Compile Data Set for Download or QSAR
Report error Found 405 Enz. Inhib. hit(s) with all data for entry = 13505
TargetSerine/threonine-protein kinase SIK2(Human)
Beone Medicines I

US Patent
LigandChemical structure of BindingDB Monomer ID 800328BDBM800328(2-(difluoromethoxy)-N-((1R,2S)-2-fluorocyclopropyl...)
Affinity DataIC50: 1.40nMAssay Description:Compounds were tested for inhibition of SIK2 kinase (full length, Thermo Fisher) in assays based on the time-resolved fluorescence-resonance energy t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/5/2026
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Beone Medicines I

US Patent
LigandChemical structure of BindingDB Monomer ID 800329BDBM800329(2-(difluoromethoxy)-N-((1R,2S)-2-fluorocyclopropyl...)
Affinity DataIC50: 1.70nMAssay Description:Compounds were tested for inhibition of SIK2 kinase (full length, Thermo Fisher) in assays based on the time-resolved fluorescence-resonance energy t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/5/2026
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Beone Medicines I

US Patent
LigandChemical structure of BindingDB Monomer ID 800330BDBM800330(2-(difluoromethoxy)-N-((1R,2S)-2-fluorocyclopropyl...)
Affinity DataIC50: 1.70nMAssay Description:Compounds were tested for inhibition of SIK2 kinase (full length, Thermo Fisher) in assays based on the time-resolved fluorescence-resonance energy t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/5/2026
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Beone Medicines I

US Patent
LigandChemical structure of BindingDB Monomer ID 800347BDBM800347(2-(8-(difluoromethoxy)-6-(6-(1-(1-methylpyrrolidin...)
Affinity DataIC50: 2.60nMAssay Description:Compounds were tested for inhibition of SIK2 kinase (full length, Thermo Fisher) in assays based on the time-resolved fluorescence-resonance energy t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/5/2026
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Beone Medicines I

US Patent
LigandChemical structure of BindingDB Monomer ID 800348BDBM800348(2-(8-(difluoromethoxy)-6-(6-(1-(1-methylazetidin-3...)
Affinity DataIC50: 2.70nMAssay Description:Compounds were tested for inhibition of SIK2 kinase (full length, Thermo Fisher) in assays based on the time-resolved fluorescence-resonance energy t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/5/2026
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Beone Medicines I

US Patent
LigandChemical structure of BindingDB Monomer ID 800344BDBM800344(8-methoxy-6-(6-(1-(1-methylazetidin-3-yl)-1H-pyraz...)
Affinity DataIC50: 2.80nMAssay Description:Compounds were tested for inhibition of SIK2 kinase (full length, Thermo Fisher) in assays based on the time-resolved fluorescence-resonance energy t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/5/2026
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Beone Medicines I

US Patent
LigandChemical structure of BindingDB Monomer ID 800338BDBM800338(8-(difluoromethoxy)-6-(6-(1-(1-methylpyrrolidin-3-...)
Affinity DataIC50: 3nMAssay Description:Compounds were tested for inhibition of SIK2 kinase (full length, Thermo Fisher) in assays based on the time-resolved fluorescence-resonance energy t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/5/2026
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Beone Medicines I

US Patent
LigandChemical structure of BindingDB Monomer ID 800316BDBM800316(2-(difluoromethoxy)-N-((1R,2S)-2-fluorocyclopropyl...)
Affinity DataIC50: 3.40nMAssay Description:Compounds were tested for inhibition of SIK2 kinase (full length, Thermo Fisher) in assays based on the time-resolved fluorescence-resonance energy t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/5/2026
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Beone Medicines I

US Patent
LigandChemical structure of BindingDB Monomer ID 800342BDBM800342(8-methoxy-6-(6-(1-(1-methylpyrrolidin-3-yl)-1H-pyr...)
Affinity DataIC50: 3.70nMAssay Description:Compounds were tested for inhibition of SIK2 kinase (full length, Thermo Fisher) in assays based on the time-resolved fluorescence-resonance energy t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/5/2026
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK3 [59-365](Human)
Beone Medicines I

US Patent
LigandChemical structure of BindingDB Monomer ID 800329BDBM800329(2-(difluoromethoxy)-N-((1R,2S)-2-fluorocyclopropyl...)
Affinity DataIC50: 3.90nMAssay Description:Compounds were tested for inhibition of SIK3 kinase (aa59-365, Thermo Fisher) in assays based on the time-resolved fluorescence-resonance energy tran...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/5/2026
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Beone Medicines I

US Patent
LigandChemical structure of BindingDB Monomer ID 800346BDBM800346(2-(8-(difluoromethoxy)-6-(6-(1-(1-methylpiperidin-...)
Affinity DataIC50: 3.90nMAssay Description:Compounds were tested for inhibition of SIK2 kinase (full length, Thermo Fisher) in assays based on the time-resolved fluorescence-resonance energy t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/5/2026
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK3 [59-365](Human)
Beone Medicines I

US Patent
LigandChemical structure of BindingDB Monomer ID 800330BDBM800330(2-(difluoromethoxy)-N-((1R,2S)-2-fluorocyclopropyl...)
Affinity DataIC50: 4.10nMAssay Description:Compounds were tested for inhibition of SIK3 kinase (aa59-365, Thermo Fisher) in assays based on the time-resolved fluorescence-resonance energy tran...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/5/2026
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK3 [59-365](Human)
Beone Medicines I

US Patent
LigandChemical structure of BindingDB Monomer ID 800328BDBM800328(2-(difluoromethoxy)-N-((1R,2S)-2-fluorocyclopropyl...)
Affinity DataIC50: 4.20nMAssay Description:Compounds were tested for inhibition of SIK3 kinase (aa59-365, Thermo Fisher) in assays based on the time-resolved fluorescence-resonance energy tran...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/5/2026
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Beone Medicines I

US Patent
LigandChemical structure of BindingDB Monomer ID 800343BDBM800343(8-methoxy-6-(6-(1-(1-methylpiperidin-4-yl)-1H-pyra...)
Affinity DataIC50: 4.90nMAssay Description:Compounds were tested for inhibition of SIK2 kinase (full length, Thermo Fisher) in assays based on the time-resolved fluorescence-resonance energy t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/5/2026
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK3 [59-365](Human)
Beone Medicines I

US Patent
LigandChemical structure of BindingDB Monomer ID 800316BDBM800316(2-(difluoromethoxy)-N-((1R,2S)-2-fluorocyclopropyl...)
Affinity DataIC50: 5nMAssay Description:Compounds were tested for inhibition of SIK3 kinase (aa59-365, Thermo Fisher) in assays based on the time-resolved fluorescence-resonance energy tran...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/5/2026
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Beone Medicines I

US Patent
LigandChemical structure of BindingDB Monomer ID 800335BDBM800335(8-(difluoromethoxy)-6-(6-(1-(1-methylazetidin-3-yl...)
Affinity DataIC50: 5.20nMAssay Description:Compounds were tested for inhibition of SIK2 kinase (full length, Thermo Fisher) in assays based on the time-resolved fluorescence-resonance energy t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/5/2026
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Beone Medicines I

US Patent
LigandChemical structure of BindingDB Monomer ID 800363BDBM800363(2-(difluoromethoxy)-N-((1R,2S)-2-fluorocyclopropyl...)
Affinity DataIC50: 6nMAssay Description:Compounds were tested for inhibition of SIK2 kinase (full length, Thermo Fisher) in assays based on the time-resolved fluorescence-resonance energy t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/5/2026
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Beone Medicines I

US Patent
LigandChemical structure of BindingDB Monomer ID 800345BDBM800345(3-(3-(4-(3-(8-methoxy-1-oxo-2-(2,2,2-trifluoroethy...)
Affinity DataIC50: 6.90nMAssay Description:Compounds were tested for inhibition of SIK2 kinase (full length, Thermo Fisher) in assays based on the time-resolved fluorescence-resonance energy t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/5/2026
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Beone Medicines I

US Patent
LigandChemical structure of BindingDB Monomer ID 800337BDBM800337(8-(difluoromethoxy)-6-(6-(1-(1-methylpiperidin-4-y...)
Affinity DataIC50: 7.80nMAssay Description:Compounds were tested for inhibition of SIK2 kinase (full length, Thermo Fisher) in assays based on the time-resolved fluorescence-resonance energy t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/5/2026
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Beone Medicines I

US Patent
LigandChemical structure of BindingDB Monomer ID 800334BDBM800334(8-(difluoromethoxy)-6-(6-(1-(piperidin-4-yl)-1H-py...)
Affinity DataIC50: 8nMAssay Description:Compounds were tested for inhibition of SIK2 kinase (full length, Thermo Fisher) in assays based on the time-resolved fluorescence-resonance energy t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/5/2026
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Beone Medicines I

US Patent
LigandChemical structure of BindingDB Monomer ID 800376BDBM800376(2-(difluoromethoxy)-N-((1R,2S)-2-fluorocyclopropyl...)
Affinity DataIC50: 8.10nMAssay Description:Compounds were tested for inhibition of SIK2 kinase (full length, Thermo Fisher) in assays based on the time-resolved fluorescence-resonance energy t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/5/2026
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Beone Medicines I

US Patent
LigandChemical structure of BindingDB Monomer ID 800375BDBM800375(2-(difluoromethoxy)-N-((1R,2S)-2-fluorocyclopropyl...)
Affinity DataIC50: 9nMAssay Description:Compounds were tested for inhibition of SIK2 kinase (full length, Thermo Fisher) in assays based on the time-resolved fluorescence-resonance energy t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/5/2026
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Beone Medicines I

US Patent
LigandChemical structure of BindingDB Monomer ID 800336BDBM800336(3-(3-(4-(3-(8-(difluoromethoxy)-1-oxo-2-(2,2,2-tri...)
Affinity DataIC50: 9.80nMAssay Description:Compounds were tested for inhibition of SIK2 kinase (full length, Thermo Fisher) in assays based on the time-resolved fluorescence-resonance energy t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/5/2026
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Beone Medicines I

US Patent
LigandChemical structure of BindingDB Monomer ID 800291BDBM800291(8-methoxy-6-(6-(1-methyl-1H-pyrazol-4-yl)benzofura...)
Affinity DataIC50: 10nMAssay Description:Compounds were tested for inhibition of SIK2 kinase (full length, Thermo Fisher) in assays based on the time-resolved fluorescence-resonance energy t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/5/2026
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Beone Medicines I

US Patent
LigandChemical structure of BindingDB Monomer ID 800311BDBM800311(2-(8-(difluoromethoxy)-6-(6-(1-methyl-1H-pyrazol-4...)
Affinity DataIC50: 11nMAssay Description:Compounds were tested for inhibition of SIK2 kinase (full length, Thermo Fisher) in assays based on the time-resolved fluorescence-resonance energy t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/5/2026
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Beone Medicines I

US Patent
LigandChemical structure of BindingDB Monomer ID 800339BDBM800339(8-(difluoromethoxy)-6-(6-(1-(pyrrolidin-3-yl)-1H-p...)
Affinity DataIC50: 11nMAssay Description:Compounds were tested for inhibition of SIK2 kinase (full length, Thermo Fisher) in assays based on the time-resolved fluorescence-resonance energy t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/5/2026
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Beone Medicines I

US Patent
LigandChemical structure of BindingDB Monomer ID 800340BDBM800340(8-methoxy-6-(6-(1-(tetrahydrofuran-3-yl)-1H-pyrazo...)
Affinity DataIC50: 11nMAssay Description:Compounds were tested for inhibition of SIK2 kinase (full length, Thermo Fisher) in assays based on the time-resolved fluorescence-resonance energy t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/5/2026
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Beone Medicines I

US Patent
LigandChemical structure of BindingDB Monomer ID 800372BDBM800372(2-(difluoromethoxy)-N-((1R,2S)-2-fluorocyclopropyl...)
Affinity DataIC50: 11nMAssay Description:Compounds were tested for inhibition of SIK2 kinase (full length, Thermo Fisher) in assays based on the time-resolved fluorescence-resonance energy t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/5/2026
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Beone Medicines I

US Patent
LigandChemical structure of BindingDB Monomer ID 800310BDBM800310(2-(8-methoxy-6-(6-(1-methyl-1H-pyrazol-4-yl)benzof...)
Affinity DataIC50: 12nMAssay Description:Compounds were tested for inhibition of SIK2 kinase (full length, Thermo Fisher) in assays based on the time-resolved fluorescence-resonance energy t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/5/2026
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Beone Medicines I

US Patent
LigandChemical structure of BindingDB Monomer ID 800374BDBM800374(2-(difluoromethoxy)-N-((1R,2S)-2-fluorocyclopropyl...)
Affinity DataIC50: 13nMAssay Description:Compounds were tested for inhibition of SIK2 kinase (full length, Thermo Fisher) in assays based on the time-resolved fluorescence-resonance energy t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/5/2026
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Beone Medicines I

US Patent
LigandChemical structure of BindingDB Monomer ID 800423BDBM800423(N-cyclopropyl-2-(difluoromethoxy)-6-methoxy-4-(6-(...)
Affinity DataIC50: 13nMAssay Description:Compounds were tested for inhibition of SIK2 kinase (full length, Thermo Fisher) in assays based on the time-resolved fluorescence-resonance energy t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/5/2026
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Beone Medicines I

US Patent
LigandChemical structure of BindingDB Monomer ID 800381BDBM800381(2-(difluoromethoxy)-N-((1R,2S)-2-fluorocyclopropyl...)
Affinity DataIC50: 13nMAssay Description:Compounds were tested for inhibition of SIK2 kinase (full length, Thermo Fisher) in assays based on the time-resolved fluorescence-resonance energy t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/5/2026
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Beone Medicines I

US Patent
LigandChemical structure of BindingDB Monomer ID 800331BDBM800331(8-(difluoromethoxy)-6-(6-(1-(tetrahydrofuran-3-yl)...)
Affinity DataIC50: 14nMAssay Description:Compounds were tested for inhibition of SIK2 kinase (full length, Thermo Fisher) in assays based on the time-resolved fluorescence-resonance energy t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/5/2026
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK3 [59-365](Human)
Beone Medicines I

US Patent
LigandChemical structure of BindingDB Monomer ID 800310BDBM800310(2-(8-methoxy-6-(6-(1-methyl-1H-pyrazol-4-yl)benzof...)
Affinity DataIC50: 14nMAssay Description:Compounds were tested for inhibition of SIK3 kinase (aa59-365, Thermo Fisher) in assays based on the time-resolved fluorescence-resonance energy tran...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/5/2026
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Beone Medicines I

US Patent
LigandChemical structure of BindingDB Monomer ID 800297BDBM800297(8-methoxy-6-(6-(1-methyl-1H-imidazol-4-yl)benzofur...)
Affinity DataIC50: 14nMAssay Description:Compounds were tested for inhibition of SIK2 kinase (full length, Thermo Fisher) in assays based on the time-resolved fluorescence-resonance energy t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/5/2026
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Beone Medicines I

US Patent
LigandChemical structure of BindingDB Monomer ID 800361BDBM800361(2-(difluoromethoxy)-N-((1R,2S)-2-fluorocyclopropyl...)
Affinity DataIC50: 14nMAssay Description:Compounds were tested for inhibition of SIK2 kinase (full length, Thermo Fisher) in assays based on the time-resolved fluorescence-resonance energy t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/5/2026
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Beone Medicines I

US Patent
LigandChemical structure of BindingDB Monomer ID 800315BDBM800315(2-(difluoromethoxy)-6-methoxy-4-(6-(1-methyl-1H-py...)
Affinity DataIC50: 15nMAssay Description:Compounds were tested for inhibition of SIK2 kinase (full length, Thermo Fisher) in assays based on the time-resolved fluorescence-resonance energy t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/5/2026
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK3 [59-365](Human)
Beone Medicines I

US Patent
LigandChemical structure of BindingDB Monomer ID 800347BDBM800347(2-(8-(difluoromethoxy)-6-(6-(1-(1-methylpyrrolidin...)
Affinity DataIC50: 15nMAssay Description:Compounds were tested for inhibition of SIK3 kinase (aa59-365, Thermo Fisher) in assays based on the time-resolved fluorescence-resonance energy tran...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/5/2026
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK3 [59-365](Human)
Beone Medicines I

US Patent
LigandChemical structure of BindingDB Monomer ID 800311BDBM800311(2-(8-(difluoromethoxy)-6-(6-(1-methyl-1H-pyrazol-4...)
Affinity DataIC50: 15nMAssay Description:Compounds were tested for inhibition of SIK3 kinase (aa59-365, Thermo Fisher) in assays based on the time-resolved fluorescence-resonance energy tran...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/5/2026
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK3 [59-365](Human)
Beone Medicines I

US Patent
LigandChemical structure of BindingDB Monomer ID 800423BDBM800423(N-cyclopropyl-2-(difluoromethoxy)-6-methoxy-4-(6-(...)
Affinity DataIC50: 15nMAssay Description:Compounds were tested for inhibition of SIK3 kinase (aa59-365, Thermo Fisher) in assays based on the time-resolved fluorescence-resonance energy tran...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/5/2026
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Beone Medicines I

US Patent
LigandChemical structure of BindingDB Monomer ID 800292BDBM800292(6-(6-(1-ethyl-1H-pyrazol-4-yl)benzofuran-3-yl)-8-m...)
Affinity DataIC50: 15nMAssay Description:Compounds were tested for inhibition of SIK2 kinase (full length, Thermo Fisher) in assays based on the time-resolved fluorescence-resonance energy t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/5/2026
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Beone Medicines I

US Patent
LigandChemical structure of BindingDB Monomer ID 800319BDBM800319((S)-8-methoxy-3-methyl-6-(6-(1-methyl-1H-pyrazol-4...)
Affinity DataIC50: 15nMAssay Description:Compounds were tested for inhibition of SIK2 kinase (full length, Thermo Fisher) in assays based on the time-resolved fluorescence-resonance energy t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/5/2026
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Beone Medicines I

US Patent
LigandChemical structure of BindingDB Monomer ID 800373BDBM800373(2-(difluoromethoxy)-N-((1R,2S)-2-fluorocyclopropyl...)
Affinity DataIC50: 15nMAssay Description:Compounds were tested for inhibition of SIK2 kinase (full length, Thermo Fisher) in assays based on the time-resolved fluorescence-resonance energy t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/5/2026
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Beone Medicines I

US Patent
LigandChemical structure of BindingDB Monomer ID 800366BDBM800366(4-(6-(2-(azetidin-1-yl) ethoxy)benzofuran-3-yl)-2-...)
Affinity DataIC50: 16nMAssay Description:Compounds were tested for inhibition of SIK2 kinase (full length, Thermo Fisher) in assays based on the time-resolved fluorescence-resonance energy t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/5/2026
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Beone Medicines I

US Patent
LigandChemical structure of BindingDB Monomer ID 800379BDBM800379(2-(difluoromethoxy)-N-((1R,2S)-2-fluorocyclopropyl...)
Affinity DataIC50: 17nMAssay Description:Compounds were tested for inhibition of SIK2 kinase (full length, Thermo Fisher) in assays based on the time-resolved fluorescence-resonance energy t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/5/2026
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK3 [59-365](Human)
Beone Medicines I

US Patent
LigandChemical structure of BindingDB Monomer ID 800348BDBM800348(2-(8-(difluoromethoxy)-6-(6-(1-(1-methylazetidin-3...)
Affinity DataIC50: 17nMAssay Description:Compounds were tested for inhibition of SIK3 kinase (aa59-365, Thermo Fisher) in assays based on the time-resolved fluorescence-resonance energy tran...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/5/2026
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Beone Medicines I

US Patent
LigandChemical structure of BindingDB Monomer ID 800341BDBM800341(8-methoxy-6-(6-(1-(tetrahydro-2H-pyran-4-yl)-1H-py...)
Affinity DataIC50: 17nMAssay Description:Compounds were tested for inhibition of SIK2 kinase (full length, Thermo Fisher) in assays based on the time-resolved fluorescence-resonance energy t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/5/2026
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Beone Medicines I

US Patent
LigandChemical structure of BindingDB Monomer ID 800377BDBM800377(2-(difluoromethoxy)-N-((1R,2S)-2-fluorocyclopropyl...)
Affinity DataIC50: 18nMAssay Description:Compounds were tested for inhibition of SIK2 kinase (full length, Thermo Fisher) in assays based on the time-resolved fluorescence-resonance energy t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/5/2026
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Beone Medicines I

US Patent
LigandChemical structure of BindingDB Monomer ID 800415BDBM800415(US20260085053, Example 124)
Affinity DataIC50: 18nMAssay Description:Compounds were tested for inhibition of SIK2 kinase (full length, Thermo Fisher) in assays based on the time-resolved fluorescence-resonance energy t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/5/2026
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK3 [59-365](Human)
Beone Medicines I

US Patent
LigandChemical structure of BindingDB Monomer ID 800346BDBM800346(2-(8-(difluoromethoxy)-6-(6-(1-(1-methylpiperidin-...)
Affinity DataIC50: 18nMAssay Description:Compounds were tested for inhibition of SIK3 kinase (aa59-365, Thermo Fisher) in assays based on the time-resolved fluorescence-resonance energy tran...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/5/2026
Entry Details
US Patent

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