Compile Data Set for Download or QSAR
Report error Found 203 Enz. Inhib. hit(s) with all data for entry = 3120
TargetLysine-specific histone demethylase 1A(Human)
Genentech

US Patent
LigandPNGBDBM391883(US10301253, Example 33 | methyl 4-((4-(((2',3'- di...)
Affinity DataIC50: 12.2nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
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TargetLysine-specific histone demethylase 1A(Human)
Genentech

US Patent
LigandPNGBDBM391883(US10301253, Example 33 | methyl 4-((4-(((2',3'- di...)
Affinity DataIC50: 14.8nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
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TargetLysine-specific histone demethylase 1A(Human)
Genentech

US Patent
LigandPNGBDBM391911(US10301253, Example 62 | N-(3- (aminomethyl)cyclob...)
Affinity DataIC50: 19.3nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
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TargetLysine-specific histone demethylase 1A(Human)
Genentech

US Patent
LigandPNGBDBM391892(US10301253, Example 42 | N-((1-methylpiperidin-4- ...)
Affinity DataIC50: 21nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
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TargetLysine-specific histone demethylase 1A(Human)
Genentech

US Patent
LigandPNGBDBM391892(US10301253, Example 42 | N-((1-methylpiperidin-4- ...)
Affinity DataIC50: 25.1nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
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TargetLysine-specific histone demethylase 1A(Human)
Genentech

US Patent
LigandPNGBDBM391938(US10301253, Example 91 | US10301253, Example 90)
Affinity DataIC50: 29.4nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
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TargetLysine-specific histone demethylase 1A(Human)
Genentech

US Patent
LigandPNGBDBM391919(US10301253, Example 70 | N-(2',3'- dihydrospiro[cy...)
Affinity DataIC50: 30.6nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
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TargetLysine-specific histone demethylase 1A(Human)
Genentech

US Patent
LigandPNGBDBM391955(US10301253, Example 107)
Affinity DataIC50: 30.9nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
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TargetLysine-specific histone demethylase 1A(Human)
Genentech

US Patent
LigandPNGBDBM391911(US10301253, Example 62 | N-(3- (aminomethyl)cyclob...)
Affinity DataIC50: 31.8nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
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TargetLysine-specific histone demethylase 1A(Human)
Genentech

US Patent
LigandPNGBDBM391919(US10301253, Example 70 | N-(2',3'- dihydrospiro[cy...)
Affinity DataIC50: 32.2nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
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TargetLysine-specific histone demethylase 1A(Human)
Genentech

US Patent
LigandPNGBDBM391912(US10301253, Example 63 | N-(piperidin-4-ylmethyl)-...)
Affinity DataIC50: 32.8nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
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TargetLysine-specific histone demethylase 1A(Human)
Genentech

US Patent
LigandPNGBDBM391955(US10301253, Example 107)
Affinity DataIC50: 33nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
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TargetLysine-specific histone demethylase 1A(Human)
Genentech

US Patent
LigandPNGBDBM391921(US10301253, Example 72 | 6'-methyl-N-(piperidin-4-...)
Affinity DataIC50: 34.4nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
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TargetLysine-specific histone demethylase 1A(Human)
Genentech

US Patent
LigandPNGBDBM391921(US10301253, Example 72 | 6'-methyl-N-(piperidin-4-...)
Affinity DataIC50: 36.4nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
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TargetLysine-specific histone demethylase 1A(Human)
Genentech

US Patent
LigandPNGBDBM391885(US10301253, Example 35 | N-((tetrahydro-2H-pyran-4...)
Affinity DataIC50: 37nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
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TargetLysine-specific histone demethylase 1A(Human)
Genentech

US Patent
LigandPNGBDBM391918(US10301253, Example 69 | N-(2-(azetidin-3-yl)ethyl...)
Affinity DataIC50: 38.2nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
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TargetLysine-specific histone demethylase 1A(Human)
Genentech

US Patent
LigandPNGBDBM391902(US10301253, Example 53 | N-(3',4'-dihydro-2'H- spi...)
Affinity DataIC50: 38.4nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
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TargetLysine-specific histone demethylase 1A(Human)
Genentech

US Patent
LigandPNGBDBM391864(US10301253, Example 13 | 6'-bromo-2',3'- dihydrosp...)
Affinity DataIC50: 38.6nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
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TargetLysine-specific histone demethylase 1A(Human)
Genentech

US Patent
LigandPNGBDBM391913(US10301253, Example 64 | 5'-chloro-N-(piperidin-4-...)
Affinity DataIC50: 40.7nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
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TargetLysine-specific histone demethylase 1A(Human)
Genentech

US Patent
LigandPNGBDBM391897(US10301253, Example 48 | 3-[(spiro[cyclopropane-2,...)
Affinity DataIC50: 43.6nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
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TargetLysine-specific histone demethylase 1A(Human)
Genentech

US Patent
LigandPNGBDBM391920(US10301253, Example 71 | 2-((piperidin-4- ylmethyl...)
Affinity DataIC50: 44nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
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TargetLysine-specific histone demethylase 1A(Human)
Genentech

US Patent
LigandPNGBDBM391888(US10301253, Example 38 | N-((1-methyl-1H-pyrazol-3...)
Affinity DataIC50: 46.2nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
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TargetLysine-specific histone demethylase 1A(Human)
Genentech

US Patent
LigandPNGBDBM391918(US10301253, Example 69 | N-(2-(azetidin-3-yl)ethyl...)
Affinity DataIC50: 46.8nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
Go to US Patent

TargetLysine-specific histone demethylase 1A(Human)
Genentech

US Patent
LigandPNGBDBM391897(US10301253, Example 48 | 3-[(spiro[cyclopropane-2,...)
Affinity DataIC50: 47.2nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
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TargetLysine-specific histone demethylase 1A(Human)
Genentech

US Patent
LigandPNGBDBM391899(US10301253, Example 50 | US10301253, Example 51 | ...)
Affinity DataIC50: 47.4nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
Go to US Patent

TargetLysine-specific histone demethylase 1A(Human)
Genentech

US Patent
LigandPNGBDBM391913(US10301253, Example 64 | 5'-chloro-N-(piperidin-4-...)
Affinity DataIC50: 47.5nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
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TargetLysine-specific histone demethylase 1A(Human)
Genentech

US Patent
LigandPNGBDBM391917(US10301253, Example 68 | N-(3- (aminomethyl)cyclob...)
Affinity DataIC50: 48.3nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
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TargetLysine-specific histone demethylase 1A(Human)
Genentech

US Patent
LigandPNGBDBM391917(US10301253, Example 68 | N-(3- (aminomethyl)cyclob...)
Affinity DataIC50: 48.3nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
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TargetLysine-specific histone demethylase 1A(Human)
Genentech

US Patent
LigandPNGBDBM391885(US10301253, Example 35 | N-((tetrahydro-2H-pyran-4...)
Affinity DataIC50: 48.5nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
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TargetLysine-specific histone demethylase 1A(Human)
Genentech

US Patent
LigandPNGBDBM391910(US10301253, Example 61 | 6'-chloro-N-(piperidin-4-...)
Affinity DataIC50: 48.9nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
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TargetLysine-specific histone demethylase 1A(Human)
Genentech

US Patent
LigandPNGBDBM391920(US10301253, Example 71 | 2-((piperidin-4- ylmethyl...)
Affinity DataIC50: 49.4nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
Go to US Patent

TargetLysine-specific histone demethylase 1A(Human)
Genentech

US Patent
LigandPNGBDBM391899(US10301253, Example 50 | US10301253, Example 51 | ...)
Affinity DataIC50: 50nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
Go to US Patent

TargetLysine-specific histone demethylase 1A(Human)
Genentech

US Patent
LigandPNGBDBM391902(US10301253, Example 53 | N-(3',4'-dihydro-2'H- spi...)
Affinity DataIC50: 52.4nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
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TargetLysine-specific histone demethylase 1A(Human)
Genentech

US Patent
LigandPNGBDBM391916(US10301253, Example 67 | N-(piperidin-4-ylmethyl)-...)
Affinity DataIC50: 53.8nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
Go to US Patent

TargetLysine-specific histone demethylase 1A(Human)
Genentech

US Patent
LigandPNGBDBM391859(US10301253, Example 8 | 6'-chloro-2',3'- dihydrosp...)
Affinity DataIC50: 54.2nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
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TargetLysine-specific histone demethylase 1A(Human)
Genentech

US Patent
LigandPNGBDBM391896(US10301253, Example 47 | N-((1-methyl-1H-pyrazol-4...)
Affinity DataIC50: 55.5nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
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TargetLysine-specific histone demethylase 1A(Human)
Genentech

US Patent
LigandPNGBDBM391910(US10301253, Example 61 | 6'-chloro-N-(piperidin-4-...)
Affinity DataIC50: 55.6nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
Go to US Patent

TargetLysine-specific histone demethylase 1A(Human)
Genentech

US Patent
LigandPNGBDBM391899(US10301253, Example 50 | US10301253, Example 51 | ...)
Affinity DataIC50: 56.7nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
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TargetLysine-specific histone demethylase 1A(Human)
Genentech

US Patent
LigandPNGBDBM391925(US10301253, Example 77 | US10301253, Example 78 | ...)
Affinity DataIC50: 57.5nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
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TargetLysine-specific histone demethylase 1A(Human)
Genentech

US Patent
LigandPNGBDBM391929(US10301253, Example 81 | 6''-fluoro-N-(piperidin-4...)
Affinity DataIC50: 57.6nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
Go to US Patent

TargetLysine-specific histone demethylase 1A(Human)
Genentech

US Patent
LigandPNGBDBM391929(US10301253, Example 81 | 6''-fluoro-N-(piperidin-4...)
Affinity DataIC50: 58.4nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
Go to US Patent

TargetLysine-specific histone demethylase 1A(Human)
Genentech

US Patent
LigandPNGBDBM391916(US10301253, Example 67 | N-(piperidin-4-ylmethyl)-...)
Affinity DataIC50: 60.7nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
Go to US Patent

TargetLysine-specific histone demethylase 1A(Human)
Genentech

US Patent
LigandPNGBDBM391925(US10301253, Example 77 | US10301253, Example 78 | ...)
Affinity DataIC50: 64.6nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
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TargetLysine-specific histone demethylase 1A(Human)
Genentech

US Patent
LigandPNGBDBM391899(US10301253, Example 50 | US10301253, Example 51 | ...)
Affinity DataIC50: 64.7nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
Go to US Patent

TargetLysine-specific histone demethylase 1A(Human)
Genentech

US Patent
LigandPNGBDBM391929(US10301253, Example 81 | 6''-fluoro-N-(piperidin-4...)
Affinity DataIC50: 64.8nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
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TargetLysine-specific histone demethylase 1A(Human)
Genentech

US Patent
LigandPNGBDBM391901(US10301253, Example 52 | Boc Deprotection)
Affinity DataIC50: 65.4nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
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TargetLysine-specific histone demethylase 1A(Human)
Genentech

US Patent
LigandPNGBDBM391864(US10301253, Example 13 | 6'-bromo-2',3'- dihydrosp...)
Affinity DataIC50: 67.2nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
Go to US Patent

TargetLysine-specific histone demethylase 1A(Human)
Genentech

US Patent
LigandPNGBDBM391925(US10301253, Example 77 | US10301253, Example 78 | ...)
Affinity DataIC50: 67.3nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
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TargetLysine-specific histone demethylase 1A(Human)
Genentech

US Patent
LigandPNGBDBM391912(US10301253, Example 63 | N-(piperidin-4-ylmethyl)-...)
Affinity DataIC50: 67.5nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
Go to US Patent

TargetLysine-specific histone demethylase 1A(Human)
Genentech

US Patent
LigandPNGBDBM391929(US10301253, Example 81 | 6''-fluoro-N-(piperidin-4...)
Affinity DataIC50: 73nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
Go to US Patent

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