Compile Data Set for Download or QSAR
Report error Found 114 Enz. Inhib. hit(s) with all data for entry = 50036603
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50039259((1S,9aR,11aS)-9a,11a-Dimethyl-7-oxo-2,3,3a,3b,4,5,...)
Affinity DataIC50: 0.120nMAssay Description:Binding affinity for human 5-alpha reductase 2 isozymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50334788((17beta-(N-tert-butylcarbamoyl)-4-aza-5alpha-andro...)
Affinity DataIC50: 0.180nMAssay Description:Binding affinity for human 5-alpha reductase 2 isozymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50057475((4aR,6aS,7S)-4a,6a-Dimethyl-2-oxo-2,4a,4b,5,6,6a,7...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human 5-alpha reductase 2 isozyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50057500((1S,9aR,11aS)-6-Chloro-9a,11a-dimethyl-7-oxo-2,3,3...)
Affinity DataKi:  0.200nMAssay Description:Binding affinity for human 5 alpha reductase 1 isozymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50057476((4aR,6aS,7S)-4a,6a-Dimethyl-2-oxo-2,4a,4b,5,6,6a,7...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human 5-alpha reductase 2 isozyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50057484((1S,9aR,11aS)-6,9a,11a-Trimethyl-7-oxo-2,3,3a,3b,4...)
Affinity DataKi:  0.200nMAssay Description:Binding affinity for human 5 alpha reductase 1 isozymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50031889((1S,9aR,11aS)-6,9a,11a-Trimethyl-7-oxo-2,3,3a,3b,4...)
Affinity DataKi:  0.300nMAssay Description:Binding affinity for human 5 alpha reductase 1 isozymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50057492((4aR,6aS,7S)-7-(Indole-1-carbonyl)-4a,6a-dimethyl-...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human 5-alpha reductase 2 isozyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50057487((4aR,6aS,7S)-4a,6a-Dimethyl-2-oxo-2,4a,4b,5,6,6a,7...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human 5-alpha reductase 2 isozyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50031897((1S,9aR,11aS)-6-Chloro-9a,11a-dimethyl-7-oxo-2,3,3...)
Affinity DataKi:  0.600nMAssay Description:Binding affinity for human 5 alpha reductase 1 isozymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50368906(MK-386 | CHEMBL25448)
Affinity DataIC50: 0.900nMAssay Description:Inhibitory concentration was tested on human 5-alpha reductase 1 isozymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50057456(3-Methyl-4-oxo-2-phenyl-4H-chromene-8-carboxylic a...)
Affinity DataIC50: 1nMAssay Description:Binding affinity was tested on CEC-pretreated rat hippocampus Alpha-1A adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50057449(3-Methyl-4-oxo-2-phenyl-4H-chromene-8-carboxylic a...)
Affinity DataIC50: 1nMAssay Description:Binding affinity was tested on CEC-pretreated rat hippocampus Alpha-1A adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed
TargetAlpha-1B adrenergic receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50057463(1-[4-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-piper...)
Affinity DataIC50: 1.20nMAssay Description:Binding affinity was tested on cloned hamster Alpha-1B adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50031892((1S,9aR,11aS)-9a,11a-Dimethyl-7-oxo-2,3,3a,3b,4,5,...)
Affinity DataIC50: 1.40nMAssay Description:Binding affinity for human 5-alpha reductase 2 isozymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50057462(8-{4-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-butyryl...)
Affinity DataIC50: 1.5nMAssay Description:Binding affinity was tested on CEC-pretreated rat hippocampus Alpha-1A adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50057458((4aR,6aR,7R)-7-(1,5-Dimethyl-hexyl)-1,4a,6a-trimet...)
Affinity DataIC50: 1.70nMAssay Description:Inhibitory concentration was tested on human 5-alpha reductase 1 isozymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50039320((4aR,6aS,7S)-1,4a,6a-Trimethyl-2-oxo-hexadecahydro...)
Affinity DataIC50: 1.70nMAssay Description:Inhibitory concentration was tested on human 5-alpha reductase 1 isozymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50039320((4aR,6aS,7S)-1,4a,6a-Trimethyl-2-oxo-hexadecahydro...)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of human 5-alpha reductase 2 isozyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50057465(3-Methyl-4-oxo-2-phenyl-4H-chromene-8-carboxylic a...)
Affinity DataIC50: 2nMAssay Description:Binding affinity was tested on CEC-pretreated rat hippocampus Alpha-1A adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50057487((4aR,6aS,7S)-4a,6a-Dimethyl-2-oxo-2,4a,4b,5,6,6a,7...)
Affinity DataIC50: 2.40nMAssay Description:Inhibitory concentration was tested on human 5-alpha reductase 1 isozymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50057459((10R,13S,17S)-4-Cyano-10,13-dimethyl-3-oxo-2,3,6,7...)
Affinity DataIC50: 2.90nMAssay Description:Inhibitory concentration on human 5-alpha reductase 2 (transfected SW-13 cells)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50039266((1S,9aR,11aS)-9a,11a-Dimethyl-7-oxo-2,3,3a,3b,4,5,...)
Affinity DataIC50: 3.20nMAssay Description:Binding affinity for human 5-alpha reductase 2 isozymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50057454((4aR,6aR,7R,10S)-7-(1,5-Dimethyl-hexyl)-1-ethyl-4a...)
Affinity DataIC50: 3.30nMAssay Description:Inhibitory concentration was tested on human 5-alpha reductase 1 isozymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50057447(4-(3-{4-[(S)-1-(4-Isobutyl-phenyl)-ethoxy]-benzoyl...)
Affinity DataIC50: 4nMAssay Description:Inhibition of human 5-alpha reductase 2 isozyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50057478((4aR,6aS,7S)-4a,6a-Dimethyl-2-oxo-2,4a,4b,5,6,6a,7...)
Affinity DataIC50: 5.60nMAssay Description:Inhibitory concentration was tested on human 5-alpha reductase 1 isozymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50039293(9a,11a-Dimethyl-1-(morpholine-4-carbonyl)-1,2,3,3a...)
Affinity DataIC50: 7.10nMAssay Description:Binding affinity for human 5-alpha reductase 2 isozymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed
LigandPNGBDBM50031880((1S,9aR,11aS)-9a,11a-Dimethyl-7-oxo-2,3,3a,3b,4,5,...)
Affinity DataKi:  7.80nMAssay Description:Binding affinity for 3-beta-hydroxysteroid dehydrogenaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50057483(4-(3-{4-[1-(4-Propyl-phenoxy)-ethyl]-benzoyl}-indo...)
Affinity DataIC50: 8nMAssay Description:Inhibitory concentration was tested on human 5-alpha reductase 1 isozymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50031880((1S,9aR,11aS)-9a,11a-Dimethyl-7-oxo-2,3,3a,3b,4,5,...)
Affinity DataKi:  8nMAssay Description:Binding affinity for human 5 alpha reductase 1 isozymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed
LigandPNGBDBM50368782(Bexlosteride | LY-191704 | CHEMBL24955)
Affinity DataKi:  8nMAssay Description:Binding affinity on rat 5-alpha reductase-1 isozymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50057475((4aR,6aS,7S)-4a,6a-Dimethyl-2-oxo-2,4a,4b,5,6,6a,7...)
Affinity DataIC50: 8.10nMAssay Description:Inhibitory concentration was tested on human 5-alpha reductase 1 isozymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed
LigandPNGBDBM50057504((1S,9aR,11aS)-9a,11a-Dimethyl-7-oxo-2,3,3a,3b,4,5,...)
Affinity DataIC50: 8.30nMAssay Description:Binding affinity on 3 beta-hydroxysteroid dehydrogenaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50031877((1S,9aR,11aS)-9a,11a-Dimethyl-7-oxo-2,3,3a,3b,4,5,...)
Affinity DataKi:  8.80nMAssay Description:Binding affinity for human 5 alpha reductase 1 isozymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50057483(4-(3-{4-[1-(4-Propyl-phenoxy)-ethyl]-benzoyl}-indo...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human 5-alpha reductase 2 isozyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50057453(8-{4-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-butoxy}...)
Affinity DataIC50: 10nMAssay Description:Binding affinity was tested on CEC-pretreated rat hippocampus Alpha-1A adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50057467(4-[4-(4-Methyl-benzoyl)-benzoyl]-benzoic acid | CH...)
Affinity DataKi:  10nMAssay Description:Inhibitory concentration on human 5alpha reductase 2 isozymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50057470(4-{3-[2,2-Bis-(4-chloro-phenyl)-benzo[1,3]dioxole-...)
Affinity DataIC50: 10nMAssay Description:Inhibitory concentration was tested on human 5-alpha reductase 1 isozymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed
LigandPNGBDBM50031892((1S,9aR,11aS)-9a,11a-Dimethyl-7-oxo-2,3,3a,3b,4,5,...)
Affinity DataKi:  10nMAssay Description:Binding affinity for 3-beta-hydroxysteroid dehydrogenaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed
LigandPNGBDBM50039266((1S,9aR,11aS)-9a,11a-Dimethyl-7-oxo-2,3,3a,3b,4,5,...)
Affinity DataKi:  12nMAssay Description:Binding affinity for 3-beta-hydroxysteroid dehydrogenaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50057464((4aR,6aS,7S)-4a,6a-Dimethyl-2-oxo-2,4a,4b,5,6,6a,7...)
Affinity DataIC50: 14nMAssay Description:Inhibitory concentration was tested on human 5-alpha reductase 1 isozymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50057496(3-Methyl-4-oxo-2-phenyl-4H-chromene-8-carboxylic a...)
Affinity DataIC50: 14nMAssay Description:Binding affinity was tested on CEC-pretreated rat hippocampus Alpha-1A adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Bovine)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50057463(1-[4-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-piper...)
Affinity DataIC50: 17nMAssay Description:Binding affinity was tested on cloned bovine Alpha-1A adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50057499((R)-8-Chloro-4,10b-dimethyl-1,4,4a,5,6,10b-hexahyd...)
Affinity DataIC50: 17nMAssay Description:Inhibitory concentration was tested on human 5-alpha reductase 1 isozymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed
LigandPNGBDBM50057484((1S,9aR,11aS)-6,9a,11a-Trimethyl-7-oxo-2,3,3a,3b,4...)
Affinity DataKi:  19nMAssay Description:Binding affinity for 3-beta-hydroxysteroid dehydrogenaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50057503((4aR,6aR,7R)-7-(1,5-Dimethyl-hexyl)-4a,6a-dimethyl...)
Affinity DataIC50: 19nMAssay Description:Inhibitory concentration was tested on human 5-alpha reductase 1 isozymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50039259((1S,9aR,11aS)-9a,11a-Dimethyl-7-oxo-2,3,3a,3b,4,5,...)
Affinity DataKi:  20nMAssay Description:Binding affinity for human 5 alpha reductase 1 isozymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50057507((4aR,6aS,7S)-4a,6a-Dimethyl-2-oxo-2,4a,4b,5,6,6a,7...)
Affinity DataIC50: 20nMAssay Description:Inhibitory concentration was tested on human 5-alpha reductase 1 isozymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50057473(4-{3-[(R)-2-(4-Isobutyl-phenyl)-2-methyl-benzo[1,3...)
Affinity DataIC50: 23nMAssay Description:Inhibition of human 5-alpha reductase 2 isozyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed
TargetAlpha-1D adrenergic receptor(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50057463(1-[4-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-piper...)
Affinity DataIC50: 23nMAssay Description:Binding affinity was tested on cloned rat Alpha-1D adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed
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