Compile Data Set for Download or QSAR
Report error Found 310 Enz. Inhib. hit(s) with all data for entry = 12315
LigandPNGBDBM694701((7S)-9-(2,6-difluorophenyl)-4,7-dimethyl-13,16-dio...)
Affinity DataKi:  0.890nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 uL (96-well plates) which contained 100 uL of cell membranes, [3H]Flumazenil ...More data for this Ligand-Target Pair
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Date in BDB:
12/21/2024
Entry Details
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LigandPNGBDBM694693((7S)-9-(2,6-difluorophenyl)-4,7-dimethyl-18-thia-2...)
Affinity DataKi:  0.980nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 uL (96-well plates) which contained 100 uL of cell membranes, [3H]Flumazenil ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
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LigandPNGBDBM694723((7S)-9-(2,6-difluorophenyl)-3,7-dimethyl-13,16-dio...)
Affinity DataKi:  0.980nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 uL (96-well plates) which contained 100 uL of cell membranes, [3H]Flumazenil ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
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LigandPNGBDBM694695(azetidin-1-yl-[(7S)-9-(2,6-difluorophenyl)-7-methy...)
Affinity DataKi:  1.12nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 uL (96-well plates) which contained 100 uL of cell membranes, [3H]Flumazenil ...More data for this Ligand-Target Pair
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In Depth
Date in BDB:
12/21/2024
Entry Details
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LigandPNGBDBM694697((3-fluoroazetidin-1-yl)-[(7S)-9-(2,6-difluoropheny...)
Affinity DataKi:  1.25nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 uL (96-well plates) which contained 100 uL of cell membranes, [3H]Flumazenil ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
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LigandPNGBDBM694674(9-(2,6-difluorophenyl)-3-methyl-18-thia-2,4,5,8-te...)
Affinity DataKi:  1.40nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 uL (96-well plates) which contained 100 uL of cell membranes, [3H]Flumazenil ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
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LigandPNGBDBM694730((7S)-9-(2,6-difluorophenyl)-4,7-dimethyl-13-oxa-18...)
Affinity DataKi:  1.53nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 uL (96-well plates) which contained 100 uL of cell membranes, [3H]Flumazenil ...More data for this Ligand-Target Pair
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In Depth
Date in BDB:
12/21/2024
Entry Details
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LigandPNGBDBM694738((7S)-9-(2,6-difluorophenyl)-N-[(1-hydroxycycloprop...)
Affinity DataKi:  1.69nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 uL (96-well plates) which contained 100 uL of cell membranes, [3H]Flumazenil ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
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LigandPNGBDBM694675((7S)-9-(2,6-difluorophenyl)-3,7-dimethyl-18-thia-2...)
Affinity DataKi:  1.70nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 uL (96-well plates) which contained 100 uL of cell membranes, [3H]Flumazenil ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
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LigandPNGBDBM694690((7S,15S)-9-(2,6-difluorophenyl)-15-fluoro-3,7-dime...)
Affinity DataKi:  1.77nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 uL (96-well plates) which contained 100 uL of cell membranes, [3H]Flumazenil ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
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LigandPNGBDBM694702((3-tert-butoxyazetidin-1-yl)-[(7S)-9-(2,6-difluoro...)
Affinity DataKi:  1.82nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 uL (96-well plates) which contained 100 uL of cell membranes, [3H]Flumazenil ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
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LigandPNGBDBM694691(9-(2,6-difluorophenyl)-3-methyl-16-oxa-18-thia-2,4...)
Affinity DataKi:  1.84nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 uL (96-well plates) which contained 100 uL of cell membranes, [3H]Flumazenil ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
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LigandPNGBDBM694692((7S)-9-(2,6-difluorophenyl)-3,7-dimethyl-16-oxa-18...)
Affinity DataKi:  1.86nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 uL (96-well plates) which contained 100 uL of cell membranes, [3H]Flumazenil ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
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LigandPNGBDBM694704([(7S)-9-(2,6-Difluorophenyl)-7-methyl-13,16-dioxa-...)
Affinity DataKi:  1.88nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 uL (96-well plates) which contained 100 uL of cell membranes, [3H]Flumazenil ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
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LigandPNGBDBM694698((7S)-9-(2,6-difluorophenyl)-N-(2-fluoroethyl)-7-me...)
Affinity DataKi:  2.10nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 uL (96-well plates) which contained 100 uL of cell membranes, [3H]Flumazenil ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
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LigandPNGBDBM694680((8S)-10-(2,6-difluorophenyl)-8-methyl-19-thia-2,6,...)
Affinity DataKi:  2.24nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 uL (96-well plates) which contained 100 uL of cell membranes, [3H]Flumazenil ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
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LigandPNGBDBM694732((7S)-9-(2,6-difluorophenyl)-N-(2-hydroxy-2-methyl-...)
Affinity DataKi:  2.27nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 uL (96-well plates) which contained 100 uL of cell membranes, [3H]Flumazenil ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
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LigandPNGBDBM694694((7S)-9-(2,6-difluorophenyl)-3,7-dimethyl-13,16-dio...)
Affinity DataKi:  2.33nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 uL (96-well plates) which contained 100 uL of cell membranes, [3H]Flumazenil ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
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LigandPNGBDBM694704([(7S)-9-(2,6-Difluorophenyl)-7-methyl-13,16-dioxa-...)
Affinity DataKi:  2.40nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 uL (96-well plates) which contained 100 uL of cell membranes, [3H]Flumazenil ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
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LigandPNGBDBM694695(azetidin-1-yl-[(7S)-9-(2,6-difluorophenyl)-7-methy...)
Affinity DataKi:  2.49nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 uL (96-well plates) which contained 100 uL of cell membranes, [3H]Flumazenil ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
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LigandPNGBDBM694731((7S)-9-(2,6-difluorophenyl)-4,7-dimethyl-13-oxa-18...)
Affinity DataKi:  2.59nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 uL (96-well plates) which contained 100 uL of cell membranes, [3H]Flumazenil ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
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LigandPNGBDBM694685((7S,16S)-9-(2,6-difluorophenyl)-16-fluoro-3,7-dime...)
Affinity DataKi:  2.65nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 uL (96-well plates) which contained 100 uL of cell membranes, [3H]Flumazenil ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
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LigandPNGBDBM694713([(7S,15S)-9-(2,6-difluorophenyl)-7,15-dimethyl-13,...)
Affinity DataKi:  2.65nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 uL (96-well plates) which contained 100 uL of cell membranes, [3H]Flumazenil ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
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LigandPNGBDBM694684((7S,16R)-9-(2,6-difluorophenyl)-16-fluoro-3,7-dime...)
Affinity DataKi:  2.70nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 uL (96-well plates) which contained 100 uL of cell membranes, [3H]Flumazenil ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
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LigandPNGBDBM694683((7S,16RS)-9-(2,6-difluorophenyl)-16-fluoro-3,7-dim...)
Affinity DataKi:  2.72nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 uL (96-well plates) which contained 100 uL of cell membranes, [3H]Flumazenil ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
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LigandPNGBDBM694682((7S,16RS)-9-(2,6-difluorophenyl)-3,7-dimethyl-18-t...)
Affinity DataKi:  2.79nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 uL (96-well plates) which contained 100 uL of cell membranes, [3H]Flumazenil ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
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LigandPNGBDBM694733((7S)-9-(2,6-difluorophenyl)-N-[(1-hydroxycycloprop...)
Affinity DataKi:  2.86nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 uL (96-well plates) which contained 100 uL of cell membranes, [3H]Flumazenil ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
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LigandPNGBDBM694715((7S)-9-(2,6-difluorophenyl)-3-ethyl-7-methyl-13,16...)
Affinity DataKi:  2.90nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 uL (96-well plates) which contained 100 uL of cell membranes, [3H]Flumazenil ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
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LigandPNGBDBM694739((7S)-9-(2,6-difluorophenyl)-N-(2-hydroxyethyl)-7-m...)
Affinity DataKi:  2.94nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 uL (96-well plates) which contained 100 uL of cell membranes, [3H]Flumazenil ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
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LigandPNGBDBM694741((7S)-9-(2,6-difluorophenyl)-N-[(1-hydroxycycloprop...)
Affinity DataKi:  2.95nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 uL (96-well plates) which contained 100 uL of cell membranes, [3H]Flumazenil ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
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LigandPNGBDBM694710(US20240294543, Example 38 | (7S)-9-(2,6-difluoroph...)
Affinity DataKi:  3.21nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 uL (96-well plates) which contained 100 uL of cell membranes, [3H]Flumazenil ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
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LigandPNGBDBM694718((7S)-9-(2,6-difluorophenyl)-N-(2-hydroxy-2-methyl-...)
Affinity DataKi:  3.25nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 uL (96-well plates) which contained 100 uL of cell membranes, [3H]Flumazenil ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
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LigandPNGBDBM694703((7S,15S)-9-(2,6-difluorophenyl)-3,7,15-trimethyl-1...)
Affinity DataKi:  3.28nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 uL (96-well plates) which contained 100 uL of cell membranes, [3H]Flumazenil ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
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LigandPNGBDBM694722((7S,15S)-9-(2,6-difluorophenyl)-4-ethyl-7,15-dimet...)
Affinity DataKi:  3.32nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 uL (96-well plates) which contained 100 uL of cell membranes, [3H]Flumazenil ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
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LigandPNGBDBM694712((7S,15S)-9-(2,6-difluorophenyl)-4,7,15-trimethyl-1...)
Affinity DataKi:  3.47nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 uL (96-well plates) which contained 100 uL of cell membranes, [3H]Flumazenil ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
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LigandPNGBDBM694719((7S)-9-(2,6-difluorophenyl)-7-methyl-N-[(2R)-3,3,3...)
Affinity DataKi:  3.54nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 uL (96-well plates) which contained 100 uL of cell membranes, [3H]Flumazenil ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
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LigandPNGBDBM694710(US20240294543, Example 38 | (7S)-9-(2,6-difluoroph...)
Affinity DataKi:  3.59nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 uL (96-well plates) which contained 100 uL of cell membranes, [3H]Flumazenil ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
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LigandPNGBDBM694709([(7S) N-cyclopropyl-9-(2,6-difluorophenyl)-7-methy...)
Affinity DataKi:  3.66nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 uL (96-well plates) which contained 100 uL of cell membranes, [3H]Flumazenil ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
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LigandPNGBDBM694676((7S)-3-cyclopropyl-9-(2,6-difluorophenyl)-7-methyl...)
Affinity DataKi:  3.69nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 uL (96-well plates) which contained 100 uL of cell membranes, [3H]Flumazenil ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
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LigandPNGBDBM694679((7S)-9-(2,6-difluorophenyl)-7-methyl-18-thia-2,4,5...)
Affinity DataKi:  3.69nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 uL (96-well plates) which contained 100 uL of cell membranes, [3H]Flumazenil ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
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LigandPNGBDBM694697((3-fluoroazetidin-1-yl)-[(7S)-9-(2,6-difluoropheny...)
Affinity DataKi:  3.75nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 uL (96-well plates) which contained 100 uL of cell membranes, [3H]Flumazenil ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
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LigandPNGBDBM694699((8S)-10-(2,6-difluorophenyl)-4,8-dimethyl-19-thia-...)
Affinity DataKi:  3.78nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 uL (96-well plates) which contained 100 uL of cell membranes, [3H]Flumazenil ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
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LigandPNGBDBM694697((3-fluoroazetidin-1-yl)-[(7S)-9-(2,6-difluoropheny...)
Affinity DataKi:  3.80nMAssay Description:Table 2: Electrophysiological experiments were performed using the Roboocyte instrument (MultiChannelSystems, Reutlingen, Germany) on days 3 to 5 aft...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
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LigandPNGBDBM694690((7S,15S)-9-(2,6-difluorophenyl)-15-fluoro-3,7-dime...)
Affinity DataKi:  4.30nMAssay Description:Table 2: Electrophysiological experiments were performed using the Roboocyte instrument (MultiChannelSystems, Reutlingen, Germany) on days 3 to 5 aft...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
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LigandPNGBDBM694690((7S,15S)-9-(2,6-difluorophenyl)-15-fluoro-3,7-dime...)
Affinity DataKi:  4.31nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 uL (96-well plates) which contained 100 uL of cell membranes, [3H]Flumazenil ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
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LigandPNGBDBM694720((7S)-9-(2,6-difluorophenyl)-7-methyl-N-[(2S)-3,3,3...)
Affinity DataKi:  4.43nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 uL (96-well plates) which contained 100 uL of cell membranes, [3H]Flumazenil ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
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LigandPNGBDBM694716((7S)-3-cyclopropyl-9-(2,6-difluorophenyl)-7-methyl...)
Affinity DataKi:  4.45nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 uL (96-well plates) which contained 100 uL of cell membranes, [3H]Flumazenil ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
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LigandPNGBDBM694687((7S,14S)-9-(2,6-difluorophenyl)-14-fluoro-3,7-dime...)
Affinity DataKi:  4.87nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 uL (96-well plates) which contained 100 uL of cell membranes, [3H]Flumazenil ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
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LigandPNGBDBM694717((7S)-9-(2,6-difluorophenyl)-3-isopropyl-7-methyl-1...)
Affinity DataKi:  4.87nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 uL (96-well plates) which contained 100 uL of cell membranes, [3H]Flumazenil ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
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LigandPNGBDBM694734((7S)-9-(2-chloro-6-fluoro-phenyl)-3,7-dimethyl-13-...)
Affinity DataKi:  4.98nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 uL (96-well plates) which contained 100 uL of cell membranes, [3H]Flumazenil ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
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