Compile Data Set for Download or QSAR
Report error Found 5 Enz. Inhib. hit(s) with all data for entry = 11912
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Revolution Medicines

US Patent
LigandPNGBDBM50546223(CHEMBL4740286 | US20240092795, Example 2)
Affinity DataIC50: 37nMAssay Description:The catalytic activity of SHP2 was monitored using the surrogate substrate DiFMUP in a prompt fluorescence assay format.The phosphatase reactions wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2024
Entry Details
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TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Revolution Medicines

US Patent
LigandPNGBDBM660323(US20240092795, Example 4)
Affinity DataIC50: 69nMAssay Description:The catalytic activity of SHP2 was monitored using the surrogate substrate DiFMUP in a prompt fluorescence assay format.The phosphatase reactions wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2024
Entry Details
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TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Revolution Medicines

US Patent
LigandPNGBDBM660320(US20240092795, Example 1)
Affinity DataIC50: 210nMAssay Description:The catalytic activity of SHP2 was monitored using the surrogate substrate DiFMUP in a prompt fluorescence assay format.The phosphatase reactions wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2024
Entry Details
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TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Revolution Medicines

US Patent
LigandPNGBDBM660324(US20240092795, Example 5)
Affinity DataIC50: 210nMAssay Description:The catalytic activity of SHP2 was monitored using the surrogate substrate DiFMUP in a prompt fluorescence assay format.The phosphatase reactions wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2024
Entry Details
Go to US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Revolution Medicines

US Patent
LigandPNGBDBM660322(US20240092795, Example 3)
Affinity DataIC50: 740nMAssay Description:The catalytic activity of SHP2 was monitored using the surrogate substrate DiFMUP in a prompt fluorescence assay format.The phosphatase reactions wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2024
Entry Details
Go to US Patent