Compile Data Set for Download or QSAR
Report error Found 101 Enz. Inhib. hit(s) with all data for entry = 11186
TargetMonoglyceride lipase(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM597927(US11608347, Example 55 | [(7R,9aR)-7-(3-chloro-4- ...)
Affinity DataIC50: 0.200nMAssay Description:In one embodiment, the present invention provides compounds of formula (Ie) and their pharmaceutically acceptable salts as described herein, wherein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2023
Entry Details
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TargetMonoglyceride lipase(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM597939(US11608347, Example 63 | (4-chlorothieno[2,3- b]py...)
Affinity DataIC50: 2.40nMAssay Description:In one embodiment, the present invention provides compounds of formula (Ie) and their pharmaceutically acceptable salts as described herein, wherein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2023
Entry Details
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TargetMonoglyceride lipase(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM597917(US11608347, Example 46 | [(7R,9aR)-7-(3,4- dichlor...)
Affinity DataIC50: 3nMAssay Description:In one embodiment, the present invention provides compounds of formula (Ie) and their pharmaceutically acceptable salts as described herein, wherein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2023
Entry Details
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TargetMonoglyceride lipase(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM597939(US11608347, Example 63 | (4-chlorothieno[2,3- b]py...)
Affinity DataIC50: 3.20nMAssay Description:In one embodiment, the present invention provides compounds of formula (Ie) and their pharmaceutically acceptable salts as described herein, wherein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2023
Entry Details
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TargetMonoglyceride lipase(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM597977(US11608347, Example 79 | (2-chloro-3- methoxypheny...)
Affinity DataIC50: 5.70nMAssay Description:In one embodiment, the present invention provides compounds of formula (Ie) and their pharmaceutically acceptable salts as described herein, wherein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2023
Entry Details
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TargetMonoglyceride lipase(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM597953(US11608347, Example 67 | (4-chloro-3-methyl-1H- in...)
Affinity DataIC50: 6.10nMAssay Description:In one embodiment, the present invention provides compounds of formula (Ie) and their pharmaceutically acceptable salts as described herein, wherein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2023
Entry Details
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TargetMonoglyceride lipase(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM597969((2-chloro-3- methoxyphenyl)-[rac- (7R,9aS)-7-(4-ch...)
Affinity DataIC50: 7.20nMAssay Description:In one embodiment, the present invention provides compounds of formula (Ie) and their pharmaceutically acceptable salts as described herein, wherein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2023
Entry Details
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TargetMonoglyceride lipase(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM597949(US11608347, Example 65 | (4-chloro-1H-indazol-5-yl...)
Affinity DataIC50: 11.4nMAssay Description:In one embodiment, the present invention provides compounds of formula (Ie) and their pharmaceutically acceptable salts as described herein, wherein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2023
Entry Details
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TargetMonoglyceride lipase(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM597950(US11608347, Example 66 | [2-chloro-3- (difluoromet...)
Affinity DataIC50: 13nMAssay Description:In one embodiment, the present invention provides compounds of formula (Ie) and their pharmaceutically acceptable salts as described herein, wherein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2023
Entry Details
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TargetMonoglyceride lipase(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM597945(US11608347, Example 63-B | [(7S,9aS)-7-(3-chloro-4...)
Affinity DataIC50: 17.5nMAssay Description:In one embodiment, the present invention provides compounds of formula (Ie) and their pharmaceutically acceptable salts as described herein, wherein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2023
Entry Details
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TargetMonoglyceride lipase(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM597969((2-chloro-3- methoxyphenyl)-[rac- (7R,9aS)-7-(4-ch...)
Affinity DataIC50: 18.5nMAssay Description:In one embodiment, the present invention provides compounds of formula (Ie) and their pharmaceutically acceptable salts as described herein, wherein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2023
Entry Details
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TargetMonoglyceride lipase(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM597950(US11608347, Example 66 | [2-chloro-3- (difluoromet...)
Affinity DataIC50: 26nMAssay Description:In one embodiment, the present invention provides compounds of formula (Ie) and their pharmaceutically acceptable salts as described herein, wherein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2023
Entry Details
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TargetMonoglyceride lipase(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM597864(US11608347, Example 3 | [(7R,9aR)-7-(4- chlorophen...)
Affinity DataIC50: 30nMAssay Description:In one embodiment, the present invention provides compounds of formula (Ie) and their pharmaceutically acceptable salts as described herein, wherein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2023
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetMonoglyceride lipase(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM597957(US11608347, Example 71 | US11608347, Example 71-A ...)
Affinity DataIC50: 30.1nMAssay Description:In one embodiment, the present invention provides compounds of formula (Ie) and their pharmaceutically acceptable salts as described herein, wherein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2023
Entry Details
Go to US Patent

TargetMonoglyceride lipase(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM597931(US11608347, Example 59 | US11608347, Example 59-A ...)
Affinity DataIC50: 31nMAssay Description:In one embodiment, the present invention provides compounds of formula (Ie) and their pharmaceutically acceptable salts as described herein, wherein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2023
Entry Details
Go to US Patent

TargetMonoglyceride lipase(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM597957(US11608347, Example 71 | US11608347, Example 71-A ...)
Affinity DataIC50: 38.2nMAssay Description:In one embodiment, the present invention provides compounds of formula (Ie) and their pharmaceutically acceptable salts as described herein, wherein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2023
Entry Details
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TargetMonoglyceride lipase(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM597946(US11608347, Example 64 | US11608347, Example 64-A ...)
Affinity DataIC50: 39.3nMAssay Description:In one embodiment, the present invention provides compounds of formula (Ie) and their pharmaceutically acceptable salts as described herein, wherein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2023
Entry Details
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TargetMonoglyceride lipase(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM597975(US11608347, Example 77 | [2-chloro-3-(2-oxa-6- aza...)
Affinity DataIC50: 39.7nMAssay Description:In one embodiment, the present invention provides compounds of formula (Ie) and their pharmaceutically acceptable salts as described herein, wherein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2023
Entry Details
Go to US Patent

TargetMonoglyceride lipase(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM597979(US11608347, Example 81 | (2-chloro-3- methoxypheny...)
Affinity DataIC50: 42.5nMAssay Description:In one embodiment, the present invention provides compounds of formula (Ie) and their pharmaceutically acceptable salts as described herein, wherein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2023
Entry Details
Go to US Patent

TargetMonoglyceride lipase(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM597868(US11608347, Example 6 | [(7R,9aR)-7-(4- chlorophen...)
Affinity DataIC50: 43nMAssay Description:In one embodiment, the present invention provides compounds of formula (Ie) and their pharmaceutically acceptable salts as described herein, wherein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2023
Entry Details
Go to US Patent

TargetMonoglyceride lipase(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM597946(US11608347, Example 64 | US11608347, Example 64-A ...)
Affinity DataIC50: 58nMAssay Description:In one embodiment, the present invention provides compounds of formula (Ie) and their pharmaceutically acceptable salts as described herein, wherein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2023
Entry Details
Go to US Patent

TargetMonoglyceride lipase(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM597929(US11608347, Example 57 | [(7R,9aR)-7-(4- chlorophe...)
Affinity DataIC50: 61.3nMAssay Description:In one embodiment, the present invention provides compounds of formula (Ie) and their pharmaceutically acceptable salts as described herein, wherein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2023
Entry Details
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TargetMonoglyceride lipase(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM597863(US11608347, Example 2 | [(7R,9aR)-7-(4- chlorophen...)
Affinity DataIC50: 63nMAssay Description:In one embodiment, the present invention provides compounds of formula (Ie) and their pharmaceutically acceptable salts as described herein, wherein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2023
Entry Details
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TargetMonoglyceride lipase(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM597973(US11608347, Example 75 | [2-chloro-3- (difluoromet...)
Affinity DataIC50: 67.6nMAssay Description:In one embodiment, the present invention provides compounds of formula (Ie) and their pharmaceutically acceptable salts as described herein, wherein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2023
Entry Details
Go to US Patent

TargetMonoglyceride lipase(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM597913(US11608347, Example 42 | [(7R,9aR)-7-(4- chlorophe...)
Affinity DataIC50: 71nMAssay Description:In one embodiment, the present invention provides compounds of formula (Ie) and their pharmaceutically acceptable salts as described herein, wherein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2023
Entry Details
Go to US Patent

TargetMonoglyceride lipase(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM597888(US11608347, Example 23 | [(7R,9aR)-7-(4- chlorophe...)
Affinity DataIC50: 72nMAssay Description:In one embodiment, the present invention provides compounds of formula (Ie) and their pharmaceutically acceptable salts as described herein, wherein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2023
Entry Details
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TargetMonoglyceride lipase(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM597955(US11608347, Example 69 | (6-amino-4-chloropyridin-...)
Affinity DataIC50: 73.1nMAssay Description:In one embodiment, the present invention provides compounds of formula (Ie) and their pharmaceutically acceptable salts as described herein, wherein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2023
Entry Details
Go to US Patent

TargetMonoglyceride lipase(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM597931(US11608347, Example 59 | US11608347, Example 59-A ...)
Affinity DataIC50: 89.5nMAssay Description:In one embodiment, the present invention provides compounds of formula (Ie) and their pharmaceutically acceptable salts as described herein, wherein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2023
Entry Details
Go to US Patent

TargetMonoglyceride lipase(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM597934(US11608347, Example 60 | US11608347, Example 60-B ...)
Affinity DataIC50: 90.1nMAssay Description:In one embodiment, the present invention provides compounds of formula (Ie) and their pharmaceutically acceptable salts as described herein, wherein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2023
Entry Details
Go to US Patent

TargetMonoglyceride lipase(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM597951(US11608347, Example 66-A | [(7S,9aS)-7-(3-chloro-4...)
Affinity DataIC50: 97.6nMAssay Description:In one embodiment, the present invention provides compounds of formula (Ie) and their pharmaceutically acceptable salts as described herein, wherein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2023
Entry Details
Go to US Patent

TargetMonoglyceride lipase(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM597961(US11608347, Example 71-B | [(7R,9aS)-7-(4- chlorop...)
Affinity DataIC50: 99.5nMAssay Description:In one embodiment, the present invention provides compounds of formula (Ie) and their pharmaceutically acceptable salts as described herein, wherein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2023
Entry Details
Go to US Patent

TargetMonoglyceride lipase(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM597918(US11608347, Example 47 | [(7S,9aS)-7-(3,4- dichlor...)
Affinity DataIC50: 100nMAssay Description:In one embodiment, the present invention provides compounds of formula (Ie) and their pharmaceutically acceptable salts as described herein, wherein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2023
Entry Details
Go to US Patent

TargetMonoglyceride lipase(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM597883(US11608347, Example 20 | [(7R,9aR)-7-(4- chlorophe...)
Affinity DataIC50: 110nMAssay Description:In one embodiment, the present invention provides compounds of formula (Ie) and their pharmaceutically acceptable salts as described herein, wherein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2023
Entry Details
Go to US Patent

TargetMonoglyceride lipase(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM597934(US11608347, Example 60 | US11608347, Example 60-B ...)
Affinity DataIC50: 111nMAssay Description:In one embodiment, the present invention provides compounds of formula (Ie) and their pharmaceutically acceptable salts as described herein, wherein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2023
Entry Details
Go to US Patent

TargetMonoglyceride lipase(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM597930(US11608347, Example 58 | [(7R,9aR)-7-(4- chlorophe...)
Affinity DataIC50: 115nMAssay Description:In one embodiment, the present invention provides compounds of formula (Ie) and their pharmaceutically acceptable salts as described herein, wherein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2023
Entry Details
Go to US Patent

TargetMonoglyceride lipase(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM597954(US11608347, Example 68 | (4-chloro-[1,2]thiazolo[5...)
Affinity DataIC50: 119nMAssay Description:In one embodiment, the present invention provides compounds of formula (Ie) and their pharmaceutically acceptable salts as described herein, wherein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2023
Entry Details
Go to US Patent

TargetMonoglyceride lipase(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM597879(US11608347, Example 17 | [(7R,9aR)-7-(4- chlorophe...)
Affinity DataIC50: 120nMAssay Description:In one embodiment, the present invention provides compounds of formula (Ie) and their pharmaceutically acceptable salts as described herein, wherein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2023
Entry Details
Go to US Patent

TargetMonoglyceride lipase(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM597884(US11608347, Example 21 | [(7R,9aR)-7-(4- chlorophe...)
Affinity DataIC50: 130nMAssay Description:In one embodiment, the present invention provides compounds of formula (Ie) and their pharmaceutically acceptable salts as described herein, wherein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2023
Entry Details
Go to US Patent

TargetMonoglyceride lipase(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM597876(US11608347, Example 14 | [(7R,9aR)-7-(4- chlorophe...)
Affinity DataIC50: 134nMAssay Description:In one embodiment, the present invention provides compounds of formula (Ie) and their pharmaceutically acceptable salts as described herein, wherein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2023
Entry Details
Go to US Patent

TargetMonoglyceride lipase(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM597866(US11608347, Example 5 | [(7R,9aR)-7-phenyl- 1,3,4,...)
Affinity DataIC50: 150nMAssay Description:In one embodiment, the present invention provides compounds of formula (Ie) and their pharmaceutically acceptable salts as described herein, wherein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2023
Entry Details
Go to US Patent

TargetMonoglyceride lipase(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM597971(US11608347, Example 73-B | [(7R,9aS)-7-(4- chlorop...)
Affinity DataIC50: 156nMAssay Description:In one embodiment, the present invention provides compounds of formula (Ie) and their pharmaceutically acceptable salts as described herein, wherein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2023
Entry Details
Go to US Patent

TargetMonoglyceride lipase(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM597916(US11608347, Example 45 | [(7R,9aR)-7-(4- chlorophe...)
Affinity DataIC50: 161nMAssay Description:In one embodiment, the present invention provides compounds of formula (Ie) and their pharmaceutically acceptable salts as described herein, wherein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2023
Entry Details
Go to US Patent

TargetMonoglyceride lipase(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM597933(US11608347, Example 59-B | [(7S,9aS)-7-(3-chloro-4...)
Affinity DataIC50: 164nMAssay Description:In one embodiment, the present invention provides compounds of formula (Ie) and their pharmaceutically acceptable salts as described herein, wherein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2023
Entry Details
Go to US Patent

TargetMonoglyceride lipase(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM597914(US11608347, Example 43 | [(7R,9aR)-7-phenyl- 1,3,4...)
Affinity DataIC50: 185nMAssay Description:In one embodiment, the present invention provides compounds of formula (Ie) and their pharmaceutically acceptable salts as described herein, wherein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2023
Entry Details
Go to US Patent

TargetMonoglyceride lipase(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM597875(US11608347, Example 13 | [(7R,9aR)-7-(4- chlorophe...)
Affinity DataIC50: 190nMAssay Description:In one embodiment, the present invention provides compounds of formula (Ie) and their pharmaceutically acceptable salts as described herein, wherein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2023
Entry Details
Go to US Patent

TargetMonoglyceride lipase(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM597872(US11608347, Example 10 | [(7R,9aR)-7-(4- chlorophe...)
Affinity DataIC50: 198nMAssay Description:In one embodiment, the present invention provides compounds of formula (Ie) and their pharmaceutically acceptable salts as described herein, wherein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2023
Entry Details
Go to US Patent

TargetMonoglyceride lipase(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM597928(US11608347, Example 56 | [(7S,9aS)-7-(3-chloro-4- ...)
Affinity DataIC50: 203nMAssay Description:In one embodiment, the present invention provides compounds of formula (Ie) and their pharmaceutically acceptable salts as described herein, wherein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2023
Entry Details
Go to US Patent

TargetMonoglyceride lipase(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM597922(US11608347, Example 51 | [(7R,9aR)-7-phenyl- 1,3,4...)
Affinity DataIC50: 208nMAssay Description:In one embodiment, the present invention provides compounds of formula (Ie) and their pharmaceutically acceptable salts as described herein, wherein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2023
Entry Details
Go to US Patent

TargetMonoglyceride lipase(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM597919(US11608347, Example 48 | [(7R,9aR)-7-(4- chlorophe...)
Affinity DataIC50: 223nMAssay Description:In one embodiment, the present invention provides compounds of formula (Ie) and their pharmaceutically acceptable salts as described herein, wherein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2023
Entry Details
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TargetMonoglyceride lipase(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM597893(US11608347, Example 26 | [(7R,9aR)-7-phenyl- 1,3,4...)
Affinity DataIC50: 250nMAssay Description:In one embodiment, the present invention provides compounds of formula (Ie) and their pharmaceutically acceptable salts as described herein, wherein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2023
Entry Details
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