Compile Data Set for Download or QSAR
Report error Found 82 Enz. Inhib. hit(s) with all data for entry = 10514
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Blueprint Medicines

US Patent
LigandPNGBDBM84747(Vandetanib | (B) ZD6474 | US10155768, Vandetanib |...)
Affinity DataIC50: 4nMAssay Description:In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Blueprint Medicines

US Patent
LigandPNGBDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)
Affinity DataIC50: 7.90nMAssay Description:In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804L](Human)
Blueprint Medicines

US Patent
LigandPNGBDBM435008(US10584114, Compound 128 | US11279688, Compound 12...)
Affinity DataIC50: 10nMAssay Description:In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Blueprint Medicines

US Patent
LigandPNGBDBM435008(US10584114, Compound 128 | US11279688, Compound 12...)
Affinity DataIC50: 10nMAssay Description:In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804L](Human)
Blueprint Medicines

US Patent
LigandPNGBDBM435010(US10584114, Compound 130 | US11279688, Compound 13...)
Affinity DataIC50: 10nMAssay Description:In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Blueprint Medicines

US Patent
LigandPNGBDBM435010(US10584114, Compound 130 | US11279688, Compound 13...)
Affinity DataIC50: 10nMAssay Description:In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804L](Human)
Blueprint Medicines

US Patent
LigandPNGBDBM435011(US10584114, Compound 131 | US11279688, Compound 13...)
Affinity DataIC50: 10nMAssay Description:In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Blueprint Medicines

US Patent
LigandPNGBDBM435011(US10584114, Compound 131 | US11279688, Compound 13...)
Affinity DataIC50: 10nMAssay Description:In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804L](Human)
Blueprint Medicines

US Patent
LigandPNGBDBM435013(US10584114, Compound 136 | US11279688, Compound 13...)
Affinity DataIC50: 10nMAssay Description:In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Blueprint Medicines

US Patent
LigandPNGBDBM435013(US10584114, Compound 136 | US11279688, Compound 13...)
Affinity DataIC50: 10nMAssay Description:In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804L](Human)
Blueprint Medicines

US Patent
LigandPNGBDBM435015(US10584114, Compound 138 | US11279688, Compound 13...)
Affinity DataIC50: 10nMAssay Description:In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Blueprint Medicines

US Patent
LigandPNGBDBM435015(US10584114, Compound 138 | US11279688, Compound 13...)
Affinity DataIC50: 10nMAssay Description:In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804L](Human)
Blueprint Medicines

US Patent
LigandPNGBDBM435000(US10584114, Compound 113 | US11279688, Compound 11...)
Affinity DataIC50: 10nMAssay Description:In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Blueprint Medicines

US Patent
LigandPNGBDBM435000(US10584114, Compound 113 | US11279688, Compound 11...)
Affinity DataIC50: 10nMAssay Description:In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804L](Human)
Blueprint Medicines

US Patent
LigandPNGBDBM435001(US10584114, Compound 114 | US11279688, Compound 11...)
Affinity DataIC50: 10nMAssay Description:In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Blueprint Medicines

US Patent
LigandPNGBDBM435001(US10584114, Compound 114 | US11279688, Compound 11...)
Affinity DataIC50: 10nMAssay Description:In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804L](Human)
Blueprint Medicines

US Patent
LigandPNGBDBM435004(US10584114, Compound 120 | US11279688, Compound 12...)
Affinity DataIC50: 10nMAssay Description:In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Blueprint Medicines

US Patent
LigandPNGBDBM435004(US10584114, Compound 120 | US11279688, Compound 12...)
Affinity DataIC50: 10nMAssay Description:In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804L](Human)
Blueprint Medicines

US Patent
LigandPNGBDBM435005(US10584114, Compound 121 | US11279688, Compound 12...)
Affinity DataIC50: 10nMAssay Description:In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Blueprint Medicines

US Patent
LigandPNGBDBM435005(US10584114, Compound 121 | US11279688, Compound 12...)
Affinity DataIC50: 10nMAssay Description:In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804L](Human)
Blueprint Medicines

US Patent
LigandPNGBDBM435024(US10584114, Compound 151 | US11279688, Compound 15...)
Affinity DataIC50: 10nMAssay Description:In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Blueprint Medicines

US Patent
LigandPNGBDBM435024(US10584114, Compound 151 | US11279688, Compound 15...)
Affinity DataIC50: 10nMAssay Description:In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Blueprint Medicines

US Patent
LigandPNGBDBM434994(US10584114, Compound 106 | US11279688, Compound 10...)
Affinity DataIC50: 10nMAssay Description:In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804L](Human)
Blueprint Medicines

US Patent
LigandPNGBDBM434995(US10584114, Compound 107 | US11279688, Compound 10...)
Affinity DataIC50: 10nMAssay Description:In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Blueprint Medicines

US Patent
LigandPNGBDBM434995(US10584114, Compound 107 | US11279688, Compound 10...)
Affinity DataIC50: 10nMAssay Description:In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804L](Human)
Blueprint Medicines

US Patent
LigandPNGBDBM434996(US10584114, Compound 109 | US11279688, Compound 10...)
Affinity DataIC50: 10nMAssay Description:In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Blueprint Medicines

US Patent
LigandPNGBDBM434996(US10584114, Compound 109 | US11279688, Compound 10...)
Affinity DataIC50: 10nMAssay Description:In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804L](Human)
Blueprint Medicines

US Patent
LigandPNGBDBM434998(US10584114, Compound 111 | US11279688, Compound 11...)
Affinity DataIC50: 10nMAssay Description:In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804L](Human)
Blueprint Medicines

US Patent
LigandPNGBDBM434999(US10584114, Compound 112 | US11279688, Compound 11...)
Affinity DataIC50: 10nMAssay Description:In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Blueprint Medicines

US Patent
LigandPNGBDBM434999(US10584114, Compound 112 | US11279688, Compound 11...)
Affinity DataIC50: 10nMAssay Description:In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804L](Human)
Blueprint Medicines

US Patent
LigandPNGBDBM435017(US10584114, Compound 142 | US11279688, Compound 14...)
Affinity DataIC50: 10nMAssay Description:In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Blueprint Medicines

US Patent
LigandPNGBDBM435017(US10584114, Compound 142 | US11279688, Compound 14...)
Affinity DataIC50: 10nMAssay Description:In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804L](Human)
Blueprint Medicines

US Patent
LigandPNGBDBM435018(US10584114, Compound 144 | US11279688, Compound 14...)
Affinity DataIC50: 10nMAssay Description:In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Blueprint Medicines

US Patent
LigandPNGBDBM435018(US10584114, Compound 144 | US11279688, Compound 14...)
Affinity DataIC50: 10nMAssay Description:In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804L](Human)
Blueprint Medicines

US Patent
LigandPNGBDBM435019(US10584114, Compound 146 | US11279688, Compound 14...)
Affinity DataIC50: 10nMAssay Description:In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Blueprint Medicines

US Patent
LigandPNGBDBM435019(US10584114, Compound 146 | US11279688, Compound 14...)
Affinity DataIC50: 10nMAssay Description:In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804L](Human)
Blueprint Medicines

US Patent
LigandPNGBDBM434989(US10584114, Compound 101 | US11279688, Compound 10...)
Affinity DataIC50: 10nMAssay Description:In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804L](Human)
Blueprint Medicines

US Patent
LigandPNGBDBM435021(US10584114, Compound 148 | US11279688, Compound 14...)
Affinity DataIC50: 10nMAssay Description:In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Blueprint Medicines

US Patent
LigandPNGBDBM434989(US10584114, Compound 101 | US11279688, Compound 10...)
Affinity DataIC50: 10nMAssay Description:In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Blueprint Medicines

US Patent
LigandPNGBDBM435021(US10584114, Compound 148 | US11279688, Compound 14...)
Affinity DataIC50: 10nMAssay Description:In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804L](Human)
Blueprint Medicines

US Patent
LigandPNGBDBM434991(US10584114, Compound 103 | US11279688, Compound 10...)
Affinity DataIC50: 10nMAssay Description:In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804L](Human)
Blueprint Medicines

US Patent
LigandPNGBDBM435023(US10584114, Compound 150 | US11279688, Compound 15...)
Affinity DataIC50: 10nMAssay Description:In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Blueprint Medicines

US Patent
LigandPNGBDBM434991(US10584114, Compound 103 | US11279688, Compound 10...)
Affinity DataIC50: 10nMAssay Description:In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Blueprint Medicines

US Patent
LigandPNGBDBM435023(US10584114, Compound 150 | US11279688, Compound 15...)
Affinity DataIC50: 10nMAssay Description:In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Blueprint Medicines

US Patent
LigandPNGBDBM50021574(CHEBI:72317 | CABOZANTINIB | BMS-907351 | Cometriq...)
Affinity DataIC50: 11nMAssay Description:In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Blueprint Medicines

US Patent
LigandPNGBDBM50363397(CHEMBL1946170 | REGORAFENIB | US10183928, Regorafe...)
Affinity DataIC50: 12nMAssay Description:In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804L](Human)
Blueprint Medicines

US Patent
LigandPNGBDBM50021574(CHEBI:72317 | CABOZANTINIB | BMS-907351 | Cometriq...)
Affinity DataIC50: 45nMAssay Description:In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804L](Human)
Blueprint Medicines

US Patent
LigandPNGBDBM50363397(CHEMBL1946170 | REGORAFENIB | US10183928, Regorafe...)
Affinity DataIC50: 53nMAssay Description:In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804L](Human)
Blueprint Medicines

US Patent
LigandPNGBDBM434993(US10584114, Compound 105 | US11279688, Compound 10...)
Affinity DataIC50: 55nMAssay Description:In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Blueprint Medicines

US Patent
LigandPNGBDBM434993(US10584114, Compound 105 | US11279688, Compound 10...)
Affinity DataIC50: 55nMAssay Description:In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

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