Compile Data Set for Download or QSAR
Report error Found 10 Enz. Inhib. hit(s) with all data for entry = 11428
TargetEKC/KEOPS complex subunit TP53RK(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM616156(US20230271966, Compound 12 | (R)-2-(3-methyl-2,6-d...)
Affinity DataKd:  280nMAssay Description:All calorimetric experiments were carried out using an Affinity ITC from TA Instruments (New Castle, Del.) equipped with an auto sampler in a buffer ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2023
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetEKC/KEOPS complex subunit TP53RK(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM616159(US20230271966, Compound 30 | (R)-2-(3-methyl-2,6-d...)
Affinity DataKd:  360nMAssay Description:All calorimetric experiments were carried out using an Affinity ITC from TA Instruments (New Castle, Del.) equipped with an auto sampler in a buffer ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2023
Entry Details
US Patent

TargetProtein cereblon(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM616157(US20230271966, Compound 13 | 2-(2,6-dioxopiperidin...)
Affinity DataKd:  540nMAssay Description:All calorimetric experiments were carried out using an Affinity ITC from TA Instruments (New Castle, Del.) equipped with an auto sampler in a buffer ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2023
Entry Details
US Patent

TargetEKC/KEOPS complex subunit TP53RK(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM616157(US20230271966, Compound 13 | 2-(2,6-dioxopiperidin...)
Affinity DataKd:  1.90E+3nMAssay Description:All calorimetric experiments were carried out using an Affinity ITC from TA Instruments (New Castle, Del.) equipped with an auto sampler in a buffer ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2023
Entry Details
US Patent

TargetProtein cereblon(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM65456(pomalidomide | US9694015, 6.2 | 19171-19-8 | 4-ami...)
Affinity DataKd:  5.10E+3nMAssay Description:All calorimetric experiments were carried out using an Affinity ITC from TA Instruments (New Castle, Del.) equipped with an auto sampler in a buffer ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2023
Entry Details
US Patent

TargetEKC/KEOPS complex subunit TP53RK(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM65456(pomalidomide | US9694015, 6.2 | 19171-19-8 | 4-ami...)
Affinity DataKd:  5.20E+3nMAssay Description:All calorimetric experiments were carried out using an Affinity ITC from TA Instruments (New Castle, Del.) equipped with an auto sampler in a buffer ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2023
Entry Details
US Patent

TargetProtein cereblon(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM616156(US20230271966, Compound 12 | (R)-2-(3-methyl-2,6-d...)
Affinity DataKd: >1.00E+6nMAssay Description:All calorimetric experiments were carried out using an Affinity ITC from TA Instruments (New Castle, Del.) equipped with an auto sampler in a buffer ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2023
Entry Details
US Patent

TargetEKC/KEOPS complex subunit TP53RK(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM616158(US20230271966, Compound 22 | (R)-4-hydroxy-2-(3-me...)
Affinity DataKd: >1.00E+6nMAssay Description:All calorimetric experiments were carried out using an Affinity ITC from TA Instruments (New Castle, Del.) equipped with an auto sampler in a buffer ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2023
Entry Details
US Patent

TargetProtein cereblon(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM616158(US20230271966, Compound 22 | (R)-4-hydroxy-2-(3-me...)
Affinity DataKd: >1.00E+6nMAssay Description:All calorimetric experiments were carried out using an Affinity ITC from TA Instruments (New Castle, Del.) equipped with an auto sampler in a buffer ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2023
Entry Details
US Patent

TargetProtein cereblon(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM616159(US20230271966, Compound 30 | (R)-2-(3-methyl-2,6-d...)
Affinity DataKd: >1.00E+6nMAssay Description:All calorimetric experiments were carried out using an Affinity ITC from TA Instruments (New Castle, Del.) equipped with an auto sampler in a buffer ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2023
Entry Details
US Patent