Compile Data Set for Download or QSAR
Report error Found 30 Enz. Inhib. hit(s) with all data for entry = 50036182
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rat)
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50368147((3R,5S,6E)-7-[3-(4-fluorophenyl)-1-isopropyl-1H-in...)
Affinity DataIC50: 2.5nMAssay Description:Inhibitory activity against partially purified rat liver HMG-CoA reductase in vitro; 0.0015-0.0040More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2012
Entry Details Article
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rat)
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50042682(Sodium; 7-[7-biphenyl-4-ylmethyl-2-(4-fluoro-pheny...)
Affinity DataIC50: 3nMAssay Description:Inhibitory activity against partially purified rat liver HMG-CoA reductase in vitro; 0.0015-0.0049More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2012
Entry Details Article
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rat)
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50042665(Sodium; 7-[2-(4-fluoro-phenyl)-7-naphthalen-2-ylme...)
Affinity DataIC50: 9nMAssay Description:Inhibitory activity against partially purified rat liver HMG-CoA reductase in vitro; 0.0050-0.016More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2012
Entry Details Article
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rat)
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50042675(Sodium;2-{2-[2,6-dimethyl-8-(2-methyl-butyryloxy)-...)
Affinity DataIC50: 9.20nMAssay Description:Inhibitory activity against partially purified rat liver HMG-CoA reductase in vitro; 0.047-0.098More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2012
Entry Details Article
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rat)
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50042681(Sodium; 7-[7-(4-tert-butyl-benzyl)-2-(4-fluoro-phe...)
Affinity DataIC50: 14nMAssay Description:Inhibitory activity against partially purified rat liver HMG-CoA reductase in vitro; 0.0040-0.053More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2012
Entry Details Article
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rat)
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50042673(Sodium; 7-[2-(4-fluoro-phenyl)-7-(4-methyl-benzyl)...)
Affinity DataIC50: 28nMAssay Description:Inhibitory activity against partially purified rat liver HMG-CoA reductase in vitro; 0.021-0.036More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2012
Entry Details Article
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rat)
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50042670(Sodium; 7-[2-(4-fluoro-phenyl)-7-(4-methoxy-benzyl...)
Affinity DataIC50: 28nMAssay Description:Inhibitory activity against partially purified rat liver HMG-CoA reductase in vitro; 0.015-0.51More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2012
Entry Details Article
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rat)
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50042678(Sodium; 7-[2-(4-fluoro-phenyl)-7-naphthalen-1-ylme...)
Affinity DataIC50: 28nMAssay Description:Inhibitory activity against partially purified rat liver HMG-CoA reductase in vitro; 0.021-0.036More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2012
Entry Details Article
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rat)
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50042672(Sodium; 7-[2-(4-fluoro-phenyl)-7-(3-methoxy-benzyl...)
Affinity DataIC50: 35nMAssay Description:Inhibitory activity against partially purified rat liver HMG-CoA reductase in vitro; 0.027-0.046More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2012
Entry Details Article
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rat)
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50042684(Sodium; 7-[2-(4-fluoro-phenyl)-7-(4-isopropyl-benz...)
Affinity DataIC50: 40nMAssay Description:Inhibitory activity against partially purified rat liver HMG-CoA reductase in vitro; 0.0040-0.053More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2012
Entry Details Article
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rat)
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50042674(Sodium; 7-[7-benzyl-2-(4-fluoro-phenyl)-4,5,6,7-te...)
Affinity DataIC50: 68nMAssay Description:Inhibitory activity against partially purified rat liver HMG-CoA reductase in vitro; 0.047-0.098More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2012
Entry Details Article
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rat)
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50042677(Sodium; 7-[2-(4-fluoro-phenyl)-7-(3-phenyl-allyl)-...)
Affinity DataIC50: 82nMAssay Description:Inhibitory activity against partially purified rat liver HMG-CoA reductase in vitro; 0.038-0.18More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2012
Entry Details Article
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rat)
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50042671(Sodium; 7-[7-(2-chloro-benzyl)-2-(4-fluoro-phenyl)...)
Affinity DataIC50: 95nMAssay Description:Inhibitory activity against partially purified rat liver HMG-CoA reductase in vitro; 0.026-0.34More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2012
Entry Details Article
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rat)
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50042667(Sodium; 7-[7-(4-chloro-benzyl)-2-(4-fluoro-phenyl)...)
Affinity DataIC50: 140nMAssay Description:Inhibitory activity against partially purified rat liver HMG-CoA reductase in vitro; 0.07-0.27More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2012
Entry Details Article
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rat)
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50042664(Sodium; 7-[2-(4-fluoro-phenyl)-7-(3-phenyl-propyl)...)
Affinity DataIC50: 160nMAssay Description:Inhibitory activity against partially purified rat liver HMG-CoA reductase in vitro; 0.12-0.21More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2012
Entry Details Article
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rat)
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50042676(Sodium; 7-[7-(4-fluoro-benzyl)-2-(4-fluoro-phenyl)...)
Affinity DataIC50: 200nMAssay Description:Inhibitory activity against partially purified rat liver HMG-CoA reductase in vitro; 0.16-0.24More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2012
Entry Details Article
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rat)
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50042683(Sodium; 7-[7-(3,4-dimethoxy-benzyl)-2-(4-fluoro-ph...)
Affinity DataIC50: 320nMAssay Description:Inhibitory activity against partially purified rat liver HMG-CoA reductase in vitro; 0.17-0.61More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2012
Entry Details Article
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rat)
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM34168(cid_53232 | SMR000058779 | MLS000069585 | LOVASTAT...)
Affinity DataIC50: 400nMAssay Description:Inhibitory activity against partially purified rat liver HMG-CoA reductase in vitro; 0.23-0.71More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2012
Entry Details Article
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rat)
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50042666(Sodium; 7-[2-(4-fluoro-phenyl)-7-phenethyl-4,5,6,7...)
Affinity DataIC50: 540nMAssay Description:Inhibitory activity against partially purified rat liver HMG-CoA reductase in vitro; 0.41-0.73More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2012
Entry Details Article
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rat)
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50042669(Sodium; 7-[7-ethyl-2-(4-fluoro-phenyl)-4,5,6,7-tet...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibitory activity against partially purified rat liver HMG-CoA reductase in vitro; 1.2-3.3More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2012
Entry Details Article
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rat)
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50042689(Sodium; 7-[2-(4-fluoro-phenyl)-7-methyl-4,5,6,7-te...)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibitory activity against partially purified rat liver HMG-CoA reductase in vitro; 1.7-2.6More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2012
Entry Details Article
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rat)
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50042680(Sodium; 7-[2-(4-fluoro-phenyl)-2,4,5,6-tetrahydro-...)
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibitory activity against partially purified rat liver HMG-CoA reductase in vitro; 1.8-3.7More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2012
Entry Details Article
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rat)
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50042663(Sodium; 7-[2-(4-fluoro-phenyl)-7-phenyl-4,5,6,7-te...)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibitory activity against partially purified rat liver HMG-CoA reductase in vitro; 0.73-10More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2012
Entry Details Article
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rat)
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50042691(Sodium; 7-[7-sec-butyl-2-(4-fluoro-phenyl)-4,5,6,7...)
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibitory activity against partially purified rat liver HMG-CoA reductase in vitro; 1.9-5.3More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2012
Entry Details Article
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rat)
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50042690(Sodium; 7-[2-(4-fluoro-phenyl)-7-propyl-4,5,6,7-te...)
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibitory activity against partially purified rat liver HMG-CoA reductase in vitro; 1.9-5.3More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2012
Entry Details Article
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rat)
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50042688(Sodium; 7-[2-(4-fluoro-phenyl)-2,4,5,6,7,8-hexahyd...)
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibitory activity against partially purified rat liver HMG-CoA reductase in vitro; 2.6-4.8More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2012
Entry Details Article
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rat)
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50042687(Sodium; 7-[2-(4-fluoro-phenyl)-4,5,6,7-tetrahydro-...)
Affinity DataIC50: 5.30E+3nMAssay Description:Inhibitory activity against partially purified rat liver HMG-CoA reductase in vitro; 3.1-9.1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2012
Entry Details Article
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rat)
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50042692(Sodium; 7-[7-cyclohexyl-2-(4-fluoro-phenyl)-4,5,6,...)
Affinity DataIC50: 8.50E+3nMAssay Description:Inhibitory activity against partially purified rat liver HMG-CoA reductase in vitro; 3.8-19More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2012
Entry Details Article
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rat)
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50042679(Sodium; 7-[2-(4-fluoro-phenyl)-4,5-dihydro-2H-benz...)
Affinity DataIC50: 9.40E+3nMAssay Description:Inhibitory activity against partially purified rat liver HMG-CoA reductase in vitro; 4.1-22More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2012
Entry Details Article
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rat)
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50042686(Sodium; 7-[2-(4-fluoro-phenyl)-2,4,5,6-tetrahydro-...)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibitory activity against partially purified rat liver HMG-CoA reductase in vitro; 2.1-54More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2012
Entry Details Article
PubMed