Compile Data Set for Download or QSAR
Report error Found 35 Enz. Inhib. hit(s) with all data for entry = 12460
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
King Saud University

US Patent
LigandPNGBDBM14390(SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...)
Affinity DataIC50: 39.4nMAssay Description:Phosphodiesterase type 5 (PDE5) inhibition assay of compounds of formula I, III, and IV and the reference drug sildenafil were performed according to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/18/2025
Entry Details
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PDB3D3D Structure (crystal)
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
King Saud University

US Patent
LigandPNGBDBM704183(US12139461, Compound C14)
Affinity DataIC50: 39.4nMAssay Description:Phosphodiesterase type 5 (PDE5) inhibition assay of compounds of formula I, III, and IV and the reference drug sildenafil were performed according to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/18/2025
Entry Details
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TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
King Saud University

US Patent
LigandPNGBDBM704190(US12139461, Compound C21)
Affinity DataIC50: 41.2nMAssay Description:Phosphodiesterase type 5 (PDE5) inhibition assay of compounds of formula I, III, and IV and the reference drug sildenafil were performed according to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/18/2025
Entry Details
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TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
King Saud University

US Patent
LigandPNGBDBM704178(US12139461, Compound C9)
Affinity DataIC50: 47.9nMAssay Description:Phosphodiesterase type 5 (PDE5) inhibition assay of compounds of formula I, III, and IV and the reference drug sildenafil were performed according to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/18/2025
Entry Details
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TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
King Saud University

US Patent
LigandPNGBDBM704177(US12139461, Compound C8)
Affinity DataIC50: 54.2nMAssay Description:Phosphodiesterase type 5 (PDE5) inhibition assay of compounds of formula I, III, and IV and the reference drug sildenafil were performed according to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/18/2025
Entry Details
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TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
King Saud University

US Patent
LigandPNGBDBM704193(US12139461, Compound C24)
Affinity DataIC50: 56.4nMAssay Description:Phosphodiesterase type 5 (PDE5) inhibition assay of compounds of formula I, III, and IV and the reference drug sildenafil were performed according to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/18/2025
Entry Details
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TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
King Saud University

US Patent
LigandPNGBDBM704197(US12139461, Compound C28)
Affinity DataIC50: 56.5nMAssay Description:Phosphodiesterase type 5 (PDE5) inhibition assay of compounds of formula I, III, and IV and the reference drug sildenafil were performed according to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/18/2025
Entry Details
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TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
King Saud University

US Patent
LigandPNGBDBM704180(US12139461, Compound C11)
Affinity DataIC50: 56.8nMAssay Description:Phosphodiesterase type 5 (PDE5) inhibition assay of compounds of formula I, III, and IV and the reference drug sildenafil were performed according to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/18/2025
Entry Details
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TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
King Saud University

US Patent
LigandPNGBDBM704199(US12139461, Compound C30)
Affinity DataIC50: 59nMAssay Description:Phosphodiesterase type 5 (PDE5) inhibition assay of compounds of formula I, III, and IV and the reference drug sildenafil were performed according to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/18/2025
Entry Details
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TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
King Saud University

US Patent
LigandPNGBDBM704203(US12139461, Compound C34)
Affinity DataIC50: 60.5nMAssay Description:Phosphodiesterase type 5 (PDE5) inhibition assay of compounds of formula I, III, and IV and the reference drug sildenafil were performed according to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/18/2025
Entry Details
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TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
King Saud University

US Patent
LigandPNGBDBM704189(US12139461, Compound C20)
Affinity DataIC50: 63.3nMAssay Description:Phosphodiesterase type 5 (PDE5) inhibition assay of compounds of formula I, III, and IV and the reference drug sildenafil were performed according to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/18/2025
Entry Details
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TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
King Saud University

US Patent
LigandPNGBDBM704200(US12139461, Compound C31)
Affinity DataIC50: 74.9nMAssay Description:Phosphodiesterase type 5 (PDE5) inhibition assay of compounds of formula I, III, and IV and the reference drug sildenafil were performed according to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/18/2025
Entry Details
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TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
King Saud University

US Patent
LigandPNGBDBM704172(US12139461, Compound C3)
Affinity DataIC50: 85.2nMAssay Description:Phosphodiesterase type 5 (PDE5) inhibition assay of compounds of formula I, III, and IV and the reference drug sildenafil were performed according to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/18/2025
Entry Details
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TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
King Saud University

US Patent
LigandPNGBDBM704202(US12139461, Compound C33)
Affinity DataIC50: 99.8nMAssay Description:Phosphodiesterase type 5 (PDE5) inhibition assay of compounds of formula I, III, and IV and the reference drug sildenafil were performed according to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/18/2025
Entry Details
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TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
King Saud University

US Patent
LigandPNGBDBM704188(US12139461, Compound C19)
Affinity DataIC50: 102nMAssay Description:Phosphodiesterase type 5 (PDE5) inhibition assay of compounds of formula I, III, and IV and the reference drug sildenafil were performed according to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/18/2025
Entry Details
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TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
King Saud University

US Patent
LigandPNGBDBM704170(US12139461, Compound C1)
Affinity DataIC50: 106nMAssay Description:Phosphodiesterase type 5 (PDE5) inhibition assay of compounds of formula I, III, and IV and the reference drug sildenafil were performed according to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/18/2025
Entry Details
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TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
King Saud University

US Patent
LigandPNGBDBM704195(US12139461, Compound C26)
Affinity DataIC50: 107nMAssay Description:Phosphodiesterase type 5 (PDE5) inhibition assay of compounds of formula I, III, and IV and the reference drug sildenafil were performed according to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/18/2025
Entry Details
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TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
King Saud University

US Patent
LigandPNGBDBM50435874(CHEMBL2391073 | US12139461, Compound C18)
Affinity DataIC50: 112nMAssay Description:Phosphodiesterase type 5 (PDE5) inhibition assay of compounds of formula I, III, and IV and the reference drug sildenafil were performed according to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/18/2025
Entry Details
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TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
King Saud University

US Patent
LigandPNGBDBM50001421(CHEMBL339866 | 4-Phenyl-1-(toluene-4-sulfonyl)-pip...)
Affinity DataIC50: 133nMAssay Description:Phosphodiesterase type 5 (PDE5) inhibition assay of compounds of formula I, III, and IV and the reference drug sildenafil were performed according to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/18/2025
Entry Details
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TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
King Saud University

US Patent
LigandPNGBDBM704196(US12139461, Compound C27)
Affinity DataIC50: 143nMAssay Description:Phosphodiesterase type 5 (PDE5) inhibition assay of compounds of formula I, III, and IV and the reference drug sildenafil were performed according to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/18/2025
Entry Details
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TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
King Saud University

US Patent
LigandPNGBDBM704184(US12139461, Compound C15)
Affinity DataIC50: 184nMAssay Description:Phosphodiesterase type 5 (PDE5) inhibition assay of compounds of formula I, III, and IV and the reference drug sildenafil were performed according to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/18/2025
Entry Details
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TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
King Saud University

US Patent
LigandPNGBDBM704171(US12139461, Compound C2)
Affinity DataIC50: 185nMAssay Description:Phosphodiesterase type 5 (PDE5) inhibition assay of compounds of formula I, III, and IV and the reference drug sildenafil were performed according to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/18/2025
Entry Details
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TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
King Saud University

US Patent
LigandPNGBDBM704201(US12139461, Compound C32)
Affinity DataIC50: 203nMAssay Description:Phosphodiesterase type 5 (PDE5) inhibition assay of compounds of formula I, III, and IV and the reference drug sildenafil were performed according to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/18/2025
Entry Details
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TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
King Saud University

US Patent
LigandPNGBDBM704192(US12139461, Compound C23)
Affinity DataIC50: 207nMAssay Description:Phosphodiesterase type 5 (PDE5) inhibition assay of compounds of formula I, III, and IV and the reference drug sildenafil were performed according to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/18/2025
Entry Details
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TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
King Saud University

US Patent
LigandPNGBDBM704194(US12139461, Compound C25)
Affinity DataIC50: 216nMAssay Description:Phosphodiesterase type 5 (PDE5) inhibition assay of compounds of formula I, III, and IV and the reference drug sildenafil were performed according to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/18/2025
Entry Details
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TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
King Saud University

US Patent
LigandPNGBDBM704182(US12139461, Compound C13)
Affinity DataIC50: 221nMAssay Description:Phosphodiesterase type 5 (PDE5) inhibition assay of compounds of formula I, III, and IV and the reference drug sildenafil were performed according to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/18/2025
Entry Details
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TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
King Saud University

US Patent
LigandPNGBDBM704191(US12139461, Compound C22)
Affinity DataIC50: 245nMAssay Description:Phosphodiesterase type 5 (PDE5) inhibition assay of compounds of formula I, III, and IV and the reference drug sildenafil were performed according to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/18/2025
Entry Details
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TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
King Saud University

US Patent
LigandPNGBDBM50435876(CHEMBL2391074 | US12139461, Compound C29)
Affinity DataIC50: 250nMAssay Description:Phosphodiesterase type 5 (PDE5) inhibition assay of compounds of formula I, III, and IV and the reference drug sildenafil were performed according to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/18/2025
Entry Details
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TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
King Saud University

US Patent
LigandPNGBDBM704186(US12139461, Compound C17)
Affinity DataIC50: 279nMAssay Description:Phosphodiesterase type 5 (PDE5) inhibition assay of compounds of formula I, III, and IV and the reference drug sildenafil were performed according to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/18/2025
Entry Details
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TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
King Saud University

US Patent
LigandPNGBDBM704175(US12139461, Compound C6)
Affinity DataIC50: 296nMAssay Description:Phosphodiesterase type 5 (PDE5) inhibition assay of compounds of formula I, III, and IV and the reference drug sildenafil were performed according to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/18/2025
Entry Details
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TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
King Saud University

US Patent
LigandPNGBDBM704173(US12139461, Compound C4)
Affinity DataIC50: 435nMAssay Description:Phosphodiesterase type 5 (PDE5) inhibition assay of compounds of formula I, III, and IV and the reference drug sildenafil were performed according to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/18/2025
Entry Details
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TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
King Saud University

US Patent
LigandPNGBDBM704185(US12139461, Compound C16)
Affinity DataIC50: 484nMAssay Description:Phosphodiesterase type 5 (PDE5) inhibition assay of compounds of formula I, III, and IV and the reference drug sildenafil were performed according to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/18/2025
Entry Details
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TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
King Saud University

US Patent
LigandPNGBDBM704176(US12139461, Compound C7)
Affinity DataIC50: 520nMAssay Description:Phosphodiesterase type 5 (PDE5) inhibition assay of compounds of formula I, III, and IV and the reference drug sildenafil were performed according to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/18/2025
Entry Details
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TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
King Saud University

US Patent
LigandPNGBDBM704174(US12139461, Compound C5)
Affinity DataIC50: 675nMAssay Description:Phosphodiesterase type 5 (PDE5) inhibition assay of compounds of formula I, III, and IV and the reference drug sildenafil were performed according to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/18/2025
Entry Details
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TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
King Saud University

US Patent
LigandPNGBDBM704181(US12139461, Compound C12)
Affinity DataIC50: 874nMAssay Description:Phosphodiesterase type 5 (PDE5) inhibition assay of compounds of formula I, III, and IV and the reference drug sildenafil were performed according to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/18/2025
Entry Details
Go to US Patent