Compile Data Set for Download or QSAR
Report error Found 49 Enz. Inhib. hit(s) with all data for entry = 50007343
Target5-hydroxytryptamine receptor 2C(Rat)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50010594(ISOCLOZAPINE | 2-Chloro-11-(4-methyl-piperazin-1-y...)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of [3H]mesulergine binding to 5-hydroxytryptamine 2C receptor in rat brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50010594(ISOCLOZAPINE | 2-Chloro-11-(4-methyl-piperazin-1-y...)
Affinity DataIC50: 6nMAssay Description:Inhibitory binding of [3H]pirenzepine to human Muscarinic acetylcholine receptor M1 in membranes from CHO-K1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataIC50: 7.5nMAssay Description:Inhibitory binding of [3H]spiperone to Dopamine receptor D2 in membranes from rat corpus striatumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50001884(8-Chloro-11-(4-methyl-piperazin-1-yl)-5H-dibenzo[b...)
Affinity DataIC50: 7.80nMAssay Description:Inhibition of [3H]ketanserin binding to 5-hydroxytryptamine 2A receptor from rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50061559(Trifluoro-methanesulfonic acid 11-(4-methyl-pipera...)
Affinity DataIC50: 8nMAssay Description:Inhibition of [3H]ketanserin binding to 5-hydroxytryptamine 2A receptor from rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50001884(8-Chloro-11-(4-methyl-piperazin-1-yl)-5H-dibenzo[b...)
Affinity DataIC50: 9.40nMAssay Description:Inhibitory binding of [3H]pirenzepine to human Muscarinic acetylcholine receptor M1 in membranes from CHO-K1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Rat)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50010594(ISOCLOZAPINE | 2-Chloro-11-(4-methyl-piperazin-1-y...)
Affinity DataIC50: 11nMAssay Description:Inhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Rat)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50001884(8-Chloro-11-(4-methyl-piperazin-1-yl)-5H-dibenzo[b...)
Affinity DataIC50: 11nMAssay Description:Inhibition of [3H]mesulergine binding to 5-hydroxytryptamine 2C receptor in rat brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50061558(2-Methoxy-11-(4-methyl-piperazin-1-yl)-5H-dibenzo[...)
Affinity DataIC50: 12nMAssay Description:Inhibition of [3H]ketanserin binding to 5-hydroxytryptamine 2A receptor from rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50010594(ISOCLOZAPINE | 2-Chloro-11-(4-methyl-piperazin-1-y...)
Affinity DataIC50: 12nMAssay Description:Inhibition of [3H]ketanserin binding to 5-hydroxytryptamine 2A receptor from rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50010594(ISOCLOZAPINE | 2-Chloro-11-(4-methyl-piperazin-1-y...)
Affinity DataIC50: 13nMAssay Description:Inhibitory binding of [3H]spiperone to Dopamine receptor D2 in membranes from rat corpus striatumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50061555(8-Methoxy-11-(4-methyl-piperazin-1-yl)-5H-dibenzo[...)
Affinity DataIC50: 19nMAssay Description:Inhibitory binding of [3H]pirenzepine to human Muscarinic acetylcholine receptor M1 in membranes from CHO-K1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Rat)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50061558(2-Methoxy-11-(4-methyl-piperazin-1-yl)-5H-dibenzo[...)
Affinity DataIC50: 21nMAssay Description:Inhibition of [3H]mesulergine binding to 5-hydroxytryptamine 2C receptor in rat brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H1 receptor(Rat)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50001884(8-Chloro-11-(4-methyl-piperazin-1-yl)-5H-dibenzo[b...)
Affinity DataIC50: 23nMAssay Description:Inhibitory binding of [3H]mepyramine to histamine H1 receptors in rat brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50061557(11-(4-Methyl-piperazin-1-yl)-5H-dibenzo[b,e][1,4]d...)
Affinity DataIC50: 27nMAssay Description:Inhibitory binding of [3H]pirenzepine to human Muscarinic acetylcholine receptor M1 in membranes from CHO-K1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50061559(Trifluoro-methanesulfonic acid 11-(4-methyl-pipera...)
Affinity DataIC50: 31nMAssay Description:Inhibitory binding of [3H]spiperone to Dopamine receptor D2 in membranes from rat corpus striatumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Rat)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50061559(Trifluoro-methanesulfonic acid 11-(4-methyl-pipera...)
Affinity DataIC50: 34nMAssay Description:Inhibition of [3H]mesulergine binding to 5-hydroxytryptamine 2C receptor in rat brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50061556(11-(4-Methyl-piperazin-1-yl)-5H-dibenzo[b,e][1,4]d...)
Affinity DataIC50: 35nMAssay Description:Inhibition of [3H]ketanserin binding to 5-hydroxytryptamine 2A receptor from rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50061560(Trifluoro-methanesulfonic acid 11-(4-methyl-pipera...)
Affinity DataIC50: 35nMAssay Description:Inhibitory binding of [3H]pirenzepine to human Muscarinic acetylcholine receptor M1 in membranes from CHO-K1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Rat)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataIC50: 36nMAssay Description:Inhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50061556(11-(4-Methyl-piperazin-1-yl)-5H-dibenzo[b,e][1,4]d...)
Affinity DataIC50: 37nMAssay Description:Inhibitory binding of [3H]pirenzepine to human Muscarinic acetylcholine receptor M1 in membranes from CHO-K1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50061558(2-Methoxy-11-(4-methyl-piperazin-1-yl)-5H-dibenzo[...)
Affinity DataIC50: 39nMAssay Description:Inhibitory binding of [3H]pirenzepine to human Muscarinic acetylcholine receptor M1 in membranes from CHO-K1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H1 receptor(Rat)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50061559(Trifluoro-methanesulfonic acid 11-(4-methyl-pipera...)
Affinity DataIC50: 47nMAssay Description:Inhibitory binding of [3H]mepyramine to histamine H1 receptors in rat brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataIC50: 55nMAssay Description:Inhibition of [3H]ketanserin binding to 5-hydroxytryptamine 2A receptor from rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Rat)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50061559(Trifluoro-methanesulfonic acid 11-(4-methyl-pipera...)
Affinity DataIC50: 64nMAssay Description:Inhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50061558(2-Methoxy-11-(4-methyl-piperazin-1-yl)-5H-dibenzo[...)
Affinity DataIC50: 68nMAssay Description:Inhibitory binding of [3H]spiperone to Dopamine receptor D2 in membranes from rat corpus striatumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Rat)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50061556(11-(4-Methyl-piperazin-1-yl)-5H-dibenzo[b,e][1,4]d...)
Affinity DataIC50: 81nMAssay Description:Inhibition of [3H]mesulergine binding to 5-hydroxytryptamine 2C receptor in rat brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Rat)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50061555(8-Methoxy-11-(4-methyl-piperazin-1-yl)-5H-dibenzo[...)
Affinity DataIC50: 86nMAssay Description:Inhibition of [3H]mesulergine binding to 5-hydroxytryptamine 2C receptor in rat brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Rat)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50001884(8-Chloro-11-(4-methyl-piperazin-1-yl)-5H-dibenzo[b...)
Affinity DataIC50: 130nMAssay Description:Inhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50061555(8-Methoxy-11-(4-methyl-piperazin-1-yl)-5H-dibenzo[...)
Affinity DataIC50: 160nMAssay Description:Inhibition of [3H]ketanserin binding to 5-hydroxytryptamine 2A receptor from rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50061557(11-(4-Methyl-piperazin-1-yl)-5H-dibenzo[b,e][1,4]d...)
Affinity DataIC50: 310nMAssay Description:Inhibition of [3H]ketanserin binding to 5-hydroxytryptamine 2A receptor from rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50001884(8-Chloro-11-(4-methyl-piperazin-1-yl)-5H-dibenzo[b...)
Affinity DataIC50: 330nMAssay Description:Inhibitory binding of [3H]spiperone to Dopamine receptor D2 in membranes from rat corpus striatumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Rat)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50061557(11-(4-Methyl-piperazin-1-yl)-5H-dibenzo[b,e][1,4]d...)
Affinity DataIC50: 440nMAssay Description:Inhibition of [3H]mesulergine binding to 5-hydroxytryptamine 2C receptor in rat brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Rat)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50061558(2-Methoxy-11-(4-methyl-piperazin-1-yl)-5H-dibenzo[...)
Affinity DataIC50: 550nMAssay Description:Inhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50061560(Trifluoro-methanesulfonic acid 11-(4-methyl-pipera...)
Affinity DataIC50: 550nMAssay Description:Inhibition of [3H]ketanserin binding to 5-hydroxytryptamine 2A receptor from rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Rat)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50061556(11-(4-Methyl-piperazin-1-yl)-5H-dibenzo[b,e][1,4]d...)
Affinity DataIC50: 550nMAssay Description:Inhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Rat)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50061560(Trifluoro-methanesulfonic acid 11-(4-methyl-pipera...)
Affinity DataIC50: 620nMAssay Description:Inhibition of [3H]mesulergine binding to 5-hydroxytryptamine 2C receptor in rat brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H1 receptor(Rat)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50061560(Trifluoro-methanesulfonic acid 11-(4-methyl-pipera...)
Affinity DataIC50: 720nMAssay Description:Inhibitory binding of [3H]mepyramine to histamine H1 receptors in rat brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Rat)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50061560(Trifluoro-methanesulfonic acid 11-(4-methyl-pipera...)
Affinity DataIC50: 930nMAssay Description:Inhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H1 receptor(Rat)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory binding of [3H]mepyramine to histamine H1 receptors in rat brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Rat)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of [3H]mesulergine binding to 5-hydroxytryptamine 2C receptor in rat brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50061559(Trifluoro-methanesulfonic acid 11-(4-methyl-pipera...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibitory binding of [3H]pirenzepine to human Muscarinic acetylcholine receptor M1 in membranes from CHO-K1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50061556(11-(4-Methyl-piperazin-1-yl)-5H-dibenzo[b,e][1,4]d...)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibitory binding of [3H]spiperone to Dopamine receptor D2 in membranes from rat corpus striatumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50061555(8-Methoxy-11-(4-methyl-piperazin-1-yl)-5H-dibenzo[...)
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibitory binding of [3H]spiperone to Dopamine receptor D2 in membranes from rat corpus striatumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataIC50: 5.50E+3nMAssay Description:Inhibitory binding of [3H]pirenzepine to human Muscarinic acetylcholine receptor M1 in membranes from CHO-K1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50061557(11-(4-Methyl-piperazin-1-yl)-5H-dibenzo[b,e][1,4]d...)
Affinity DataIC50: 6.40E+3nMAssay Description:Inhibitory binding of [3H]spiperone to Dopamine receptor D2 in membranes from rat corpus striatumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Rat)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50061555(8-Methoxy-11-(4-methyl-piperazin-1-yl)-5H-dibenzo[...)
Affinity DataIC50: 7.40E+3nMAssay Description:Inhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50061560(Trifluoro-methanesulfonic acid 11-(4-methyl-pipera...)
Affinity DataIC50: 8.10E+3nMAssay Description:Inhibitory binding of [3H]spiperone to Dopamine receptor D2 in membranes from rat corpus striatumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Rat)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50061557(11-(4-Methyl-piperazin-1-yl)-5H-dibenzo[b,e][1,4]d...)
Affinity DataIC50: 9.80E+3nMAssay Description:Inhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed