Compile Data Set for Download or QSAR
Report error Found 19 Enz. Inhib. hit(s) with all data for entry = 2754
TargetHistone-lysine N-methyltransferase EZH2(Human)
Mirati Therapeutics

US Patent
LigandPNGBDBM378893(US10266542, Example 5 | 5,8-dichloro-2-((7-methyl-...)
Affinity DataIC50: 0.5nMAssay Description:Ten-point dose-response curves for a subset of compounds shown in Table 1 were determined using a Transcreener EPIGEN Methyltransferase HTS assay usi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
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TargetHistone-lysine N-methyltransferase EZH2(Human)
Mirati Therapeutics

US Patent
LigandPNGBDBM378912(US10266542, Example 17 | 5,8-dichloro-7-[methoxy(o...)
Affinity DataIC50: 1nMAssay Description:Ten-point dose-response curves for a subset of compounds shown in Table 1 were determined using a Transcreener EPIGEN Methyltransferase HTS assay usi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
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TargetHistone-lysine N-methyltransferase EZH2(Human)
Mirati Therapeutics

US Patent
LigandPNGBDBM378914(US10266542, Example 19 | 5,8-dichloro-2-[(7-methyl...)
Affinity DataIC50: 2nMAssay Description:Ten-point dose-response curves for a subset of compounds shown in Table 1 were determined using a Transcreener EPIGEN Methyltransferase HTS assay usi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
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TargetHistone-lysine N-methyltransferase EZH2(Human)
Mirati Therapeutics

US Patent
LigandPNGBDBM378913(US10266542, Example 18 | 7-((5,8-dichloro-7-((1,1-...)
Affinity DataIC50: 2nMAssay Description:Ten-point dose-response curves for a subset of compounds shown in Table 1 were determined using a Transcreener EPIGEN Methyltransferase HTS assay usi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
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TargetHistone-lysine N-methyltransferase EZH2(Human)
Mirati Therapeutics

US Patent
LigandPNGBDBM378909(US10266542, Example 15 | 5,8-dichloro-7-(3,5-dimet...)
Affinity DataIC50: 2nMAssay Description:Ten-point dose-response curves for a subset of compounds shown in Table 1 were determined using a Transcreener EPIGEN Methyltransferase HTS assay usi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
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TargetHistone-lysine N-methyltransferase EZH2(Human)
Mirati Therapeutics

US Patent
LigandPNGBDBM378907(US10266542, Example 13 | 5,8-dichloro-7-(3,5-dimet...)
Affinity DataIC50: 2nMAssay Description:Ten-point dose-response curves for a subset of compounds shown in Table 1 were determined using a Transcreener EPIGEN Methyltransferase HTS assay usi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
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TargetHistone-lysine N-methyltransferase EZH2(Human)
Mirati Therapeutics

US Patent
LigandPNGBDBM378911(US10266542, Example 16 | 7-((5,8-dichloro-7-(3,5-d...)
Affinity DataIC50: 3nMAssay Description:Ten-point dose-response curves for a subset of compounds shown in Table 1 were determined using a Transcreener EPIGEN Methyltransferase HTS assay usi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
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TargetHistone-lysine N-methyltransferase EZH2(Human)
Mirati Therapeutics

US Patent
LigandPNGBDBM378899(US10266542, Example 7 | 7-[[5-bromo-8-chloro-7-(3,...)
Affinity DataIC50: 3nMAssay Description:Ten-point dose-response curves for a subset of compounds shown in Table 1 were determined using a Transcreener EPIGEN Methyltransferase HTS assay usi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
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TargetHistone-lysine N-methyltransferase EZH2(Human)
Mirati Therapeutics

US Patent
LigandPNGBDBM378903(US10266542, Example 9 | 7-((5,8-dichloro-7-(methox...)
Affinity DataIC50: 4nMAssay Description:Ten-point dose-response curves for a subset of compounds shown in Table 1 were determined using a Transcreener EPIGEN Methyltransferase HTS assay usi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
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TargetHistone-lysine N-methyltransferase EZH2(Human)
Mirati Therapeutics

US Patent
LigandPNGBDBM378886(US10266542, Example 2 | 7-((5,8-dichloro-1-oxo-7-(...)
Affinity DataIC50: 5nMAssay Description:Ten-point dose-response curves for a subset of compounds shown in Table 1 were determined using a Transcreener EPIGEN Methyltransferase HTS assay usi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
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TargetHistone-lysine N-methyltransferase EZH2(Human)
Mirati Therapeutics

US Patent
LigandPNGBDBM378891(US10266542, Example 3 | 7-((5,8-dichloro-7-(ethyl(...)
Affinity DataIC50: 5nMAssay Description:Ten-point dose-response curves for a subset of compounds shown in Table 1 were determined using a Transcreener EPIGEN Methyltransferase HTS assay usi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
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TargetHistone-lysine N-methyltransferase EZH2(Human)
Mirati Therapeutics

US Patent
LigandPNGBDBM378861(US10266542, Example 1 | 7-((5,8-dichloro-7-isoprop...)
Affinity DataIC50: 6nMAssay Description:Ten-point dose-response curves for a subset of compounds shown in Table 1 were determined using a Transcreener EPIGEN Methyltransferase HTS assay usi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
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TargetHistone-lysine N-methyltransferase EZH2(Human)
Mirati Therapeutics

US Patent
LigandPNGBDBM378895(US10266542, Example 6 | 7-((8-chloro-7-isopropoxy-...)
Affinity DataIC50: 7nMAssay Description:Ten-point dose-response curves for a subset of compounds shown in Table 1 were determined using a Transcreener EPIGEN Methyltransferase HTS assay usi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
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TargetHistone-lysine N-methyltransferase EZH2(Human)
Mirati Therapeutics

US Patent
LigandPNGBDBM378905(US10266542, Example 11 | US10266542, Example 12 | ...)
Affinity DataIC50: 10nMAssay Description:Ten-point dose-response curves for a subset of compounds shown in Table 1 were determined using a Transcreener EPIGEN Methyltransferase HTS assay usi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
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TargetHistone-lysine N-methyltransferase EZH2(Human)
Mirati Therapeutics

US Patent
LigandPNGBDBM378908(US10266542, Example 14 | 7-((5,8-dichloro-7-(1,4-d...)
Affinity DataIC50: 10nMAssay Description:Ten-point dose-response curves for a subset of compounds shown in Table 1 were determined using a Transcreener EPIGEN Methyltransferase HTS assay usi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
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TargetHistone-lysine N-methyltransferase EZH2(Human)
Mirati Therapeutics

US Patent
LigandPNGBDBM378904(US10266542, Example 10 | 7-((5,8-dichloro-7-(metho...)
Affinity DataIC50: 12nMAssay Description:Ten-point dose-response curves for a subset of compounds shown in Table 1 were determined using a Transcreener EPIGEN Methyltransferase HTS assay usi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
Go to US Patent

TargetHistone-lysine N-methyltransferase EZH2(Human)
Mirati Therapeutics

US Patent
LigandPNGBDBM378905(US10266542, Example 11 | US10266542, Example 12 | ...)
Affinity DataIC50: 37nMAssay Description:Ten-point dose-response curves for a subset of compounds shown in Table 1 were determined using a Transcreener EPIGEN Methyltransferase HTS assay usi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
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TargetHistone-lysine N-methyltransferase EZH2(Human)
Mirati Therapeutics

US Patent
LigandPNGBDBM378901(US10266542, Example 8 | 7-((5,8-dichloro-7-isoprop...)
Affinity DataIC50: 95nMAssay Description:Ten-point dose-response curves for a subset of compounds shown in Table 1 were determined using a Transcreener EPIGEN Methyltransferase HTS assay usi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
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TargetHistone-lysine N-methyltransferase EZH2(Human)
Mirati Therapeutics

US Patent
LigandPNGBDBM378892(US10266542, Example 4 | 5,8-dichloro-7-isopropoxy-...)
Affinity DataIC50: 202nMAssay Description:Ten-point dose-response curves for a subset of compounds shown in Table 1 were determined using a Transcreener EPIGEN Methyltransferase HTS assay usi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
Go to US Patent