandPNGBDBM50635875(CHEMBL5518057)
Affinity DataKd:  13nMAssay Description:Binding affinity to RIPK1 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Lanzhou University Second Hospital

Curated by ChEMBL
LigandPNGBDBM50602054(CHEMBL5209456)
Affinity DataKd:  15nMAssay Description:Binding affinity to human recombinant RIPK1 assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Lanzhou University Second Hospital

Curated by ChEMBL
LigandPNGBDBM50442165(CHEMBL2441341)
Affinity DataIC50: 18nMAssay Description:Inhibition of GST-tagged human recombinant RIPK1 incubated for 4 hrs by ADP-glo reagent based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Lanzhou University Second Hospital

Curated by ChEMBL
LigandPNGBDBM50113499(CHEMBL3604619)
Affinity DataIC50: 18nMAssay Description:Inhibition of GST-tagged human recombinant RIPK1 incubated for 4 hrs by ADP-glo reagent based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetRegulator of chromosome condensation(Homo sapiens)
Lanzhou University Second Hospital

Curated by ChEMBL
LigandPNGBDBM185674(Rebastinib | 4-[4-[(5-tert-butyl-2-quinolin-6-ylpy...)
Affinity DataEC50:  19nMAssay Description:Inhibition of RCC1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
Lanzhou University Second Hospital

Curated by ChEMBL
LigandPNGBDBM185674(Rebastinib | 4-[4-[(5-tert-butyl-2-quinolin-6-ylpy...)
Affinity DataIC50: 19nMAssay Description:Inhibition of recombinant RIPK3 (unknown origin) by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
Lanzhou University Second Hospital

Curated by ChEMBL
LigandPNGBDBM50323777(N-(4-Methyl-3-(1-methyl-7-(6-methylpyridin-3-ylami...)
Affinity DataIC50: 19nMAssay Description:Inhibition of RIPK3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Lanzhou University Second Hospital

Curated by ChEMBL
LigandPNGBDBM50323777(N-(4-Methyl-3-(1-methyl-7-(6-methylpyridin-3-ylami...)
Affinity DataIC50: 19nMAssay Description:Inhibition of RIPK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Lanzhou University Second Hospital

Curated by ChEMBL
LigandPNGBDBM50322535(3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-meth...)
Affinity DataKd:  37nMAssay Description:Binding affinity to human recombinant RIPK1 (1 to 327 residues) using myelin basic protein as substrate assessed as dissociation constant measured fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetAurora kinase A(Human)
Lanzhou University Second Hospital

Curated by ChEMBL
LigandPNGBDBM50355496(CHEMBL1908397)
Affinity DataIC50: 48nMAssay Description:Inhibition of Aurora-A (unknown origin) by kinase-glo luminescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Lanzhou University Second Hospital

Curated by ChEMBL
LigandPNGBDBM50323777(N-(4-Methyl-3-(1-methyl-7-(6-methylpyridin-3-ylami...)
Affinity DataKd:  56nMAssay Description:Binding affinity to RIPK1 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Lanzhou University Second Hospital

Curated by ChEMBL
LigandPNGBDBM50442167(CHEMBL2441339)
Affinity DataIC50: 69nMAssay Description:Inhibition of GST-tagged human recombinant RIPK1 incubated for 4 hrs by ADP-glo reagent based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Lanzhou University Second Hospital

Curated by ChEMBL
LigandPNGBDBM50602055(CHEMBL5182551)
Affinity DataKd:  78nMAssay Description:Binding affinity to human full length GST-tagged RIPK1 expressed in baculovirus infected Sf9 cells assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Lanzhou University Second Hospital

Curated by ChEMBL
LigandPNGBDBM50635877(CHEMBL5537068)
Affinity DataIC50: 90nMAssay Description:Inhibition of RIPK1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
Lanzhou University Second Hospital

Curated by ChEMBL
LigandPNGBDBM50635877(CHEMBL5537068)
Affinity DataIC50: 90nMAssay Description:Inhibition of human recombinant RIPK3 incubated for 1 hr by ADP-Glo kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Lanzhou University Second Hospital

Curated by ChEMBL
LigandPNGBDBM31084(1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-...)
Affinity DataIC50: 95nMAssay Description:Inhibition of RIPK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Lanzhou University Second Hospital

Curated by ChEMBL
LigandPNGBDBM50355496(CHEMBL1908397)
Affinity DataKd:  100nMAssay Description:Inhibition of RIPK1 (unknown origin) assessed as dissociation constant by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Lanzhou University Second Hospital

Curated by ChEMBL
LigandPNGBDBM423400(US10501473, Example 39)
Affinity DataIC50: 110nMAssay Description:Inhibition of RIPK1 (unknown origin) in presence of [gamma33P]ATP measured after 30 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Lanzhou University Second Hospital

Curated by ChEMBL
LigandPNGBDBM50635881(CHEMBL5556669)
Affinity DataIC50: 160nMAssay Description:Inhibition of human recombinant RIPK1More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Lanzhou University Second Hospital

Curated by ChEMBL
LigandPNGBDBM50263059(CHEMBL4105556)
Affinity DataIC50: 170nMAssay Description:Inhibition of human recombinant RIPK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Lanzhou University Second Hospital

Curated by ChEMBL
LigandPNGBDBM50635880(CHEMBL5568050)
Affinity DataKd:  199nMAssay Description:Binding affinity to RIPK1 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
Lanzhou University Second Hospital

Curated by ChEMBL
LigandPNGBDBM50635880(CHEMBL5568050)
Affinity DataKd:  209nMAssay Description:Binding affinity to RIPK3 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Lanzhou University Second Hospital

Curated by ChEMBL
LigandPNGBDBM50519641(CHEMBL4439426)
Affinity DataKd:  218nMAssay Description:Binding affinity to human full length GST-tagged RIPK1 expressed in baculovirus infected Sf9 cells assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Lanzhou University Second Hospital

Curated by ChEMBL
LigandPNGBDBM50635876(CHEMBL5567128)
Affinity DataIC50: 250nMAssay Description:Inhibition of RIPK1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Lanzhou University Second Hospital

Curated by ChEMBL
LigandPNGBDBM50065454(CHEMBL3348846 | CHEBI:63453)
Affinity DataIC50: 259nMAssay Description:Inhibition of human recombinant RIPK2 incubated for 1 hr by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Lanzhou University Second Hospital

Curated by ChEMBL
LigandPNGBDBM26474(GW-786034 | JMC514632 Compound 13 | 5-({4-[(2,3-di...)
Affinity DataKd:  260nMAssay Description:Binding affinity to RIPK1 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetAurora kinase A(Human)
Lanzhou University Second Hospital

Curated by ChEMBL
LigandPNGBDBM50263059(CHEMBL4105556)
Affinity DataIC50: 293nMAssay Description:Inhibition of human recombinant AURORA-A by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Lanzhou University Second Hospital

Curated by ChEMBL
LigandPNGBDBM50635874(CHEMBL365607)
Affinity DataIC50: 320nMAssay Description:Inhibition of RIPK1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Lanzhou University Second Hospital

Curated by ChEMBL
LigandPNGBDBM50635878(CHEMBL5567010)
Affinity DataIC50: 366nMAssay Description:Inhibition of RIPK1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
Lanzhou University Second Hospital

Curated by ChEMBL
LigandPNGBDBM50635878(CHEMBL5567010)
Affinity DataIC50: 366nMAssay Description:Inhibition of human recombinant RIPK3 incubated for 1 hr by ADP-Glo kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Lanzhou University Second Hospital

Curated by ChEMBL
LigandPNGBDBM50519651(CHEMBL4534082)
Affinity DataKd:  400nMAssay Description:Binding affinity to RIPK1 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetAurora kinase A(Human)
Lanzhou University Second Hospital

Curated by ChEMBL
LigandPNGBDBM50635881(CHEMBL5556669)
Affinity DataIC50: 430nMAssay Description:Inhibition of human recombinant AURORA-A by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Lanzhou University Second Hospital

Curated by ChEMBL
LigandPNGBDBM50300690(CHEMBL576982 | N-(5-tert-Butyl-isoxazol-3-yl)-N'-{...)
Affinity DataIC50: 618nMAssay Description:Inhibition of RIPK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
Lanzhou University Second Hospital

Curated by ChEMBL
LigandPNGBDBM50300690(CHEMBL576982 | N-(5-tert-Butyl-isoxazol-3-yl)-N'-{...)
Affinity DataIC50: 618nMAssay Description:Inhibition of human recombinant RIPK3 incubated for 1 hr by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
Lanzhou University Second Hospital

Curated by ChEMBL
LigandPNGBDBM50322535(3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-meth...)
Affinity DataIC50: 640nMAssay Description:Inhibition of recombinant RIPK3 (unknown origin) by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Lanzhou University Second Hospital

Curated by ChEMBL
LigandPNGBDBM50263057(CHEMBL381230)
Affinity DataIC50: 910nMAssay Description:Inhibition of RIPK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Lanzhou University Second Hospital

Curated by ChEMBL
LigandPNGBDBM50519641(CHEMBL4439426)
Affinity DataIC50: 1.03E+3nMAssay Description:Inhibition of human full length GST-tagged RIPK1 expressed in baculovirus infected Sf9 cells using measured after 120 mins in presence of [gamma33P]A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Lanzhou University Second Hospital

Curated by ChEMBL
LigandPNGBDBM31084(1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-...)
Affinity DataKd:  1.60E+3nMAssay Description:Binding affinity to RIPK1 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Lanzhou University Second Hospital

Curated by ChEMBL
LigandPNGBDBM36371(CID2828334 | 5-(1H-indol-3-ylmethyl)-3-methyl-2-th...)
Affinity DataIC50: 1.98E+3nMAssay Description:Inhibition of RIPK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Lanzhou University Second Hospital

Curated by ChEMBL
LigandPNGBDBM50306682((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...)
Affinity DataIC50: 2.12E+3nMAssay Description:Inhibition of RIPK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
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