Compile Data Set for Download or QSAR
Report error Found 69 Enz. Inhib. hit(s) with all data for entry = 9175
TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM447439(US10689339, Example 47 | (2S,4R)-4-[4-(5-Methyl-te...)
Affinity DataIC50: 0.349nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details
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TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM447446(US10689339, Example 54 | (2S,4R)-4-(4-[1,2,3]Triaz...)
Affinity DataIC50: 0.382nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details
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TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM447418(US10689339, Example 26 | (2S,4R)-4-(4-(1H-1,2,4-tr...)
Affinity DataIC50: 0.391nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details
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TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM447431(US10689339, Example 39 | (2S,4R)-4-(4-(2-aminopyri...)
Affinity DataIC50: 0.483nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details
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TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM447444(US10689339, Example 52 | (2S,4R)-4-(2-chloro-4-(5-...)
Affinity DataIC50: 0.486nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details
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TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM447445(US10689339, Example 53 | (2S,4R)-4-(4-[1,2,3]Triaz...)
Affinity DataIC50: 0.506nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details
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TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM447436(US10689339, Example 44 | (2S,4R)-4-(4-(2-aminopyri...)
Affinity DataIC50: 0.510nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details
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TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM447448(US10689339, Example 56 | (2S,4R)-4-[4-(1-Difluorom...)
Affinity DataIC50: 0.526nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details
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TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM447360(US10689339, Example 14 | (2S,4R)-4-(2-chloro-4-(3-...)
Affinity DataIC50: 0.529nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details
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TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM447313(US10689339, Example 8 | (2S,4R)-4-(2-chloro-4-(5-m...)
Affinity DataIC50: 0.533nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details
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TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM447423(US10689339, Example 31 | (2S,4R) N-(1-cyanocyclopr...)
Affinity DataIC50: 0.540nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details
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TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM447419(US10689339, Example 27 | (2S,4R)-4-[4-(3,5-Dimethy...)
Affinity DataIC50: 0.558nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details
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TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM447340(US10689339, Example 12 | (2S,4R)-4-(2-chloro-4-(2H...)
Affinity DataIC50: 0.560nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details
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TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM447408(US10689339, Example 16 | (2S,4R)-4-(2-chloro-4-(3-...)
Affinity DataIC50: 0.563nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details
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TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM447449(US10689339, Example 57 | (2S,4R)-4-[4-(5-Methyl-te...)
Affinity DataIC50: 0.564nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details
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TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM447343(US10689339, Example 13 | (2S,4R)-4-(2-chloro-4-(1H...)
Affinity DataIC50: 0.568nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details
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TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM447457(US10689339, Example 65 | (2S,4R)-4-(4-Tetrazol-1-y...)
Affinity DataIC50: 0.584nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details
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TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM447455(US10689339, Example 63 | (2S,4R)-4-[4-(2-Methyl-th...)
Affinity DataIC50: 0.585nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details
Go to US Patent

TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM447454(US10689339, Example 62 | (2S,4R) N-(1-cyanocyclopr...)
Affinity DataIC50: 0.592nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details
Go to US Patent

TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM447407(US10689339, Example 15 | (2S,4R)-4-(2-chloro-4-(3,...)
Affinity DataIC50: 0.610nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details
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TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM447453(US10689339, Example 61 | (2S,4R) N-(1-cyanocyclopr...)
Affinity DataIC50: 0.613nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details
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TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM447452(US10689339, Example 60 | (2S,4R) N-(1-cyanocyclopr...)
Affinity DataIC50: 0.614nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details
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TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM447422(US10689339, Example 30 | (2S,4R)-4-[4-(3-Chloro-[1...)
Affinity DataIC50: 0.625nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details
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TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM447456(US10689339, Example 64 | (2S,4R) N-(1-cyanocyclopr...)
Affinity DataIC50: 0.650nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details
Go to US Patent

TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM447314(US10689339, Example 9 | (2S,4R)-4-(2-chloro-4-(5-m...)
Affinity DataIC50: 0.683nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details
Go to US Patent

TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM447316(US10689339, Example 10 | (2S,4R)-4-(2-chloro-4-(1H...)
Affinity DataIC50: 0.686nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details
Go to US Patent

TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM447409(US10689339, Example 17 | (2S,4R)-4-(2-chloro-4-(3-...)
Affinity DataIC50: 0.704nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details
Go to US Patent

TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM447442(US10689339, Example 50 | (2S,4R) N-(1-cyanocyclopr...)
Affinity DataIC50: 0.728nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details
Go to US Patent

TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM447438(US10689339, Example 46 | (2S,4R)-1-(1-Trifluoromet...)
Affinity DataIC50: 0.752nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details
Go to US Patent

TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM446861(US10689339, Example 2 | (2S,4R)-4-[4-(2-Methyl-1-o...)
Affinity DataIC50: 0.770nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details
Go to US Patent

TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM447416(US10689339, Example 24 | (2S,4R)-4-[4-(3-Methyl-[1...)
Affinity DataIC50: 0.772nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details
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TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM447421(US10689339, Example 29 | (2S,4R) N-(1-cyanocyclopr...)
Affinity DataIC50: 0.811nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details
Go to US Patent

TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM447460(US10689339, Example 68 | (2S,4R)-4-[4-(1-Methyl-3-...)
Affinity DataIC50: 0.829nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details
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TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM447015(US10689339, Example 5 | (2S,4R)-4-(2′-Ethoxy...)
Affinity DataIC50: 0.836nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details
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TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM447433(US10689339, Example 41 | (2S,4R)-4-(2′-cyano...)
Affinity DataIC50: 0.860nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details
Go to US Patent

TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM447443(US10689339, Example 51 | (2S,4R) N-(1-cyanocyclopr...)
Affinity DataIC50: 0.882nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details
Go to US Patent

TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM447441(US10689339, Example 49 | (2S,4R) N-(1-cyanocyclopr...)
Affinity DataIC50: 0.909nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details
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TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM447308(US10689339, Example 7 | (2S,4R)-4-(4-Cyclobutoxy-2...)
Affinity DataIC50: 0.910nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details
Go to US Patent

TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM447451(US10689339, Example 59 | (2S,4R) N-(1-cyanocyclopr...)
Affinity DataIC50: 0.943nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details
Go to US Patent

TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM447424(US10689339, Example 32 | (2S,4R) N-(1-cyanocyclopr...)
Affinity DataIC50: 0.955nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details
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TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM446809(US10689339, Example 1 | (2S,4R)-4-[4-(2-Chloro-1-o...)
Affinity DataIC50: 0.968nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details
Go to US Patent

TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM446923(US10689339, Example 4 | (2S,4R)-4-(2′-Triflu...)
Affinity DataIC50: 0.978nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details
Go to US Patent

TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM447410(US10689339, Example 18 | (2S,4R)-4-(2-chloro-4-(5-...)
Affinity DataIC50: 0.980nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details
Go to US Patent

TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM447427(US10689339, Example 35 | (2S,4R) N-(1-cyanocyclopr...)
Affinity DataIC50: 1.02nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details
Go to US Patent

TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM446862(US10689339, Example 3 | (2S,4R)-4-[4-(2-Methyl-5-t...)
Affinity DataIC50: 1.02nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details
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TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM447282(US10689339, Example 6 | (2S,4R)-4-(2′-Cyclop...)
Affinity DataIC50: 1.06nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details
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TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM447426(US10689339, Example 34 | (2S,4R)-4-(4-(1H-1,2,3-tr...)
Affinity DataIC50: 1.06nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details
Go to US Patent

TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM447437(US10689339, Example 45 | (2S,4R)-4-[4-(2,2-Difluor...)
Affinity DataIC50: 1.07nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details
Go to US Patent

TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM447413(US10689339, Example 21 | (2S,4R)-4-(2-chloro-4-cyc...)
Affinity DataIC50: 1.07nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details
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TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM447415(US10689339, Example 23 | (2S,4R)-4-[4-(5-Methyl-3-...)
Affinity DataIC50: 1.12nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details
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