Compile Data Set for Download or QSAR
Report error Found 42 Enz. Inhib. hit(s) with all data for entry = 50036412
Target5-hydroxytryptamine receptor 1A(Rat)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50048867(1-Benzyl-4-[3-(5-methoxy-1,2,3,4-tetrahydro-naphth...)
Affinity DataKi:  3.60nMAssay Description:Displacement of [3H]5-HT from rat hippocampal 5-hydroxytryptamine 1A receptor with 10e-6 M ketanserinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  4.20nMAssay Description:Inhibitory activity against sigma receptor isolated from guinea pig brain cortex membrane using [3H]DTG as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 1A(Rat)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM21393(cid_1220 | CHEMBL56 | 7-(dipropylamino)-5,6,7,8-te...)
Affinity DataKi:  4.30nMAssay Description:Displacement of [3H]5-HT from rat hippocampal 5-hydroxytryptamine 1A receptor with 10e-6 M ketanserinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50048876([3-(5-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl)-...)
Affinity DataKi:  4.40nMAssay Description:Displacement of [3H]5-HT from rat hippocampal 5-hydroxytryptamine 1A receptor with 10e-6 M ketanserinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50048866(1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronap...)
Affinity DataKi:  5.30nMAssay Description:Inhibition of [3H]DTG binding to sigma receptor from guinea pig brain cortex membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50048867(1-Benzyl-4-[3-(5-methoxy-1,2,3,4-tetrahydro-naphth...)
Affinity DataKi:  7nMAssay Description:Inhibition of [3H]DTG binding to sigma receptor from guinea pig brain cortex membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  10nMAssay Description:Inhibitory activity against Opioid receptor sigma 1 isolated from whole rat membranes using [3H](+)-pentazocine as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 1A(Rat)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50048875(N-[3-(5-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl...)
Affinity DataKi:  14nMAssay Description:Displacement of [3H]5-HT from rat hippocampal 5-hydroxytryptamine 1A receptor with 10e-6 M ketanserinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50048868([3-(5-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl)-...)
Affinity DataKi:  23nMAssay Description:Displacement of [3H]5-HT from rat hippocampal 5-hydroxytryptamine 1A receptor with 10e-6 M ketanserinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50048867(1-Benzyl-4-[3-(5-methoxy-1,2,3,4-tetrahydro-naphth...)
Affinity DataKi:  26nMAssay Description:Inhibitory activity against Sigma opioid receptor type 1 isolated from whole rat membranes using [3H](+)-pentazocine as radioligand.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50048870(1-[3-(7-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl...)
Affinity DataKi:  29nMAssay Description:Inhibition of [3H]DTG binding to sigma receptor from guinea pig brain cortex membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50048866(1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronap...)
Affinity DataKi:  29nMAssay Description:Displacement of [3H]5-HT from rat hippocampal 5-hydroxytryptamine 1A receptor with 10e-6 M ketanserinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50048869([3-(5-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl)-...)
Affinity DataKi:  31nMAssay Description:Displacement of [3H]5-HT from rat hippocampal 5-hydroxytryptamine 1A receptor with 10e-6 M ketanserinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM81982(CAS_97-39-2 | cid_7333 | Di-o-tolylguanidine | DIT...)
Affinity DataKi:  37nMAssay Description:Inhibitory activity against sigma receptor isolated from guinea pig brain cortex membrane using [3H]DTG as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50048871(1-[4-(5-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl...)
Affinity DataKi:  37nMAssay Description:Displacement of [3H]5-HT from rat hippocampal 5-hydroxytryptamine 1A receptor with 10e-6 M ketanserinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50048878(1-[3-(1,2,3,4-Tetrahydro-naphthalen-1-yl)-propyl]-...)
Affinity DataKi:  44nMAssay Description:Displacement of [3H]5-HT from rat hippocampal 5-hydroxytryptamine 1A receptor with 10e-6 M ketanserinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50048878(1-[3-(1,2,3,4-Tetrahydro-naphthalen-1-yl)-propyl]-...)
Affinity DataKi:  44nMAssay Description:Inhibition of [3H]DTG binding to sigma receptor from guinea pig brain cortex membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50048871(1-[4-(5-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl...)
Affinity DataKi:  47nMAssay Description:Inhibition of [3H]DTG binding to sigma receptor from guinea pig brain cortex membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50048873(1-Benzyl-4-[3-(3,4-dihydro-naphthalen-1-yl)-propyl...)
Affinity DataKi:  66nMAssay Description:Inhibition of [3H]DTG binding to sigma receptor from guinea pig brain cortex membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50048866(1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronap...)
Affinity DataKi:  71nMAssay Description:Inhibitory activity against Sigma opioid receptor type 1 isolated from whole rat membranes using [3H](+)-pentazocine as radioligand.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50048878(1-[3-(1,2,3,4-Tetrahydro-naphthalen-1-yl)-propyl]-...)
Affinity DataKi:  111nMAssay Description:Inhibitory activity against Sigma opioid receptor type 1 isolated from whole rat membranes using [3H](+)-pentazocine as radioligand.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50048877(1-Benzyl-4-[3-(5-methoxy-3,4-dihydro-naphthalen-1-...)
Affinity DataKi:  139nMAssay Description:Inhibitory activity against sigma receptor isolated from guinea pig brain cortex membrane using [3H]DTG as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50048876([3-(5-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl)-...)
Affinity DataKi:  152nMAssay Description:Inhibition of [3H]DTG binding to sigma receptor from guinea pig brain cortex membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50048869([3-(5-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl)-...)
Affinity DataKi:  159nMAssay Description:Inhibition of [3H]DTG binding to sigma receptor from guinea pig brain cortex membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50048873(1-Benzyl-4-[3-(3,4-dihydro-naphthalen-1-yl)-propyl...)
Affinity DataKi:  214nMAssay Description:Displacement of [3H]5-HT from rat hippocampal 5-hydroxytryptamine 1A receptor with 10e-6 M ketanserinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50048875(N-[3-(5-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl...)
Affinity DataKi:  265nMAssay Description:Inhibition of [3H]DTG binding to sigma receptor from guinea pig brain cortex membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50048872(1-[3-(7-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl...)
Affinity DataKi:  270nMAssay Description:Inhibition of [3H]DTG binding to sigma receptor from guinea pig brain cortex membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2C(Rat)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50368882(SK&F-10047 | SK-10047 | CHEMBL147585)
Affinity DataKi:  370nMAssay Description:Inhibitory activity against sigma receptor isolated from guinea pig brain cortex membrane using PCP as radioligand at a concentration of 10e-5 MMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50048871(1-[4-(5-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl...)
Affinity DataKi:  396nMAssay Description:Inhibitory activity against Sigma opioid receptor type 1 isolated from whole rat membranes using [3H](+)-pentazocine as radioligand.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50048870(1-[3-(7-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl...)
Affinity DataKi:  414nMAssay Description:Displacement of [3H]5-HT from rat hippocampal 5-hydroxytryptamine 1A receptor with 10e-6 M ketanserinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50048868([3-(5-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl)-...)
Affinity DataKi:  469nMAssay Description:Inhibition of [3H]DTG binding to sigma receptor from guinea pig brain cortex membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50048874(1-(3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)...)
Affinity DataKi: >877nMAssay Description:Inhibition of [3H]DTG binding to sigma receptor from guinea pig brain cortex membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50048874(1-(3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)...)
Affinity DataKi: >1.43E+3nMAssay Description:Displacement of [3H]5-HT from rat hippocampal 5-hydroxytryptamine 1A receptor with 10e-6 M ketanserinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50048877(1-Benzyl-4-[3-(5-methoxy-3,4-dihydro-naphthalen-1-...)
Affinity DataKi: >1.43E+3nMAssay Description:Inhibitory activity against 5-hydroxytryptamine 1A receptor isolated from rat hippocampus membranes membrane using [3H]5-HT as radioligand in the pre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50048872(1-[3-(7-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl...)
Affinity DataKi: >1.43E+3nMAssay Description:Displacement of [3H]5-HT from rat hippocampal 5-hydroxytryptamine 1A receptor with 10e-6 M ketanserinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2C(Rat)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50048875(N-[3-(5-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl...)
Affinity DataKi:  2.13E+3nMAssay Description:Inhibitory activity against sigma receptor isolated from guinea pig brain cortex membrane using PCP as radioligand at a concentration of 10e-5 MMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2C(Rat)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50048867(1-Benzyl-4-[3-(5-methoxy-1,2,3,4-tetrahydro-naphth...)
Affinity DataKi:  3.89E+3nMAssay Description:Inhibitory activity against sigma receptor isolated from guinea pig brain cortex membrane using PCP as radioligand at a concentration of 10e-5 MMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2C(Rat)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50048871(1-[4-(5-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl...)
Affinity DataKi:  8.33E+3nMAssay Description:Inhibitory activity against sigma receptor isolated from guinea pig brain cortex membrane using PCP as radioligand at a concentration of 10e-5 MMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2C(Rat)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50048873(1-Benzyl-4-[3-(3,4-dihydro-naphthalen-1-yl)-propyl...)
Affinity DataKi:  8.43E+3nMAssay Description:Inhibitory activity against sigma receptor isolated from guinea pig brain cortex membrane using PCP as radioligand at a concentration of 10e-5 MMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2C(Rat)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50048869([3-(5-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl)-...)
Affinity DataKi:  2.04E+4nMAssay Description:Inhibitory activity against sigma receptor isolated from guinea pig brain cortex membrane using PCP as radioligand at a concentration of 10e-5 MMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2C(Rat)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50048876([3-(5-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl)-...)
Affinity DataKi:  2.50E+4nMAssay Description:Inhibitory activity against sigma receptor isolated from guinea pig brain cortex membrane using PCP as radioligand at a concentration of 10e-5 MMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2C(Rat)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50048866(1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronap...)
Affinity DataKi: >9.26E+4nMAssay Description:Inhibitory activity against sigma receptor isolated from guinea pig brain cortex membrane using PCP as radioligand at a concentration of 10e-5 MMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMed