Compile Data Set for Download or QSAR
Report error Found 79 Enz. Inhib. hit(s) with all data for entry = 50005872
TargetDihydrofolate reductase(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM18268(5-methyl-6-{[(3,4,5-trimethoxyphenyl)amino]methyl}...)
Affinity DataIC50: 1.40nMAssay Description:Tested for inhibitory activity against dihydrofolate reductase in humanMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Rat)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM18224(6-[(2,5-dimethoxyphenyl)methyl]-5-methylpyrido[2,3...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of rat liver dihydrofolate reductase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDihydrofolate reductase(Rat)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM18268(5-methyl-6-{[(3,4,5-trimethoxyphenyl)amino]methyl}...)
Affinity DataIC50: 3nMAssay Description:Inhibition of rat liver dihydrofolate reductase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Escherichia coli (strain K12))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM18268(5-methyl-6-{[(3,4,5-trimethoxyphenyl)amino]methyl}...)
Affinity DataIC50: 10nMAssay Description:Inhibition of dihydrofolate reductase in Toxoplasma gondii.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Escherichia coli (strain K12))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM18224(6-[(2,5-dimethoxyphenyl)methyl]-5-methylpyrido[2,3...)
Affinity DataIC50: 11nMAssay Description:Inhibition of dihydrofolate reductase in Toxoplasma gondii.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Escherichia coli (strain K12))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM18224(6-[(2,5-dimethoxyphenyl)methyl]-5-methylpyrido[2,3...)
Affinity DataIC50: 38nMAssay Description:Inhibition of dihydrofolate reductase in pneumocystis carinii.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Escherichia coli (strain K12))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM18268(5-methyl-6-{[(3,4,5-trimethoxyphenyl)amino]methyl}...)
Affinity DataIC50: 42nMAssay Description:Inhibition of dihydrofolate reductase in pneumocystis carinii.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Escherichia coli (strain K12))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50041943(6-(2,5-dimethoxybenzyl)-5-methylthieno[2,3-d]pyrim...)
Affinity DataIC50: 70nMAssay Description:Inhibition of dihydrofolate reductase in Toxoplasma gondii.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Escherichia coli (strain K12))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50041929(6-(2,5-Dimethoxy-phenyl)-5-methyl-thieno[2,3-d]pyr...)
Affinity DataIC50: 130nMAssay Description:Inhibition of dihydrofolate reductase in Toxoplasma gondii.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Lactobacillus casei)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50041927(5,6,7,8,9,10,11,12,13,14-Decahydro-15-thia-1,3-dia...)
Affinity DataIC50: 200nMAssay Description:Tested for inhibitory activity against dihydrofolate reductase in Beef liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Escherichia coli (strain K12))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50041939(5-Methyl-6-(3,4,5-trimethoxy-phenyl)-thieno[2,3-d]...)
Affinity DataIC50: 320nMAssay Description:Inhibition of dihydrofolate reductase in Toxoplasma gondii.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Rat)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50041929(6-(2,5-Dimethoxy-phenyl)-5-methyl-thieno[2,3-d]pyr...)
Affinity DataIC50: 370nMAssay Description:Inhibition of rat liver dihydrofolate reductase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Rat)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50041943(6-(2,5-dimethoxybenzyl)-5-methylthieno[2,3-d]pyrim...)
Affinity DataIC50: 400nMAssay Description:Inhibition of rat liver dihydrofolate reductase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Lactobacillus casei)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50041935(5,6,7,8,9,10-Hexahydro-11-thia-1,3-diaza-cycloocta...)
Affinity DataIC50: 400nMAssay Description:Tested for inhibitory activity against dihydrofolate reductase in Beef liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Rat)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50041928(7-Benzyl-5,6,7,8-tetrahydro-9-thia-1,3,7-triaza-fl...)
Affinity DataIC50: 570nMAssay Description:Inhibition of rat liver dihydrofolate reductase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Escherichia coli (strain K12))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50041934(6-(3,4,5-trimethoxybenzyl)-5-methylthieno[2,3-d]py...)
Affinity DataIC50: 630nMAssay Description:Inhibition of dihydrofolate reductase in Toxoplasma gondii.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Lactobacillus casei)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50041940(6-Benzyl-5-methyl-thieno[2,3-d]pyrimidine-2,4-diam...)
Affinity DataIC50: 640nMAssay Description:Tested for inhibitory activity against dihydrofolate reductase in Beef liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Lactobacillus casei)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50041942(5-Methyl-6-phenyl-thieno[2,3-d]pyrimidine-2,4-diam...)
Affinity DataIC50: 650nMAssay Description:Tested for inhibitory activity against dihydrofolate reductase in Beef liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50041943(6-(2,5-dimethoxybenzyl)-5-methylthieno[2,3-d]pyrim...)
Affinity DataIC50: 730nMAssay Description:Tested for inhibitory activity against dihydrofolate reductase in humanMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50041929(6-(2,5-Dimethoxy-phenyl)-5-methyl-thieno[2,3-d]pyr...)
Affinity DataIC50: 750nMAssay Description:Tested for inhibitory activity against dihydrofolate reductase in humanMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50041928(7-Benzyl-5,6,7,8-tetrahydro-9-thia-1,3,7-triaza-fl...)
Affinity DataIC50: 850nMAssay Description:Tested for inhibitory activity against dihydrofolate reductase in Toxoplasma gondiiMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Escherichia coli (strain K12))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50041941(6,7,8,9-Tetrahydro-5H-10-thia-1,3-diaza-benzo[a]az...)
Affinity DataIC50: 860nMAssay Description:Inhibition of dihydrofolate reductase in Toxoplasma gondii.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Escherichia coli (strain K12))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50029769(6-[2-(2,5-Dimethoxy-phenyl)-ethyl]-5-methyl-thieno...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of dihydrofolate reductase in pneumocystis carinii.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Rat)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50041941(6,7,8,9-Tetrahydro-5H-10-thia-1,3-diaza-benzo[a]az...)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of rat liver dihydrofolate reductase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Lactobacillus casei)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50041940(6-Benzyl-5-methyl-thieno[2,3-d]pyrimidine-2,4-diam...)
Affinity DataIC50: 1.30E+3nMAssay Description:Tested for inhibitory activity against dihydrofolate reductase in Lactobacillus caseiMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Escherichia coli (strain K12))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50041941(6,7,8,9-Tetrahydro-5H-10-thia-1,3-diaza-benzo[a]az...)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of dihydrofolate reductase in pneumocystis carinii.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Lactobacillus casei)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50041942(5-Methyl-6-phenyl-thieno[2,3-d]pyrimidine-2,4-diam...)
Affinity DataIC50: 1.50E+3nMAssay Description:Tested for inhibitory activity against dihydrofolate reductase in Lactobacillus caseiMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Rat)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50041939(5-Methyl-6-(3,4,5-trimethoxy-phenyl)-thieno[2,3-d]...)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of rat liver dihydrofolate reductase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Rat)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50041935(5,6,7,8,9,10-Hexahydro-11-thia-1,3-diaza-cycloocta...)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of rat liver dihydrofolate reductase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Lactobacillus casei)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50041936(6-(3,4-Dichloro-phenyl)-5-methyl-thieno[2,3-d]pyri...)
Affinity DataIC50: 2.00E+3nMAssay Description:Tested for inhibitory activity against dihydrofolate reductase in Lactobacillus caseiMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Escherichia coli (strain K12))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50041932(5,6,7,8-Tetrahydro-benzo[4,5]thieno[2,3-d]pyrimidi...)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of dihydrofolate reductase in pneumocystis carinii.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Escherichia coli (strain K12))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50041932(5,6,7,8-Tetrahydro-benzo[4,5]thieno[2,3-d]pyrimidi...)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of dihydrofolate reductase in Toxoplasma gondii.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Rat)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50041931(5-[2-(2,5-Dimethoxy-phenyl)-ethyl]-thieno[2,3-d]py...)
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of rat liver dihydrofolate reductase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Escherichia coli (strain K12))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50029769(6-[2-(2,5-Dimethoxy-phenyl)-ethyl]-5-methyl-thieno...)
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of dihydrofolate reductase in Toxoplasma gondii.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Rat)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50041932(5,6,7,8-Tetrahydro-benzo[4,5]thieno[2,3-d]pyrimidi...)
Affinity DataIC50: 3.90E+3nMAssay Description:Inhibition of rat liver dihydrofolate reductase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Escherichia coli (strain K12))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50041942(5-Methyl-6-phenyl-thieno[2,3-d]pyrimidine-2,4-diam...)
Affinity DataIC50: 3.90E+3nMAssay Description:Inhibition of dihydrofolate reductase in Toxoplasma gondii.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Lactobacillus casei)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50041936(6-(3,4-Dichloro-phenyl)-5-methyl-thieno[2,3-d]pyri...)
Affinity DataIC50: 4.60E+3nMAssay Description:Tested for inhibitory activity against dihydrofolate reductase in Beef liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Rat)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50041936(6-(3,4-Dichloro-phenyl)-5-methyl-thieno[2,3-d]pyri...)
Affinity DataIC50: 4.60E+3nMAssay Description:Inhibition of rat liver dihydrofolate reductase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Escherichia coli (strain K12))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50041929(6-(2,5-Dimethoxy-phenyl)-5-methyl-thieno[2,3-d]pyr...)
Affinity DataIC50: 4.80E+3nMAssay Description:Inhibition of dihydrofolate reductase in pneumocystis carinii.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50041928(7-Benzyl-5,6,7,8-tetrahydro-9-thia-1,3,7-triaza-fl...)
Affinity DataIC50: 5.20E+3nMAssay Description:Tested for inhibitory activity against dihydrofolate reductase in pneumocystis cariniiMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Escherichia coli (strain K12))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50041931(5-[2-(2,5-Dimethoxy-phenyl)-ethyl]-thieno[2,3-d]py...)
Affinity DataIC50: 5.80E+3nMAssay Description:Inhibition of dihydrofolate reductase in Toxoplasma gondii.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Rat)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50029769(6-[2-(2,5-Dimethoxy-phenyl)-ethyl]-5-methyl-thieno...)
Affinity DataIC50: 5.90E+3nMAssay Description:Inhibition of rat liver dihydrofolate reductase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Escherichia coli (strain K12))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50041940(6-Benzyl-5-methyl-thieno[2,3-d]pyrimidine-2,4-diam...)
Affinity DataIC50: 6.50E+3nMAssay Description:Inhibition of dihydrofolate reductase in Toxoplasma gondii.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Escherichia coli (strain K12))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50041935(5,6,7,8,9,10-Hexahydro-11-thia-1,3-diaza-cycloocta...)
Affinity DataIC50: 6.50E+3nMAssay Description:Inhibition of dihydrofolate reductase in pneumocystis carinii.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Lactobacillus casei)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50041930(5-(4-Chloro-phenyl)-6-methyl-thieno[2,3-d]pyrimidi...)
Affinity DataIC50: 7.70E+3nMAssay Description:Tested for inhibitory activity against dihydrofolate reductase in Beef liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Escherichia coli (strain K12))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50041934(6-(3,4,5-trimethoxybenzyl)-5-methylthieno[2,3-d]py...)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of dihydrofolate reductase in pneumocystis carinii.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Escherichia coli (strain K12))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50041933(5-Methyl-6-[2-(3,4,5-trimethoxy-phenyl)-ethyl]-thi...)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of dihydrofolate reductase in pneumocystis carinii.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Escherichia coli (strain K12))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50041939(5-Methyl-6-(3,4,5-trimethoxy-phenyl)-thieno[2,3-d]...)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of dihydrofolate reductase in pneumocystis carinii.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Rat)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50041927(5,6,7,8,9,10,11,12,13,14-Decahydro-15-thia-1,3-dia...)
Affinity DataIC50: 9.30E+3nMAssay Description:Inhibition of rat liver dihydrofolate reductase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50041933(5-Methyl-6-[2-(3,4,5-trimethoxy-phenyl)-ethyl]-thi...)
Affinity DataIC50: 1.00E+4nMAssay Description:Tested for inhibitory activity against dihydrofolate reductase in humanMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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