Report error Found 114 Enz. Inhib. hit(s) with all data for entry = 50034979
TargetSodium-dependent serotonin transporter(Human)
Hong Kong University of Science and Technology
Curated by ChEMBL
Hong Kong University of Science and Technology
Curated by ChEMBL
Affinity DataKd: 0.130nMAssay Description:Equilibrium dissociation constant (KD) for Competitive binding between [3H]- imipramine and the compound at human transporter -hSERTMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Human)
Hong Kong University of Science and Technology
Curated by ChEMBL
Hong Kong University of Science and Technology
Curated by ChEMBL
Affinity DataKd: 0.290nMAssay Description:Equilibrium dissociation constant (KD) for Competitive binding between [3H]- imipramine and the compound at human transporter -hSERTMore data for this Ligand-Target Pair
Affinity DataKi: 0.700nMAssay Description:Inhibition of [3H]- NE reuptake into rat hippocampal synaptosomesMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rat)
Hong Kong University of Science and Technology
Curated by ChEMBL
Hong Kong University of Science and Technology
Curated by ChEMBL
Affinity DataKi: 0.730nMAssay Description:Inhibition of [3H]5-HT reuptake into rat frontal cortex synaptosomesMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Human)
Hong Kong University of Science and Technology
Curated by ChEMBL
Hong Kong University of Science and Technology
Curated by ChEMBL
Affinity DataKd: 0.810nMAssay Description:Equilibrium dissociation constant (KD) for Competitive binding between [3H]- imipramine and the compound at human transporter -hSERTMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Human)
Hong Kong University of Science and Technology
Curated by ChEMBL
Hong Kong University of Science and Technology
Curated by ChEMBL
Affinity DataKd: 1.20nMAssay Description:Equilibrium dissociation constant (KD) for Competitive binding between [3H]- imipramine and the compound at human transporter -hSERTMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Human)
Hong Kong University of Science and Technology
Curated by ChEMBL
Hong Kong University of Science and Technology
Curated by ChEMBL
Affinity DataKd: 2nMAssay Description:Equilibrium dissociation constant (KD) for Competitive binding between [3H]- nisoxatine and the compound at human Norepinephrine transporterMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rat)
Hong Kong University of Science and Technology
Curated by ChEMBL
Hong Kong University of Science and Technology
Curated by ChEMBL
Affinity DataKi: 2.60nMAssay Description:Inhibition of [3H]5-HT reuptake into rat frontal cortex synaptosomesMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rat)
Hong Kong University of Science and Technology
Curated by ChEMBL
Hong Kong University of Science and Technology
Curated by ChEMBL
Affinity DataKi: 3.40nMAssay Description:Inhibition of [3H]5-HT reuptake into rat frontal cortex synaptosomesMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rat)
Hong Kong University of Science and Technology
Curated by ChEMBL
Hong Kong University of Science and Technology
Curated by ChEMBL
Affinity DataKi: 4.10nMAssay Description:Inhibition of [3H]5-HT reuptake into rat frontal cortex synaptosomesMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Human)
Hong Kong University of Science and Technology
Curated by ChEMBL
Hong Kong University of Science and Technology
Curated by ChEMBL
Affinity DataKd: 5.60nMAssay Description:Equilibrium dissociation constant (KD) for Competitive binding between [3H]- imipramine and the compound at human transporter -hSERTMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Human)
Hong Kong University of Science and Technology
Curated by ChEMBL
Hong Kong University of Science and Technology
Curated by ChEMBL
Affinity DataKd: 6.10nMAssay Description:Equilibrium dissociation constant (KD) for Competitive binding between [3H]- imipramine and the compound at human transporter -hSERTMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Human)
Hong Kong University of Science and Technology
Curated by ChEMBL
Hong Kong University of Science and Technology
Curated by ChEMBL
Affinity DataKd: 6.20nMAssay Description:Equilibrium dissociation constant (KD) for Competitive binding between [3H]- imipramine and the compound at human transporter -hSERTMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rat)
Hong Kong University of Science and Technology
Curated by ChEMBL
Hong Kong University of Science and Technology
Curated by ChEMBL
Affinity DataKi: 6.20nMAssay Description:Inhibition of [3H]- DA reuptake into rat striatal synaptosomesMore data for this Ligand-Target Pair
Affinity DataKi: 7.70nMAssay Description:Inhibition of [3H]- NE reuptake into rat hippocampal synaptosomesMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Human)
Hong Kong University of Science and Technology
Curated by ChEMBL
Hong Kong University of Science and Technology
Curated by ChEMBL
Affinity DataKd: 8.5nMAssay Description:Equilibrium dissociation constant (KD) for Competitive binding between [3H]- imipramine and the compound at human transporter -hSERTMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Human)
Hong Kong University of Science and Technology
Curated by ChEMBL
Hong Kong University of Science and Technology
Curated by ChEMBL
Affinity DataKd: 8.90nMAssay Description:Equilibrium dissociation constant (KD) for Competitive binding between [3H]- imipramine and the compound at human transporter -hSERTMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Human)
Hong Kong University of Science and Technology
Curated by ChEMBL
Hong Kong University of Science and Technology
Curated by ChEMBL
Affinity DataKd: 8.90nMAssay Description:Equilibrium dissociation constant (KD) for Competitive binding between [3H]- imipramine and the compound at human transporter -hSERTMore data for this Ligand-Target Pair
Affinity DataKi: 10nMAssay Description:Inhibition of [3H]- NE reuptake into rat hippocampal synaptosomesMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rat)
Hong Kong University of Science and Technology
Curated by ChEMBL
Hong Kong University of Science and Technology
Curated by ChEMBL
Affinity DataKi: 12nMAssay Description:Inhibition of [3H]- DA reuptake into rat striatal synaptosomesMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rat)
Hong Kong University of Science and Technology
Curated by ChEMBL
Hong Kong University of Science and Technology
Curated by ChEMBL
Affinity DataKi: 14nMAssay Description:Inhibition of [3H]5-HT reuptake into rat frontal cortex synaptosomesMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rat)
Hong Kong University of Science and Technology
Curated by ChEMBL
Hong Kong University of Science and Technology
Curated by ChEMBL
Affinity DataKi: 14nMAssay Description:Inhibition of [3H]5-HT reuptake into rat frontal cortex synaptosomesMore data for this Ligand-Target Pair
Affinity DataKi: 15nMAssay Description:Inhibition of [3H]- NE reuptake into rat hippocampal synaptosomesMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Human)
Hong Kong University of Science and Technology
Curated by ChEMBL
Hong Kong University of Science and Technology
Curated by ChEMBL
Affinity DataKd: 21nMAssay Description:Equilibrium dissociation constant (KD) for Competitive binding between [3H]- nisoxatine and the compound at human Norepinephrine transporterMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Human)
Hong Kong University of Science and Technology
Curated by ChEMBL
Hong Kong University of Science and Technology
Curated by ChEMBL
Affinity DataKd: 25nMAssay Description:Equilibrium dissociation constant (KD) for Competitive binding between [3H]WIN-35428 and the compound at human transporter-hDATMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rat)
Hong Kong University of Science and Technology
Curated by ChEMBL
Hong Kong University of Science and Technology
Curated by ChEMBL
Affinity DataKi: 27nMAssay Description:Inhibition of [3H]5-HT reuptake into rat frontal cortex synaptosomesMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rat)
Hong Kong University of Science and Technology
Curated by ChEMBL
Hong Kong University of Science and Technology
Curated by ChEMBL
Affinity DataKi: 30nMAssay Description:Inhibition of [3H]5-HT reuptake into rat frontal cortex synaptosomesMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Human)
Hong Kong University of Science and Technology
Curated by ChEMBL
Hong Kong University of Science and Technology
Curated by ChEMBL
Affinity DataKd: 30nMAssay Description:Equilibrium dissociation constant (KD) for Competitive binding between [3H]- imipramine and the compound at human transporter -hSERTMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Human)
Hong Kong University of Science and Technology
Curated by ChEMBL
Hong Kong University of Science and Technology
Curated by ChEMBL
Affinity DataKd: 30nMAssay Description:Equilibrium dissociation constant (KD) for Competitive binding between [3H]- nisoxatine and the compound at human Norepinephrine transporterMore data for this Ligand-Target Pair
Affinity DataKi: 33nMAssay Description:Inhibition of [3H]- NE reuptake into rat hippocampal synaptosomesMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rat)
Hong Kong University of Science and Technology
Curated by ChEMBL
Hong Kong University of Science and Technology
Curated by ChEMBL
Affinity DataKi: 37nMAssay Description:Inhibition of [3H]5-HT reuptake into rat frontal cortex synaptosomesMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Human)
Hong Kong University of Science and Technology
Curated by ChEMBL
Hong Kong University of Science and Technology
Curated by ChEMBL
Affinity DataKd: 40nMAssay Description:Equilibrium dissociation constant (KD) for Competitive binding between [3H]- nisoxatine and the compound at human Norepinephrine transporterMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Human)
Hong Kong University of Science and Technology
Curated by ChEMBL
Hong Kong University of Science and Technology
Curated by ChEMBL
Affinity DataKd: 40nMAssay Description:Equilibrium dissociation constant (KD) for Competitive binding between [3H]- imipramine and the compound at human transporter -hSERTMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rat)
Hong Kong University of Science and Technology
Curated by ChEMBL
Hong Kong University of Science and Technology
Curated by ChEMBL
Affinity DataKi: 43nMAssay Description:Inhibition of [3H]5-HT reuptake into rat frontal cortex synaptosomesMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Human)
Hong Kong University of Science and Technology
Curated by ChEMBL
Hong Kong University of Science and Technology
Curated by ChEMBL
Affinity DataKd: 44nMAssay Description:Equilibrium dissociation constant (KD) for Competitive binding between [3H]- nisoxatine and the compound at human Norepinephrine transporterMore data for this Ligand-Target Pair
Affinity DataKi: 44nMAssay Description:Inhibition of [3H]- NE reuptake into rat hippocampal synaptosomesMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Human)
Hong Kong University of Science and Technology
Curated by ChEMBL
Hong Kong University of Science and Technology
Curated by ChEMBL
Affinity DataKd: 48nMAssay Description:Equilibrium dissociation constant (KD) for Competitive binding between [3H]- imipramine and the compound at human transporter -hSERTMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Human)
Hong Kong University of Science and Technology
Curated by ChEMBL
Hong Kong University of Science and Technology
Curated by ChEMBL
Affinity DataKd: 55nMAssay Description:Equilibrium dissociation constant (KD) for Competitive binding between [3H]- nisoxatine and the compound at human Norepinephrine transporterMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rat)
Hong Kong University of Science and Technology
Curated by ChEMBL
Hong Kong University of Science and Technology
Curated by ChEMBL
Affinity DataKi: 57nMAssay Description:Inhibition of [3H]5-HT reuptake into rat frontal cortex synaptosomesMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rat)
Hong Kong University of Science and Technology
Curated by ChEMBL
Hong Kong University of Science and Technology
Curated by ChEMBL
Affinity DataKi: 60nMAssay Description:Inhibition of [3H]5-HT reuptake into rat frontal cortex synaptosomesMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rat)
Hong Kong University of Science and Technology
Curated by ChEMBL
Hong Kong University of Science and Technology
Curated by ChEMBL
Affinity DataKi: 60nMAssay Description:Inhibition of [3H]- DA reuptake into rat striatal synaptosomesMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Human)
Hong Kong University of Science and Technology
Curated by ChEMBL
Hong Kong University of Science and Technology
Curated by ChEMBL
Affinity DataKd: 70nMAssay Description:Equilibrium dissociation constant (KD) for Competitive binding between [3H]WIN-35428 and the compound at human transporter-hDATMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Human)
Hong Kong University of Science and Technology
Curated by ChEMBL
Hong Kong University of Science and Technology
Curated by ChEMBL
Affinity DataKd: 76nMAssay Description:Equilibrium dissociation constant (KD) for Competitive binding between [3H]- imipramine and the compound at human transporter -hSERTMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Human)
Hong Kong University of Science and Technology
Curated by ChEMBL
Hong Kong University of Science and Technology
Curated by ChEMBL
Affinity DataKd: 118nMAssay Description:Equilibrium dissociation constant (KD) for Competitive binding between [3H]- imipramine and the compound at human transporter -hSERTMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rat)
Hong Kong University of Science and Technology
Curated by ChEMBL
Hong Kong University of Science and Technology
Curated by ChEMBL
Affinity DataKi: 120nMAssay Description:Inhibition of [3H]- DA reuptake into rat striatal synaptosomesMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rat)
Hong Kong University of Science and Technology
Curated by ChEMBL
Hong Kong University of Science and Technology
Curated by ChEMBL
Affinity DataKi: 137nMAssay Description:Inhibition of [3H]5-HT reuptake into rat frontal cortex synaptosomesMore data for this Ligand-Target Pair
Affinity DataKi: 138nMAssay Description:Inhibition of [3H]- NE reuptake into rat hippocampal synaptosomesMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Human)
Hong Kong University of Science and Technology
Curated by ChEMBL
Hong Kong University of Science and Technology
Curated by ChEMBL
Affinity DataKd: 140nMAssay Description:Equilibrium dissociation constant (KD) for Competitive binding between [3H]WIN-35428 and the compound at human transporter-hDATMore data for this Ligand-Target Pair
Affinity DataKi: 143nMAssay Description:Inhibition of [3H]- NE reuptake into rat hippocampal synaptosomesMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Human)
Hong Kong University of Science and Technology
Curated by ChEMBL
Hong Kong University of Science and Technology
Curated by ChEMBL
Affinity DataKd: 155nMAssay Description:Equilibrium dissociation constant (KD) for Competitive binding between [3H]- nisoxatine and the compound at human Norepinephrine transporterMore data for this Ligand-Target Pair

3D Structure (crystal)














