Compile Data Set for Download or QSAR
Report error Found 53 Enz. Inhib. hit(s) with all data for entry = 2982
TargetInterleukin-2(Human)
Lupin

US Patent
LigandPNGBDBM387265(US10292981, Example 33 | 2,6- Difluoro-N-(2′...)
Affinity DataIC50: 100nMAssay Description:Jurkat T cells were seeded at a density of 0.5 to 1 million cells per well in RPMI medium. Test compounds from this invention were added to the cells...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
US Patent

TargetInterleukin-2(Human)
Lupin

US Patent
LigandPNGBDBM387264(US10292981, Example 29 | N-(3′- (5,5-Dimethy...)
Affinity DataIC50: 100nMAssay Description:Jurkat T cells were seeded at a density of 0.5 to 1 million cells per well in RPMI medium. Test compounds from this invention were added to the cells...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
US Patent

TargetInterleukin-2(Human)
Lupin

US Patent
LigandPNGBDBM387263(US10292981, Example 19 | N-(2′- acetamido-5&...)
Affinity DataIC50: 100nMAssay Description:Jurkat T cells were seeded at a density of 0.5 to 1 million cells per well in RPMI medium. Test compounds from this invention were added to the cells...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
US Patent

TargetInterleukin-2(Human)
Lupin

US Patent
LigandPNGBDBM387262(US10292981, Example 16 | N-(5′- (5,5-Dimethy...)
Affinity DataIC50: 100nMAssay Description:Jurkat T cells were seeded at a density of 0.5 to 1 million cells per well in RPMI medium. Test compounds from this invention were added to the cells...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
US Patent

TargetInterleukin-2(Human)
Lupin

US Patent
LigandPNGBDBM387269(US10292981, Example 80 | 2- Chloro-N-(5-(5-(5,5- d...)
Affinity DataIC50: 100nMAssay Description:Jurkat T cells were seeded at a density of 0.5 to 1 million cells per well in RPMI medium. Test compounds from this invention were added to the cells...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
US Patent

TargetInterleukin-2(Human)
Lupin

US Patent
LigandPNGBDBM387268(US10292981, Example 46 | N-(2′- Chloro-5R...)
Affinity DataIC50: 100nMAssay Description:Jurkat T cells were seeded at a density of 0.5 to 1 million cells per well in RPMI medium. Test compounds from this invention were added to the cells...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
US Patent

TargetInterleukin-2(Human)
Lupin

US Patent
LigandPNGBDBM387267(US10292981, Example 40 | 2,6- Difluoro-N-(2′...)
Affinity DataIC50: 100nMAssay Description:Jurkat T cells were seeded at a density of 0.5 to 1 million cells per well in RPMI medium. Test compounds from this invention were added to the cells...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
US Patent

TargetInterleukin-2(Human)
Lupin

US Patent
LigandPNGBDBM387266(US10292981, Example 34 | N-(5′- (4-Ethyl-5-...)
Affinity DataIC50: 100nMAssay Description:Jurkat T cells were seeded at a density of 0.5 to 1 million cells per well in RPMI medium. Test compounds from this invention were added to the cells...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
US Patent

TargetInterleukin-2(Human)
Lupin

US Patent
LigandPNGBDBM387261(US10292981, Example 3 | N-(5′- (5,5-Dimethyl...)
Affinity DataIC50: 100nMAssay Description:Jurkat T cells were seeded at a density of 0.5 to 1 million cells per well in RPMI medium. Test compounds from this invention were added to the cells...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
US Patent

TargetInterleukin-2(Human)
Lupin

US Patent
LigandPNGBDBM387280(US10292981, Example 176 | N-(2,6- Difluorophenyl)-...)
Affinity DataIC50: 100nMAssay Description:Jurkat T cells were seeded at a density of 0.5 to 1 million cells per well in RPMI medium. Test compounds from this invention were added to the cells...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
US Patent

TargetInterleukin-2(Human)
Lupin

US Patent
LigandPNGBDBM387279(US10292981, Example 173 | 5-(2- (Difluoromethoxy)-...)
Affinity DataIC50: 100nMAssay Description:Jurkat T cells were seeded at a density of 0.5 to 1 million cells per well in RPMI medium. Test compounds from this invention were added to the cells...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
US Patent

TargetInterleukin-2(Human)
Lupin

US Patent
LigandPNGBDBM387273(US10292981, Example 135)
Affinity DataIC50: 100nMAssay Description:Jurkat T cells were seeded at a density of 0.5 to 1 million cells per well in RPMI medium. Test compounds from this invention were added to the cells...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
US Patent

TargetInterleukin-2(Human)
Lupin

US Patent
LigandPNGBDBM387272(US10292981, Example 114 | N-(5-(5- (5,5-dimethyl-4...)
Affinity DataIC50: 100nMAssay Description:Jurkat T cells were seeded at a density of 0.5 to 1 million cells per well in RPMI medium. Test compounds from this invention were added to the cells...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
US Patent

TargetInterleukin-2(Human)
Lupin

US Patent
LigandPNGBDBM387271(US10292981, Example 93 | 2,6- Difluoro-N-(5-(2- me...)
Affinity DataIC50: 100nMAssay Description:Jurkat T cells were seeded at a density of 0.5 to 1 million cells per well in RPMI medium. Test compounds from this invention were added to the cells...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
US Patent

TargetInterleukin-2(Human)
Lupin

US Patent
LigandPNGBDBM387270(US10292981, Example 87 | 2,6- Difluoro-N-(5-(2- me...)
Affinity DataIC50: 100nMAssay Description:Jurkat T cells were seeded at a density of 0.5 to 1 million cells per well in RPMI medium. Test compounds from this invention were added to the cells...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
US Patent

TargetInterleukin-2(Human)
Lupin

US Patent
LigandPNGBDBM387278(US10292981, Example 171 | N-(2,6- Difluorophenyl)-...)
Affinity DataIC50: 100nMAssay Description:Jurkat T cells were seeded at a density of 0.5 to 1 million cells per well in RPMI medium. Test compounds from this invention were added to the cells...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
US Patent

TargetInterleukin-2(Human)
Lupin

US Patent
LigandPNGBDBM387277(US10292981, Example 160 | N-(2,6- Difluorophenyl)-...)
Affinity DataIC50: 100nMAssay Description:Jurkat T cells were seeded at a density of 0.5 to 1 million cells per well in RPMI medium. Test compounds from this invention were added to the cells...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
US Patent

TargetInterleukin-2(Human)
Lupin

US Patent
LigandPNGBDBM387276(US10292981, Example 158 | 5-(5- (5,5-Dimethyl-4-ox...)
Affinity DataIC50: 100nMAssay Description:Jurkat T cells were seeded at a density of 0.5 to 1 million cells per well in RPMI medium. Test compounds from this invention were added to the cells...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
US Patent

TargetInterleukin-2(Human)
Lupin

US Patent
LigandPNGBDBM387274(US10292981, Example 157 | N-(2,6- Difluorophenyl)-...)
Affinity DataIC50: 100nMAssay Description:Jurkat T cells were seeded at a density of 0.5 to 1 million cells per well in RPMI medium. Test compounds from this invention were added to the cells...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
US Patent

LigandPNGBDBM387280(US10292981, Example 176 | N-(2,6- Difluorophenyl)-...)
Affinity DataIC50: 500nMAssay Description:HEK 293 cells were stably transfected with a NFAT-Luc reporter gene. 30,000-80,000 cells were seeded per well. Test compounds from this invention wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
US Patent

LigandPNGBDBM387273(US10292981, Example 135)
Affinity DataIC50: 500nMAssay Description:HEK 293 cells were stably transfected with a NFAT-Luc reporter gene. 30,000-80,000 cells were seeded per well. Test compounds from this invention wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
US Patent

LigandPNGBDBM387315(US10292981, Example 50 | 4- Methyl-N-(2′-met...)
Affinity DataIC50: 500nMAssay Description:HEK 293 cells were stably transfected with a NFAT-Luc reporter gene. 30,000-80,000 cells were seeded per well. Test compounds from this invention wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
US Patent

LigandPNGBDBM387264(US10292981, Example 29 | N-(3′- (5,5-Dimethy...)
Affinity DataIC50: 500nMAssay Description:HEK 293 cells were stably transfected with a NFAT-Luc reporter gene. 30,000-80,000 cells were seeded per well. Test compounds from this invention wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
US Patent

TargetInterleukin-2(Human)
Lupin

US Patent
LigandPNGBDBM387299(US10292981, Example 126 | N-(5-(5- (5,5-dimethyl-4...)
Affinity DataIC50: 550nMAssay Description:Jurkat T cells were seeded at a density of 0.5 to 1 million cells per well in RPMI medium. Test compounds from this invention were added to the cells...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
US Patent

TargetInterleukin-2(Human)
Lupin

US Patent
LigandPNGBDBM387297(US10292981, Example 121)
Affinity DataIC50: 550nMAssay Description:Jurkat T cells were seeded at a density of 0.5 to 1 million cells per well in RPMI medium. Test compounds from this invention were added to the cells...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
US Patent

TargetInterleukin-2(Human)
Lupin

US Patent
LigandPNGBDBM387296(US10292981, Example 107 | N-(5-(5- (5,5-dimethyl-4...)
Affinity DataIC50: 550nMAssay Description:Jurkat T cells were seeded at a density of 0.5 to 1 million cells per well in RPMI medium. Test compounds from this invention were added to the cells...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
US Patent

TargetInterleukin-2(Human)
Lupin

US Patent
LigandPNGBDBM387295(US10292981, Example 103 | 3,5- Dichloro-N-(5-(5-(5...)
Affinity DataIC50: 550nMAssay Description:Jurkat T cells were seeded at a density of 0.5 to 1 million cells per well in RPMI medium. Test compounds from this invention were added to the cells...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
US Patent

TargetInterleukin-2(Human)
Lupin

US Patent
LigandPNGBDBM387307(US10292981, Example 138)
Affinity DataIC50: 550nMAssay Description:Jurkat T cells were seeded at a density of 0.5 to 1 million cells per well in RPMI medium. Test compounds from this invention were added to the cells...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
US Patent

TargetInterleukin-2(Human)
Lupin

US Patent
LigandPNGBDBM387306(US10292981, Example 136)
Affinity DataIC50: 550nMAssay Description:Jurkat T cells were seeded at a density of 0.5 to 1 million cells per well in RPMI medium. Test compounds from this invention were added to the cells...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
US Patent

TargetInterleukin-2(Human)
Lupin

US Patent
LigandPNGBDBM387301(US10292981, Example 132 | N-(2′- (allyloxy)-...)
Affinity DataIC50: 550nMAssay Description:Jurkat T cells were seeded at a density of 0.5 to 1 million cells per well in RPMI medium. Test compounds from this invention were added to the cells...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
US Patent

TargetInterleukin-2(Human)
Lupin

US Patent
LigandPNGBDBM387290(US10292981, Example 53 | N-(5- (5,5-Dimethyl-4,5- ...)
Affinity DataIC50: 550nMAssay Description:Jurkat T cells were seeded at a density of 0.5 to 1 million cells per well in RPMI medium. Test compounds from this invention were added to the cells...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
US Patent

TargetInterleukin-2(Human)
Lupin

US Patent
LigandPNGBDBM387289(US10292981, Example 113 | N-(5-(5- (5,5-dimethyl-4...)
Affinity DataIC50: 550nMAssay Description:Jurkat T cells were seeded at a density of 0.5 to 1 million cells per well in RPMI medium. Test compounds from this invention were added to the cells...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
US Patent

TargetInterleukin-2(Human)
Lupin

US Patent
LigandPNGBDBM387288(US10292981, Example 31 | N-(3′- (5,5-Dimethy...)
Affinity DataIC50: 550nMAssay Description:Jurkat T cells were seeded at a density of 0.5 to 1 million cells per well in RPMI medium. Test compounds from this invention were added to the cells...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
US Patent

TargetInterleukin-2(Human)
Lupin

US Patent
LigandPNGBDBM387287(US10292981, Example 24 | 2,6- Difluoro-N-(5′...)
Affinity DataIC50: 550nMAssay Description:Jurkat T cells were seeded at a density of 0.5 to 1 million cells per well in RPMI medium. Test compounds from this invention were added to the cells...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
US Patent

TargetInterleukin-2(Human)
Lupin

US Patent
LigandPNGBDBM387294(US10292981, Example 78)
Affinity DataIC50: 550nMAssay Description:Jurkat T cells were seeded at a density of 0.5 to 1 million cells per well in RPMI medium. Test compounds from this invention were added to the cells...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
US Patent

TargetInterleukin-2(Human)
Lupin

US Patent
LigandPNGBDBM387293(US10292981, Example 67 | N-(5-(5- (5,5-Dimethyl-4-...)
Affinity DataIC50: 550nMAssay Description:Jurkat T cells were seeded at a density of 0.5 to 1 million cells per well in RPMI medium. Test compounds from this invention were added to the cells...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
US Patent

TargetInterleukin-2(Human)
Lupin

US Patent
LigandPNGBDBM387292(US10292981, Example 61 | N-(5′- (4,4-dimeth...)
Affinity DataIC50: 550nMAssay Description:Jurkat T cells were seeded at a density of 0.5 to 1 million cells per well in RPMI medium. Test compounds from this invention were added to the cells...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
US Patent

TargetInterleukin-2(Human)
Lupin

US Patent
LigandPNGBDBM387291(US10292981, Example 58 | 2,6- Difluoro-N-(2′...)
Affinity DataIC50: 550nMAssay Description:Jurkat T cells were seeded at a density of 0.5 to 1 million cells per well in RPMI medium. Test compounds from this invention were added to the cells...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
US Patent

TargetInterleukin-2(Human)
Lupin

US Patent
LigandPNGBDBM387282(US10292981, Example 7 | N-(6-(5- (5,5-dimethyl-4-o...)
Affinity DataIC50: 550nMAssay Description:Jurkat T cells were seeded at a density of 0.5 to 1 million cells per well in RPMI medium. Test compounds from this invention were added to the cells...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
US Patent

TargetInterleukin-2(Human)
Lupin

US Patent
LigandPNGBDBM387281(US10292981, Example 4 | N-(5-(5- (5,5-Dimethyl-4-o...)
Affinity DataIC50: 550nMAssay Description:Jurkat T cells were seeded at a density of 0.5 to 1 million cells per well in RPMI medium. Test compounds from this invention were added to the cells...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
US Patent

TargetInterleukin-2(Human)
Lupin

US Patent
LigandPNGBDBM387286(US10292981, Example 23 | 2,6- difluoro-N-(5-(5-(4-...)
Affinity DataIC50: 550nMAssay Description:Jurkat T cells were seeded at a density of 0.5 to 1 million cells per well in RPMI medium. Test compounds from this invention were added to the cells...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
US Patent

TargetInterleukin-2(Human)
Lupin

US Patent
LigandPNGBDBM387285(US10292981, Example 18 | N-(6-(5- (5,5-dimethyl-4-...)
Affinity DataIC50: 550nMAssay Description:Jurkat T cells were seeded at a density of 0.5 to 1 million cells per well in RPMI medium. Test compounds from this invention were added to the cells...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
US Patent

TargetInterleukin-2(Human)
Lupin

US Patent
LigandPNGBDBM387284(US10292981, Example 11 | N-(2′- chloro-5R...)
Affinity DataIC50: 550nMAssay Description:Jurkat T cells were seeded at a density of 0.5 to 1 million cells per well in RPMI medium. Test compounds from this invention were added to the cells...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
US Patent

TargetInterleukin-2(Human)
Lupin

US Patent
LigandPNGBDBM387283(US10292981, Example 8 | N-(5-(5- (5,5-dimethyl-4-o...)
Affinity DataIC50: 550nMAssay Description:Jurkat T cells were seeded at a density of 0.5 to 1 million cells per well in RPMI medium. Test compounds from this invention were added to the cells...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
US Patent

TargetInterleukin-2(Human)
Lupin

US Patent
LigandPNGBDBM387308(US10292981, Example 10 | N-(2′- (tert-butyl)...)
Affinity DataIC50: 1.00E+3nMAssay Description:Jurkat T cells were seeded at a density of 0.5 to 1 million cells per well in RPMI medium. Test compounds from this invention were added to the cells...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
US Patent

LigandPNGBDBM387313(US10292981, Example 15 | N-(5′- (5,5-dimeth...)
Affinity DataIC50: 1.00E+3nMAssay Description:Jurkat E6.1 cells were seeded at a density of 1-2×105 cells per well in calcium-4 dye prepared in calcium free HBSS (Sigma, USA). Test compounds from...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
US Patent

TargetInterleukin-2(Human)
Lupin

US Patent
LigandPNGBDBM387312(US10292981, Example 145 | 2,6- Difluoro-N-(5′...)
Affinity DataIC50: 1.00E+3nMAssay Description:Jurkat T cells were seeded at a density of 0.5 to 1 million cells per well in RPMI medium. Test compounds from this invention were added to the cells...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
US Patent

TargetInterleukin-2(Human)
Lupin

US Patent
LigandPNGBDBM387310(US10292981, Example 69 | N-(5-(5- (5,5-Dimethyl-4-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Jurkat T cells were seeded at a density of 0.5 to 1 million cells per well in RPMI medium. Test compounds from this invention were added to the cells...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
US Patent

TargetInterleukin-2(Human)
Lupin

US Patent
LigandPNGBDBM387309(US10292981, Example 17 | N-(5-(5- (5,5-dimethyl-4-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Jurkat T cells were seeded at a density of 0.5 to 1 million cells per well in RPMI medium. Test compounds from this invention were added to the cells...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
US Patent

LigandPNGBDBM387280(US10292981, Example 176 | N-(2,6- Difluorophenyl)-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Jurkat E6.1 cells were seeded at a density of 1-2×105 cells per well in calcium-4 dye prepared in calcium free HBSS (Sigma, USA). Test compounds from...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
US Patent

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