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Report error Found 12 Enz. Inhib. hit(s) with all data for entry = 12429
TargetTyrosine-protein kinase BTK(Human)
Pharmacyclics

US Patent
LigandPNGBDBM50357312(IBRUTINIB | US9181263, 1 | US9108973, Ref 1 | US92...)
Affinity DataIC50: 0.5nMAssay Description:Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. Measurements were performed in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2025
Entry Details
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TargetTyrosine-protein kinase BTK(Human)
Pharmacyclics

US Patent
LigandPNGBDBM97673(US8497277, 6 | US8476284, 41 | US20240358707, Comp...)
Affinity DataIC50: 0.520nMAssay Description:Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. Measurements were performed in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2025
Entry Details
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TargetTyrosine-protein kinase BTK(Human)
Pharmacyclics

US Patent
LigandPNGBDBM97677(US8497277, 7 | US8476284, 7 | US9133201, 7 | US202...)
Affinity DataIC50: 0.580nMAssay Description:Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. Measurements were performed in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2025
Entry Details
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TargetTyrosine-protein kinase BTK(Human)
Pharmacyclics

US Patent
LigandPNGBDBM97672(US8476284, 40 | US9133201, 10 | US9181263, 9 | US9...)
Affinity DataIC50: 0.580nMAssay Description:Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. Measurements were performed in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2025
Entry Details
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TargetTyrosine-protein kinase BTK(Human)
Pharmacyclics

US Patent
LigandPNGBDBM98652(US8497277, 13 | US8497277, 4)
Affinity DataIC50: 0.720nMAssay Description:Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. Measurements were performed in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2025
Entry Details
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TargetTyrosine-protein kinase BTK(Human)
Pharmacyclics

US Patent
LigandPNGBDBM97674(US8497277, 8 | US8476284, 42 | US9133201, 8 | US20...)
Affinity DataIC50: 0.720nMAssay Description:Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. Measurements were performed in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Pharmacyclics

US Patent
LigandPNGBDBM97669(US8497277, 14 | US8476284, 37 | US20240358707, Com...)
Affinity DataIC50: 1.40nMAssay Description:Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. Measurements were performed in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2025
Entry Details
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TargetTyrosine-protein kinase BTK(Human)
Pharmacyclics

US Patent
LigandPNGBDBM97671(US8476284, 39 | US9133201, 11 | US20240358707, Com...)
Affinity DataIC50: 1.60nMAssay Description:Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. Measurements were performed in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2025
Entry Details
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TargetTyrosine-protein kinase BTK(Human)
Pharmacyclics

US Patent
LigandPNGBDBM97670(US8476284, 38 | US9133201, 12 | US20240358707, Com...)
Affinity DataIC50: 1.90nMAssay Description:Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. Measurements were performed in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2025
Entry Details
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TargetTyrosine-protein kinase BTK(Human)
Pharmacyclics

US Patent
LigandPNGBDBM702022(Synthesis of (E)-1-(3-(4-amino-3-(4-phenoxyphenyl)...)
Affinity DataIC50: 2.5nMAssay Description:Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. Measurements were performed in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2025
Entry Details
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TargetTyrosine-protein kinase BTK(Human)
Pharmacyclics

US Patent
LigandPNGBDBM98653(US8497277, 9 | US20240358707, Compound 9)
Affinity DataIC50: 3.60nMAssay Description:Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. Measurements were performed in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2025
Entry Details
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TargetTyrosine-protein kinase BTK(Human)
Pharmacyclics

US Patent
LigandPNGBDBM97676(US8497277, 5 | US8476284, 5 | US9133201, 5 | US202...)
Affinity DataIC50: 20nMAssay Description:Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. Measurements were performed in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2025
Entry Details
Go to US Patent