Compile Data Set for Download or QSAR
Report error Found 6 Enz. Inhib. hit(s) with all data for entry = 8888
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Intra-Cellular Therapies

US Patent
LigandPNGBDBM50166893(2-(3,4-Dimethoxy-benzyl)-7-[(R)-1-((R)-1-hydroxy-e...)
Affinity DataIC50: 1nMAssay Description:r-hPDE2A (Accession No. NM_002599, Homo sapiens phosphodiesterase 2A, cGMP-stimulated, transcript variant 1) A mammalian expression cloning vector wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2020
Entry Details
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PDB3D3D Structure (crystal)
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Intra-Cellular Therapies

US Patent
LigandPNGBDBM292716(US10105349, Example 22 | 1-(2-Chloro-5-(cyclobutyl...)
Affinity DataIC50: 5.90nMAssay Description:r-hPDE2A (Accession No. NM_002599, Homo sapiens phosphodiesterase 2A, cGMP-stimulated, transcript variant 1) A mammalian expression cloning vector wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2020
Entry Details
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TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Intra-Cellular Therapies

US Patent
LigandPNGBDBM292715(US10105349, Example 21 | 1-(5-Butoxy-2-chloropheny...)
Affinity DataIC50: 9.40nMAssay Description:r-hPDE2A (Accession No. NM_002599, Homo sapiens phosphodiesterase 2A, cGMP-stimulated, transcript variant 1) A mammalian expression cloning vector wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2020
Entry Details
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TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Intra-Cellular Therapies

US Patent
LigandPNGBDBM292713(US10105349, Example 20 | 1-(5-Butoxy-2-chloropheny...)
Affinity DataIC50: 12nMAssay Description:r-hPDE2A (Accession No. NM_002599, Homo sapiens phosphodiesterase 2A, cGMP-stimulated, transcript variant 1) A mammalian expression cloning vector wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2020
Entry Details
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TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Intra-Cellular Therapies

US Patent
LigandPNGBDBM292714(US10105349, Example 17 | 1-(5-Butoxy-2-chloropheny...)
Affinity DataIC50: 28nMAssay Description:r-hPDE2A (Accession No. NM_002599, Homo sapiens phosphodiesterase 2A, cGMP-stimulated, transcript variant 1) A mammalian expression cloning vector wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2020
Entry Details
Go to US Patent

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Intra-Cellular Therapies

US Patent
LigandPNGBDBM292712(US10105349, Example 19 | 8-Chloro-1-(2,5-dichlorop...)
Affinity DataIC50: 73nMAssay Description:r-hPDE2A (Accession No. NM_002599, Homo sapiens phosphodiesterase 2A, cGMP-stimulated, transcript variant 1) A mammalian expression cloning vector wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2020
Entry Details
Go to US Patent