Compile Data Set for Download or QSAR
Report error Found 15 Enz. Inhib. hit(s) with all data for entry = 10917
Target5-hydroxytryptamine receptor 2A(Human)
Exciva

US Patent
LigandPNGBDBM578158(US11478467, Compound (-)-148)
Affinity DataKi:  0.631nMAssay Description:Evaluation of the affinity of compounds for the human 5-HT2A receptor in transfected HEK-293 cells determined in a radioligand binding assay. Cell me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2A(Human)
Exciva

US Patent
LigandPNGBDBM578155(US11478467, Compound (+)-147)
Affinity DataKi:  0.794nMAssay Description:Evaluation of the affinity of compounds for the human 5-HT2A receptor in transfected HEK-293 cells determined in a radioligand binding assay. Cell me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2A(Human)
Exciva

US Patent
LigandPNGBDBM578155(US11478467, Compound (+)-147)
Affinity DataIC50: 1.20nMAssay Description:Evaluation of the affinity of compounds for the human 5-HT2A receptor in transfected HEK-293 cells determined in a radioligand binding assay. Cell me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2A(Human)
Exciva

US Patent
LigandPNGBDBM578158(US11478467, Compound (-)-148)
Affinity DataIC50: 1.30nMAssay Description:Evaluation of the affinity of compounds for the human 5-HT2A receptor in transfected HEK-293 cells determined in a radioligand binding assay. Cell me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2A(Human)
Exciva

US Patent
LigandPNGBDBM578153(US11478467, Compound (+)-51)
Affinity DataKi:  3.98nMAssay Description:Evaluation of the affinity of compounds for the human 5-HT2A receptor in transfected HEK-293 cells determined in a radioligand binding assay. Cell me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2A(Human)
Exciva

US Patent
LigandPNGBDBM578152(US11478467, Compound 50)
Affinity DataKi:  5.01nMAssay Description:Evaluation of the affinity of compounds for the human 5-HT2A receptor in transfected HEK-293 cells determined in a radioligand binding assay. Cell me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2A(Human)
Exciva

US Patent
LigandPNGBDBM578154(US11478467, Compound (-)-52)
Affinity DataKi:  6.31nMAssay Description:Evaluation of the affinity of compounds for the human 5-HT2A receptor in transfected HEK-293 cells determined in a radioligand binding assay. Cell me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2A(Human)
Exciva

US Patent
LigandPNGBDBM578153(US11478467, Compound (+)-51)
Affinity DataIC50: 7.5nMAssay Description:Evaluation of the affinity of compounds for the human 5-HT2A receptor in transfected HEK-293 cells determined in a radioligand binding assay. Cell me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2A(Human)
Exciva

US Patent
LigandPNGBDBM578152(US11478467, Compound 50)
Affinity DataIC50: 9.60nMAssay Description:Evaluation of the affinity of compounds for the human 5-HT2A receptor in transfected HEK-293 cells determined in a radioligand binding assay. Cell me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2A(Human)
Exciva

US Patent
LigandPNGBDBM578154(US11478467, Compound (-)-52)
Affinity DataIC50: 11nMAssay Description:Evaluation of the affinity of compounds for the human 5-HT2A receptor in transfected HEK-293 cells determined in a radioligand binding assay. Cell me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

TargetCytochrome P450 2D6(Human)
Exciva

US Patent
LigandPNGBDBM578155(US11478467, Compound (+)-147)
Affinity DataIC50: 38nMAssay Description:Dextromethorphan O-demethylase activity was determined in human liver microsomes. Sarpogrelate (1.0E-8 M to 3.0E-5 M) or M−1 (concentration: 3....More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

TargetCytochrome P450 2D6(Human)
Exciva

US Patent
LigandPNGBDBM578158(US11478467, Compound (-)-148)
Affinity DataIC50: 96nMAssay Description:Dextromethorphan O-demethylase activity was determined in human liver microsomes. Sarpogrelate (1.0E-8 M to 3.0E-5 M) or M−1 (concentration: 3....More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

TargetCytochrome P450 2D6(Human)
Exciva

US Patent
LigandPNGBDBM578153(US11478467, Compound (+)-51)
Affinity DataIC50: 580nMAssay Description:Dextromethorphan O-demethylase activity was determined in human liver microsomes. Sarpogrelate (1.0E-8 M to 3.0E-5 M) or M−1 (concentration: 3....More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

TargetCytochrome P450 2D6(Human)
Exciva

US Patent
LigandPNGBDBM578152(US11478467, Compound 50)
Affinity DataIC50: 1.20E+3nMAssay Description:Dextromethorphan O-demethylase activity was determined in human liver microsomes. Sarpogrelate (1.0E-8 M to 3.0E-5 M) or M−1 (concentration: 3....More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

TargetCytochrome P450 2D6(Human)
Exciva

US Patent
LigandPNGBDBM578154(US11478467, Compound (-)-52)
Affinity DataIC50: 1.30E+3nMAssay Description:Dextromethorphan O-demethylase activity was determined in human liver microsomes. Sarpogrelate (1.0E-8 M to 3.0E-5 M) or M−1 (concentration: 3....More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent