Compile Data Set for Download or QSAR
Report error Found 25 Enz. Inhib. hit(s) with all data for entry = 50007319
TargetGastrin/cholecystokinin type B receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50006878(1-(1-Methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e]...)
Affinity DataIC50: 2nMAssay Description:Half maximal inhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cerebral cortex.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50061207(3-(2,4-Dichloro-phenyl)-N-[1-(2-dimethylamino-ethy...)
Affinity DataIC50: 100nMAssay Description:Inhibition of Ikr current in isolated guinea pig myocytes during a 0.5 s voltage clamp step from -50 to -10 mV.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGastrin/cholecystokinin type B receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50061220(CHEMBL70380 | L-365,260 | 1-(1-Methyl-2-oxo-5-phen...)
Affinity DataIC50: 151nMAssay Description:Half maximal inhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cerebral cortex.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGastrin/cholecystokinin type B receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50061205(2-(3,5-Dichloro-phenyl)-N-((R)-1-isopropyl-2-oxo-5...)
Affinity DataIC50: 1.00E+3nMAssay Description:Half maximal inhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cerebral cortex.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGastrin/cholecystokinin type B receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50061224(2-Amino-N-((R)-1-methyl-2-oxo-5-phenyl-2,3-dihydro...)
Affinity DataIC50: 1.00E+3nMAssay Description:Half maximal inhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cerebral cortex.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGastrin/cholecystokinin type B receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50061227(2-(2,4-Bis-trifluoromethyl-phenyl)-N-[(S)-2-oxo-5-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Half maximal inhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cerebral cortex.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGastrin/cholecystokinin type B receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50061222(3-Cyclohexyl-N-((R)-1-methyl-2-oxo-5-phenyl-2,3-di...)
Affinity DataIC50: 1.00E+3nMAssay Description:Half maximal inhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cerebral cortex.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGastrin/cholecystokinin type B receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50061216(3-(4-Acetylamino-phenyl)-N-((R)-1-methyl-2-oxo-5-p...)
Affinity DataIC50: 1.00E+3nMAssay Description:Half maximal inhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cerebral cortex.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGastrin/cholecystokinin type B receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50061209(2-(2,4-Bis-trifluoromethyl-phenyl)-N-[(R)-2-oxo-5-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Half maximal inhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cerebral cortex.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGastrin/cholecystokinin type B receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50061225(3-(2,4-Dichloro-phenyl)-N-((R)-1-methyl-2-oxo-5-ph...)
Affinity DataIC50: 1.00E+3nMAssay Description:Half maximal inhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cerebral cortex.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50061222(3-Cyclohexyl-N-((R)-1-methyl-2-oxo-5-phenyl-2,3-di...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of Ikr current in isolated guinea pig myocytes during a 0.5 s voltage clamp step from -50 to -10 mV.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGastrin/cholecystokinin type B receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50061208(N-((R)-1-Methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benz...)
Affinity DataIC50: 1.00E+3nMAssay Description:Half maximal inhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cerebral cortex.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGastrin/cholecystokinin type B receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50061218((E)-3-(2,4-Dichloro-phenyl)-N-((R)-1-methyl-2-oxo-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Half maximal inhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cerebral cortex.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGastrin/cholecystokinin type B receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50061217(3-Cyclohexyl-N-((R)-1-isopropyl-2-oxo-5-phenyl-2,3...)
Affinity DataIC50: 1.00E+3nMAssay Description:Half maximal inhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cerebral cortex.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGastrin/cholecystokinin type B receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50061212((R)-N-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benz...)
Affinity DataIC50: 1.00E+3nMAssay Description:Half maximal inhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cerebral cortex.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGastrin/cholecystokinin type B receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50061214(3-(4-Amino-phenyl)-N-((R)-1-methyl-2-oxo-5-phenyl-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Half maximal inhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cerebral cortex.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGastrin/cholecystokinin type B receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50061207(3-(2,4-Dichloro-phenyl)-N-[1-(2-dimethylamino-ethy...)
Affinity DataIC50: 1.00E+3nMAssay Description:Half maximal inhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cerebral cortex.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGastrin/cholecystokinin type B receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50061206(N-((R)-1-Methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benz...)
Affinity DataIC50: 1.00E+3nMAssay Description:Half maximal inhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cerebral cortex.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50061218((E)-3-(2,4-Dichloro-phenyl)-N-((R)-1-methyl-2-oxo-...)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of Ikr current in isolated guinea pig myocytes during a 0.5 s voltage clamp step from -50 to -10 mV.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50061213(2-(2,4-Dichloro-phenyl)-N-[(R)-2-oxo-5-phenyl-1-(2...)
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of Ikr current in isolated guinea pig myocytes during a 0.5 s voltage clamp step from -50 to -10 mV.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50061221(2-(3,5-Dichloro-phenyl)-N-[(R)-2-oxo-5-phenyl-1-(2...)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of Ikr current in isolated guinea pig myocytes during a 0.5 s voltage clamp step from -50 to -10 mV.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50006878(1-(1-Methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e]...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of Ikr current in isolated guinea pig myocytes during a 0.5 s voltage clamp step from -50 to -10 mV.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50061209(2-(2,4-Bis-trifluoromethyl-phenyl)-N-[(R)-2-oxo-5-...)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of Ikr current in isolated guinea pig myocytes during a 0.5 s voltage clamp step from -50 to -10 mV.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50061224(2-Amino-N-((R)-1-methyl-2-oxo-5-phenyl-2,3-dihydro...)
Affinity DataIC50: 8.80E+3nMAssay Description:Inhibition of Ikr current in isolated guinea pig myocytes during a 0.5 s voltage clamp step from -50 to -10 mV.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50061220(CHEMBL70380 | L-365,260 | 1-(1-Methyl-2-oxo-5-phen...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Ikr current in isolated guinea pig myocytes during a 0.5 s voltage clamp step from -50 to -10 mV.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed