Compile Data Set for Download or QSAR
Report error Found 12 Enz. Inhib. hit(s) with all data for entry = 50036236
TargetDihydrofolate reductase(Lactobacillus casei)
Eisai

Curated by ChEMBL
LigandPNGBDBM18050(MTX | cid_126941 | Methotrexate | 2-[(4-{[(2,4-dia...)
Affinity DataIC50: 1.30nMAssay Description:Compound was tested for the inhibition of dihydrofolate reductase in Bovine liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2012
Entry Details Article
PubMed
TargetDihydrofolate reductase(Mouse)
Eisai

Curated by ChEMBL
LigandPNGBDBM50041670(2-{4-[2-(2-Amino-4-hydroxy-6,7-dihydro-5H-cyclopen...)
Affinity DataIC50: 2.10nMAssay Description:Compound was tested for the inhibition of dihydrofolate reductase in P388 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2012
Entry Details Article
PubMed
TargetDihydrofolate reductase(Lactobacillus casei)
Eisai

Curated by ChEMBL
LigandPNGBDBM50041672(2-{4-[3-(2,4-Diamino-6,7-dihydro-5H-cyclopentapyri...)
Affinity DataIC50: 2.5nMAssay Description:Compound was tested for the inhibition of dihydrofolate reductase in Bovine liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2012
Entry Details Article
PubMed
TargetDihydrofolate reductase(Lactobacillus casei)
Eisai

Curated by ChEMBL
LigandPNGBDBM50016460(Edatrexate | GNF-Pf-63 | (S)-2-{4-[1-(2,4-Diamino-...)
Affinity DataIC50: 3.80nMAssay Description:Compound was tested for the inhibition of dihydrofolate reductase in Bovine liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2012
Entry Details Article
PubMed
TargetDihydrofolate reductase(Mouse)
Eisai

Curated by ChEMBL
LigandPNGBDBM18050(MTX | cid_126941 | Methotrexate | 2-[(4-{[(2,4-dia...)
Affinity DataIC50: 6.60nMAssay Description:Compound was tested for the inhibition of dihydrofolate reductase in P388 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2012
Entry Details Article
PubMed
TargetDihydrofolate reductase(Mouse)
Eisai

Curated by ChEMBL
LigandPNGBDBM50041672(2-{4-[3-(2,4-Diamino-6,7-dihydro-5H-cyclopentapyri...)
Affinity DataIC50: 7.10nMAssay Description:Compound was tested for the inhibition of dihydrofolate reductase in P388 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2012
Entry Details Article
PubMed
TargetDihydrofolate reductase(Mouse)
Eisai

Curated by ChEMBL
LigandPNGBDBM50016460(Edatrexate | GNF-Pf-63 | (S)-2-{4-[1-(2,4-Diamino-...)
Affinity DataIC50: 11nMAssay Description:Compound was tested for the inhibition of dihydrofolate reductase in P388 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2012
Entry Details Article
PubMed
TargetDihydrofolate reductase(Lactobacillus casei)
Eisai

Curated by ChEMBL
LigandPNGBDBM50041673(2-{4-[2-(2,4-Diamino-6,7-dihydro-5H-cyclopentapyri...)
Affinity DataIC50: 22nMAssay Description:Compound was tested for the inhibition of dihydrofolate reductase in Bovine liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2012
Entry Details Article
PubMed
TargetDihydrofolate reductase(Mouse)
Eisai

Curated by ChEMBL
LigandPNGBDBM50041671(2-{4-[3-(2-Amino-4-hydroxy-6,7-dihydro-5H-cyclopen...)
Affinity DataIC50: 60nMAssay Description:Compound was tested for the inhibition of dihydrofolate reductase in P388 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2012
Entry Details Article
PubMed
TargetDihydrofolate reductase(Mouse)
Eisai

Curated by ChEMBL
LigandPNGBDBM50041673(2-{4-[2-(2,4-Diamino-6,7-dihydro-5H-cyclopentapyri...)
Affinity DataIC50: 72nMAssay Description:Compound was tested for the inhibition of dihydrofolate reductase in P388 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2012
Entry Details Article
PubMed
TargetThymidylate synthase(Lactobacillus casei)
Eisai

Curated by ChEMBL
LigandPNGBDBM50028122(2-Amino-3,7-dihydro-pyrrolo[2,3-d]pyrimidin-4-one ...)
Affinity DataKi:  550nMAssay Description:Binding affinity against TSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2012
Entry Details Article
PubMed
TargetDihydrofolate reductase(Mouse)
Eisai

Curated by ChEMBL
LigandPNGBDBM50028122(2-Amino-3,7-dihydro-pyrrolo[2,3-d]pyrimidin-4-one ...)
Affinity DataKi:  560nMAssay Description:Binding affinity against dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2012
Entry Details Article
PubMed