Compile Data Set for Download or QSAR
Report error Found 130 Enz. Inhib. hit(s) with all data for entry = 537
TargetMetabotropic glutamate receptor 2(Human)
TBA

US Patent
LigandPNGBDBM277097(US10072003, Example 1-15B | (S) or (R)-4-(2,4- dif...)
Affinity DataIC50: 5.30E+3nMAssay Description:The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
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TargetMetabotropic glutamate receptor 2(Human)
TBA

US Patent
LigandPNGBDBM277085(US10072003, Example 1-5B | US10072003, Example 1-5...)
Affinity DataIC50: 5.60E+3nMAssay Description:The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
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TargetMetabotropic glutamate receptor 2(Human)
TBA

US Patent
LigandPNGBDBM277130(US10072003, Example 2-23 | 4-(2,4-difluorophenyl)-...)
Affinity DataIC50: 5.70E+3nMAssay Description:The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
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TargetMetabotropic glutamate receptor 2(Human)
TBA

US Patent
LigandPNGBDBM277201(US10072003, Example 13-4 | 4-(2-chloro-4-fluorophe...)
Affinity DataIC50: 5.70E+3nMAssay Description:The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
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TargetMetabotropic glutamate receptor 2(Human)
TBA

US Patent
LigandPNGBDBM277097(US10072003, Example 1-15B | (S) or (R)-4-(2,4- dif...)
Affinity DataIC50: 5.80E+3nMAssay Description:The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
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TargetMetabotropic glutamate receptor 2(Human)
TBA

US Patent
LigandPNGBDBM277189(US10072003, Example 11-9 | 4-(4-chloro-2,6-difluor...)
Affinity DataIC50: 6.50E+3nMAssay Description:The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
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TargetMetabotropic glutamate receptor 2(Human)
TBA

US Patent
LigandPNGBDBM277199(US10072003, Example 13-2 | 4-(2-fluoro-4-methoxyph...)
Affinity DataIC50: 6.60E+3nMAssay Description:The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
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TargetMetabotropic glutamate receptor 2(Human)
TBA

US Patent
LigandPNGBDBM277183(US10072003, Example 11-3 | 4-(4-chloro-2-fluorophe...)
Affinity DataIC50: 7.20E+3nMAssay Description:The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
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TargetMetabotropic glutamate receptor 2(Human)
TBA

US Patent
LigandPNGBDBM277100(US10072003, Example 1-17 | 7-[(1-tert-butyl-1H-1,2...)
Affinity DataIC50: 7.40E+3nMAssay Description:The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
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TargetMetabotropic glutamate receptor 2(Human)
TBA

US Patent
LigandPNGBDBM277178(US10072003, Example 10-2 | 4-(4-chloro-2-fluorophe...)
Affinity DataIC50: 7.40E+3nMAssay Description:The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
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TargetMetabotropic glutamate receptor 2(Human)
TBA

US Patent
LigandPNGBDBM277085(US10072003, Example 1-5B | US10072003, Example 1-5...)
Affinity DataIC50: 7.50E+3nMAssay Description:The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
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TargetMetabotropic glutamate receptor 2(Human)
TBA

US Patent
LigandPNGBDBM277114(US10072003, Example 2-7 | 4-(2,4-difluorophenyl)-7...)
Affinity DataIC50: 7.60E+3nMAssay Description:The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
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TargetMetabotropic glutamate receptor 2(Human)
TBA

US Patent
LigandPNGBDBM277190(US10072003, Example 11-10 | 4-(4-fluorophenyl)-7-{...)
Affinity DataIC50: 7.60E+3nMAssay Description:The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
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TargetMetabotropic glutamate receptor 2(Human)
TBA

US Patent
LigandPNGBDBM277198(US10072003, Example 13-1)
Affinity DataIC50: 7.80E+3nMAssay Description:The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
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TargetMetabotropic glutamate receptor 2(Human)
TBA

US Patent
LigandPNGBDBM277175(US10072003, Example 9-6 | 4-(4-chloro-2-fluorophen...)
Affinity DataIC50: 8.00E+3nMAssay Description:The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
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TargetMetabotropic glutamate receptor 2(Human)
TBA

US Patent
LigandPNGBDBM277090(US10072003, Example 1-9 | 4-(2,4-difluorophenyl)-7...)
Affinity DataIC50: 8.20E+3nMAssay Description:The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
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TargetMetabotropic glutamate receptor 2(Human)
TBA

US Patent
LigandPNGBDBM277119(US10072003, Example 2-12 | 7-{[2-(difluoromethoxy)...)
Affinity DataIC50: 8.50E+3nMAssay Description:The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
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TargetMetabotropic glutamate receptor 2(Human)
TBA

US Patent
LigandPNGBDBM277089(US10072003, Example 1-8 | 4-(4-chloro-2- fluorophe...)
Affinity DataIC50: 8.70E+3nMAssay Description:The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
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TargetMetabotropic glutamate receptor 2(Human)
TBA

US Patent
LigandPNGBDBM277104(US10072003, Example 1-21 | (S) or (R)-4-(4-chloro-...)
Affinity DataIC50: 9.30E+3nMAssay Description:The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
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TargetMetabotropic glutamate receptor 2(Human)
TBA

US Patent
LigandPNGBDBM277137(US10072003, Example 3-2A | US10072003, Example 3-2...)
Affinity DataIC50: 9.60E+3nMAssay Description:The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
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TargetMetabotropic glutamate receptor 2(Human)
TBA

US Patent
LigandPNGBDBM277171(US10072003, Example 9-2 | 4-(4-chloro-2-fluorophen...)
Affinity DataIC50: 9.70E+3nMAssay Description:The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
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TargetMetabotropic glutamate receptor 2(Human)
TBA

US Patent
LigandPNGBDBM277094(US10072003, Example 1-12 | 4-(2-fluoro-4- methylph...)
Affinity DataIC50: 9.90E+3nMAssay Description:The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
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TargetMetabotropic glutamate receptor 2(Human)
TBA

US Patent
LigandPNGBDBM277166(US10072003, Example 8-2A | US10072003, Example 8-2...)
Affinity DataIC50: 9.90E+3nMAssay Description:The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
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TargetMetabotropic glutamate receptor 2(Human)
TBA

US Patent
LigandPNGBDBM277192(US10072003, Example 11-12 | 4-(4-chloro-2-fluoroph...)
Affinity DataIC50: 1.00E+4nMAssay Description:The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
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TargetMetabotropic glutamate receptor 2(Human)
TBA

US Patent
LigandPNGBDBM277118(US10072003, Example 2-11 | 4-(2-chloro-4-fluorophe...)
Affinity DataIC50: 1.04E+4nMAssay Description:The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
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TargetMetabotropic glutamate receptor 2(Human)
TBA

US Patent
LigandPNGBDBM277116(US10072003, Example 2-9 | 7-[(2-cyclopropylpyridin...)
Affinity DataIC50: 1.08E+4nMAssay Description:The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
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TargetMetabotropic glutamate receptor 2(Human)
TBA

US Patent
LigandPNGBDBM277127(US10072003, Example 2-20 | 4-(4-chloro-2,6-difluor...)
Affinity DataIC50: 1.10E+4nMAssay Description:The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
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TargetMetabotropic glutamate receptor 2(Human)
TBA

US Patent
LigandPNGBDBM277137(US10072003, Example 3-2A | US10072003, Example 3-2...)
Affinity DataIC50: 1.14E+4nMAssay Description:The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
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TargetMetabotropic glutamate receptor 2(Human)
TBA

US Patent
LigandPNGBDBM277166(US10072003, Example 8-2A | US10072003, Example 8-2...)
Affinity DataIC50: 1.15E+4nMAssay Description:The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
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TargetMetabotropic glutamate receptor 2(Human)
TBA

US Patent
LigandPNGBDBM277155(US10072003, Example 6-1)
Affinity DataIC50: 1.17E+4nMAssay Description:The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
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TargetMetabotropic glutamate receptor 2(Human)
TBA

US Patent
LigandPNGBDBM277176(US10072003, Example 9-7 | 4-(4-chloro-2-fluorophen...)
Affinity DataIC50: 1.17E+4nMAssay Description:The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
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TargetMetabotropic glutamate receptor 2(Human)
TBA

US Patent
LigandPNGBDBM277188(US10072003, Example 11-8 | 4-(2-fluorophenyl)-7-{[...)
Affinity DataIC50: 1.18E+4nMAssay Description:The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
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TargetMetabotropic glutamate receptor 2(Human)
TBA

US Patent
LigandPNGBDBM277179(US10072003, Example 10-3 | 4-(4-chloro-2-fluorophe...)
Affinity DataIC50: 1.20E+4nMAssay Description:The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
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TargetMetabotropic glutamate receptor 2(Human)
TBA

US Patent
LigandPNGBDBM277101(US10072003, Example 1-18 | (S) or (R)-4-(4-chloro-...)
Affinity DataIC50: 1.23E+4nMAssay Description:The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
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TargetMetabotropic glutamate receptor 2(Human)
TBA

US Patent
LigandPNGBDBM277164(US10072003, Example 8-1A | US10072003, Example 8-3...)
Affinity DataIC50: 1.27E+4nMAssay Description:The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
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TargetMetabotropic glutamate receptor 2(Human)
TBA

US Patent
LigandPNGBDBM277164(US10072003, Example 8-1A | US10072003, Example 8-3...)
Affinity DataIC50: 1.27E+4nMAssay Description:The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
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TargetMetabotropic glutamate receptor 2(Human)
TBA

US Patent
LigandPNGBDBM277174(US10072003, Example 9-5 | 4-(4-chloro-2-fluorophen...)
Affinity DataIC50: 1.27E+4nMAssay Description:The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
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TargetMetabotropic glutamate receptor 2(Human)
TBA

US Patent
LigandPNGBDBM277147(US10072003, Example 5-5B | (S) or (R)-4-(3- methyl...)
Affinity DataIC50: 1.29E+4nMAssay Description:The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
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TargetMetabotropic glutamate receptor 2(Human)
TBA

US Patent
LigandPNGBDBM277133(US10072003, Example 2-26 | 4-(2,4-difluorophenyl)-...)
Affinity DataIC50: 1.31E+4nMAssay Description:The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
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TargetMetabotropic glutamate receptor 2(Human)
TBA

US Patent
LigandPNGBDBM277194(US10072003, Example 12-2 | 4-(6-azaspiro[2.5]oct-6...)
Affinity DataIC50: 1.31E+4nMAssay Description:The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
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TargetMetabotropic glutamate receptor 2(Human)
TBA

US Patent
LigandPNGBDBM277102(US10072003, Example 1-19 | (S) or (R)-8-methyl-7- ...)
Affinity DataIC50: 1.32E+4nMAssay Description:The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
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TargetMetabotropic glutamate receptor 2(Human)
TBA

US Patent
LigandPNGBDBM277186(US10072003, Example 11-6 | 7-{[2-(trifluoromethyl)...)
Affinity DataIC50: 1.32E+4nMAssay Description:The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
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TargetMetabotropic glutamate receptor 2(Human)
TBA

US Patent
LigandPNGBDBM277088(US10072003, Example 1-7 | 4-(2,4-difluorophenyl)-7...)
Affinity DataIC50: 1.38E+4nMAssay Description:The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
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TargetMetabotropic glutamate receptor 2(Human)
TBA

US Patent
LigandPNGBDBM277099(US10072003, Example 1-16 | 4-(4-chloro-2- fluoroph...)
Affinity DataIC50: 1.41E+4nMAssay Description:The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
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TargetMetabotropic glutamate receptor 2(Human)
TBA

US Patent
LigandPNGBDBM277172(US10072003, Example 9-3 | 4-(4-chloro-2-fluorophen...)
Affinity DataIC50: 1.42E+4nMAssay Description:The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
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TargetMetabotropic glutamate receptor 2(Human)
TBA

US Patent
LigandPNGBDBM277087(US10072003, Example 1-6 | 4-(2,4-difluorophenyl)-7...)
Affinity DataIC50: 1.45E+4nMAssay Description:The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
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TargetMetabotropic glutamate receptor 2(Human)
TBA

US Patent
LigandPNGBDBM277180(US10072003, Example 10-4 | 4-(4-chloro-2-fluorophe...)
Affinity DataIC50: 1.46E+4nMAssay Description:The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
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TargetMetabotropic glutamate receptor 2(Human)
TBA

US Patent
LigandPNGBDBM277106(US10072003, Example 1-23B | US10072003, Example 1-...)
Affinity DataIC50: 1.47E+4nMAssay Description:The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
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TargetMetabotropic glutamate receptor 2(Human)
TBA

US Patent
LigandPNGBDBM277200(US10072003, Example 13-3 | 4-(4-chloro-2-fluorophe...)
Affinity DataIC50: 1.60E+4nMAssay Description:The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
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TargetMetabotropic glutamate receptor 2(Human)
TBA

US Patent
LigandPNGBDBM277149(US10072003, Example 5-6A | US10072003, Example 5-6...)
Affinity DataIC50: 1.73E+4nMAssay Description:The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
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