Compile Data Set for Download or QSAR
Report error Found 32 Enz. Inhib. hit(s) with all data for entry = 50036691
TargetMethylated-DNA--protein-cysteine methyltransferase(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50068794(6-(5-Bromo-thiophen-2-ylmethoxy)-6,9-dihydro-1H-pu...)
Affinity DataIC50: 5nMAssay Description:O6-Alkylguanine-DNA Alkyltransferase-Inactivating Activity (Concentration of inactivator required to produce 50% reduction in ATPase activity) More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2012
Entry Details Article
PubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50068794(6-(5-Bromo-thiophen-2-ylmethoxy)-6,9-dihydro-1H-pu...)
Affinity DataIC50: 10nMAssay Description:O6-Alkylguanine-DNA Alkyltransferase-Inactivating Activity in Raji cells (Concentration of inactivator required to produce 50% reduction in ATPase ac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2012
Entry Details Article
PubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50068792(6-(Thiophen-2-ylmethoxy)-6,9-dihydro-1H-purin-2-yl...)
Affinity DataIC50: 18nMAssay Description:O6-Alkylguanine-DNA Alkyltransferase-Inactivating Activity (Concentration of inactivator required to produce 50% reduction in ATPase activity) More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2012
Entry Details Article
PubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50068792(6-(Thiophen-2-ylmethoxy)-6,9-dihydro-1H-purin-2-yl...)
Affinity DataIC50: 30nMAssay Description:O6-Alkylguanine-DNA Alkyltransferase-Inactivating Activity in Raji cells (Concentration of inactivator required to produce 50% reduction in ATPase ac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2012
Entry Details Article
PubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50068785(6-(Thiazol-5-ylmethoxy)-6,9-dihydro-1H-purin-2-yla...)
Affinity DataIC50: 33nMAssay Description:O6-Alkylguanine-DNA Alkyltransferase-Inactivating Activity (Concentration of inactivator required to produce 50% reduction in ATPase activity) More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2012
Entry Details Article
PubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM5491(6-(benzyloxy)-9H-purin-2-amine | CHEMBL407874 | O6...)
Affinity DataIC50: 40nMAssay Description:O6-Alkylguanine-DNA Alkyltransferase-Inactivating Activity (Concentration of inactivator required to produce 50% reduction in ATPase activity) More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2012
Entry Details Article
PubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50068786(6-(2-Chloro-pyridin-4-ylmethoxy)-6,9-dihydro-1H-pu...)
Affinity DataIC50: 40nMAssay Description:O6-Alkylguanine-DNA Alkyltransferase-Inactivating Activity (Concentration of inactivator required to produce 50% reduction in ATPase activity) More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2012
Entry Details Article
PubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50068786(6-(2-Chloro-pyridin-4-ylmethoxy)-6,9-dihydro-1H-pu...)
Affinity DataIC50: 50nMAssay Description:O6-Alkylguanine-DNA Alkyltransferase-Inactivating Activity in Raji cells (Concentration of inactivator required to produce 50% reduction in ATPase ac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2012
Entry Details Article
PubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50068785(6-(Thiazol-5-ylmethoxy)-6,9-dihydro-1H-purin-2-yla...)
Affinity DataIC50: 60nMAssay Description:O6-Alkylguanine-DNA Alkyltransferase-Inactivating Activity in Raji cells (Concentration of inactivator required to produce 50% reduction in ATPase ac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2012
Entry Details Article
PubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50068784(6-(Isothiazol-4-ylmethoxy)-6,9-dihydro-1H-purin-2-...)
Affinity DataIC50: 70nMAssay Description:O6-Alkylguanine-DNA Alkyltransferase-Inactivating Activity (Concentration of inactivator required to produce 50% reduction in ATPase activity) More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2012
Entry Details Article
PubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50068784(6-(Isothiazol-4-ylmethoxy)-6,9-dihydro-1H-purin-2-...)
Affinity DataIC50: 70nMAssay Description:O6-Alkylguanine-DNA Alkyltransferase-Inactivating Activity in Raji cells (Concentration of inactivator required to produce 50% reduction in ATPase ac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2012
Entry Details Article
PubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50068783(6-(Furan-2-ylmethoxy)-6,9-dihydro-1H-purin-2-ylami...)
Affinity DataIC50: 80nMAssay Description:O6-Alkylguanine-DNA Alkyltransferase-Inactivating Activity (Concentration of inactivator required to produce 50% reduction in ATPase activity) More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2012
Entry Details Article
PubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50068789(6-([1,3]Dioxolo[4,5-b]pyridin-6-ylmethoxy)-6,9-dih...)
Affinity DataIC50: 90nMAssay Description:O6-Alkylguanine-DNA Alkyltransferase-Inactivating Activity in Raji cells (Concentration of inactivator required to produce 50% reduction in ATPase ac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2012
Entry Details Article
PubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM5491(6-(benzyloxy)-9H-purin-2-amine | CHEMBL407874 | O6...)
Affinity DataIC50: 100nMAssay Description:O6-Alkylguanine-DNA Alkyltransferase-Inactivating Activity in Raji cells (Concentration of inactivator required to produce 50% reduction in ATPase ac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2012
Entry Details Article
PubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50068793(6-(6-Chloro-pyridin-3-ylmethoxy)-6,9-dihydro-1H-pu...)
Affinity DataIC50: 120nMAssay Description:O6-Alkylguanine-DNA Alkyltransferase-Inactivating Activity in Raji cells (Concentration of inactivator required to produce 50% reduction in ATPase ac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2012
Entry Details Article
PubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50068783(6-(Furan-2-ylmethoxy)-6,9-dihydro-1H-purin-2-ylami...)
Affinity DataIC50: 120nMAssay Description:O6-Alkylguanine-DNA Alkyltransferase-Inactivating Activity in Raji cells (Concentration of inactivator required to produce 50% reduction in ATPase ac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2012
Entry Details Article
PubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50068780(6-(Pyridin-4-ylmethoxy)-6,9-dihydro-1H-purin-2-yla...)
Affinity DataIC50: 130nMAssay Description:O6-Alkylguanine-DNA Alkyltransferase-Inactivating Activity (Concentration of inactivator required to produce 50% reduction in ATPase activity) More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2012
Entry Details Article
PubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50068780(6-(Pyridin-4-ylmethoxy)-6,9-dihydro-1H-purin-2-yla...)
Affinity DataIC50: 200nMAssay Description:O6-Alkylguanine-DNA Alkyltransferase-Inactivating Activity in Raji cells (Concentration of inactivator required to produce 50% reduction in ATPase ac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2012
Entry Details Article
PubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50068793(6-(6-Chloro-pyridin-3-ylmethoxy)-6,9-dihydro-1H-pu...)
Affinity DataIC50: 200nMAssay Description:O6-Alkylguanine-DNA Alkyltransferase-Inactivating Activity (Concentration of inactivator required to produce 50% reduction in ATPase activity) More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2012
Entry Details Article
PubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50068788(6-(5-Bromo-pyridin-3-ylmethoxy)-6,9-dihydro-1H-pur...)
Affinity DataIC50: 200nMAssay Description:O6-Alkylguanine-DNA Alkyltransferase-Inactivating Activity in Raji cells (Concentration of inactivator required to produce 50% reduction in ATPase ac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2012
Entry Details Article
PubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50068781(6-(Oxazol-5-ylmethoxy)-6,9-dihydro-1H-purin-2-ylam...)
Affinity DataIC50: 220nMAssay Description:O6-Alkylguanine-DNA Alkyltransferase-Inactivating Activity in Raji cells (Concentration of inactivator required to produce 50% reduction in ATPase ac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2012
Entry Details Article
PubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50068791(6-(Pyridin-3-ylmethoxy)-6,9-dihydro-1H-purin-2-yla...)
Affinity DataIC50: 220nMAssay Description:O6-Alkylguanine-DNA Alkyltransferase-Inactivating Activity in Raji cells (Concentration of inactivator required to produce 50% reduction in ATPase ac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2012
Entry Details Article
PubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50068789(6-([1,3]Dioxolo[4,5-b]pyridin-6-ylmethoxy)-6,9-dih...)
Affinity DataIC50: 230nMAssay Description:O6-Alkylguanine-DNA Alkyltransferase-Inactivating Activity (Concentration of inactivator required to produce 50% reduction in ATPase activity) More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2012
Entry Details Article
PubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50068788(6-(5-Bromo-pyridin-3-ylmethoxy)-6,9-dihydro-1H-pur...)
Affinity DataIC50: 250nMAssay Description:O6-Alkylguanine-DNA Alkyltransferase-Inactivating Activity (Concentration of inactivator required to produce 50% reduction in ATPase activity) More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2012
Entry Details Article
PubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50068781(6-(Oxazol-5-ylmethoxy)-6,9-dihydro-1H-purin-2-ylam...)
Affinity DataIC50: 350nMAssay Description:O6-Alkylguanine-DNA Alkyltransferase-Inactivating Activity (Concentration of inactivator required to produce 50% reduction in ATPase activity) More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2012
Entry Details Article
PubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50068791(6-(Pyridin-3-ylmethoxy)-6,9-dihydro-1H-purin-2-yla...)
Affinity DataIC50: 430nMAssay Description:O6-Alkylguanine-DNA Alkyltransferase-Inactivating Activity (Concentration of inactivator required to produce 50% reduction in ATPase activity) More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2012
Entry Details Article
PubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50068790(6-(1-Oxy-pyridin-3-ylmethoxy)-6,9-dihydro-1H-purin...)
Affinity DataIC50: 1.40E+3nMAssay Description:O6-Alkylguanine-DNA Alkyltransferase-Inactivating Activity (Concentration of inactivator required to produce 50% reduction in ATPase activity) More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2012
Entry Details Article
PubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50068790(6-(1-Oxy-pyridin-3-ylmethoxy)-6,9-dihydro-1H-purin...)
Affinity DataIC50: 5.40E+3nMAssay Description:O6-Alkylguanine-DNA Alkyltransferase-Inactivating Activity in Raji cells (Concentration of inactivator required to produce 50% reduction in ATPase ac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2012
Entry Details Article
PubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50068782(6-(Pyridin-2-ylmethoxy)-6,9-dihydro-1H-purin-2-yla...)
Affinity DataIC50: 6.00E+3nMAssay Description:O6-Alkylguanine-DNA Alkyltransferase-Inactivating Activity in Raji cells (Concentration of inactivator required to produce 50% reduction in ATPase ac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2012
Entry Details Article
PubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50068787(6-(3-Methyl-3H-imidazol-4-ylmethoxy)-6,9-dihydro-1...)
Affinity DataIC50: 8.50E+3nMAssay Description:O6-Alkylguanine-DNA Alkyltransferase-Inactivating Activity (Concentration of inactivator required to produce 50% reduction in ATPase activity) More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2012
Entry Details Article
PubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50068787(6-(3-Methyl-3H-imidazol-4-ylmethoxy)-6,9-dihydro-1...)
Affinity DataIC50: 2.10E+4nMAssay Description:O6-Alkylguanine-DNA Alkyltransferase-Inactivating Activity in Raji cells (Concentration of inactivator required to produce 50% reduction in ATPase ac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2012
Entry Details Article
PubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50068782(6-(Pyridin-2-ylmethoxy)-6,9-dihydro-1H-purin-2-yla...)
Affinity DataIC50: 3.50E+4nMAssay Description:O6-Alkylguanine-DNA Alkyltransferase-Inactivating Activity (Concentration of inactivator required to produce 50% reduction in ATPase activity) More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2012
Entry Details Article
PubMed