Compile Data Set for Download or QSAR
Report error Found 27 Enz. Inhib. hit(s) with all data for entry = 2478
TargetMetallo-beta-lactamase GIM-1(Pseudomonas aeruginosa)
Universitetet | Oslo

US Patent
LigandPNGBDBM367681(US10227327, Example 7 | 1-(pyridin-2-yl)-N-(pyridi...)
Affinity DataIC50: 140nMAssay Description:a. Transfer 50 μl LB with 0.8 mM IPTG (0.4 mM final concentration in assay) to each wellb. Add 1 μl inhibitor/positive control (500/1000 &#...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
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TargetVIM-2 type metallo-beta-lactamase(Pseudomonas aeruginosa)
Universitetet | Oslo

US Patent
LigandPNGBDBM367675(US10227327, TPEN | N,N,N′,N′-Tetrakis(...)
Affinity DataIC50: 300nMAssay Description:a. Transfer 50 μl LB with 0.8 mM IPTG (0.4 mM final concentration in assay) to each wellb. Add 1 μl inhibitor/positive control (500/1000 &#...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
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TargetMetallo-beta-lactamase type 2(Pseudomonas aeruginosa (g-Proteobacteria))
Universitetet | Oslo

US Patent
LigandPNGBDBM367676(US10227327, Example 3 | 1-(1-(4-methoxybenzyl)-1H-...)
Affinity DataIC50: 380nMAssay Description:a. Transfer 50 μl LB with 0.8 mM IPTG (0.4 mM final concentration in assay) to each wellb. Add 1 μl inhibitor/positive control (500/1000 &#...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
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TargetMetallo-beta-lactamase GIM-1(Pseudomonas aeruginosa)
Universitetet | Oslo

US Patent
LigandPNGBDBM367678(US10227327, Example 24 | (R)-1-(((R)-1-((4-(2-(bis...)
Affinity DataIC50: 400nMAssay Description:a. Transfer 50 μl LB with 0.8 mM IPTG (0.4 mM final concentration in assay) to each wellb. Add 1 μl inhibitor/positive control (500/1000 &#...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
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TargetMetallo-beta-lactamase type 2(Pseudomonas aeruginosa (g-Proteobacteria))
Universitetet | Oslo

US Patent
LigandPNGBDBM367678(US10227327, Example 24 | (R)-1-(((R)-1-((4-(2-(bis...)
Affinity DataIC50: 520nMAssay Description:a. Transfer 50 μl LB with 0.8 mM IPTG (0.4 mM final concentration in assay) to each wellb. Add 1 μl inhibitor/positive control (500/1000 &#...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
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TargetMetallo-beta-lactamase type 2(Pseudomonas aeruginosa (g-Proteobacteria))
Universitetet | Oslo

US Patent
LigandPNGBDBM367683(US10227327, Example 9 | 1-(1-β-bromo-4-methox...)
Affinity DataIC50: 600nMAssay Description:a. Transfer 50 μl LB with 0.8 mM IPTG (0.4 mM final concentration in assay) to each wellb. Add 1 μl inhibitor/positive control (500/1000 &#...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
Go to US Patent

TargetMetallo-beta-lactamase GIM-1(Pseudomonas aeruginosa)
Universitetet | Oslo

US Patent
LigandPNGBDBM367675(US10227327, TPEN | N,N,N′,N′-Tetrakis(...)
Affinity DataIC50: 610nMAssay Description:a. Transfer 50 μl LB with 0.8 mM IPTG (0.4 mM final concentration in assay) to each wellb. Add 1 μl inhibitor/positive control (500/1000 &#...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
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TargetMetallo-beta-lactamase GIM-1(Pseudomonas aeruginosa)
Universitetet | Oslo

US Patent
LigandPNGBDBM367680(US10227327, Example 6 | 1-(1-(4-nitrobenzyl)-1H-1,...)
Affinity DataIC50: 710nMAssay Description:a. Transfer 50 μl LB with 0.8 mM IPTG (0.4 mM final concentration in assay) to each wellb. Add 1 μl inhibitor/positive control (500/1000 &#...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
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TargetMetallo-beta-lactamase type 2(Pseudomonas aeruginosa (g-Proteobacteria))
Universitetet | Oslo

US Patent
LigandPNGBDBM367677(US10227327, Example 13 | 1-(1-(4-methoxyphenyl)-1H...)
Affinity DataIC50: 720nMAssay Description:a. Transfer 50 μl LB with 0.8 mM IPTG (0.4 mM final concentration in assay) to each wellb. Add 1 μl inhibitor/positive control (500/1000 &#...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
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TargetMetallo-beta-lactamase GIM-1(Pseudomonas aeruginosa)
Universitetet | Oslo

US Patent
LigandPNGBDBM367679(US10227327, Example 5 | 1-(pyridin-2-yl)-N-(pyridi...)
Affinity DataIC50: 790nMAssay Description:a. Transfer 50 μl LB with 0.8 mM IPTG (0.4 mM final concentration in assay) to each wellb. Add 1 μl inhibitor/positive control (500/1000 &#...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
Go to US Patent

TargetMetallo-beta-lactamase GIM-1(Pseudomonas aeruginosa)
Universitetet | Oslo

US Patent
LigandPNGBDBM367684(US10227327, Example 11 | 1-(1-(2,4-dimethoxyphenyl...)
Affinity DataIC50: 860nMAssay Description:a. Transfer 50 μl LB with 0.8 mM IPTG (0.4 mM final concentration in assay) to each wellb. Add 1 μl inhibitor/positive control (500/1000 &#...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
Go to US Patent

TargetMetallo-beta-lactamase GIM-1(Pseudomonas aeruginosa)
Universitetet | Oslo

US Patent
LigandPNGBDBM367682(US10227327, Example 8 | 1-(1-(4-methoxy-3-nitroben...)
Affinity DataIC50: 1.03E+3nMAssay Description:a. Transfer 50 μl LB with 0.8 mM IPTG (0.4 mM final concentration in assay) to each wellb. Add 1 μl inhibitor/positive control (500/1000 &#...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
Go to US Patent

TargetMetallo-beta-lactamase type 2(Pseudomonas aeruginosa (g-Proteobacteria))
Universitetet | Oslo

US Patent
LigandPNGBDBM367682(US10227327, Example 8 | 1-(1-(4-methoxy-3-nitroben...)
Affinity DataIC50: 1.06E+3nMAssay Description:a. Transfer 50 μl LB with 0.8 mM IPTG (0.4 mM final concentration in assay) to each wellb. Add 1 μl inhibitor/positive control (500/1000 &#...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
Go to US Patent

TargetMetallo-beta-lactamase GIM-1(Pseudomonas aeruginosa)
Universitetet | Oslo

US Patent
LigandPNGBDBM367685(US10227327, Example 12 | 1-(pyridin-2-yl)-N-(pyrid...)
Affinity DataIC50: 1.10E+3nMAssay Description:a. Transfer 50 μl LB with 0.8 mM IPTG (0.4 mM final concentration in assay) to each wellb. Add 1 μl inhibitor/positive control (500/1000 &#...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
Go to US Patent

TargetMetallo-beta-lactamase GIM-1(Pseudomonas aeruginosa)
Universitetet | Oslo

US Patent
LigandPNGBDBM367677(US10227327, Example 13 | 1-(1-(4-methoxyphenyl)-1H...)
Affinity DataIC50: 1.43E+3nMAssay Description:a. Transfer 50 μl LB with 0.8 mM IPTG (0.4 mM final concentration in assay) to each wellb. Add 1 μl inhibitor/positive control (500/1000 &#...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
Go to US Patent

TargetMetallo-beta-lactamase GIM-1(Pseudomonas aeruginosa)
Universitetet | Oslo

US Patent
LigandPNGBDBM367676(US10227327, Example 3 | 1-(1-(4-methoxybenzyl)-1H-...)
Affinity DataIC50: 2.26E+3nMAssay Description:a. Transfer 50 μl LB with 0.8 mM IPTG (0.4 mM final concentration in assay) to each wellb. Add 1 μl inhibitor/positive control (500/1000 &#...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
Go to US Patent

TargetMetallo-beta-lactamase GIM-1(Pseudomonas aeruginosa)
Universitetet | Oslo

US Patent
LigandPNGBDBM367683(US10227327, Example 9 | 1-(1-β-bromo-4-methox...)
Affinity DataIC50: 3.15E+3nMAssay Description:a. Transfer 50 μl LB with 0.8 mM IPTG (0.4 mM final concentration in assay) to each wellb. Add 1 μl inhibitor/positive control (500/1000 &#...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
Go to US Patent

TargetVIM-2 type metallo-beta-lactamase(Pseudomonas aeruginosa)
Universitetet | Oslo

US Patent
LigandPNGBDBM367679(US10227327, Example 5 | 1-(pyridin-2-yl)-N-(pyridi...)
Affinity DataIC50: 1.15E+4nMAssay Description:a. Transfer 50 μl LB with 0.8 mM IPTG (0.4 mM final concentration in assay) to each wellb. Add 1 μl inhibitor/positive control (500/1000 &#...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
Go to US Patent

TargetVIM-2 type metallo-beta-lactamase(Pseudomonas aeruginosa)
Universitetet | Oslo

US Patent
LigandPNGBDBM367684(US10227327, Example 11 | 1-(1-(2,4-dimethoxyphenyl...)
Affinity DataIC50: 1.22E+4nMAssay Description:a. Transfer 50 μl LB with 0.8 mM IPTG (0.4 mM final concentration in assay) to each wellb. Add 1 μl inhibitor/positive control (500/1000 &#...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
Go to US Patent

TargetVIM-2 type metallo-beta-lactamase(Pseudomonas aeruginosa)
Universitetet | Oslo

US Patent
LigandPNGBDBM367685(US10227327, Example 12 | 1-(pyridin-2-yl)-N-(pyrid...)
Affinity DataIC50: 1.29E+4nMAssay Description:a. Transfer 50 μl LB with 0.8 mM IPTG (0.4 mM final concentration in assay) to each wellb. Add 1 μl inhibitor/positive control (500/1000 &#...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
Go to US Patent

TargetVIM-2 type metallo-beta-lactamase(Pseudomonas aeruginosa)
Universitetet | Oslo

US Patent
LigandPNGBDBM367682(US10227327, Example 8 | 1-(1-(4-methoxy-3-nitroben...)
Affinity DataIC50: 1.48E+4nMAssay Description:a. Transfer 50 μl LB with 0.8 mM IPTG (0.4 mM final concentration in assay) to each wellb. Add 1 μl inhibitor/positive control (500/1000 &#...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
Go to US Patent

TargetVIM-2 type metallo-beta-lactamase(Pseudomonas aeruginosa)
Universitetet | Oslo

US Patent
LigandPNGBDBM367681(US10227327, Example 7 | 1-(pyridin-2-yl)-N-(pyridi...)
Affinity DataIC50: 1.87E+4nMAssay Description:a. Transfer 50 μl LB with 0.8 mM IPTG (0.4 mM final concentration in assay) to each wellb. Add 1 μl inhibitor/positive control (500/1000 &#...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
Go to US Patent

TargetVIM-2 type metallo-beta-lactamase(Pseudomonas aeruginosa)
Universitetet | Oslo

US Patent
LigandPNGBDBM367683(US10227327, Example 9 | 1-(1-β-bromo-4-methox...)
Affinity DataIC50: 1.90E+4nMAssay Description:a. Transfer 50 μl LB with 0.8 mM IPTG (0.4 mM final concentration in assay) to each wellb. Add 1 μl inhibitor/positive control (500/1000 &#...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
Go to US Patent

TargetVIM-2 type metallo-beta-lactamase(Pseudomonas aeruginosa)
Universitetet | Oslo

US Patent
LigandPNGBDBM367676(US10227327, Example 3 | 1-(1-(4-methoxybenzyl)-1H-...)
Affinity DataIC50: 1.98E+4nMAssay Description:a. Transfer 50 μl LB with 0.8 mM IPTG (0.4 mM final concentration in assay) to each wellb. Add 1 μl inhibitor/positive control (500/1000 &#...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
Go to US Patent

TargetVIM-2 type metallo-beta-lactamase(Pseudomonas aeruginosa)
Universitetet | Oslo

US Patent
LigandPNGBDBM367678(US10227327, Example 24 | (R)-1-(((R)-1-((4-(2-(bis...)
Affinity DataIC50: 2.28E+4nMAssay Description:a. Transfer 50 μl LB with 0.8 mM IPTG (0.4 mM final concentration in assay) to each wellb. Add 1 μl inhibitor/positive control (500/1000 &#...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
Go to US Patent

TargetVIM-2 type metallo-beta-lactamase(Pseudomonas aeruginosa)
Universitetet | Oslo

US Patent
LigandPNGBDBM367677(US10227327, Example 13 | 1-(1-(4-methoxyphenyl)-1H...)
Affinity DataIC50: 2.49E+4nMAssay Description:a. Transfer 50 μl LB with 0.8 mM IPTG (0.4 mM final concentration in assay) to each wellb. Add 1 μl inhibitor/positive control (500/1000 &#...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
Go to US Patent

TargetVIM-2 type metallo-beta-lactamase(Pseudomonas aeruginosa)
Universitetet | Oslo

US Patent
LigandPNGBDBM367680(US10227327, Example 6 | 1-(1-(4-nitrobenzyl)-1H-1,...)
Affinity DataIC50: 4.09E+4nMAssay Description:a. Transfer 50 μl LB with 0.8 mM IPTG (0.4 mM final concentration in assay) to each wellb. Add 1 μl inhibitor/positive control (500/1000 &#...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
Go to US Patent