Compile Data Set for Download or QSAR
Report error Found 11 Enz. Inhib. hit(s) with all data for entry = 355
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Bristol-Myers Squibb

LigandPNGBDBM914(tert-butyl N-[(2S,3R)-4-{[(2R,3S)-3-{[(tert-butoxy...)
Affinity DataKi:  100nM ΔG°:  -41.6kJ/mole IC50: 125nMpH: 5.5 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2004
Entry Details Article
PubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Bristol-Myers Squibb

LigandPNGBDBM918(BMS-186318 analog 4 | tert-butyl N-[(2S,3R)-4-{[(2...)
Affinity DataIC50: 100nMpH: 5.5 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2004
Entry Details Article
PubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Bristol-Myers Squibb

LigandPNGBDBM923(tert-butyl N-[(2S,3R)-4-{[(2R,3S)-3-[(tert-butylca...)
Affinity DataIC50: 400nMpH: 5.5 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2004
Entry Details Article
PubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Bristol-Myers Squibb

LigandPNGBDBM917(tert-butyl N-[(2S,3R)-4-{[(2R,3S)-3-{[(tert-butoxy...)
Affinity DataIC50: 500nMpH: 5.5 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2004
Entry Details Article
PubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Bristol-Myers Squibb

LigandPNGBDBM922((1S-(1R*,2S*(2S*,3R*)))-[3-[[3-[[[(1,1-Dimethyleth...)
Affinity DataIC50: 700nMpH: 5.5 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2004
Entry Details Article
PubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Bristol-Myers Squibb

LigandPNGBDBM915((R,S)-[Iminobis[1-(cyclohexylmethyl)-2-hydroxy-3,1...)
Affinity DataIC50: 800nMpH: 5.5 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2004
Entry Details Article
PubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Bristol-Myers Squibb

LigandPNGBDBM920(propan-2-yl N-[(2S,3R)-3-hydroxy-4-{[(2R,3S)-2-hyd...)
Affinity DataIC50: 900nMpH: 5.5 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2004
Entry Details Article
PubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Bristol-Myers Squibb

LigandPNGBDBM919((R-(R*,S*))-[Iminobis[2-hydroxy-1-(phenylmethyl)-3...)
Affinity DataIC50: 3.40E+3nMpH: 5.5 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2004
Entry Details Article
PubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Bristol-Myers Squibb

LigandPNGBDBM924(tert-butyl N-[(2S,3R)-4-{[(2R,3S)-3-(3,3-dimethylb...)
Affinity DataIC50: 4.00E+3nMpH: 5.5 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2004
Entry Details Article
PubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Bristol-Myers Squibb

LigandPNGBDBM921((1S-(1R*,2S*))-[Iminobis[2-hydroxy-1-(phenylmethyl...)
Affinity DataIC50: 6.00E+3nMpH: 5.5 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2004
Entry Details Article
PubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Bristol-Myers Squibb

LigandPNGBDBM925(tert-butyl N-[(2S,3R)-4-{[(2R,3S)-3-{[(tert-butoxy...)
Affinity DataIC50: 8.50E+3nMpH: 5.5 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2004
Entry Details Article
PubMed