Compile Data Set for Download or QSAR
Report error Found 22 Enz. Inhib. hit(s) with all data for entry = 12176
TargetInterleukin-1 receptor-associated kinase 4(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM395298(6-(Difluoromethyl)-N-[2-(3-hydroxy-3-methylbutyl)-...)
Affinity DataIC50: 1.30nMAssay Description:The IRAK4-inhibitory activity of the inventive substances was measured in the IRAK4 TR-FRET assay (TR-FRET=Time Resolved Fluorescence Resonance Energ...More data for this Ligand-Target Pair
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Date in BDB:
10/21/2024
Entry Details
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TargetInterleukin-1 receptor-associated kinase 4(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM395296(N-[2-(3-Hydroxy-3-methylbutyl)-6-(2-hydroxypropan-...)
Affinity DataIC50: 3.40nMAssay Description:The IRAK4-inhibitory activity of the inventive substances was measured in the IRAK4 TR-FRET assay (TR-FRET=Time Resolved Fluorescence Resonance Energ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2024
Entry Details
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PDB3D3D Structure (crystal)
TargetInterleukin-1 receptor-associated kinase 4(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM395307(N-{2-[2-(1-Hydroxycyclopropyl)ethyl]-6-(2-hydroxyp...)
Affinity DataIC50: 3.70nMAssay Description:The IRAK4-inhibitory activity of the inventive substances was measured in the IRAK4 TR-FRET assay (TR-FRET=Time Resolved Fluorescence Resonance Energ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2024
Entry Details
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TargetInterleukin-1 receptor-associated kinase 4(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM395288(N-[6-(2-Hydroxypropan-2-yl)-2-(3-methoxypropyl)-2H...)
Affinity DataIC50: 7.20nMAssay Description:The IRAK4-inhibitory activity of the inventive substances was measured in the IRAK4 TR-FRET assay (TR-FRET=Time Resolved Fluorescence Resonance Energ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2024
Entry Details
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TargetInterleukin-1 receptor-associated kinase 4(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM395304(5-Fluoro-N-[2-(3-hydroxy-3-methylbutyl)-6-(2-hydro...)
Affinity DataIC50: 8.90nMAssay Description:The IRAK4-inhibitory activity of the inventive substances was measured in the IRAK4 TR-FRET assay (TR-FRET=Time Resolved Fluorescence Resonance Energ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2024
Entry Details
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TargetInterleukin-1 receptor-associated kinase 4(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM395297(N-{6-(2-Hydroxypropan-2-yl)-2-[2-(methylsulphonyl)...)
Affinity DataIC50: 10.7nMAssay Description:The IRAK4-inhibitory activity of the inventive substances was measured in the IRAK4 TR-FRET assay (TR-FRET=Time Resolved Fluorescence Resonance Energ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2024
Entry Details
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TargetInterleukin-1 receptor-associated kinase 4(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM395299(6-(Difluoromethyl)-N-{6-(2-hydroxypropan-2-yl)-2-[...)
Affinity DataIC50: 10.8nMAssay Description:The IRAK4-inhibitory activity of the inventive substances was measured in the IRAK4 TR-FRET assay (TR-FRET=Time Resolved Fluorescence Resonance Energ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2024
Entry Details
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TargetInterleukin-1 receptor-associated kinase 4(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM395300(6-(Difluoromethyl)-N-[6-(2-hydroxypropan-2-yl)-2-(...)
Affinity DataIC50: 12.3nMAssay Description:The IRAK4-inhibitory activity of the inventive substances was measured in the IRAK4 TR-FRET assay (TR-FRET=Time Resolved Fluorescence Resonance Energ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2024
Entry Details
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TargetInterleukin-1 receptor-associated kinase 4(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM395305(N-[2-(3-Hydroxy-3-methylbutyl)-6-(2-hydroxypropan-...)
Affinity DataIC50: 13.3nMAssay Description:The IRAK4-inhibitory activity of the inventive substances was measured in the IRAK4 TR-FRET assay (TR-FRET=Time Resolved Fluorescence Resonance Energ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2024
Entry Details
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TargetInterleukin-1 receptor-associated kinase 4(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM395293(N-[6-(2-Hydroxypropan-2-yl)-2-(oxetan-3-ylmethyl)-...)
Affinity DataIC50: 15nMAssay Description:The IRAK4-inhibitory activity of the inventive substances was measured in the IRAK4 TR-FRET assay (TR-FRET=Time Resolved Fluorescence Resonance Energ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2024
Entry Details
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TargetInterleukin-1 receptor-associated kinase 4(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM395295(N-{6-(2-Hydroxypropan-2-yl)-2-[3-(methylsulphonyl)...)
Affinity DataIC50: 18.5nMAssay Description:The IRAK4-inhibitory activity of the inventive substances was measured in the IRAK4 TR-FRET assay (TR-FRET=Time Resolved Fluorescence Resonance Energ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2024
Entry Details
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TargetInterleukin-1 receptor-associated kinase 4(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM395301(N-[6-(2-Hydroxypropan-2-yl)-2-(4,4,4-trifluorobuty...)
Affinity DataIC50: 21.5nMAssay Description:The IRAK4-inhibitory activity of the inventive substances was measured in the IRAK4 TR-FRET assay (TR-FRET=Time Resolved Fluorescence Resonance Energ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2024
Entry Details
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TargetInterleukin-1 receptor-associated kinase 4(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM395286(N-[6-(2-Hydroxypropan-2-yl)-2-(2-methoxyethyl)-2H-...)
Affinity DataIC50: 30.6nMAssay Description:The IRAK4-inhibitory activity of the inventive substances was measured in the IRAK4 TR-FRET assay (TR-FRET=Time Resolved Fluorescence Resonance Energ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2024
Entry Details
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TargetInterleukin-1 receptor-associated kinase 4(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM395291(N-[6-(2-Hydroxypropan-2-yl)-2-(3-hydroxypropyl)-2H...)
Affinity DataIC50: 35.7nMAssay Description:The IRAK4-inhibitory activity of the inventive substances was measured in the IRAK4 TR-FRET assay (TR-FRET=Time Resolved Fluorescence Resonance Energ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2024
Entry Details
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TargetInterleukin-1 receptor-associated kinase 4(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM395302(N-{6-(2-Hydroxypropan-2-yl)-2-[3-(trifluoromethoxy...)
Affinity DataIC50: 36nMAssay Description:The IRAK4-inhibitory activity of the inventive substances was measured in the IRAK4 TR-FRET assay (TR-FRET=Time Resolved Fluorescence Resonance Energ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2024
Entry Details
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TargetInterleukin-1 receptor-associated kinase 4(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM395303(N-{6-(2-Hydroxypropan-2-yl)-2-[3-(2,2,2-trifluoroe...)
Affinity DataIC50: 47.5nMAssay Description:The IRAK4-inhibitory activity of the inventive substances was measured in the IRAK4 TR-FRET assay (TR-FRET=Time Resolved Fluorescence Resonance Energ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2024
Entry Details
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TargetInterleukin-1 receptor-associated kinase 4(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM395289(N-[6-(Hydroxymethyl)-2-(3-methoxypropyl)-2H-indazo...)
Affinity DataIC50: 52.7nMAssay Description:The IRAK4-inhibitory activity of the inventive substances was measured in the IRAK4 TR-FRET assay (TR-FRET=Time Resolved Fluorescence Resonance Energ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2024
Entry Details
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TargetInterleukin-1 receptor-associated kinase 4(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM395294(N-[6-(Hydroxymethyl)-2-(oxetan-3-ylmethyl)-2H-inda...)
Affinity DataIC50: 104nMAssay Description:The IRAK4-inhibitory activity of the inventive substances was measured in the IRAK4 TR-FRET assay (TR-FRET=Time Resolved Fluorescence Resonance Energ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2024
Entry Details
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TargetInterleukin-1 receptor-associated kinase 4(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM395306(6-(2-Hydroxypropan-2-yl)-N-[6-(2-hydroxypropan-2-y...)
Affinity DataIC50: 117nMAssay Description:The IRAK4-inhibitory activity of the inventive substances was measured in the IRAK4 TR-FRET assay (TR-FRET=Time Resolved Fluorescence Resonance Energ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2024
Entry Details
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TargetInterleukin-1 receptor-associated kinase 4(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM395287(N-[6-(Hydroxymethyl)-2-(2-methoxyethyl)-2H-indazol...)
Affinity DataIC50: 136nMAssay Description:The IRAK4-inhibitory activity of the inventive substances was measured in the IRAK4 TR-FRET assay (TR-FRET=Time Resolved Fluorescence Resonance Energ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2024
Entry Details
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TargetInterleukin-1 receptor-associated kinase 4(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM395290(N-[2-(2-Hydroxyethyl)-6-(2-hydroxypropan-2-yl)-2H-...)
Affinity DataIC50: 264nMAssay Description:The IRAK4-inhibitory activity of the inventive substances was measured in the IRAK4 TR-FRET assay (TR-FRET=Time Resolved Fluorescence Resonance Energ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2024
Entry Details
Go to US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM395292(N-[2-(2-Hydroxyethyl)-6-(hydroxymethyl)-2H-indazol...)
Affinity DataIC50: 867nMAssay Description:The IRAK4-inhibitory activity of the inventive substances was measured in the IRAK4 TR-FRET assay (TR-FRET=Time Resolved Fluorescence Resonance Energ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2024
Entry Details
Go to US Patent