Compile Data Set for Download or QSAR
Report error Found 201 Enz. Inhib. hit(s) with all data for entry = 12578
TargetMelanocortin receptor 4(Human)
Pfizer

US Patent
LigandPNGBDBM50598700(CHEMBL5194472 | US20250084084, Example 91)
Affinity DataKi:  0.0440nMAssay Description:Compounds were solubilized in 100% dimethyl sulfoxide (DMSO) to a concentration of 30 mM. A 10-point intermediate dilution series using half log dilu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2025
Entry Details
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TargetMelanocortin receptor 4(Human)
Pfizer

US Patent
LigandPNGBDBM711525(2-[3-(difluoromethoxy)-5-methoxyphenyl]-1-[(2S)-7-...)
Affinity DataKi:  0.150nMAssay Description:Compounds were solubilized in 100% dimethyl sulfoxide (DMSO) to a concentration of 30 mM. A 10-point intermediate dilution series using half log dilu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/20/2025
Entry Details
Go to US Patent

TargetMelanocortin receptor 4(Human)
Pfizer

US Patent
LigandPNGBDBM711481((2R)-2-(5-Fluoro-2-methoxypyridin-4-yl)-1-{(2S)-7-...)
Affinity DataKi:  0.180nMAssay Description:Compounds were solubilized in 100% dimethyl sulfoxide (DMSO) to a concentration of 30 mM. A 10-point intermediate dilution series using half log dilu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/20/2025
Entry Details
Go to US Patent

TargetMelanocortin receptor 4(Human)
Pfizer

US Patent
LigandPNGBDBM50598690(CHEMBL5181223 | US20250084084, Example 1)
Affinity DataKi:  0.210nMAssay Description:Compounds were solubilized in 100% dimethyl sulfoxide (DMSO) to a concentration of 30 mM. A 10-point intermediate dilution series using half log dilu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2025
Entry Details
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TargetMelanocortin receptor 4(Human)
Pfizer

US Patent
LigandPNGBDBM711586(1-{(2S)-6-[5-(difluoromethyl)-1-methyl-1H-1,2,4-tr...)
Affinity DataKi:  0.220nMAssay Description:Compounds were solubilized in 100% dimethyl sulfoxide (DMSO) to a concentration of 30 mM. A 10-point intermediate dilution series using half log dilu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/20/2025
Entry Details
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TargetMelanocortin receptor 4(Human)
Pfizer

US Patent
LigandPNGBDBM711478((2R)-2-(5-Chloro-2-methoxypyridin-4-yl)-1-[(2S)-7-...)
Affinity DataKi:  0.25nMAssay Description:Compounds were solubilized in 100% dimethyl sulfoxide (DMSO) to a concentration of 30 mM. A 10-point intermediate dilution series using half log dilu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/20/2025
Entry Details
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TargetMelanocortin receptor 4(Human)
Pfizer

US Patent
LigandPNGBDBM711574((2R)-2-(5-fluoro-2-methoxypyridin-4-yl)-1-[(2S)-7-...)
Affinity DataKi:  0.25nMAssay Description:Compounds were solubilized in 100% dimethyl sulfoxide (DMSO) to a concentration of 30 mM. A 10-point intermediate dilution series using half log dilu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/20/2025
Entry Details
Go to US Patent

TargetMelanocortin receptor 4(Human)
Pfizer

US Patent
LigandPNGBDBM711655(2-[2-(difluoromethoxy)-6-methoxypyridin-4-yl]-1-[(...)
Affinity DataKi:  0.270nMAssay Description:Compounds were solubilized in 100% dimethyl sulfoxide (DMSO) to a concentration of 30 mM. A 10-point intermediate dilution series using half log dilu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/20/2025
Entry Details
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TargetMelanocortin receptor 4(Human)
Pfizer

US Patent
LigandPNGBDBM711580((2R)-2-(5-chloro-2-methoxypyridin-4-yl)-1-[(2S)-7-...)
Affinity DataKi:  0.280nMAssay Description:Compounds were solubilized in 100% dimethyl sulfoxide (DMSO) to a concentration of 30 mM. A 10-point intermediate dilution series using half log dilu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/20/2025
Entry Details
Go to US Patent

TargetMelanocortin receptor 4(Human)
Pfizer

US Patent
LigandPNGBDBM711479((2R)-2-(5-Fluoro-2-methoxypyridin-4-yl)-1-[7-methy...)
Affinity DataKi:  0.360nMAssay Description:Compounds were solubilized in 100% dimethyl sulfoxide (DMSO) to a concentration of 30 mM. A 10-point intermediate dilution series using half log dilu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/20/2025
Entry Details
Go to US Patent

TargetMelanocortin receptor 4(Human)
Pfizer

US Patent
LigandPNGBDBM711511(1-[(2S)-7-methyl-6-(pyrimidin-2-yl)-3,4-dihydro-1H...)
Affinity DataKi:  0.360nMAssay Description:Compounds were solubilized in 100% dimethyl sulfoxide (DMSO) to a concentration of 30 mM. A 10-point intermediate dilution series using half log dilu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/20/2025
Entry Details
Go to US Patent

TargetMelanocortin receptor 4(Human)
Pfizer

US Patent
LigandPNGBDBM50598703(CHEMBL5170290 | US20250084084, Example 120)
Affinity DataKi:  0.400nMAssay Description:Compounds were solubilized in 100% dimethyl sulfoxide (DMSO) to a concentration of 30 mM. A 10-point intermediate dilution series using half log dilu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2025
Entry Details
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TargetMelanocortin receptor 4(Human)
Pfizer

US Patent
LigandPNGBDBM711651((2R)-1-{(2S)-6-[1-(difluoromethyl)-5-methyl-1H-1,2...)
Affinity DataKi:  0.410nMAssay Description:Compounds were solubilized in 100% dimethyl sulfoxide (DMSO) to a concentration of 30 mM. A 10-point intermediate dilution series using half log dilu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/20/2025
Entry Details
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TargetMelanocortin receptor 4(Human)
Pfizer

US Patent
LigandPNGBDBM50598694(CHEMBL5208472 | US20250084084, Example 5)
Affinity DataKi:  0.440nMAssay Description:Compounds were solubilized in 100% dimethyl sulfoxide (DMSO) to a concentration of 30 mM. A 10-point intermediate dilution series using half log dilu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2025
Entry Details
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TargetMelanocortin receptor 4(Human)
Pfizer

US Patent
LigandPNGBDBM711592(2-[2-(difluoromethyl)-6-methoxypyrimidin-4-yl]-1-[...)
Affinity DataKi:  0.440nMAssay Description:Compounds were solubilized in 100% dimethyl sulfoxide (DMSO) to a concentration of 30 mM. A 10-point intermediate dilution series using half log dilu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/20/2025
Entry Details
Go to US Patent

TargetMelanocortin receptor 4(Human)
Pfizer

US Patent
LigandPNGBDBM711555((2R)-2-(5-fluoro-2-methoxypyridin-4-yl)-1-{7-methy...)
Affinity DataKi:  0.450nMAssay Description:Compounds were solubilized in 100% dimethyl sulfoxide (DMSO) to a concentration of 30 mM. A 10-point intermediate dilution series using half log dilu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/20/2025
Entry Details
Go to US Patent

TargetMelanocortin receptor 4(Human)
Pfizer

US Patent
LigandPNGBDBM50598696(CHEMBL5183637 | US20250084084, Example 106)
Affinity DataKi:  0.460nMAssay Description:Compounds were solubilized in 100% dimethyl sulfoxide (DMSO) to a concentration of 30 mM. A 10-point intermediate dilution series using half log dilu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2025
Entry Details
Go to US Patent

TargetMelanocortin receptor 4(Human)
Pfizer

US Patent
LigandPNGBDBM711567((2R)-2-(5-chloro-2-methoxypyridin-4-yl)-1-[7-methy...)
Affinity DataKi:  0.480nMAssay Description:Compounds were solubilized in 100% dimethyl sulfoxide (DMSO) to a concentration of 30 mM. A 10-point intermediate dilution series using half log dilu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/20/2025
Entry Details
Go to US Patent

TargetMelanocortin receptor 4(Human)
Pfizer

US Patent
LigandPNGBDBM711577((2R)-2-(5-chloro-2-methoxypyridin-4-yl)-1-[6-(5-me...)
Affinity DataKi:  0.480nMAssay Description:Compounds were solubilized in 100% dimethyl sulfoxide (DMSO) to a concentration of 30 mM. A 10-point intermediate dilution series using half log dilu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/20/2025
Entry Details
Go to US Patent

TargetMelanocortin receptor 4(Human)
Pfizer

US Patent
LigandPNGBDBM711584(1-{(2S)-6-[5-(difluoromethyl)-1-methyl-1H-1,2,4-tr...)
Affinity DataKi:  0.490nMAssay Description:Compounds were solubilized in 100% dimethyl sulfoxide (DMSO) to a concentration of 30 mM. A 10-point intermediate dilution series using half log dilu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/20/2025
Entry Details
Go to US Patent

TargetMelanocortin receptor 4(Human)
Pfizer

US Patent
LigandPNGBDBM711585((2R)-1-{(2S)-6-[5-(difluoromethyl)-1-methyl-1H-1,2...)
Affinity DataKi:  0.490nMAssay Description:Compounds were solubilized in 100% dimethyl sulfoxide (DMSO) to a concentration of 30 mM. A 10-point intermediate dilution series using half log dilu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/20/2025
Entry Details
Go to US Patent

TargetMelanocortin receptor 4(Human)
Pfizer

US Patent
LigandPNGBDBM711519(1-[(2S)-7-methyl-6-(pyrimidin-2-yl)-3,4-dihydro-1H...)
Affinity DataKi:  0.510nMAssay Description:Compounds were solubilized in 100% dimethyl sulfoxide (DMSO) to a concentration of 30 mM. A 10-point intermediate dilution series using half log dilu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/20/2025
Entry Details
Go to US Patent

TargetMelanocortin receptor 4(Human)
Pfizer

US Patent
LigandPNGBDBM711499(2-[5-(difluoromethyl)-2-methoxypyridin-4-yl]-1-[(2...)
Affinity DataKi:  0.520nMAssay Description:Compounds were solubilized in 100% dimethyl sulfoxide (DMSO) to a concentration of 30 mM. A 10-point intermediate dilution series using half log dilu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/20/2025
Entry Details
Go to US Patent

TargetMelanocortin receptor 4(Human)
Pfizer

US Patent
LigandPNGBDBM711504(2-[2-methoxy-5-(trifluoromethyl)pyridin-4-yl]-1-[(...)
Affinity DataKi:  0.530nMAssay Description:Compounds were solubilized in 100% dimethyl sulfoxide (DMSO) to a concentration of 30 mM. A 10-point intermediate dilution series using half log dilu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/20/2025
Entry Details
Go to US Patent

TargetMelanocortin receptor 4(Human)
Pfizer

US Patent
LigandPNGBDBM711466(2-(6-Methoxy-2-methylpyrimidin-4-yl)-1-[(2S)-7-met...)
Affinity DataKi:  0.540nMAssay Description:Compounds were solubilized in 100% dimethyl sulfoxide (DMSO) to a concentration of 30 mM. A 10-point intermediate dilution series using half log dilu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/20/2025
Entry Details
Go to US Patent

TargetMelanocortin receptor 4(Human)
Pfizer

US Patent
LigandPNGBDBM711523(2-[5-chloro-2-(difluoromethoxy)pyridin-4-yl]-1-[(2...)
Affinity DataKi:  0.540nMAssay Description:Compounds were solubilized in 100% dimethyl sulfoxide (DMSO) to a concentration of 30 mM. A 10-point intermediate dilution series using half log dilu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/20/2025
Entry Details
Go to US Patent

TargetMelanocortin receptor 4(Human)
Pfizer

US Patent
LigandPNGBDBM711476((2R)-2-(5-Fluoro-2-methoxypyridin-4-yl)-1-[(2S)-7-...)
Affinity DataKi:  0.600nMAssay Description:Compounds were solubilized in 100% dimethyl sulfoxide (DMSO) to a concentration of 30 mM. A 10-point intermediate dilution series using half log dilu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/20/2025
Entry Details
Go to US Patent

TargetMelanocortin receptor 4(Human)
Pfizer

US Patent
LigandPNGBDBM711483(2-(4-Fluorophenyl)-1-[7-methyl-6-(1-methyl-1H-pyra...)
Affinity DataKi:  0.600nMAssay Description:Compounds were solubilized in 100% dimethyl sulfoxide (DMSO) to a concentration of 30 mM. A 10-point intermediate dilution series using half log dilu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/20/2025
Entry Details
Go to US Patent

TargetMelanocortin receptor 4(Human)
Pfizer

US Patent
LigandPNGBDBM711470(1-[(2S)-7-Methyl-6-(pyrimidin-2-yl)-3,4-dihydro-1H...)
Affinity DataKi:  0.620nMAssay Description:Compounds were solubilized in 100% dimethyl sulfoxide (DMSO) to a concentration of 30 mM. A 10-point intermediate dilution series using half log dilu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/20/2025
Entry Details
Go to US Patent

TargetMelanocortin receptor 4(Human)
Pfizer

US Patent
LigandPNGBDBM711541(2-[2-(difluoromethoxy)-5-fluoropyridin-4-yl]-1-[(2...)
Affinity DataKi:  0.620nMAssay Description:Compounds were solubilized in 100% dimethyl sulfoxide (DMSO) to a concentration of 30 mM. A 10-point intermediate dilution series using half log dilu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/20/2025
Entry Details
Go to US Patent

TargetMelanocortin receptor 4(Human)
Pfizer

US Patent
LigandPNGBDBM711610((2R)-1-[(2S)-6-(7,7-difluoro-6,7-dihydro-5H-pyrrol...)
Affinity DataKi:  0.620nMAssay Description:Compounds were solubilized in 100% dimethyl sulfoxide (DMSO) to a concentration of 30 mM. A 10-point intermediate dilution series using half log dilu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/20/2025
Entry Details
Go to US Patent

TargetMelanocortin receptor 4(Human)
Pfizer

US Patent
LigandPNGBDBM711546(2-(2,6-dimethoxypyridin-4-yl)-1-[(2S)-7-methyl-6-(...)
Affinity DataKi:  0.670nMAssay Description:Compounds were solubilized in 100% dimethyl sulfoxide (DMSO) to a concentration of 30 mM. A 10-point intermediate dilution series using half log dilu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/20/2025
Entry Details
Go to US Patent

TargetMelanocortin receptor 4(Human)
Pfizer

US Patent
LigandPNGBDBM711515(1-[(2S)-7-methyl-6-(pyrimidin-2-yl)-3,4-dihydro-1H...)
Affinity DataKi:  0.680nMAssay Description:Compounds were solubilized in 100% dimethyl sulfoxide (DMSO) to a concentration of 30 mM. A 10-point intermediate dilution series using half log dilu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/20/2025
Entry Details
Go to US Patent

TargetMelanocortin receptor 4(Human)
Pfizer

US Patent
LigandPNGBDBM711617((2R)-2-(5-fluoro-2-methoxypyridin-4-yl)-1-[(2S)-7-...)
Affinity DataKi:  0.720nMAssay Description:Compounds were solubilized in 100% dimethyl sulfoxide (DMSO) to a concentration of 30 mM. A 10-point intermediate dilution series using half log dilu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/20/2025
Entry Details
Go to US Patent

TargetMelanocortin receptor 4(Human)
Pfizer

US Patent
LigandPNGBDBM711572(1-[(2S)-7-methyl-6-(2-methyl-2H-tetrazol-5-yl)-3,4...)
Affinity DataKi:  0.730nMAssay Description:Compounds were solubilized in 100% dimethyl sulfoxide (DMSO) to a concentration of 30 mM. A 10-point intermediate dilution series using half log dilu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/20/2025
Entry Details
Go to US Patent

TargetMelanocortin receptor 4(Human)
Pfizer

US Patent
LigandPNGBDBM711575((2R)-2-(5-fluoro-2-methoxypyridin-4-yl)-1-[6-(5-me...)
Affinity DataKi:  0.780nMAssay Description:Compounds were solubilized in 100% dimethyl sulfoxide (DMSO) to a concentration of 30 mM. A 10-point intermediate dilution series using half log dilu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/20/2025
Entry Details
Go to US Patent

TargetMelanocortin receptor 4(Human)
Pfizer

US Patent
LigandPNGBDBM711513(2-(3,4-difluorophenyl)-1-[(2S)-7-methyl-6-(pyrimid...)
Affinity DataKi:  0.810nMAssay Description:Compounds were solubilized in 100% dimethyl sulfoxide (DMSO) to a concentration of 30 mM. A 10-point intermediate dilution series using half log dilu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/20/2025
Entry Details
Go to US Patent

TargetMelanocortin receptor 4(Human)
Pfizer

US Patent
LigandPNGBDBM711663((2R)-1-{(2S)-6-[4-(difluoromethyl)pyrimidin-2-yl]-...)
Affinity DataKi:  0.820nMAssay Description:Compounds were solubilized in 100% dimethyl sulfoxide (DMSO) to a concentration of 30 mM. A 10-point intermediate dilution series using half log dilu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/20/2025
Entry Details
Go to US Patent

TargetMelanocortin receptor 4(Human)
Pfizer

US Patent
LigandPNGBDBM711581((2R)-2-(5-fluoro-2-methoxypyridin-4-yl)-1-[(2S)-7-...)
Affinity DataKi:  0.830nMAssay Description:Compounds were solubilized in 100% dimethyl sulfoxide (DMSO) to a concentration of 30 mM. A 10-point intermediate dilution series using half log dilu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/20/2025
Entry Details
Go to US Patent

TargetMelanocortin receptor 4(Human)
Pfizer

US Patent
LigandPNGBDBM711497(2-(2,4-dichlorophenyl)-1-[(2S)-7-methyl-6-(pyrimid...)
Affinity DataKi:  0.900nMAssay Description:Compounds were solubilized in 100% dimethyl sulfoxide (DMSO) to a concentration of 30 mM. A 10-point intermediate dilution series using half log dilu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/20/2025
Entry Details
Go to US Patent

TargetMelanocortin receptor 4(Human)
Pfizer

US Patent
LigandPNGBDBM711601((2R)-1-{(2S)-6-[1-(difluoromethyl)-2-methyl-1H-imi...)
Affinity DataKi:  0.900nMAssay Description:Compounds were solubilized in 100% dimethyl sulfoxide (DMSO) to a concentration of 30 mM. A 10-point intermediate dilution series using half log dilu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/20/2025
Entry Details
Go to US Patent

TargetMelanocortin receptor 4(Human)
Pfizer

US Patent
LigandPNGBDBM711517(1-[(2S)-7-methyl-6-(pyrimidin-2-yl)-3,4-dihydro-1H...)
Affinity DataKi:  0.930nMAssay Description:Compounds were solubilized in 100% dimethyl sulfoxide (DMSO) to a concentration of 30 mM. A 10-point intermediate dilution series using half log dilu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/20/2025
Entry Details
Go to US Patent

TargetMelanocortin receptor 4(Human)
Pfizer

US Patent
LigandPNGBDBM711508(2-[6-(difluoromethoxy)-2-methylpyrimidin-4-yl]-1-[...)
Affinity DataKi:  0.950nMAssay Description:Compounds were solubilized in 100% dimethyl sulfoxide (DMSO) to a concentration of 30 mM. A 10-point intermediate dilution series using half log dilu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/20/2025
Entry Details
Go to US Patent

TargetMelanocortin receptor 4(Human)
Pfizer

US Patent
LigandPNGBDBM711590(2-[2-(difluoromethyl)-6-methoxypyrimidin-4-yl]-1-[...)
Affinity DataKi:  0.970nMAssay Description:Compounds were solubilized in 100% dimethyl sulfoxide (DMSO) to a concentration of 30 mM. A 10-point intermediate dilution series using half log dilu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/20/2025
Entry Details
Go to US Patent

TargetMelanocortin receptor 4(Human)
Pfizer

US Patent
LigandPNGBDBM50598697(CHEMBL5179337 | US12187727, Example 64)
Affinity DataKi:  1nMAssay Description:Compounds were solubilized in 100% dimethyl sulfoxide (DMSO) to a concentration of 30 mM. A 10-point intermediate dilution series using half log dilu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2025
Entry Details
Go to US Patent

TargetMelanocortin receptor 4(Human)
Pfizer

US Patent
LigandPNGBDBM711563((2R)-2-(5-chloro-2-methoxypyridin-4-yl)-1-(7-methy...)
Affinity DataKi:  1.10nMAssay Description:Compounds were solubilized in 100% dimethyl sulfoxide (DMSO) to a concentration of 30 mM. A 10-point intermediate dilution series using half log dilu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/20/2025
Entry Details
Go to US Patent

TargetMelanocortin receptor 4(Human)
Pfizer

US Patent
LigandPNGBDBM711557((2R)-2-(5-chloro-2-methoxypyridin-4-yl)-1-{7-methy...)
Affinity DataKi:  1.20nMAssay Description:Compounds were solubilized in 100% dimethyl sulfoxide (DMSO) to a concentration of 30 mM. A 10-point intermediate dilution series using half log dilu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/20/2025
Entry Details
Go to US Patent

TargetMelanocortin receptor 4(Human)
Pfizer

US Patent
LigandPNGBDBM711571(2-[6-(difluoromethoxy)pyridin-3-yl]-1-[(2S)-7-meth...)
Affinity DataKi:  1.20nMAssay Description:Compounds were solubilized in 100% dimethyl sulfoxide (DMSO) to a concentration of 30 mM. A 10-point intermediate dilution series using half log dilu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/20/2025
Entry Details
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TargetMelanocortin receptor 4(Human)
Pfizer

US Patent
LigandPNGBDBM711609((2R)-2-(5-fluoro-2-methoxypyridin-4-yl)-1-[(2S)-6-...)
Affinity DataKi:  1.20nMAssay Description:Compounds were solubilized in 100% dimethyl sulfoxide (DMSO) to a concentration of 30 mM. A 10-point intermediate dilution series using half log dilu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/20/2025
Entry Details
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TargetMelanocortin receptor 4(Human)
Pfizer

US Patent
LigandPNGBDBM711658(2-[2-(difluoromethoxy)pyridin-4-yl]-1-[(2S)-7-meth...)
Affinity DataKi:  1.20nMAssay Description:Compounds were solubilized in 100% dimethyl sulfoxide (DMSO) to a concentration of 30 mM. A 10-point intermediate dilution series using half log dilu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/20/2025
Entry Details
Go to US Patent

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