Compile Data Set for Download or QSAR
Report error Found 44 Enz. Inhib. hit(s) with all data for entry = 11650
TargetPoly [ADP-ribose] polymerase 2(Human)
Nuvation Bio

US Patent
LigandPNGBDBM636722((R) N-(4-cyano-3-(trifluoromethyl)phenyl)-3-(1-(2-...)
Affinity DataIC50: 0.200nMAssay Description:i. PARP1 assay: Human recombinant PARP1 at a final concentration of 2.5 nM was combined with histone H4 (20 μM) and test articles at various con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2024
Entry Details
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TargetPoly [ADP-ribose] polymerase 2(Human)
Nuvation Bio

US Patent
LigandPNGBDBM636718(US11826430, Compound 1.2a)
Affinity DataIC50: 0.300nMAssay Description:i. PARP1 assay: Human recombinant PARP1 at a final concentration of 2.5 nM was combined with histone H4 (20 μM) and test articles at various con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2024
Entry Details
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TargetPoly [ADP-ribose] polymerase 2(Human)
Nuvation Bio

US Patent
LigandPNGBDBM636723((S) N-(4-cyano-3-(trifluoromethyl)phenyl)-3-(1-(2-...)
Affinity DataIC50: 0.400nMAssay Description:i. PARP1 assay: Human recombinant PARP1 at a final concentration of 2.5 nM was combined with histone H4 (20 μM) and test articles at various con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2024
Entry Details
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TargetPoly [ADP-ribose] polymerase 2(Human)
Nuvation Bio

US Patent
LigandPNGBDBM636724(N-(2-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-di...)
Affinity DataIC50: 0.600nMAssay Description:i. PARP1 assay: Human recombinant PARP1 at a final concentration of 2.5 nM was combined with histone H4 (20 μM) and test articles at various con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2024
Entry Details
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TargetPoly [ADP-ribose] polymerase 2(Human)
Nuvation Bio

US Patent
LigandPNGBDBM636721(4-(3-(1-(2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-...)
Affinity DataIC50: 0.600nMAssay Description:i. PARP1 assay: Human recombinant PARP1 at a final concentration of 2.5 nM was combined with histone H4 (20 μM) and test articles at various con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2024
Entry Details
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TargetPoly [ADP-ribose] polymerase 1(Human)
Nuvation Bio

US Patent
LigandPNGBDBM636722((R) N-(4-cyano-3-(trifluoromethyl)phenyl)-3-(1-(2-...)
Affinity DataIC50: 0.600nMAssay Description:i. PARP1 assay: Human recombinant PARP1 at a final concentration of 2.5 nM was combined with histone H4 (20 μM) and test articles at various con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2024
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Nuvation Bio

US Patent
LigandPNGBDBM636718(US11826430, Compound 1.2a)
Affinity DataIC50: 1nMAssay Description:i. PARP1 assay: Human recombinant PARP1 at a final concentration of 2.5 nM was combined with histone H4 (20 μM) and test articles at various con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2024
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 2(Human)
Nuvation Bio

US Patent
LigandPNGBDBM636726(imidazolidin-1-yl)ethyl)-2-fluoro-5-((4-oxo-3,4-di...)
Affinity DataIC50: 1nMAssay Description:i. PARP1 assay: Human recombinant PARP1 at a final concentration of 2.5 nM was combined with histone H4 (20 μM) and test articles at various con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2024
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 2(Human)
Nuvation Bio

US Patent
LigandPNGBDBM636725(N-(2-(5,5-dimethyl-3-(4-nitro-3-(trifluoromethyl)p...)
Affinity DataIC50: 1nMAssay Description:i. PARP1 assay: Human recombinant PARP1 at a final concentration of 2.5 nM was combined with histone H4 (20 μM) and test articles at various con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2024
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Nuvation Bio

US Patent
LigandPNGBDBM636723((S) N-(4-cyano-3-(trifluoromethyl)phenyl)-3-(1-(2-...)
Affinity DataIC50: 2nMAssay Description:i. PARP1 assay: Human recombinant PARP1 at a final concentration of 2.5 nM was combined with histone H4 (20 μM) and test articles at various con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2024
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 2(Human)
Nuvation Bio

US Patent
LigandPNGBDBM636728(4-(3-(4-(6-(3,5-difluoro-4-((1R,3R)-2-(2-fluoro-2-...)
Affinity DataIC50: 3nMAssay Description:i. PARP1 assay: Human recombinant PARP1 at a final concentration of 2.5 nM was combined with histone H4 (20 μM) and test articles at various con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2024
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Nuvation Bio

US Patent
LigandPNGBDBM636721(4-(3-(1-(2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-...)
Affinity DataIC50: 3nMAssay Description:i. PARP1 assay: Human recombinant PARP1 at a final concentration of 2.5 nM was combined with histone H4 (20 μM) and test articles at various con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2024
Entry Details
Go to US Patent

TargetEstrogen receptor(Human)
Nuvation Bio

US Patent
LigandPNGBDBM636731((E)-4-(3-(4-(2-(3-(4-(2-(4-chloro-2-fluorophenyl)-...)
Affinity DataIC50: 3.40nMAssay Description:ERα binding was assessed by the LanthaScreen TR-FRET ER Alpha Competitive Binding Assay at Thermo Fisher. In this assay, a terbium-labeled anti-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2024
Entry Details
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TargetPoly [ADP-ribose] polymerase 2(Human)
Nuvation Bio

US Patent
LigandPNGBDBM636729(4-(3-(4-(2-(3,5-difluoro-4-((1S,3S)-2-(2-fluoro-2-...)
Affinity DataIC50: 4nMAssay Description:i. PARP1 assay: Human recombinant PARP1 at a final concentration of 2.5 nM was combined with histone H4 (20 μM) and test articles at various con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2024
Entry Details
Go to US Patent

TargetEstrogen receptor(Human)
Nuvation Bio

US Patent
LigandPNGBDBM636727((E)-4-(3-(4-(6-(4-(2-(4-chloro-2-fluorophenyl)-1-(...)
Affinity DataIC50: 4.40nMAssay Description:ERα binding was assessed by the LanthaScreen TR-FRET ER Alpha Competitive Binding Assay at Thermo Fisher. In this assay, a terbium-labeled anti-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2024
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 2(Human)
Nuvation Bio

US Patent
LigandPNGBDBM636732((E)-4-(3-(4-(2-(3-(4-(2-(4-chloro-2-fluorophenyl)-...)
Affinity DataIC50: 5nMAssay Description:i. PARP1 assay: Human recombinant PARP1 at a final concentration of 2.5 nM was combined with histone H4 (20 μM) and test articles at various con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2024
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Nuvation Bio

US Patent
LigandPNGBDBM636724(N-(2-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-di...)
Affinity DataIC50: 5nMAssay Description:i. PARP1 assay: Human recombinant PARP1 at a final concentration of 2.5 nM was combined with histone H4 (20 μM) and test articles at various con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2024
Entry Details
Go to US Patent

TargetEstrogen receptor(Human)
Nuvation Bio

US Patent
LigandPNGBDBM636730(E)-4-(3-(4-(6-(4-(2-(4-chloro-2-fluorophenyl)-1-(1...)
Affinity DataIC50: 5.30nMAssay Description:ERα binding was assessed by the LanthaScreen TR-FRET ER Alpha Competitive Binding Assay at Thermo Fisher. In this assay, a terbium-labeled anti-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2024
Entry Details
Go to US Patent

TargetEstrogen receptor(Human)
Nuvation Bio

US Patent
LigandPNGBDBM636728(4-(3-(4-(6-(3,5-difluoro-4-((1R,3R)-2-(2-fluoro-2-...)
Affinity DataIC50: 5.70nMAssay Description:ERα binding was assessed by the LanthaScreen TR-FRET ER Alpha Competitive Binding Assay at Thermo Fisher. In this assay, a terbium-labeled anti-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2024
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 2(Human)
Nuvation Bio

US Patent
LigandPNGBDBM636731((E)-4-(3-(4-(2-(3-(4-(2-(4-chloro-2-fluorophenyl)-...)
Affinity DataIC50: 6nMAssay Description:i. PARP1 assay: Human recombinant PARP1 at a final concentration of 2.5 nM was combined with histone H4 (20 μM) and test articles at various con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2024
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Nuvation Bio

US Patent
LigandPNGBDBM636725(N-(2-(5,5-dimethyl-3-(4-nitro-3-(trifluoromethyl)p...)
Affinity DataIC50: 7nMAssay Description:i. PARP1 assay: Human recombinant PARP1 at a final concentration of 2.5 nM was combined with histone H4 (20 μM) and test articles at various con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2024
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 2(Human)
Nuvation Bio

US Patent
LigandPNGBDBM636727((E)-4-(3-(4-(6-(4-(2-(4-chloro-2-fluorophenyl)-1-(...)
Affinity DataIC50: 9nMAssay Description:i. PARP1 assay: Human recombinant PARP1 at a final concentration of 2.5 nM was combined with histone H4 (20 μM) and test articles at various con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2024
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Nuvation Bio

US Patent
LigandPNGBDBM636726(imidazolidin-1-yl)ethyl)-2-fluoro-5-((4-oxo-3,4-di...)
Affinity DataIC50: 10nMAssay Description:i. PARP1 assay: Human recombinant PARP1 at a final concentration of 2.5 nM was combined with histone H4 (20 μM) and test articles at various con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2024
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 2(Human)
Nuvation Bio

US Patent
LigandPNGBDBM636720((Peak-2) | US11826430, Compound 1.2b)
Affinity DataIC50: 20nMAssay Description:i. PARP1 assay: Human recombinant PARP1 at a final concentration of 2.5 nM was combined with histone H4 (20 μM) and test articles at various con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2024
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Nuvation Bio

US Patent
LigandPNGBDBM636728(4-(3-(4-(6-(3,5-difluoro-4-((1R,3R)-2-(2-fluoro-2-...)
Affinity DataIC50: 21nMAssay Description:i. PARP1 assay: Human recombinant PARP1 at a final concentration of 2.5 nM was combined with histone H4 (20 μM) and test articles at various con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2024
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Nuvation Bio

US Patent
LigandPNGBDBM636729(4-(3-(4-(2-(3,5-difluoro-4-((1S,3S)-2-(2-fluoro-2-...)
Affinity DataIC50: 28nMAssay Description:i. PARP1 assay: Human recombinant PARP1 at a final concentration of 2.5 nM was combined with histone H4 (20 μM) and test articles at various con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2024
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 2(Human)
Nuvation Bio

US Patent
LigandPNGBDBM636730(E)-4-(3-(4-(6-(4-(2-(4-chloro-2-fluorophenyl)-1-(1...)
Affinity DataIC50: 29nMAssay Description:i. PARP1 assay: Human recombinant PARP1 at a final concentration of 2.5 nM was combined with histone H4 (20 μM) and test articles at various con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2024
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 2(Human)
Nuvation Bio

US Patent
LigandPNGBDBM636719((S) N-(4-cyano-3-(trifluoromethyl)phenyl)-3-(4-((8...)
Affinity DataIC50: 30nMAssay Description:i. PARP1 assay: Human recombinant PARP1 at a final concentration of 2.5 nM was combined with histone H4 (20 μM) and test articles at various con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2024
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Nuvation Bio

US Patent
LigandPNGBDBM636732((E)-4-(3-(4-(2-(3-(4-(2-(4-chloro-2-fluorophenyl)-...)
Affinity DataIC50: 40nMAssay Description:i. PARP1 assay: Human recombinant PARP1 at a final concentration of 2.5 nM was combined with histone H4 (20 μM) and test articles at various con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2024
Entry Details
Go to US Patent

TargetEstrogen receptor(Human)
Nuvation Bio

US Patent
LigandPNGBDBM636729(4-(3-(4-(2-(3,5-difluoro-4-((1S,3S)-2-(2-fluoro-2-...)
Affinity DataIC50: 44nMAssay Description:ERα binding was assessed by the LanthaScreen TR-FRET ER Alpha Competitive Binding Assay at Thermo Fisher. In this assay, a terbium-labeled anti-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2024
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Nuvation Bio

US Patent
LigandPNGBDBM636720((Peak-2) | US11826430, Compound 1.2b)
Affinity DataIC50: 50nMAssay Description:i. PARP1 assay: Human recombinant PARP1 at a final concentration of 2.5 nM was combined with histone H4 (20 μM) and test articles at various con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2024
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Nuvation Bio

US Patent
LigandPNGBDBM636719((S) N-(4-cyano-3-(trifluoromethyl)phenyl)-3-(4-((8...)
Affinity DataIC50: 60nMAssay Description:i. PARP1 assay: Human recombinant PARP1 at a final concentration of 2.5 nM was combined with histone H4 (20 μM) and test articles at various con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2024
Entry Details
Go to US Patent

TargetEstrogen receptor(Human)
Nuvation Bio

US Patent
LigandPNGBDBM636732((E)-4-(3-(4-(2-(3-(4-(2-(4-chloro-2-fluorophenyl)-...)
Affinity DataIC50: 64.1nMAssay Description:ERα binding was assessed by the LanthaScreen TR-FRET ER Alpha Competitive Binding Assay at Thermo Fisher. In this assay, a terbium-labeled anti-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2024
Entry Details
Go to US Patent

TargetAndrogen receptor(Human)
Nuvation Bio

US Patent
LigandPNGBDBM636724(N-(2-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-di...)
Affinity DataIC50: 94nMAssay Description:AR in LNCaP cytosol was used for determining the binding affinity of test articles and the reference compound progesterone (Sigma, Cat: E2785, St. Lo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2024
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Nuvation Bio

US Patent
LigandPNGBDBM636731((E)-4-(3-(4-(2-(3-(4-(2-(4-chloro-2-fluorophenyl)-...)
Affinity DataIC50: 95nMAssay Description:i. PARP1 assay: Human recombinant PARP1 at a final concentration of 2.5 nM was combined with histone H4 (20 μM) and test articles at various con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2024
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Nuvation Bio

US Patent
LigandPNGBDBM636730(E)-4-(3-(4-(6-(4-(2-(4-chloro-2-fluorophenyl)-1-(1...)
Affinity DataIC50: 187nMAssay Description:i. PARP1 assay: Human recombinant PARP1 at a final concentration of 2.5 nM was combined with histone H4 (20 μM) and test articles at various con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2024
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Nuvation Bio

US Patent
LigandPNGBDBM636727((E)-4-(3-(4-(6-(4-(2-(4-chloro-2-fluorophenyl)-1-(...)
Affinity DataIC50: 204nMAssay Description:i. PARP1 assay: Human recombinant PARP1 at a final concentration of 2.5 nM was combined with histone H4 (20 μM) and test articles at various con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2024
Entry Details
Go to US Patent

TargetAndrogen receptor(Human)
Nuvation Bio

US Patent
LigandPNGBDBM636726(imidazolidin-1-yl)ethyl)-2-fluoro-5-((4-oxo-3,4-di...)
Affinity DataIC50: 503nMAssay Description:AR in LNCaP cytosol was used for determining the binding affinity of test articles and the reference compound progesterone (Sigma, Cat: E2785, St. Lo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2024
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 2(Human)
Nuvation Bio

US Patent
LigandPNGBDBM636717((S) N-(4-cyano-3-(trifluoromethyl)phenyl)-3-(4-((8...)
Affinity DataIC50: 1.00E+3nMAssay Description:i. PARP1 assay: Human recombinant PARP1 at a final concentration of 2.5 nM was combined with histone H4 (20 μM) and test articles at various con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2024
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Nuvation Bio

US Patent
LigandPNGBDBM636717((S) N-(4-cyano-3-(trifluoromethyl)phenyl)-3-(4-((8...)
Affinity DataIC50: 1.00E+3nMAssay Description:i. PARP1 assay: Human recombinant PARP1 at a final concentration of 2.5 nM was combined with histone H4 (20 μM) and test articles at various con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2024
Entry Details
Go to US Patent

TargetAndrogen receptor(Human)
Nuvation Bio

US Patent
LigandPNGBDBM636722((R) N-(4-cyano-3-(trifluoromethyl)phenyl)-3-(1-(2-...)
Affinity DataIC50: 1.03E+3nMAssay Description:AR in LNCaP cytosol was used for determining the binding affinity of test articles and the reference compound progesterone (Sigma, Cat: E2785, St. Lo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2024
Entry Details
Go to US Patent

TargetAndrogen receptor(Human)
Nuvation Bio

US Patent
LigandPNGBDBM636718(US11826430, Compound 1.2a)
Affinity DataIC50: 3.75E+3nMAssay Description:AR in LNCaP cytosol was used for determining the binding affinity of test articles and the reference compound progesterone (Sigma, Cat: E2785, St. Lo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2024
Entry Details
Go to US Patent

TargetAndrogen receptor(Human)
Nuvation Bio

US Patent
LigandPNGBDBM636725(N-(2-(5,5-dimethyl-3-(4-nitro-3-(trifluoromethyl)p...)
Affinity DataIC50: 4.62E+3nMAssay Description:AR in LNCaP cytosol was used for determining the binding affinity of test articles and the reference compound progesterone (Sigma, Cat: E2785, St. Lo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2024
Entry Details
Go to US Patent

TargetAndrogen receptor(Human)
Nuvation Bio

US Patent
LigandPNGBDBM636723((S) N-(4-cyano-3-(trifluoromethyl)phenyl)-3-(1-(2-...)
Affinity DataIC50: 6.67E+3nMAssay Description:AR in LNCaP cytosol was used for determining the binding affinity of test articles and the reference compound progesterone (Sigma, Cat: E2785, St. Lo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2024
Entry Details
Go to US Patent