Compile Data Set for Download or QSAR
Report error Found 9 Enz. Inhib. hit(s) with all data for entry = 10215
LigandPNGBDBM520651(US11147816, PD318088 | US11701360, PD318088)
Affinity DataIC50: 1.40nMAssay Description:The IC50 for MEK1 and 2 can be measured by methods in references such as [Yamaguchi et al. (2011) International Journal of Oncology 39:23-31].More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2022
Entry Details
US Patent
PDB3D3D Structure (crystal)
LigandPNGBDBM50531540(CHEBI:75998 | GSK-1120212 | GSK1120212 | JTP 74057...)
Affinity DataIC50: 2.16nMAssay Description:The IC50 for MEK1 and 2 can be measured by methods in references such as [Yamaguchi et al. (2011) International Journal of Oncology 39:23-31].More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2022
Entry Details
US Patent
PDB3D3D Structure (crystal)
LigandPNGBDBM520648(US11147816, AZD8330 | US11701360, AZD8330)
Affinity DataIC50: 7nMAssay Description:The IC50 for MEK1 and 2 can be measured by methods in references such as [Yamaguchi et al. (2011) International Journal of Oncology 39:23-31].More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2022
Entry Details
US Patent

LigandPNGBDBM520649(US11147816, Binimetinib (ARRY-162, ARRY-438162) | ...)
Affinity DataIC50: 12nMAssay Description:The IC50 for MEK1 and 2 can be measured by methods in references such as [Yamaguchi et al. (2011) International Journal of Oncology 39:23-31].More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2022
Entry Details
US Patent
PDB3D3D Structure (crystal)
LigandPNGBDBM104963(CHEMBL507361 | US8575391, Q | US11147816, PD032590...)
Affinity DataIC50: 13.8nMAssay Description:The IC50 for MEK1 and 2 can be measured by methods in references such as [Yamaguchi et al. (2011) International Journal of Oncology 39:23-31].More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2022
Entry Details
US Patent

LigandPNGBDBM520650(US11147816, Refametinib (RDEA119, Bay | US11701360...)
Affinity DataIC50: 19nMAssay Description:The IC50 for MEK1 and 2 can be measured by methods in references such as [Yamaguchi et al. (2011) International Journal of Oncology 39:23-31].More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2022
Entry Details
US Patent

LigandPNGBDBM520650(US11147816, Refametinib (RDEA119, Bay | US11701360...)
Affinity DataIC50: 47nMAssay Description:The IC50 for MEK1 and 2 can be measured by methods in references such as [Yamaguchi et al. (2011) International Journal of Oncology 39:23-31].More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2022
Entry Details
US Patent

LigandPNGBDBM50010462(CHEMBL3264002 | CHEBI:78825 | US11147816, RO512676...)
Affinity DataIC50: 160nMAssay Description:The IC50 for MEK1 and 2 can be measured by methods in references such as [Yamaguchi et al. (2011) International Journal of Oncology 39:23-31].More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2022
Entry Details
US Patent
PDB3D3D Structure (crystal)
LigandPNGBDBM50014412(Pimasertib | US11147816, Pimasertib (AS703026) | U...)
Affinity DataIC50: 1.00E+3nMAssay Description:The IC50 for MEK1 and 2 can be measured by methods in references such as [Yamaguchi et al. (2011) International Journal of Oncology 39:23-31].More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2022
Entry Details
US Patent
PDB3D3D Structure (crystal)