Compile Data Set for Download or QSAR
Report error Found 421 Enz. Inhib. hit(s) with all data for entry = 13327
TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM50547925(CHEMBL4798938 | US12441703, Compound 320)
Affinity DataIC50: 0.400nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM50547926(CHEMBL4753280 | US12441703, Compound 323)
Affinity DataIC50: 0.800nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM50547929(CHEMBL4744908 | US12441703, Compound 326)
Affinity DataIC50: 1.30nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM50547924(CHEMBL4750365 | US12441703, Compound 309)
Affinity DataIC50: 1.40nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM50547928(CHEMBL4787299 | US12441703, Compound 325)
Affinity DataIC50: 1.60nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM50547927(CHEMBL4756380 | US12441703, Compound 324)
Affinity DataIC50: 1.70nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM50547930(CHEMBL4782190 | US12441703, Compound 352)
Affinity DataIC50: 1.80nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM781487(4-[[2-Fluoro-4-Methoxy-6-[2-Methoxy-4-(Trifluorome...)
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM781533(4-[[6-[2-Methoxy-4-(Trifluoromethoxy)Phenoxy]-2-Me...)
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM781276(4-[[2-Fluoro-6-[2-Methoxy-4-(Trifluoromethoxy)Phen...)
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM781243(US12441703, Compound 117)
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM50547922(CHEMBL4761578 | US12441703, Compound 194)
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM50547921(CHEMBL4785523 | US12441703, Compound 191)
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM50547923(CHEMBL4763419 | US12441703, Compound 305)
Affinity DataIC50: 2.30nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM781471(US12441703, Compound 345)
Affinity DataIC50: 2.5nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM781438(4-[[3-Cyclobutyl-2-Fluoro-6-[3-Fluoro-2-Methoxy-4-...)
Affinity DataIC50: 2.5nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM781459(N-(2-Carbamoyl-4-Pyridyl)-3-Fluoro-5-[3-Fluoro-2-M...)
Affinity DataIC50: 2.70nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM781394(4-[[3-Chloro-2-Fluoro-4-Methoxy-6-[2-Methoxy-4-(Tr...)
Affinity DataIC50: 2.80nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM781488(4-[[2-Chloro-4-Methoxy-6-[2-Methoxy-4-(Trifluorome...)
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM50547919(CHEMBL4764805 | US12441703, Compound 147)
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM781473(4-[[6-[2-Ethoxy-4-(Trifluoromethoxy)Phenoxy]-2-Flu...)
Affinity DataIC50: 3.10nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM781482(US12441703, Compound 356)
Affinity DataIC50: 3.30nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM781406(4-[[2-Fluoro-6-[2-Methoxy-4-(Trifluoromethoxy)Phen...)
Affinity DataIC50: 3.60nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM781421(4-[[2-Fluoro-6-[3-Fluoro-2-Methyl-4-(Trifluorometh...)
Affinity DataIC50: 3.90nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM781412(4-[[2-Fluoro-3-Methoxy-6-[2-Methoxy-4-(Trifluorome...)
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM781408(4-[[2-Fluoro-6-[2-Methoxy-4-(Trifluoromethoxy)Phen...)
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM50547920(CHEMBL4759624 | US12441703, Compound 151)
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM781320(US12441703, Compound 192)
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM781411(4-[[4-Methoxy-6-[2-Methoxy-4-(Trifluoromethoxy)Phe...)
Affinity DataIC50: 4.20nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM781458(US12441703, Compound 331)
Affinity DataIC50: 4.60nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM781470(US12441703, Compound 344)
Affinity DataIC50: 4.70nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM781469(US12441703, Compound 343)
Affinity DataIC50: 4.80nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM781460(N-(2-Carbamoyl-4-Pyridyl)-5-[3-Fluoro-2-Methoxy-4-...)
Affinity DataIC50: 4.90nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM781493(4-[[6-[2-Chloro-4-(Trifluoromethoxy)Phenoxy]-2-Flu...)
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM781506(4-(6-(2-Chloro-4-Fluorophenoxy)-2-Fluoro-3-Methoxy...)
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM781323(US12441703, Compound 195)
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM781447(4-[[3-(Difluoromethyl)-6-[3-Fluoro-2-(Trideuteriom...)
Affinity DataIC50: 5.20nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM781463(N-(2-Carbamoyl-5-Methyl-4-Pyridyl)-5-[3-Fluoro-2-M...)
Affinity DataIC50: 5.60nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM781472(4-[[6-[2-Ethoxy-4-(Trifluoromethoxy)Phenoxy]-2-Flu...)
Affinity DataIC50: 5.80nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM781435(4-[[2,3,4-Trifluoro-6-[3-Fluoro-2-Methoxy-4-(Trifl...)
Affinity DataIC50: 5.90nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM781330(4-[[2,2-Difluoro-6-[2-Methoxy-4-(Trifluoromethoxy)...)
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM781548(US12441703, Compound 1040)
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM781321(US12441703, Compound 193)
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM781497(4-[[4-Chloro-6-(3,4-Difluoro-2-Methoxy-Phenoxy)-2-...)
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM781352(5-[[6-[3-Fluoro-2-Methoxy-4-(Trifluoromethoxy)Phen...)
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM781450(4-[[2-Fluoro-6-[3-Fluoro-2-Methoxy-4-(Trifluoromet...)
Affinity DataIC50: 6.10nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM781427(4-[[6-(3,4-Difluoro-2-Methoxy-Phenoxy)-2-Fluoro-4-...)
Affinity DataIC50: 6.40nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM781442(US12441703, Compound 314)
Affinity DataIC50: 6.5nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM781423(4-[[3-Chloro-2-Fluoro-6-[3-Fluoro-2-Methyl-4-(Trif...)
Affinity DataIC50: 6.5nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM781422(4-[[2-Fluoro-6-[3-Fluoro-2-Methyl-4-(Trifluorometh...)
Affinity DataIC50: 6.80nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

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