Compile Data Set for Download or QSAR
Report error Found 44 Enz. Inhib. hit(s) with all data for entry = 11974
TargetInterleukin-1 receptor-associated kinase 4(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM667802(N-(3-(difluoromethyl)-1-(1-(1-(2-hydroxy-2-methylp...)
Affinity DataIC50: 0.430nMAssay Description:The compounds were prepared with DMSO to 100 times the final reaction concentration and diluted to 10 concentrations in sequence at a 3-fold dilution...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
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TargetInterleukin-1 receptor-associated kinase 4(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM667788(N-(3-(difluoromethyl)-1-(1-(1-(2-hydroxyacetyl)pip...)
Affinity DataIC50: 0.510nMAssay Description:The compounds were prepared with DMSO to 100 times the final reaction concentration and diluted to 10 concentrations in sequence at a 3-fold dilution...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
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TargetInterleukin-1 receptor-associated kinase 4(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM667787(N-(3-(difluoromethyl)-1-(1-(1-propionylpiperidin-4...)
Affinity DataIC50: 0.540nMAssay Description:The compounds were prepared with DMSO to 100 times the final reaction concentration and diluted to 10 concentrations in sequence at a 3-fold dilution...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
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TargetInterleukin-1 receptor-associated kinase 4(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM667778(6-(1-(1-Amino-2-methylpropan-2-yl)-1H-pyrazol-4-yl...)
Affinity DataIC50: 0.570nMAssay Description:The compounds were prepared with DMSO to 100 times the final reaction concentration and diluted to 10 concentrations in sequence at a 3-fold dilution...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
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TargetInterleukin-1 receptor-associated kinase 4(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM667785(N-(1-(1-(1-acetylpiperidin-4-yl)azetidin-3-yl)-3-(...)
Affinity DataIC50: 0.590nMAssay Description:The compounds were prepared with DMSO to 100 times the final reaction concentration and diluted to 10 concentrations in sequence at a 3-fold dilution...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
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TargetInterleukin-1 receptor-associated kinase 4(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM667801((R)—N-(3-(difluoromethyl)-1-(1-(1-(2-hydroxyp...)
Affinity DataIC50: 0.590nMAssay Description:The compounds were prepared with DMSO to 100 times the final reaction concentration and diluted to 10 concentrations in sequence at a 3-fold dilution...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
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TargetInterleukin-1 receptor-associated kinase 4(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM667784(N-(1-(1-(1-acryloylpiperidin-4-yl)azetidin-3-yl)-3...)
Affinity DataIC50: 0.630nMAssay Description:The compounds were prepared with DMSO to 100 times the final reaction concentration and diluted to 10 concentrations in sequence at a 3-fold dilution...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
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TargetInterleukin-1 receptor-associated kinase 4(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM667786(Methyl 4-(3-(4-(6-(1H-pyrazol-3-yl)-2-picolinamide...)
Affinity DataIC50: 0.650nMAssay Description:The compounds were prepared with DMSO to 100 times the final reaction concentration and diluted to 10 concentrations in sequence at a 3-fold dilution...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
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TargetInterleukin-1 receptor-associated kinase 4(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM667779(Methyl 4-(3-(4-(6-(1-(1-amino-2-methylpropan-2-yl)...)
Affinity DataIC50: 0.670nMAssay Description:The compounds were prepared with DMSO to 100 times the final reaction concentration and diluted to 10 concentrations in sequence at a 3-fold dilution...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
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TargetInterleukin-1 receptor-associated kinase 4(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM667765(N-(3-(difluoromethyl)-1-(1-(1-(2-hydroxyacetyl)pip...)
Affinity DataIC50: 0.680nMAssay Description:The compounds were prepared with DMSO to 100 times the final reaction concentration and diluted to 10 concentrations in sequence at a 3-fold dilution...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
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TargetInterleukin-1 receptor-associated kinase 4(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM667789(N-(3-(difluoromethyl)-1-(1-(1-(dimethylcarbamoyl)p...)
Affinity DataIC50: 0.680nMAssay Description:The compounds were prepared with DMSO to 100 times the final reaction concentration and diluted to 10 concentrations in sequence at a 3-fold dilution...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
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TargetInterleukin-1 receptor-associated kinase 4(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM667800((S)—N-(3-(difluoromethyl)-1-(1-(1-(2-hydroxyp...)
Affinity DataIC50: 0.690nMAssay Description:The compounds were prepared with DMSO to 100 times the final reaction concentration and diluted to 10 concentrations in sequence at a 3-fold dilution...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
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TargetInterleukin-1 receptor-associated kinase 4(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM667774(N-(1-(1-(1-acetylpiperidin-4-yl)azetidin-3-yl)-3-(...)
Affinity DataIC50: 0.730nMAssay Description:The compounds were prepared with DMSO to 100 times the final reaction concentration and diluted to 10 concentrations in sequence at a 3-fold dilution...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
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TargetInterleukin-1 receptor-associated kinase 4(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM667792((R)—N-(3-(difluoromethyl)-1-(1-(1-(2-hydroxyp...)
Affinity DataIC50: 0.790nMAssay Description:The compounds were prepared with DMSO to 100 times the final reaction concentration and diluted to 10 concentrations in sequence at a 3-fold dilution...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
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TargetInterleukin-1 receptor-associated kinase 4(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM667790(N-(3-(difluoromethyl)-1-(1-(1-isobutyrylpiperidin-...)
Affinity DataIC50: 0.810nMAssay Description:The compounds were prepared with DMSO to 100 times the final reaction concentration and diluted to 10 concentrations in sequence at a 3-fold dilution...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
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TargetInterleukin-1 receptor-associated kinase 4(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM667764(US11958831, Example 3)
Affinity DataIC50: 0.870nMAssay Description:The compounds were prepared with DMSO to 100 times the final reaction concentration and diluted to 10 concentrations in sequence at a 3-fold dilution...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
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TargetInterleukin-1 receptor-associated kinase 4(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM667773(US11958831, Example 12)
Affinity DataIC50: 0.910nMAssay Description:The compounds were prepared with DMSO to 100 times the final reaction concentration and diluted to 10 concentrations in sequence at a 3-fold dilution...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
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TargetInterleukin-1 receptor-associated kinase 4(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM667797(6-(1-(2,2-Difluoroethyl)-1H-pyrazol-4-yl)-N-(3-(di...)
Affinity DataIC50: 0.960nMAssay Description:The compounds were prepared with DMSO to 100 times the final reaction concentration and diluted to 10 concentrations in sequence at a 3-fold dilution...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
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TargetInterleukin-1 receptor-associated kinase 4(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM667793(N-(3-(difluoromethyl)-1-(1-(1-(2-hydroxy-2-methylp...)
Affinity DataIC50: 0.970nMAssay Description:The compounds were prepared with DMSO to 100 times the final reaction concentration and diluted to 10 concentrations in sequence at a 3-fold dilution...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
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TargetInterleukin-1 receptor-associated kinase 4(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM667804(6-(1-(2-Cyanopropan-2-yl)-1H-pyrazol-4-yl)-N-(3-(d...)
Affinity DataIC50: 0.970nMAssay Description:The compounds were prepared with DMSO to 100 times the final reaction concentration and diluted to 10 concentrations in sequence at a 3-fold dilution...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
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TargetInterleukin-1 receptor-associated kinase 4(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM667763(US11958831, Example 2)
Affinity DataIC50: 0.990nMAssay Description:The compounds were prepared with DMSO to 100 times the final reaction concentration and diluted to 10 concentrations in sequence at a 3-fold dilution...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
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TargetInterleukin-1 receptor-associated kinase 4(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM667795((S)-6-(1-(2,2-difluoroethyl)-1H-pyrazol-4-yl)-N-(3...)
Affinity DataIC50: 1nMAssay Description:The compounds were prepared with DMSO to 100 times the final reaction concentration and diluted to 10 concentrations in sequence at a 3-fold dilution...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
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TargetInterleukin-1 receptor-associated kinase 4(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM667803(N-(3-(difluoromethyl)-1-(1-(1-(methylsulfonyl)pipe...)
Affinity DataIC50: 1.20nMAssay Description:The compounds were prepared with DMSO to 100 times the final reaction concentration and diluted to 10 concentrations in sequence at a 3-fold dilution...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
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TargetInterleukin-1 receptor-associated kinase 4(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM667762(US11958831, Example 1)
Affinity DataIC50: 1.20nMAssay Description:The compounds were prepared with DMSO to 100 times the final reaction concentration and diluted to 10 concentrations in sequence at a 3-fold dilution...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
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TargetInterleukin-1 receptor-associated kinase 4(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM667796((R)-6-(1-(2,2-difluoroethyl)-1H-pyrazol-4-yl)-N-(3...)
Affinity DataIC50: 1.30nMAssay Description:The compounds were prepared with DMSO to 100 times the final reaction concentration and diluted to 10 concentrations in sequence at a 3-fold dilution...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
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TargetInterleukin-1 receptor-associated kinase 4(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM667799(6-(1-(2,2-Difluoroethyl)-1H-pyrazol-4-yl)-N-(3-(di...)
Affinity DataIC50: 1.5nMAssay Description:The compounds were prepared with DMSO to 100 times the final reaction concentration and diluted to 10 concentrations in sequence at a 3-fold dilution...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
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TargetInterleukin-1 receptor-associated kinase 4(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM667772(N-(1-(1-(1-acetylpiperidin-4-yl)azetidin-3-yl)-3-(...)
Affinity DataIC50: 1.60nMAssay Description:The compounds were prepared with DMSO to 100 times the final reaction concentration and diluted to 10 concentrations in sequence at a 3-fold dilution...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
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TargetInterleukin-1 receptor-associated kinase 4(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM667782(Methyl 4-(3-(4-(6-(1H-pyrazol-4-yl)-2-picolinamide...)
Affinity DataIC50: 1.70nMAssay Description:The compounds were prepared with DMSO to 100 times the final reaction concentration and diluted to 10 concentrations in sequence at a 3-fold dilution...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
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TargetInterleukin-1 receptor-associated kinase 4(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM667777(N-(1-(1-(1-acetylpiperidin-4-yl)azetidin-3-yl)-3-(...)
Affinity DataIC50: 1.80nMAssay Description:The compounds were prepared with DMSO to 100 times the final reaction concentration and diluted to 10 concentrations in sequence at a 3-fold dilution...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
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TargetInterleukin-1 receptor-associated kinase 4(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM667769(N-(1-(1-(1-acetylpiperidin-4-yl)azetidin-3-yl)-3-(...)
Affinity DataIC50: 1.90nMAssay Description:The compounds were prepared with DMSO to 100 times the final reaction concentration and diluted to 10 concentrations in sequence at a 3-fold dilution...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
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TargetInterleukin-1 receptor-associated kinase 4(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM667780(N-(1-(1-(1-acetylpiperidin-4-yl)azetidin-3-yl)-3-(...)
Affinity DataIC50: 1.90nMAssay Description:The compounds were prepared with DMSO to 100 times the final reaction concentration and diluted to 10 concentrations in sequence at a 3-fold dilution...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
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TargetInterleukin-1 receptor-associated kinase 4(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM667771(N-(1-(1-(1-acetylpiperidin-4-yl)azetidin-3-yl)-3-(...)
Affinity DataIC50: 2nMAssay Description:The compounds were prepared with DMSO to 100 times the final reaction concentration and diluted to 10 concentrations in sequence at a 3-fold dilution...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
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TargetInterleukin-1 receptor-associated kinase 4(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM667770(N-(1-(1-(1-acetylpiperidin-4-yl)azetidin-3-yl)-3-(...)
Affinity DataIC50: 2.5nMAssay Description:The compounds were prepared with DMSO to 100 times the final reaction concentration and diluted to 10 concentrations in sequence at a 3-fold dilution...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
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TargetInterleukin-1 receptor-associated kinase 4(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM667783(N-(1-(1-(1-acryloylpiperidin-4-yl)azetidin-3-yl)-3...)
Affinity DataIC50: 2.5nMAssay Description:The compounds were prepared with DMSO to 100 times the final reaction concentration and diluted to 10 concentrations in sequence at a 3-fold dilution...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
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TargetInterleukin-1 receptor-associated kinase 4(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM667775(US11958831, Example 14)
Affinity DataIC50: 3.20nMAssay Description:The compounds were prepared with DMSO to 100 times the final reaction concentration and diluted to 10 concentrations in sequence at a 3-fold dilution...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
Go to US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM667781(N-(3-(difluoromethyl)-1-(1-(1-(dimethylcarbamoyl)p...)
Affinity DataIC50: 3.20nMAssay Description:The compounds were prepared with DMSO to 100 times the final reaction concentration and diluted to 10 concentrations in sequence at a 3-fold dilution...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
Go to US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM667791((S)—N-(3-(difluoromethyl)-1-(1-(1-(2-hydroxyp...)
Affinity DataIC50: 3.30nMAssay Description:The compounds were prepared with DMSO to 100 times the final reaction concentration and diluted to 10 concentrations in sequence at a 3-fold dilution...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
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TargetInterleukin-1 receptor-associated kinase 4(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM667768(N-(1-(1-(1-acetylpiperidin-4-yl)azetidin-3-yl)-3-(...)
Affinity DataIC50: 3.30nMAssay Description:The compounds were prepared with DMSO to 100 times the final reaction concentration and diluted to 10 concentrations in sequence at a 3-fold dilution...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
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TargetInterleukin-1 receptor-associated kinase 4(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM667776(US11958831, Example 15)
Affinity DataIC50: 3.90nMAssay Description:The compounds were prepared with DMSO to 100 times the final reaction concentration and diluted to 10 concentrations in sequence at a 3-fold dilution...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
Go to US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM667767(N-(1-(1-(1-acetylpiperidin-4-yl)azetidin-3-yl)-3-(...)
Affinity DataIC50: 4.20nMAssay Description:The compounds were prepared with DMSO to 100 times the final reaction concentration and diluted to 10 concentrations in sequence at a 3-fold dilution...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
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TargetInterleukin-1 receptor-associated kinase 4(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM667766(US11958831, Example 5)
Affinity DataIC50: 4.30nMAssay Description:The compounds were prepared with DMSO to 100 times the final reaction concentration and diluted to 10 concentrations in sequence at a 3-fold dilution...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
Go to US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM667794(N-(3-(difluoromethyl)-1-(1-(1-(methylsulfonyl)pipe...)
Affinity DataIC50: 4.90nMAssay Description:The compounds were prepared with DMSO to 100 times the final reaction concentration and diluted to 10 concentrations in sequence at a 3-fold dilution...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
Go to US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM667798(6-(1-(2,2-Difluoroethyl)-1H-pyrazol-4-yl)-N-(3-(di...)
Affinity DataIC50: 5.80nMAssay Description:The compounds were prepared with DMSO to 100 times the final reaction concentration and diluted to 10 concentrations in sequence at a 3-fold dilution...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
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TargetInterleukin-1 receptor-associated kinase 4(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 33nMAssay Description:The compounds were prepared with DMSO to 100 times the final reaction concentration and diluted to 10 concentrations in sequence at a 3-fold dilution...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
Go to US Patent