Compile Data Set for Download or QSAR
Report error Found 35 Enz. Inhib. hit(s) with all data for entry = 50005028
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50031677((S)-13-Methyl-17-pyridin-3-yl-7,8,9,11,12,13,14,15...)
Affinity DataIC50: 1.80nMAssay Description:Ability to inhibit the C17,20-lyase enzyme by 50% using 17-alpha-hydroxyprogesterone as substrate.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50031666((10R,13S)-10,13-Dimethyl-17-pyridin-3-yl-1,2,6,7,8...)
Affinity DataIC50: 2.10nMAssay Description:Ability to inhibit the C17,20-lyase enzyme by 50% using 17-alpha-hydroxyprogesterone as substrate.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50031669((3R,5S,10S,13S)-10,13-Dimethyl-17-pyridin-3-yl-2,3...)
Affinity DataIC50: 2.5nMAssay Description:Ability to inhibit the C17,20-lyase enzyme by 50% using 17-alpha-hydroxyprogesterone as substrate.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50031677((S)-13-Methyl-17-pyridin-3-yl-7,8,9,11,12,13,14,15...)
Affinity DataIC50: 2.60nMAssay Description:Ability to inhibit the Steroid 17-alpha-hydroxylase/17,20 lyase enzyme by 50%.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50031666((10R,13S)-10,13-Dimethyl-17-pyridin-3-yl-1,2,6,7,8...)
Affinity DataIC50: 2.80nMAssay Description:Ability to inhibit the Steroid 17-alpha-hydroxylase/17,20 lyase enzyme by 50%.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50031665((10R,13S)-10,13-Dimethyl-17-pyridin-3-yl-1,6,7,8,9...)
Affinity DataIC50: 2.90nMAssay Description:Ability to inhibit the C17,20-lyase enzyme by 50% using 17-alpha-hydroxyprogesterone as substrate.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM25458(ABT | CHEMBL254328 | CB 7598 | (1S,2R,5S,10R,11S,1...)
Affinity DataIC50: 2.90nMAssay Description:Ability to inhibit the C17,20-lyase enzyme by 50% using 17-alpha-hydroxyprogesterone as substrate.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50031676((5S,10S,13S)-10,13-Dimethyl-17-pyridin-3-yl-1,2,4,...)
Affinity DataIC50: 3nMAssay Description:Ability to inhibit the C17,20-lyase enzyme by 50% using 17-alpha-hydroxyprogesterone as substrate.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM25458(ABT | CHEMBL254328 | CB 7598 | (1S,2R,5S,10R,11S,1...)
Affinity DataIC50: 4nMAssay Description:Ability to inhibit the Steroid 17-alpha-hydroxylase/17,20 lyase enzyme by 50%.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50031669((3R,5S,10S,13S)-10,13-Dimethyl-17-pyridin-3-yl-2,3...)
Affinity DataIC50: 4.30nMAssay Description:Ability to inhibit the Steroid 17-alpha-hydroxylase/17,20 lyase enzyme by 50%.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50031676((5S,10S,13S)-10,13-Dimethyl-17-pyridin-3-yl-1,2,4,...)
Affinity DataIC50: 4.70nMAssay Description:Ability to inhibit the Steroid 17-alpha-hydroxylase/17,20 lyase enzyme by 50%.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50031667(3-((10R,13S)-10,13-Dimethyl-2,7,8,9,10,11,12,13,14...)
Affinity DataIC50: 5.60nMAssay Description:Ability to inhibit the C17,20-lyase enzyme by 50% using 17-alpha-hydroxyprogesterone as substrate.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50031665((10R,13S)-10,13-Dimethyl-17-pyridin-3-yl-1,6,7,8,9...)
Affinity DataIC50: 13nMAssay Description:Ability to inhibit the Steroid 17-alpha-hydroxylase/17,20 lyase enzyme by 50%.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50031667(3-((10R,13S)-10,13-Dimethyl-2,7,8,9,10,11,12,13,14...)
Affinity DataIC50: 13nMAssay Description:Ability to inhibit the Steroid 17-alpha-hydroxylase/17,20 lyase enzyme by 50%.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50407398(CB7630 | Zytiga | ABIRATERONE ACETATE)
Affinity DataIC50: 17nMAssay Description:Ability to inhibit the C17,20-lyase enzyme by 50% using 17-alpha-hydroxyprogesterone as substrate.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50407398(CB7630 | Zytiga | ABIRATERONE ACETATE)
Affinity DataIC50: 18nMAssay Description:Ability to inhibit the Steroid 17-alpha-hydroxylase/17,20 lyase enzyme by 50%.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50031671((3S,10R,13S,17S)-10,13-Dimethyl-17-pyridin-3-yl-2,...)
Affinity DataIC50: 23nMAssay Description:Ability to inhibit the C17,20-lyase enzyme by 50% using 17-alpha-hydroxyprogesterone as substrate.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM31768(Nizoral | CHEMBL295698 | Panfungol | Ketoconazole)
Affinity DataIC50: 26nMAssay Description:Ability to inhibit the C17,20-lyase enzyme by 50% using 17-alpha-hydroxyprogesterone as substrate.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50031671((3S,10R,13S,17S)-10,13-Dimethyl-17-pyridin-3-yl-2,...)
Affinity DataIC50: 47nMAssay Description:Ability to inhibit the Steroid 17-alpha-hydroxylase/17,20 lyase enzyme by 50%.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50031674((3S,10R,13S,17R)-10,13-Dimethyl-17-pyridin-4-yl-2,...)
Affinity DataIC50: 53nMAssay Description:Ability to inhibit the C17,20-lyase enzyme by 50% using 17-alpha-hydroxyprogesterone as substrate.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM31768(Nizoral | CHEMBL295698 | Panfungol | Ketoconazole)
Affinity DataIC50: 65nMAssay Description:Ability to inhibit the Steroid 17-alpha-hydroxylase/17,20 lyase enzyme by 50%.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50407397(CHEMBL2112301)
Affinity DataIC50: 76nMAssay Description:Ability to inhibit the C17,20-lyase enzyme by 50% using 17-alpha-hydroxyprogesterone as substrate.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50031674((3S,10R,13S,17R)-10,13-Dimethyl-17-pyridin-4-yl-2,...)
Affinity DataIC50: 160nMAssay Description:Ability to inhibit the Steroid 17-alpha-hydroxylase/17,20 lyase enzyme by 50%.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50407397(CHEMBL2112301)
Affinity DataIC50: 270nMAssay Description:Ability to inhibit the Steroid 17-alpha-hydroxylase/17,20 lyase enzyme by 50%.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50407396(CHEMBL2112299)
Affinity DataIC50: 1.00E+3nMAssay Description:Ability to inhibit the C17,20-lyase enzyme by 50% using 17-alpha-hydroxyprogesterone as substrate.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAromatase(Human)
Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50031666((10R,13S)-10,13-Dimethyl-17-pyridin-3-yl-1,2,6,7,8...)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of Cytochrome P450 19A1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50407396(CHEMBL2112299)
Affinity DataIC50: 4.00E+3nMAssay Description:Ability to inhibit the Steroid 17-alpha-hydroxylase/17,20 lyase enzyme by 50%.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50031672(3-[(10R,13S)-10,13-Dimethyl-3-(2,3,5,6-tetrafluoro...)
Affinity DataIC50: 1.00E+4nMAssay Description:Ability to inhibit the C17,20-lyase enzyme by 50% using 17-alpha-hydroxyprogesterone as substrate.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50031675((10R,13S)-10,13-Dimethyl-17-pyridin-2-ylmethyl-2,3...)
Affinity DataIC50: 1.00E+4nMAssay Description:Ability to inhibit the C17,20-lyase enzyme by 50% using 17-alpha-hydroxyprogesterone as substrate.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50031675((10R,13S)-10,13-Dimethyl-17-pyridin-2-ylmethyl-2,3...)
Affinity DataIC50: 1.00E+4nMAssay Description:Ability to inhibit the Steroid 17-alpha-hydroxylase/17,20 lyase enzyme by 50%.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50031672(3-[(10R,13S)-10,13-Dimethyl-3-(2,3,5,6-tetrafluoro...)
Affinity DataIC50: 1.00E+4nMAssay Description:Ability to inhibit the Steroid 17-alpha-hydroxylase/17,20 lyase enzyme by 50%.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAromatase(Human)
Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50407396(CHEMBL2112299)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of Cytochrome P450 19A1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAromatase(Human)
Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM25458(ABT | CHEMBL254328 | CB 7598 | (1S,2R,5S,10R,11S,1...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of Cytochrome P450 19A1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAromatase(Human)
Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50407397(CHEMBL2112301)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of Cytochrome P450 19A1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAromatase(Human)
Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50031676((5S,10S,13S)-10,13-Dimethyl-17-pyridin-3-yl-1,2,4,...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of Cytochrome P450 19A1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed