Compile Data Set for Download or QSAR
Report error Found 18 Enz. Inhib. hit(s) with all data for entry = 50007597
TargetSigma non-opioid intracellular receptor 1(Human)
The George Washington University Medical Center

Curated by ChEMBL
LigandPNGBDBM50065136(N-(2-Azepan-1-yl-ethyl)-4-iodo-N-methyl-benzenesul...)
Affinity DataKi:  0.140nMAssay Description:Inhibition of [3H](+)-pentazocine binding to sigma-1 receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
The George Washington University Medical Center

Curated by ChEMBL
LigandPNGBDBM50065134(N-(2-Azepan-1-yl-ethyl)-4-bromo-N-methyl-benzenesu...)
Affinity DataKi:  0.180nMAssay Description:Inhibition of [3H](+)-pentazocine binding to sigma-1 receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
The George Washington University Medical Center

Curated by ChEMBL
LigandPNGBDBM50065140(4-Iodo-N-(2-piperidin-1-yl-ethyl)-benzenesulfonami...)
Affinity DataKi:  0.460nMAssay Description:Inhibition of [3H](+)-pentazocine binding to sigma-1 receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
The George Washington University Medical Center

Curated by ChEMBL
LigandPNGBDBM50065144(N-(2-Azepan-1-yl-ethyl)-4-bromo-benzenesulfonamide...)
Affinity DataKi:  0.630nMAssay Description:Inhibition of [3H](+)-pentazocine binding to sigma-1 receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
The George Washington University Medical Center

Curated by ChEMBL
LigandPNGBDBM50000069(CHEMBL20377 | [2-(3,4-Dichloro-phenyl)-ethyl]-meth...)
Affinity DataKi:  0.700nMAssay Description:Inhibition Constant for 4-[125I]-IPBS binding to sigma 1 receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
The George Washington University Medical Center

Curated by ChEMBL
LigandPNGBDBM50065142(N-(2-Azepan-1-yl-ethyl)-4-iodo-benzenesulfonamide ...)
Affinity DataKi:  1.32nMAssay Description:Inhibition of [3H](+)-pentazocine binding to sigma-1 receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
The George Washington University Medical Center

Curated by ChEMBL
LigandPNGBDBM50065135(4-Iodo-N-(2-pyrrolidin-1-yl-ethyl)-benzenesulfonam...)
Affinity DataKi:  1.46nMAssay Description:Inhibition Constant for 4-[125I]-IPBS binding to sigma 1 receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
The George Washington University Medical Center

Curated by ChEMBL
LigandPNGBDBM50065141(4-Bromo-N-(2-piperidin-1-yl-ethyl)-benzenesulfonam...)
Affinity DataKi:  1.54nMAssay Description:Inhibition of [3H](+)-pentazocine binding to sigma-1 receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
The George Washington University Medical Center

Curated by ChEMBL
LigandPNGBDBM50065143(N-(2-Azepan-1-yl-ethyl)-3-iodo-4-methoxy-N-methyl-...)
Affinity DataKi:  3.11nMAssay Description:Inhibition of [3H](+)-pentazocine binding to sigma-1 receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
The George Washington University Medical Center

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  3.70nMAssay Description:Compound was evaluated for its in vitro competition binding studies using sigma-ligand (0.05-10000 nM) - [3H](+)-pentazocine (sigma1 receptor) in gui...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSigma non-opioid intracellular receptor 1(Human)
The George Washington University Medical Center

Curated by ChEMBL
LigandPNGBDBM50065135(4-Iodo-N-(2-pyrrolidin-1-yl-ethyl)-benzenesulfonam...)
Affinity DataKi:  4.30nMAssay Description:Inhibition of [3H](+)-pentazocine binding to sigma-1 receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
The George Washington University Medical Center

Curated by ChEMBL
LigandPNGBDBM50065138(N-(2-Diethylamino-ethyl)-4-iodo-benzenesulfonamide...)
Affinity DataKi:  4.97nMAssay Description:Inhibition of [3H](+)-pentazocine binding to sigma-1 receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
The George Washington University Medical Center

Curated by ChEMBL
LigandPNGBDBM50065133(4-Bromo-N-(2-pyrrolidin-1-yl-ethyl)-benzenesulfona...)
Affinity DataKi:  6.65nMAssay Description:Inhibition of [3H](+)-pentazocine binding to sigma-1 receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
The George Washington University Medical Center

Curated by ChEMBL
LigandPNGBDBM50065139(4-Bromo-N-(2-diethylamino-ethyl)-benzenesulfonamid...)
Affinity DataKi:  10.1nMAssay Description:Inhibition of [3H](+)-pentazocine binding to sigma-1 receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
The George Washington University Medical Center

Curated by ChEMBL
LigandPNGBDBM50010774(CHEMBL83430 | CHEMBL539782 | N,N'-Dibenzyl-guanidi...)
Affinity DataKi:  27.7nMAssay Description:Inhibition of [3H](+)-pentazocine binding to sigma-1 receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
The George Washington University Medical Center

Curated by ChEMBL
LigandPNGBDBM50065145(3-Iodo-4-methoxy-N-(2-piperidin-1-yl-ethyl)-benzen...)
Affinity DataKi:  41.8nMAssay Description:Inhibition of [3H](+)-pentazocine binding to sigma-1 receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
The George Washington University Medical Center

Curated by ChEMBL
LigandPNGBDBM50035131((1S,9S,13S)-1,13-dimethyl-10-(3-methylbut-2-enyl)-...)
Affinity DataKi:  152nMAssay Description:Compound was evaluated for its inhibition constant from the competition binding assays for sigma-1 receptor in guinea pig membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
The George Washington University Medical Center

Curated by ChEMBL
LigandPNGBDBM50035131((1S,9S,13S)-1,13-dimethyl-10-(3-methylbut-2-enyl)-...)
Affinity DataKi:  152nMAssay Description:Compound was evaluated for its inhibition constant from the competition binding assays for sigma-1 receptor in guinea pig membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed