Compile Data Set for Download or QSAR
Report error Found 14 Enz. Inhib. hit(s) with all data for entry = 8692
TargetBromodomain-containing protein 4 [368-440](Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM223491(US9320741, JQ6 | US10407441, Compound JQ6 | US1092...)
Affinity DataIC50: 0.240nMAssay Description:All reagents were diluted in 50 mM HEPES, 100 mM NaCl, 0.1% BSA, pH 7.4 supplemented with 0.05% CHAPS and allowed to equilibrate to room temperature ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/27/2020
Entry Details
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TargetBromodomain-containing protein 4 [368-440](Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM223492(US9320741, JQ8 | US10407441, Compound JQ8 | US1092...)
Affinity DataIC50: 0.427nMAssay Description:All reagents were diluted in 50 mM HEPES, 100 mM NaCl, 0.1% BSA, pH 7.4 supplemented with 0.05% CHAPS and allowed to equilibrate to room temperature ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/27/2020
Entry Details
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TargetBromodomain-containing protein 4 [368-440](Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM223493(US9320741, JQ13 | US10407441, Compound JQ13 | US10...)
Affinity DataIC50: 0.584nMAssay Description:All reagents were diluted in 50 mM HEPES, 100 mM NaCl, 0.1% BSA, pH 7.4 supplemented with 0.05% CHAPS and allowed to equilibrate to room temperature ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/27/2020
Entry Details
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TargetBromodomain-containing protein 4 [75-147](Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM223492(US9320741, JQ8 | US10407441, Compound JQ8 | US1092...)
Affinity DataIC50: 2.19nMAssay Description:All reagents were diluted in 50 mM HEPES, 100 mM NaCl, 0.1% BSA, pH 7.4 supplemented with 0.05% CHAPS and allowed to equilibrate to room temperature ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/27/2020
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [75-147](Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM223493(US9320741, JQ13 | US10407441, Compound JQ13 | US10...)
Affinity DataIC50: 2.49nMAssay Description:All reagents were diluted in 50 mM HEPES, 100 mM NaCl, 0.1% BSA, pH 7.4 supplemented with 0.05% CHAPS and allowed to equilibrate to room temperature ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/27/2020
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [75-147](Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM223491(US9320741, JQ6 | US10407441, Compound JQ6 | US1092...)
Affinity DataIC50: 3.48nMAssay Description:All reagents were diluted in 50 mM HEPES, 100 mM NaCl, 0.1% BSA, pH 7.4 supplemented with 0.05% CHAPS and allowed to equilibrate to room temperature ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/27/2020
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [368-440](Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM223495(US9320741, JQ35 | US10407441, Compound JQ35)
Affinity DataIC50: 6.13nMAssay Description:All reagents were diluted in 50 mM HEPES, 100 mM NaCl, 0.1% BSA, pH 7.4 supplemented with 0.05% CHAPS and allowed to equilibrate to room temperature ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/27/2020
Entry Details
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TargetBromodomain-containing protein 4 [368-440](Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM50365262(CHEMBL1957266 | (S)-JQ1 (1) | US9320741, (S)-JQ1 |...)
Affinity DataIC50: 14nMAssay Description:All reagents were diluted in 50 mM HEPES, 100 mM NaCl, 0.1% BSA, pH 7.4 supplemented with 0.05% CHAPS and allowed to equilibrate to room temperature ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/27/2020
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [75-147](Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM50365262(CHEMBL1957266 | (S)-JQ1 (1) | US9320741, (S)-JQ1 |...)
Affinity DataIC50: 18nMAssay Description:All reagents were diluted in 50 mM HEPES, 100 mM NaCl, 0.1% BSA, pH 7.4 supplemented with 0.05% CHAPS and allowed to equilibrate to room temperature ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/27/2020
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [75-147](Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM223495(US9320741, JQ35 | US10407441, Compound JQ35)
Affinity DataIC50: 24.3nMAssay Description:All reagents were diluted in 50 mM HEPES, 100 mM NaCl, 0.1% BSA, pH 7.4 supplemented with 0.05% CHAPS and allowed to equilibrate to room temperature ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/27/2020
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [368-440](Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM223494(US9320741, JQ33 | US10407441, Compound JQ33)
Affinity DataIC50: 29.5nMAssay Description:All reagents were diluted in 50 mM HEPES, 100 mM NaCl, 0.1% BSA, pH 7.4 supplemented with 0.05% CHAPS and allowed to equilibrate to room temperature ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/27/2020
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [75-147](Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM223494(US9320741, JQ33 | US10407441, Compound JQ33)
Affinity DataIC50: 85nMAssay Description:All reagents were diluted in 50 mM HEPES, 100 mM NaCl, 0.1% BSA, pH 7.4 supplemented with 0.05% CHAPS and allowed to equilibrate to room temperature ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/27/2020
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [75-147](Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM205429( (R)-JQ1 (3) | US9320741, (R)-JQ1 | US10407441, Co...)
Affinity DataIC50: 8.35E+6nMAssay Description:All reagents were diluted in 50 mM HEPES, 100 mM NaCl, 0.1% BSA, pH 7.4 supplemented with 0.05% CHAPS and allowed to equilibrate to room temperature ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/27/2020
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [368-440](Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM205429( (R)-JQ1 (3) | US9320741, (R)-JQ1 | US10407441, Co...)
Affinity DataIC50: 5.21E+7nMAssay Description:All reagents were diluted in 50 mM HEPES, 100 mM NaCl, 0.1% BSA, pH 7.4 supplemented with 0.05% CHAPS and allowed to equilibrate to room temperature ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/27/2020
Entry Details
Go to US Patent