Compile Data Set for Download or QSAR
Report error Found 18 Enz. Inhib. hit(s) with all data for entry = 10395
TargetMacrophage colony-stimulating factor 1 receptor(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM276745(US10071991, Compound (I-M2-2R,4S) | US10800764, Co...)
Affinity DataIC50: 1.80nMAssay Description:In this assay, recombinant human, dog or rat c-fms catalyzed the phosphorylation of the FMS peptide substrate, SYEGNSYTFIDPTQ, with the phosphorylate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2022
Entry Details
US Patent

TargetReceptor protein-tyrosine kinase(Dog)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM276744(US10071991, Compound (I-M2-2S,4R) | US10800764, Co...)
Affinity DataIC50: 2nMAssay Description:In this assay, recombinant human, dog or rat c-fms catalyzed the phosphorylation of the FMS peptide substrate, SYEGNSYTFIDPTQ, with the phosphorylate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2022
Entry Details
US Patent

TargetReceptor protein-tyrosine kinase(Dog)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM276745(US10071991, Compound (I-M2-2R,4S) | US10800764, Co...)
Affinity DataIC50: 2nMAssay Description:In this assay, recombinant human, dog or rat c-fms catalyzed the phosphorylation of the FMS peptide substrate, SYEGNSYTFIDPTQ, with the phosphorylate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2022
Entry Details
US Patent

TargetMacrophage colony-stimulating factor 1 receptor(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM276744(US10071991, Compound (I-M2-2S,4R) | US10800764, Co...)
Affinity DataIC50: 2.20nMAssay Description:In this assay, recombinant human, dog or rat c-fms catalyzed the phosphorylation of the FMS peptide substrate, SYEGNSYTFIDPTQ, with the phosphorylate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2022
Entry Details
US Patent

TargetMacrophage colony-stimulating factor 1 receptor(Rat)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM276744(US10071991, Compound (I-M2-2S,4R) | US10800764, Co...)
Affinity DataIC50: 2.20nMAssay Description:In this assay, recombinant human, dog or rat c-fms catalyzed the phosphorylation of the FMS peptide substrate, SYEGNSYTFIDPTQ, with the phosphorylate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2022
Entry Details
US Patent

TargetMacrophage colony-stimulating factor 1 receptor(Rat)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM276745(US10071991, Compound (I-M2-2R,4S) | US10800764, Co...)
Affinity DataIC50: 2.5nMAssay Description:In this assay, recombinant human, dog or rat c-fms catalyzed the phosphorylation of the FMS peptide substrate, SYEGNSYTFIDPTQ, with the phosphorylate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2022
Entry Details
US Patent

TargetReceptor protein-tyrosine kinase(Dog)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM276746(US10071991, Compound (I-M7-2S,4R) | US11214566, Co...)
Affinity DataIC50: 6.60nMAssay Description:In this assay, recombinant human, dog or rat c-fms catalyzed the phosphorylation of the FMS peptide substrate, SYEGNSYTFIDPTQ, with the phosphorylate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2022
Entry Details
US Patent

TargetMacrophage colony-stimulating factor 1 receptor(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM532954(US11214566, Compound (I-M7-2R,4S))
Affinity DataIC50: 7.10nMAssay Description:In this assay, recombinant human, dog or rat c-fms catalyzed the phosphorylation of the FMS peptide substrate, SYEGNSYTFIDPTQ, with the phosphorylate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2022
Entry Details
US Patent

TargetMacrophage colony-stimulating factor 1 receptor(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM276746(US10071991, Compound (I-M7-2S,4R) | US11214566, Co...)
Affinity DataIC50: 7.90nMAssay Description:In this assay, recombinant human, dog or rat c-fms catalyzed the phosphorylation of the FMS peptide substrate, SYEGNSYTFIDPTQ, with the phosphorylate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2022
Entry Details
US Patent

TargetMacrophage colony-stimulating factor 1 receptor(Rat)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM276746(US10071991, Compound (I-M7-2S,4R) | US11214566, Co...)
Affinity DataIC50: 7.90nMAssay Description:In this assay, recombinant human, dog or rat c-fms catalyzed the phosphorylation of the FMS peptide substrate, SYEGNSYTFIDPTQ, with the phosphorylate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2022
Entry Details
US Patent

TargetReceptor protein-tyrosine kinase(Dog)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM532954(US11214566, Compound (I-M7-2R,4S))
Affinity DataIC50: 8nMAssay Description:In this assay, recombinant human, dog or rat c-fms catalyzed the phosphorylation of the FMS peptide substrate, SYEGNSYTFIDPTQ, with the phosphorylate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2022
Entry Details
US Patent

TargetMacrophage colony-stimulating factor 1 receptor(Rat)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM532954(US11214566, Compound (I-M7-2R,4S))
Affinity DataIC50: 9.60nMAssay Description:In this assay, recombinant human, dog or rat c-fms catalyzed the phosphorylation of the FMS peptide substrate, SYEGNSYTFIDPTQ, with the phosphorylate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2022
Entry Details
US Patent

TargetMacrophage colony-stimulating factor 1 receptor(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM276743(US10071991, Compound (P) | US9611259, Compound (P)...)
Affinity DataIC50: 10nMAssay Description:In this assay, recombinant human, dog or rat c-fms catalyzed the phosphorylation of the FMS peptide substrate, SYEGNSYTFIDPTQ, with the phosphorylate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2022
Entry Details
US Patent

TargetMacrophage colony-stimulating factor 1 receptor(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM532949(US11214566, Compound (I-M7))
Affinity DataIC50: 10nMAssay Description:c-fms(h) was incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 250 μM KKKSPGEYVNIEFG, 10 mM MgAcetate and [γ-33P-ATP] (specific activity approx...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2022
Entry Details
US Patent

TargetMacrophage colony-stimulating factor 1 receptor(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM276741(US10071991, Compound (I-M2) | US9611259, Compound ...)
Affinity DataIC50: 11nMAssay Description:c-fms(h) was incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 250 μM KKKSPGEYVNIEFG, 10 mM MgAcetate and [γ-33P-ATP] (specific activity approx...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2022
Entry Details
US Patent

TargetMacrophage colony-stimulating factor 1 receptor(Rat)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM276743(US10071991, Compound (P) | US9611259, Compound (P)...)
Affinity DataIC50: 11nMAssay Description:In this assay, recombinant human, dog or rat c-fms catalyzed the phosphorylation of the FMS peptide substrate, SYEGNSYTFIDPTQ, with the phosphorylate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2022
Entry Details
US Patent

TargetReceptor protein-tyrosine kinase(Dog)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM276743(US10071991, Compound (P) | US9611259, Compound (P)...)
Affinity DataIC50: 16nMAssay Description:In this assay, recombinant human, dog or rat c-fms catalyzed the phosphorylation of the FMS peptide substrate, SYEGNSYTFIDPTQ, with the phosphorylate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2022
Entry Details
US Patent

TargetMacrophage colony-stimulating factor 1 receptor(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM276743(US10071991, Compound (P) | US9611259, Compound (P)...)
Affinity DataIC50: 18nMAssay Description:c-fms(h) was incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 250 μM KKKSPGEYVNIEFG, 10 mM MgAcetate and [γ-33P-ATP] (specific activity approx...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2022
Entry Details
US Patent